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Conserved domains on  [gi|51701936|sp|Q62361|]
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RecName: Full=Pro-thyrotropin-releasing hormone; Short=Pro-TRH; AltName: Full=Prothyroliberin; Contains: RecName: Full=Thyrotropin-releasing hormone; Short=TRH; AltName: Full=Protirelin; AltName: Full=TSH-releasing factor; AltName: Full=Thyroliberin; AltName: Full=Thyrotropin-releasing factor; Short=TRF; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRH super family cl05155
Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing ...
 6-223 3.13e-35

Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.


The actual alignment was detected with superfamily member pfam05438:

Pssm-ID: 461653 [Multi-domain]  Cd Length: 220  Bit Score: 125.30  E-value: 3.13e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51701936     6 LMMALALIFVLTGIPKSCALLEAAQEEGAVTpdlpgLEKVQVRPERRFLRKDLQRVRGDLG-----AALDSWITKRQHPG 80
Cdd:pfam05438   1 LLLLLSLTLCNLTVNGGQSIPEEDEQDGRSP-----LDDILQRAESLLLRSILKKLQDEDGrndgeSSQPEWLSKRQHPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51701936    81 KREEK--EEDVEAEERGDLGEVGAWRPHKRQHPGRRANQDkdswsdegdsdwlppswlpdffldsWFSDAPQVKRQHPGR 158
Cdd:pfam05438  76 KRYEEdlEKRQHPGRREEEEEESYGDIQKRQHPGKREDEA-------------------------WDSYLELQKRQHPGR 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51701936   159 RSFPW--------MESDVTKRQHPGRRFI----DPELQRSWEETEGEEG---GLMPEKRQHPGKRA-------VGHPCGP 216
Cdd:pfam05438 131 RSLLDqfsdnplgYLSELSKRQHPGRRYLmskrQHPGKRSWEDEDEELDeedLLELEKRQHPGKRFwdnsspdLGSPCDV 210


                  ....*....
gi 51701936   217 QG--ICGQT 223
Cdd:pfam05438 211 LDpaSCSKT 219
 
Name Accession Description Interval E-value
TRH pfam05438
Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing ...
 6-223 3.13e-35

Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.


Pssm-ID: 461653 [Multi-domain]  Cd Length: 220  Bit Score: 125.30  E-value: 3.13e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51701936     6 LMMALALIFVLTGIPKSCALLEAAQEEGAVTpdlpgLEKVQVRPERRFLRKDLQRVRGDLG-----AALDSWITKRQHPG 80
Cdd:pfam05438   1 LLLLLSLTLCNLTVNGGQSIPEEDEQDGRSP-----LDDILQRAESLLLRSILKKLQDEDGrndgeSSQPEWLSKRQHPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51701936    81 KREEK--EEDVEAEERGDLGEVGAWRPHKRQHPGRRANQDkdswsdegdsdwlppswlpdffldsWFSDAPQVKRQHPGR 158
Cdd:pfam05438  76 KRYEEdlEKRQHPGRREEEEEESYGDIQKRQHPGKREDEA-------------------------WDSYLELQKRQHPGR 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51701936   159 RSFPW--------MESDVTKRQHPGRRFI----DPELQRSWEETEGEEG---GLMPEKRQHPGKRA-------VGHPCGP 216
Cdd:pfam05438 131 RSLLDqfsdnplgYLSELSKRQHPGRRYLmskrQHPGKRSWEDEDEELDeedLLELEKRQHPGKRFwdnsspdLGSPCDV 210


                  ....*....
gi 51701936   217 QG--ICGQT 223
Cdd:pfam05438 211 LDpaSCSKT 219
 
Name Accession Description Interval E-value
TRH pfam05438
Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing ...
 6-223 3.13e-35

Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.


Pssm-ID: 461653 [Multi-domain]  Cd Length: 220  Bit Score: 125.30  E-value: 3.13e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51701936     6 LMMALALIFVLTGIPKSCALLEAAQEEGAVTpdlpgLEKVQVRPERRFLRKDLQRVRGDLG-----AALDSWITKRQHPG 80
Cdd:pfam05438   1 LLLLLSLTLCNLTVNGGQSIPEEDEQDGRSP-----LDDILQRAESLLLRSILKKLQDEDGrndgeSSQPEWLSKRQHPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51701936    81 KREEK--EEDVEAEERGDLGEVGAWRPHKRQHPGRRANQDkdswsdegdsdwlppswlpdffldsWFSDAPQVKRQHPGR 158
Cdd:pfam05438  76 KRYEEdlEKRQHPGRREEEEEESYGDIQKRQHPGKREDEA-------------------------WDSYLELQKRQHPGR 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51701936   159 RSFPW--------MESDVTKRQHPGRRFI----DPELQRSWEETEGEEG---GLMPEKRQHPGKRA-------VGHPCGP 216
Cdd:pfam05438 131 RSLLDqfsdnplgYLSELSKRQHPGRRYLmskrQHPGKRSWEDEDEELDeedLLELEKRQHPGKRFwdnsspdLGSPCDV 210


                  ....*....
gi 51701936   217 QG--ICGQT 223
Cdd:pfam05438 211 LDpaSCSKT 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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