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Conserved domains on  [gi|516279992|ref|WP_017683955|]
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IS21-like element ISPsy14 family helper ATPase IstB [Pseudomonas syringae]

Protein Classification

ATP-binding protein( domain architecture ID 11445237)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to the ATPase region of Aquifex aeolicus DnaC helicase loader and to Mycobacterium tuberculosis putative ATP-binding protein Rv3427c in insertion sequence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
1-240 1.28e-112

DNA replication protein DnaC [Replication, recombination and repair];


:

Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 323.27  E-value: 1.28e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992   1 MLPNPTLDKLQTLRLHGMIKALGEQHATPDINDLSFDERLGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPR 80
Cdd:COG1484    1 MLMEELKELLKALKLPGMAEALDELLAQAACDELSYEEFLALLLEAEVAEREQRRIERRLKAARFPAAKTLEDFDFDAQP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  81 GLDKALILQLGSGQWLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAK 160
Cdd:COG1484   81 GLDRRQILELATLDFIERGENLILLGPPGTGKTHLAIALGHEACRAGYRVRFTTAPDLVNELKEARADGRLERLLKRLAK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992 161 TDLLILDDWGLAPFTAAQRRDMLELLDDRYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDRLVHNAYRIELKGESMRRR 240
Cdd:COG1484  161 VDLLILDELGYLPLDAEGAELLFELISDRYERRSTIITSNLPFSEWGEVFGDPTLATAILDRLVHHAHIIELKGESYRLK 240
 
Name Accession Description Interval E-value
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
1-240 1.28e-112

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 323.27  E-value: 1.28e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992   1 MLPNPTLDKLQTLRLHGMIKALGEQHATPDINDLSFDERLGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPR 80
Cdd:COG1484    1 MLMEELKELLKALKLPGMAEALDELLAQAACDELSYEEFLALLLEAEVAEREQRRIERRLKAARFPAAKTLEDFDFDAQP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  81 GLDKALILQLGSGQWLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAK 160
Cdd:COG1484   81 GLDRRQILELATLDFIERGENLILLGPPGTGKTHLAIALGHEACRAGYRVRFTTAPDLVNELKEARADGRLERLLKRLAK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992 161 TDLLILDDWGLAPFTAAQRRDMLELLDDRYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDRLVHNAYRIELKGESMRRR 240
Cdd:COG1484  161 VDLLILDELGYLPLDAEGAELLFELISDRYERRSTIITSNLPFSEWGEVFGDPTLATAILDRLVHHAHIIELKGESYRLK 240
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 10-240 2.52e-110

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 317.11  E-value: 2.52e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  10 LQTLRLHGMIKALGEQHATPDINDLSFDERLGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPRGLDKALILQ 89
Cdd:NF038214   1 LRQLKLPGMARALEELAEQAAREELSFEEFLALLLEAELAERENRRIERRLKRARFPAAKTLEDFDFTAAPGLDKAQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  90 LGSGQWLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAKTDLLILDDW 169
Cdd:NF038214  81 LATLDFIERAENVLLLGPPGTGKTHLAIALGYAACRQGYRVRFTTAADLVEQLAQARADGRLGRLLRRLARYDLLIIDEL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516279992 170 GLAPFTAAQRRDMLELLDDRYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDRLVHNAYRIELKGESMRRR 240
Cdd:NF038214 161 GYLPFSREGANLLFELIADRYERGSTIITSNLPFSEWGEVFGDPTLAAAILDRLVHHAHILELKGESYRLK 231
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 10-240 6.12e-81

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 242.74  E-value: 6.12e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992   10 LQTLRLHGMIKALGEQHATPDINDLSFDERLGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPRGLDKALILQ 89
Cdd:pfam01695   3 LKQLKLPGMAEAWEELSQQAASTSLSYEEFLEHLLEEELAWRDTRRLERLLRMAKLPPHKTLEDFDFTFAPGLDQRIVAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992   90 LGSGQWLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAKTDLLILDDW 169
Cdd:pfam01695  83 LASLSFIDRAQNVVLLGPPGVGKTHLAIALGVEACRAGYSVRFTSAADLVNQLKRAHGDGKLTRKLQQLLKPDVLILDEW 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516279992  170 GLAPFTAAQRRDMLELLDDRYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDRLVHNAYRIELKGESMRRR 240
Cdd:pfam01695 163 GYLPLDQAEANLLFQVISKRYEHRSIILTSNLPFGEWGQVFGDAVLATAILDRLLHHCHIVPIKGESYRLK 233
PRK06526 PRK06526
transposase; Provisional
 10-250 2.97e-37

transposase; Provisional


Pssm-ID: 180607  Cd Length: 254  Bit Score: 131.53  E-value: 2.97e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  10 LQTLRLHGMIKALGEQHATpdiNDLSFDERLGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPRGLDKALILQ 89
Cdd:PRK06526  12 LKAPTLAGAVERLAERARA---ESWSHEEFLAACLQREVAARESHGGEGRIRAARFPARKSLEEFDFDHQRSLKRDTIAH 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  90 LGSGQWLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAKTDLLILDDW 169
Cdd:PRK06526  89 LGTLDFVTGKENVVFLGPPGTGKTHLAIGLGIRACQAGHRVLFATAAQWVARLAAAHHAGRLQAELVKLGRYPLLIVDEV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992 170 GLAPFTAAQRRDMLELLDDRYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDRLVHNAYRIELKGESMRRRATKLTSAGA 249
Cdd:PRK06526 169 GYIPFEPEAANLFFQLVSSRYERASLIVTSNKPFGRWGEVFGDDVVAAAMIDRLVHHAEVISLKGDSYRLKDRDLGRVPA 248


                 .
gi 516279992 250 S 250
Cdd:PRK06526 249 A 249
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 95-197 3.01e-12

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 62.55  E-value: 3.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  95 WLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLA----HGDGRFAKLMAGYAKTDLLILDDWG 170
Cdd:cd00009   15 ELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAelfgHFLVRLLFELAEKAKPGVLFIDEID 94

                         90       100
                 ....*....|....*....|....*....
gi 516279992 171 LAP--FTAAQRRDMLELLDDRYGNRSTLV 197
Cdd:cd00009   95 SLSrgAQNALLRVLETLNDLRIDRENVRV 123
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 99-222 4.47e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.36  E-value: 4.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992    99 GLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDG---------------RFAKLMAGYAKTDL 163
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIivggkkasgsgelrlRLALALARKLKPDV 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516279992   164 LILDDWGLA--PFTAAQRRDMLELLDD----RYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDR 222
Cdd:smart00382  82 LILDEITSLldAEQEALLLLLEELRLLlllkSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLL 146
bioD TIGR00347
dethiobiotin synthase; Dethiobiotin synthase is involved in biotin biosynthesis and catalyses ...
 102-135 2.30e-03

dethiobiotin synthase; Dethiobiotin synthase is involved in biotin biosynthesis and catalyses the reaction (CO2 + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP). The enzyme binds ATP (see motif in first 12 residues of the SEED alignment) and requires magnesium as a co-factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 129447 [Multi-domain]  Cd Length: 166  Bit Score: 37.72  E-value: 2.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 516279992  102 LIIGGPTGVGKTWLACALAHKACRDGYSVRYLRL 135
Cdd:TIGR00347   1 FVTGTDTGVGKTVASSALAAKLKKAGYSVGYYKP 34
 
Name Accession Description Interval E-value
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
1-240 1.28e-112

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 323.27  E-value: 1.28e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992   1 MLPNPTLDKLQTLRLHGMIKALGEQHATPDINDLSFDERLGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPR 80
Cdd:COG1484    1 MLMEELKELLKALKLPGMAEALDELLAQAACDELSYEEFLALLLEAEVAEREQRRIERRLKAARFPAAKTLEDFDFDAQP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  81 GLDKALILQLGSGQWLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAK 160
Cdd:COG1484   81 GLDRRQILELATLDFIERGENLILLGPPGTGKTHLAIALGHEACRAGYRVRFTTAPDLVNELKEARADGRLERLLKRLAK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992 161 TDLLILDDWGLAPFTAAQRRDMLELLDDRYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDRLVHNAYRIELKGESMRRR 240
Cdd:COG1484  161 VDLLILDELGYLPLDAEGAELLFELISDRYERRSTIITSNLPFSEWGEVFGDPTLATAILDRLVHHAHIIELKGESYRLK 240
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 10-240 2.52e-110

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 317.11  E-value: 2.52e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  10 LQTLRLHGMIKALGEQHATPDINDLSFDERLGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPRGLDKALILQ 89
Cdd:NF038214   1 LRQLKLPGMARALEELAEQAAREELSFEEFLALLLEAELAERENRRIERRLKRARFPAAKTLEDFDFTAAPGLDKAQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  90 LGSGQWLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAKTDLLILDDW 169
Cdd:NF038214  81 LATLDFIERAENVLLLGPPGTGKTHLAIALGYAACRQGYRVRFTTAADLVEQLAQARADGRLGRLLRRLARYDLLIIDEL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516279992 170 GLAPFTAAQRRDMLELLDDRYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDRLVHNAYRIELKGESMRRR 240
Cdd:NF038214 161 GYLPFSREGANLLFELIADRYERGSTIITSNLPFSEWGEVFGDPTLAAAILDRLVHHAHILELKGESYRLK 231
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 10-240 6.12e-81

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 242.74  E-value: 6.12e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992   10 LQTLRLHGMIKALGEQHATPDINDLSFDERLGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPRGLDKALILQ 89
Cdd:pfam01695   3 LKQLKLPGMAEAWEELSQQAASTSLSYEEFLEHLLEEELAWRDTRRLERLLRMAKLPPHKTLEDFDFTFAPGLDQRIVAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992   90 LGSGQWLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAKTDLLILDDW 169
Cdd:pfam01695  83 LASLSFIDRAQNVVLLGPPGVGKTHLAIALGVEACRAGYSVRFTSAADLVNQLKRAHGDGKLTRKLQQLLKPDVLILDEW 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516279992  170 GLAPFTAAQRRDMLELLDDRYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDRLVHNAYRIELKGESMRRR 240
Cdd:pfam01695 163 GYLPLDQAEANLLFQVISKRYEHRSIILTSNLPFGEWGQVFGDAVLATAILDRLLHHCHIVPIKGESYRLK 233
PRK06526 PRK06526
transposase; Provisional
 10-250 2.97e-37

transposase; Provisional


Pssm-ID: 180607  Cd Length: 254  Bit Score: 131.53  E-value: 2.97e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  10 LQTLRLHGMIKALGEQHATpdiNDLSFDERLGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPRGLDKALILQ 89
Cdd:PRK06526  12 LKAPTLAGAVERLAERARA---ESWSHEEFLAACLQREVAARESHGGEGRIRAARFPARKSLEEFDFDHQRSLKRDTIAH 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  90 LGSGQWLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAKTDLLILDDW 169
Cdd:PRK06526  89 LGTLDFVTGKENVVFLGPPGTGKTHLAIGLGIRACQAGHRVLFATAAQWVARLAAAHHAGRLQAELVKLGRYPLLIVDEV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992 170 GLAPFTAAQRRDMLELLDDRYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDRLVHNAYRIELKGESMRRRATKLTSAGA 249
Cdd:PRK06526 169 GYIPFEPEAANLFFQLVSSRYERASLIVTSNKPFGRWGEVFGDDVVAAAMIDRLVHHAEVISLKGDSYRLKDRDLGRVPA 248


                 .
gi 516279992 250 S 250
Cdd:PRK06526 249 A 249
PRK09183 PRK09183
transposase/IS protein; Provisional
 8-238 1.73e-32

transposase/IS protein; Provisional


Pssm-ID: 181681  Cd Length: 259  Bit Score: 119.04  E-value: 1.73e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992   8 DKLQTLRLHGMIKALGEQHATpdiNDLSFDERLGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPRGLDKALI 87
Cdd:PRK09183  14 GQLQLESLISAAPALAQQAVD---QEWSYMDFLEHLLHEEKLARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGAPQKQL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  88 LQLGSGQWLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMA-GYAKTDLLIL 166
Cdd:PRK09183  91 QSLRSLSFIERNENIVLLGPSGVGKTHLAIALGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQrGVMAPRLLII 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516279992 167 DDWGLAPFTAAQRRDMLELLDDRYGNRSTLVTSQMPVDKWH-ALIGDPTLGDAILDRLVHNAYRIELKGESMR 238
Cdd:PRK09183 171 DEIGYLPFSQEEANLFFQVIAKRYEKGSMILTSNLPFGQWDqTFAGDAALTSAMLDRLLHHSHVVQIKGESYR 243
PRK08181 PRK08181
transposase; Validated
 40-241 2.47e-30

transposase; Validated


Pssm-ID: 136670 [Multi-domain]  Cd Length: 269  Bit Score: 113.87  E-value: 2.47e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  40 LGLMVDRELTEREDARMTTRLKAARLRHNACLEDIDYRSPRGLDKALILQLGSGQ-WLRDGLNLIIGGPTGVGKTWLACA 118
Cdd:PRK08181  46 LAAIAEHELAERARRRIERHLAEAHLPPGKTLDSFDFEAVPMVSKAQVMAIAAGDsWLAKGANLLLFGPPGGGKSHLAAA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992 119 LAHKACRDGYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAKTDLLILDDWGLAPFTAAQRRDMLELLDDRYGNRSTLVT 198
Cdd:PRK08181 126 IGLALIENGWRVLFTRTTDLVQKLQVARRELQLESAIAKLDKFDLLILDDLAYVTKDQAETSVLFELISARYERRSILIT 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 516279992 199 SQMPVDKWHALIGDPTLGDAILDRLVHNAYRIELKGESMRRRA 241
Cdd:PRK08181 206 ANQPFGEWNRVFPDPAMTLAAVDRLVHHATIFEMNVESYRRRT 248
PRK08116 PRK08116
hypothetical protein; Validated
 45-243 3.08e-13

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 67.35  E-value: 3.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  45 DRELTEREDARMTTRLKAARLRH--NACLEDIDYR------------SPRGLDKALILQLGSGQWLRDGLNLIIGGPTGV 110
Cdd:PRK08116  46 EREAEEAKEREEENREKQRRIERlkSNSLLDEKFRnstfenflfdkgSEKAYKIARKYVKKFEEMKKENVGLLLWGSVGT 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992 111 GKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGD-GRFAK--LMAGYAKTDLLILDDWGLAPFTAAQRRDMLELLD 187
Cdd:PRK08116 126 GKTYLAACIANELIEKGVPVIFVNFPQLLNRIKSTYKSsGKEDEneIIRSLVNADLLILDDLGAERDTEWAREKVYNIID 205

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 516279992 188 DRYGN-RSTLVTSQMPVDKWHAligdpTLGDAILDRLVHNAYRIELKGESMRRRATK 243
Cdd:PRK08116 206 SRYRKgLPTIVTTNLSLEELKN-----QYGKRIYDRILEMCTPVENEGKSYRKEIAK 257
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 95-197 3.01e-12

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 62.55  E-value: 3.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  95 WLRDGLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLA----HGDGRFAKLMAGYAKTDLLILDDWG 170
Cdd:cd00009   15 ELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAelfgHFLVRLLFELAEKAKPGVLFIDEID 94

                         90       100
                 ....*....|....*....|....*....
gi 516279992 171 LAP--FTAAQRRDMLELLDDRYGNRSTLV 197
Cdd:cd00009   95 SLSrgAQNALLRVLETLNDLRIDRENVRV 123
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 101-240 2.05e-10

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 59.91  E-value: 2.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992 101 NLIIGGPTGVGKTWLACALAhKACRD-GYSVRYLRLPRLMEELglahGDGRFAKLMAGYAKT------DLLILDDWGLAP 173
Cdd:PRK06835 185 NLLFYGNTGTGKTFLSNCIA-KELLDrGKSVIYRTADELIEIL----REIRFNNDKELEEVYdllincDLLIIDDLGTEK 259

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516279992 174 FTAAQRRDMLELLDDRY-GNRSTLVTSQMPVDKwhalIGDpTLGDAILDRLVHNAYRIELKGESMRRR 240
Cdd:PRK06835 260 ITEFSKSELFNLINKRLlRQKKMIISTNLSLEE----LLK-TYSERISSRLLGNFTLLKFYGEDIRIK 322
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 67-170 5.42e-07

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 49.48  E-value: 5.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  67 HNACLEDIDyRSPRGLDKAL------ILQLGSGQWLRdGLNLIigGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLME 140
Cdd:PRK08939 122 LQASLADID-LDDRDRLDALmaaldfLEAYPPGEKVK-GLYLY--GDFGVGKSYLLAAIANELAKKGVSSTLLHFPEFIR 197

                         90       100       110
                 ....*....|....*....|....*....|
gi 516279992 141 ELGLAHGDGRFAKLMAGYAKTDLLILDDWG 170
Cdd:PRK08939 198 ELKNSISDGSVKEKIDAVKEAPVLMLDDIG 227
PRK12377 PRK12377
putative replication protein; Provisional
 101-238 5.73e-07

putative replication protein; Provisional


Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 49.06  E-value: 5.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992 101 NLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDGRF-AKLMAGYAKTDLLILDDWGLAPFTAAQR 179
Cdd:PRK12377 103 NFVFSGKPGTGKNHLAAAIGNRLLAKGRSVIVVTVPDVMSRLHESYDNGQSgEKFLQELCKVDLLVLDEIGIQRETKNEQ 182

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992 180 RDMLELLDDRYgnrSTLVTSQMPVDKWHALIGDpTLGDAILDRLVHNAYR-IELKGESMR 238
Cdd:PRK12377 183 VVLNQIIDRRT---ASMRSVGMLTNLNHEAMST-LLGERVMDRMTMNGGRwVNFNWESWR 238
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
102-168 3.61e-05

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 44.03  E-value: 3.61e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516279992 102 LIIGGPTGVGKTWLACALAHKACRD--GYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAKTDLLILDD 168
Cdd:COG0593   37 LFLYGGVGLGKTHLLHAIGNEALENnpGARVVYLTAEEFTNDFINAIRNNTIEEFKEKYRSVDVLLIDD 105
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 99-222 4.47e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.36  E-value: 4.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992    99 GLNLIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPRLMEELGLAHGDG---------------RFAKLMAGYAKTDL 163
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIivggkkasgsgelrlRLALALARKLKPDV 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516279992   164 LILDDWGLA--PFTAAQRRDMLELLDD----RYGNRSTLVTSQMPVDKWHALIGDPTLGDAILDR 222
Cdd:smart00382  82 LILDEITSLldAEQEALLLLLEELRLLlllkSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLL 146
Bac_DnaA pfam00308
Bacterial dnaA protein;
102-168 4.45e-04

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 40.39  E-value: 4.45e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516279992  102 LIIGGPTGVGKTWLACALAHKACRD--GYSVRYLRLPRLMEELGLAHGDGRFAKLMAGYAKTDLLILDD 168
Cdd:pfam00308  37 LFIYGGVGLGKTHLLHAIGNYALQNapNLRVVYLTAEEFLNDFVDAIRDNKTNQFKEKYRNVDVLLIDD 105
BioD COG0132
Dethiobiotin synthetase [Coenzyme transport and metabolism]; Dethiobiotin synthetase is part ...
 108-133 8.62e-04

Dethiobiotin synthetase [Coenzyme transport and metabolism]; Dethiobiotin synthetase is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439902 [Multi-domain]  Cd Length: 222  Bit Score: 39.37  E-value: 8.62e-04
                         10        20
                 ....*....|....*....|....*.
gi 516279992 108 TGVGKTWLACALAHKACRDGYSVRYL 133
Cdd:COG0132   11 TDVGKTVVTAALAAALRAAGLRVGYY 36
bioD TIGR00347
dethiobiotin synthase; Dethiobiotin synthase is involved in biotin biosynthesis and catalyses ...
 102-135 2.30e-03

dethiobiotin synthase; Dethiobiotin synthase is involved in biotin biosynthesis and catalyses the reaction (CO2 + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP). The enzyme binds ATP (see motif in first 12 residues of the SEED alignment) and requires magnesium as a co-factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 129447 [Multi-domain]  Cd Length: 166  Bit Score: 37.72  E-value: 2.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 516279992  102 LIIGGPTGVGKTWLACALAHKACRDGYSVRYLRL 135
Cdd:TIGR00347   1 FVTGTDTGVGKTVASSALAAKLKKAGYSVGYYKP 34
PspF COG1221
Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain ...
 98-116 2.70e-03

Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription, Signal transduction mechanisms];


Pssm-ID: 440834 [Multi-domain]  Cd Length: 835  Bit Score: 38.94  E-value: 2.70e-03
                         10
                 ....*....|....*....
gi 516279992  98 DGLNLIIGGPTGVGKTWLA 116
Cdd:COG1221  129 KGLHTLILGPTGVGKSFFA 147
AAA_22 pfam13401
AAA domain;
102-197 6.91e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 35.78  E-value: 6.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  102 LIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLP------------------RLMEELGLAHGDGRFAKLMAGYAKTDL 163
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQLPEVRDSVVFVDLPsgtspkdllrallralglPLSGRLSKEELLAALQQLLLALAVAVV 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 516279992  164 LILDDwglapftaAQR--RDMLELLDDRYGNRSTLV 197
Cdd:pfam13401  88 LIIDE--------AQHlsLEALEELRDLLNLSSKLL 115
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 84-225 6.94e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 36.07  E-value: 6.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516279992  84 KALILQLGSGQWLrdglnlIIGGPTGVGKTWLACALAH-------KACRDGYSVRYLRLPRLMEELGLAHG--DG---RF 151
Cdd:cd00267   16 DNVSLTLKAGEIV------ALVGPNGSGKSTLLRAIAGllkptsgEILIDGKDIAKLPLEELRRRIGYVPQlsGGqrqRV 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516279992 152 AKLMAGYAKTDLLILD--DWGLAPFTAAQRRDMLELLDDRygNRSTLVTSQmpvdkwhaligDPTLGDAILDRLVH 225
Cdd:cd00267   90 ALARALLLNPDLLLLDepTSGLDPASRERLLELLRELAEE--GRTVIIVTH-----------DPELAELAADRVIV 152
SIMIBI cd01983
SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal ...
 102-166 8.74e-03

SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal recognition particle, MinD, and BioD), consists of signal recognition particle (SRP) GTPases, the assemblage of MinD-like ATPases, which are involved in protein localization, chromosome partitioning, and membrane transport, and a group of metabolic enzymes with kinase or related phosphate transferase activity. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349751 [Multi-domain]  Cd Length: 107  Bit Score: 35.10  E-value: 8.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516279992 102 LIIGGPTGVGKTWLACALAHKACRDGYSVRYLRLPR--LMEELGLAHGDGRFAKLMAGYA--KTDLLIL 166
Cdd:cd01983    4 AVTGGKGGVGKTTLAAALAVALAAKGYKVLLIDLDDyvLIDGGGGLETGLLLGTIVALLAlkKADEVIV 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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