NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|51527288|ref|YP_068041|]
View 

E3 gp19K [Human mastadenovirus E]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Adeno_GP19K super family cl04819
Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I ...
 41-131 5.32e-11

Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER). The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes.


The actual alignment was detected with superfamily member pfam04881:

Pssm-ID: 461465  Cd Length: 132  Bit Score: 57.43  E-value: 5.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51527288    41 CQLSFQPDGNRCAVLIKCGWECQSVAIQYKNKTRNNTLASTWQPGDPEWYTVSVPGADGfLRTVNNTFIFEHMCNTAMFM 120
Cdd:pfam04881   1 CNVMFKGEAAEAATCIAAKKEEEKEIACHKDFIGEAAECAILIKCDTEDEKLIIFHGDK-IGKFAVKAIFQEGCDIDMNM 79

                          90
                  ....*....|.
gi 51527288   121 SRQYHMWPPRK 131
Cdd:pfam04881  80 SKFQGENPKQF 90
 
Name Accession Description Interval E-value
Adeno_GP19K pfam04881
Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I ...
 41-131 5.32e-11

Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER). The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes.


Pssm-ID: 461465  Cd Length: 132  Bit Score: 57.43  E-value: 5.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51527288    41 CQLSFQPDGNRCAVLIKCGWECQSVAIQYKNKTRNNTLASTWQPGDPEWYTVSVPGADGfLRTVNNTFIFEHMCNTAMFM 120
Cdd:pfam04881   1 CNVMFKGEAAEAATCIAAKKEEEKEIACHKDFIGEAAECAILIKCDTEDEKLIIFHGDK-IGKFAVKAIFQEGCDIDMNM 79

                          90
                  ....*....|.
gi 51527288   121 SRQYHMWPPRK 131
Cdd:pfam04881  80 SKFQGENPKQF 90
 
Name Accession Description Interval E-value
Adeno_GP19K pfam04881
Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I ...
 41-131 5.32e-11

Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER). The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes.


Pssm-ID: 461465  Cd Length: 132  Bit Score: 57.43  E-value: 5.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51527288    41 CQLSFQPDGNRCAVLIKCGWECQSVAIQYKNKTRNNTLASTWQPGDPEWYTVSVPGADGfLRTVNNTFIFEHMCNTAMFM 120
Cdd:pfam04881   1 CNVMFKGEAAEAATCIAAKKEEEKEIACHKDFIGEAAECAILIKCDTEDEKLIIFHGDK-IGKFAVKAIFQEGCDIDMNM 79

                          90
                  ....*....|.
gi 51527288   121 SRQYHMWPPRK 131
Cdd:pfam04881  80 SKFQGENPKQF 90
Adeno_GP19K pfam04881
Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I ...
 16-131 6.44e-09

Adenovirus GP19K; This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER). The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes.


Pssm-ID: 461465  Cd Length: 132  Bit Score: 51.66  E-value: 6.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51527288    16 SILGLGSAAVVTEKADPcLTFNPDKCQLSFQPDGNRCAVLIKCGWECQSVAIQYKNKTRNNTLASTWQPGDPEWYTVSV- 94
Cdd:pfam04881   4 MFKGEAAEAATCIAAKK-EEEKEIACHKDFIGEAAECAILIKCDTEDEKLIIFHGDKIGKFAVKAIFQEGCDIDMNMSKf 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 51527288    95 PGADGFLRTVNNTFIFehMCNTAMFMSRQYHMWPPRK 131
Cdd:pfam04881  83 QGENPKQFCLEFPFTE--CCDALLIMAKALKCTLLQK 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH