|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
28-506 |
0e+00 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 872.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 28 SPIVPTDTTAKFALPVDSEHKAKVFRIWSLANPHMRTFHLSWVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTS 107
Cdd:PLN00028 1 QPASPDPKYSKFALPVDSEHKATEFRLFSFARPHMRAFHLSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 108 VSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSAPTVFCMSFVSDAAGYIAVRFMIGFSLATFVSCQYWMSTMFNSQIIGLV 187
Cdd:PLN00028 81 VSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 188 NGTAAGWGNMGGGATQLIMPLLYEVIQRAGATPFTAWRIAFFIPGFLHVLMGILVLTLGQDLPDGNLASLQKKGNVAKDK 267
Cdd:PLN00028 161 NGIAAGWGNLGGGVTQLLMPLVFPLIKDAGAPSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPDGNYRELKKSGTMPKDS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 268 FSNVLWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAEYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDVAARYFG 347
Cdd:PLN00028 241 FSKVLRYGVTNYRTWILALTYGYSFGVELTMDNIIAEYFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARRFG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 348 MRGRLWTLWILQTFGGVFCMWLGKATKLPIAIAAMILFSIGAQAACGATFGIIPFISRRSLGIISGLTGAGGNFGSGLTQ 427
Cdd:PLN00028 321 MRGRLWALWIVQTLGGVFCIWLGRANSLGAAIVVMILFSIFVQAACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVLTQ 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514995788 428 LVFFSTTKYSTDTGLFLMGIMIVCCTLPVTLVHFPQWGSMFLPPTKHVEkstEEFYYGSEWTEDEKKKGLHQQSIKFAE 506
Cdd:PLN00028 401 LLFFTGSSYSTETGISLMGVMIIACTLPVAFIHFPQWGGMFFGPSKDAV---EEDYYASEWTEEEKEKGLHQGSLKFAE 476
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
65-458 |
5.53e-133 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 391.23 E-value: 5.53e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 65 FHLSWVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPR-YGCAFLIMLSAPTVF 143
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRrVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 144 CMSFVSDAAGYIAVRFMIGFSLATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLYEVIQRAGatPFTA 223
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDG--GFVG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 224 WRIAFFIPGFLHVLMGILVLTLGQDLPDGNLASLQkkgnvakdkFSNVLWYAVTNYRTWIFVLLYGYSMGVELSTDNVIA 303
Cdd:cd17341 159 WRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALE---------FLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 304 EYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDVaaryFGMRGRLWTLWILQTFGGVFCMWLGK--ATKLPIAIAA 381
Cdd:cd17341 230 TYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDR----FGGRRRLWWLFIVMTIGAALLSLSLPtsGTNLVLFLAL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514995788 382 MILFSIGAQAACGATFGIIPFISRRSLGIISGLTGAGGNFGSGLTQLVFFSTTK--YSTDTGLFLMGIMIVCCTLPVTL 458
Cdd:cd17341 306 FVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALmtGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
63-422 |
1.39e-83 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 263.39 E-value: 1.39e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 63 RTFHLSWVSFFTCFVSTFAAAPLVP-IIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSAPT 141
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVfLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 142 VFCMSFV-SDAAGYIAVRFMIGFSLATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLL-YEVIQRAGAT 219
Cdd:TIGR00886 81 CLWAGLAvQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIiGSLIFGGGQP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 220 PFTAWRIAF-FIPGFLHVLMGILVLTLGQDLPDGNLASLQKKGNVAKDKFsnvlwyavTNYRTWIFVLLYGYSMGVELST 298
Cdd:TIGR00886 161 AHLAWGWAFvIVPAGILLLPALLIFFVGADTPPGKPATGKLSFKEALKVF--------GNRHTWILALLYSVTFGSFLGV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 299 DNVIAEYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDVAAryfgmRGRLWTLWILQTFGGVFCMWLGKATK--LP 376
Cdd:TIGR00886 233 SSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLG-----GARKLLMNFLGVAMGAFLVVLGLVSDgsLA 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 514995788 377 IAIAAMILFSIGAQAACGATFGIIPFISRRSLGIISGLTGAGGNFG 422
Cdd:TIGR00886 308 AFIVLFVALFFFAGAGNGSTFALVPHIFRRATGAVSGLIGAIGNLG 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
61-454 |
2.29e-49 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 174.68 E-value: 2.29e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 61 HMRTFHLSWVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSAP 140
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 141 TVFCMSFVSDAAGYIAVRFMIGFSL-ATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLYEVIqragat 219
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 220 pftAWRIAFFIPGFLHVLMGILVLTLGQDLPDGNLASlqkkgnvAKDKFSNVLwYAVTNYRTWIFVLLYGYSMGVELSTD 299
Cdd:COG2223 157 ---GWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA-------AKASLRDQL-EALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 300 NVIAEYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDvaaRYfgmrGRLWTLWILQTFGGVFCMWLGKATK-LPIA 378
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD---RI----GGRRVLLIVFALMALGLLLLALALGsLWLF 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514995788 379 IAAMILFSIGAQAACGATFGIIPFI-SRRSLGIISGLTGAGGNFGSGLTQLVF--FSTTKYSTDTGLFLMGIMIVCCTL 454
Cdd:COG2223 299 LVLFLLLGLALGGGNGAVFALVPDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFgaLLDATGSYTAAFLVFAVLALVALV 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
67-459 |
6.33e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.17 E-value: 6.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 67 LSWVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSAPTVFCMS 146
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 147 FVSDAAGYIAVRFMIGFSLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLyeviqragaTPFTAWR 225
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL---------LAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 226 IAFFIPGFLHVLMGILvltlgqdlpdgnlaslqkkgnvakdkfsnvlwyavtnyRTWIFVLLYGYSMGVELSTDNVIAEY 305
Cdd:COG2271 165 AAFLILGLPGLLLALL--------------------------------------RFWLLALAYFLVYFALYGFLTWLPTY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 306 FYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDvaaRYFgmRGRLWTLWILQTFGGVFCMWLGKATKLPIAIAAMILF 385
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD---RLG--RRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLA 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514995788 386 SIGAQAACGATFGIIP-FISRRSLGIISGLTGAGGNFGSGLTQLVF-FSTTKYSTDTGLFLMGIMIVCCTLPVTLV 459
Cdd:COG2271 282 GFGLGGAFGLLWALAAeLFPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
67-425 |
1.33e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 81.31 E-value: 1.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 67 LSWVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSAPTVFCMS 146
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 147 FVSDAAGYIAVRFMIGFSLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLYEVIQragatpftaWR 225
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---------WR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 226 IAFFIPGFLHVLMGILVLTLGQDLPDGNLASLQKKGNVAKDKFSnvlwYAVTNYRTWIFVLLYGYSMGveLSTDNVIAEY 305
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWK----ALLRDPVLWLLLALLLFGFA--FFGLLTYLPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 306 FYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDvaarYFGMRGRLWTLWILQTFGGVFCMWLGKATKLPIAIAAMILF 385
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 514995788 386 SIGAQAACGATFGIIP-FISRRSLGIISGLTGAGGNFGSGL 425
Cdd:pfam07690 302 GFGFGLVFPALNALVSdLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
69-451 |
2.04e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.85 E-value: 2.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 69 WVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGC-AFLIMLSAPTVFcMSF 147
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLlLGLLLFALGALL-FAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 148 VSDAAGYIAVRFMIGFSLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLYEVIqragatpFTAWRI 226
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-------GFGWRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 227 AFFIPGFLHVLMGILVLTLgqdLPDGNLASLQKKGNVAKDKFSNVLWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAEYF 306
Cdd:cd06174 154 VFLIAAALALLAAILLLLV---VPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 307 YDRFDLKLHTAGIIAATFGMANLVARPFGGYASDVAaryfgmRGRLWTLWILQTFGGVFCMWLGKATKLPIAIAAMILFS 386
Cdd:cd06174 231 LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL------IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514995788 387 IGAQAACGATFGIIPFI-SRRSLGIISGLTGAGGNFGSGLTQLVFFSTTKYSTDTGLFLMGIMIVC 451
Cdd:cd06174 305 FGLGGLLPLSFALIAELfPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
69-425 |
1.09e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 75.40 E-value: 1.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 69 WVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSAPTVFCMSFV 148
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 149 SDAAGYIAVRFMIGFSLATFVS-CQYWMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLYEVIqragatpftAWRIA 227
Cdd:COG2814 96 PSLWLLLAARFLQGLGAGALFPaALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---------GWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 228 FFIPGFLHVLMGILVLTLgqdlpdgnlasLQKKGNVAKDKFSNVLWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAEYFY 307
Cdd:COG2814 167 FLVNAVLALLALLLLLRL-----------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 308 DRFDLKLHTAGIIAATFGMANLVARPFGGYASDVaaryfgmRGRLWTLWILQTFGGVFCMWLGKATKLPIAIAAMILFSI 387
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADR-------FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGF 308
|
330 340 350
....*....|....*....|....*....|....*....
gi 514995788 388 GAQAACGATFGIIP-FISRRSLGIISGLTGAGGNFGSGL 425
Cdd:COG2814 309 GFGLLFPLLQALVAeLAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
87-451 |
1.80e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 62.59 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 87 PIIRDNLNLTKVDIGN-AGVTSVSGSIFSrLVMGAVCDLLGPRYGCAFLIMLSAPTVFCMSFVSDAAGYIAVRFMIGFSL 165
Cdd:cd17319 27 PTIMKDLGLSPTQYGLiASAFFLGYALFQ-VPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 166 ATFVSC-----QYWMSTMFNSQIIGLVNgTAAGWGNMGGGatqLIMPLLYEVIqragatpftAWRIAFFIPGFLHVLMGI 240
Cdd:cd17319 106 AGFFPGaikalAEWFPARERGRATGLFN-SGAPLGAAIGP---PLSGWLLLLF---------GWRWAFIIEGLLGLLLAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 241 LVL-TLGQDLPDgnlaslqkkgnvakdkfsnVLWYAVTNYRTWIFVLLygysmgvelstdnvIAEYFYDRFDLKLHTAGI 319
Cdd:cd17319 173 LWWfYLRQVWGL-------------------ALGYFGINYALYGLLTW--------------LPTYLKQARGFSLKQVGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 320 IAATFGMANLVARPFGGYASDvaaRYFGMRgRLWTLWILQTFGGVFCMWLGKATKLPIAIAAMILFSIGAQAACGATFGI 399
Cdd:cd17319 220 LAAIPFLAGAIGMILGGRLSD---RLLRGA-RRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSL 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 514995788 400 IP-FISRRSLGIISGLTGAGGNFGSGLTQLV--FFSTTKYSTDTGLFLMGIMIVC 451
Cdd:cd17319 296 PAdLLPGEAAATAGGLINSGGNLGGFVAPLLigYLVDATGSYTAAFLFLAAVALL 350
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
59-389 |
3.54e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.79 E-value: 3.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 59 NPHMRTFHLSWVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLS 138
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 139 APTVFCMSFVSDAAGYIAVRFMIGFSLATF-VSCQYWMSTMFN---SQIIGLVNGtaagwGNMGGGatqLIMPLLYEVIQ 214
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAALGPetaASRLNLLHA-----FFSLGA---LLGPLLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 215 RAGATPftAWRIAFFIPGFLHVLMGILVLTlgQDLPDGNLASLQKKGNVAKDKFsnvlwyAVTNYRTWIFVLLYGYSMGV 294
Cdd:COG0738 156 LLGLSL--SWHLPYLILAVLLLLLALLFLR--SKLPEIEEEEEEAAGSAASLKS------LLKNPRLLLGGLAIFLYVGA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 295 ELSTDNVIAEYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYasdvAARYFgmrGRLWTLWILQTFGGVFCMWLGKATK 374
Cdd:COG0738 226 EGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGF----LLKRF---GPVRLLRLSALLAAVGLLLALLAPG 298
|
330
....*....|....*
gi 514995788 375 LPIAIAAMILFSIGA 389
Cdd:COG0738 299 PWLALIGLALVGLGL 313
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
61-454 |
5.93e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 58.05 E-value: 5.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 61 HMRTFHLSWVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSAP 140
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 141 TVFCMSFVSDAAGYIAVRFMIG-FSLATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGatqLIMPLLYEVIQRAGat 219
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGlFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGI---LAPILAASLASYYG-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 220 pftaWRIAFFIPGFLHVLMGILVLtlgqdlpdgnlaslqkkgnvakdkfsnvLWYAVTNYRTWIFVLLYGYSMGVELSTD 299
Cdd:cd17312 156 ----WRAAFLVPGIVGLVVAIILF----------------------------FFLRDSPPYVWVLSLAYAFVYIVRYACL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 300 NVIAEYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDVAARyfGMRGRLWTLWILQTFGGVFCMWLGKATKLPIAI 379
Cdd:cd17312 204 DWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFG--GRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIV 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514995788 380 A-AMILFSIGAQAACGATFGIIPFISRRSLGIISGLTGAGGNFGSGLTQLVFFS-TTKYSTDTGLFLMGIMIVCCTL 454
Cdd:cd17312 282 LlFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYiIDHYGWSTVFYFLISAALLSVL 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
69-454 |
8.64e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 8.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 69 WVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNA-GVTSVSGSIFSrLVMGAVCDLLGPRYgcAFLIMLSAPTV--FCM 145
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIvAAYALAQLLFS-PPAGRLSDRFGRKR--LLLLGLLLLAVstLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 146 SFVSDAAGYIAVRFMIGFSLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLYEviqragatpFTAW 224
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD---------ALGY 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 225 RIAFFIPGFLHVLMGILVLTLgqdLPDGNLASlqKKGNVAKDKFSNVLWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAE 304
Cdd:cd17325 150 RAPFLVCAALALLALVLALLL---LPEPRPPP--NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 305 YFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDvaaRYfgmrGRLWTLWILQTFGGVFCMWLGKATKLPIAIAAMIL 384
Cdd:cd17325 225 YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD---RI----GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLAL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514995788 385 FSIGAQAACGATFGII-PFISRRSLGIISGLTGAGGNFGSGLTQLVF-FSTTKYSTDTGLFLMGIMIVCCTL 454
Cdd:cd17325 298 LGLGLGLVFPATLALLaDIVPPEGRGTAMGLFNTAFSLGMVLGPLLGgFLYDAFGFATPFLAAAALLLLAAV 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
63-246 |
5.47e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.88 E-value: 5.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 63 RTFHLSWVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIM--LSAP 140
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGllLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 141 TVFCMSFVSDAAGYIAVRFMIGFSLATFVSCQY-WMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLYEviqragat 219
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWaLAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD-------- 332
|
170 180
....*....|....*....|....*..
gi 514995788 220 pFTAWRIAFFIPGFLHVLMGILVLTLG 246
Cdd:COG2271 333 -ATGYQAAFLLLAALALLAALLALLLL 358
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
113-250 |
7.43e-07 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 51.63 E-value: 7.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 113 FSRLVMGAVCDLLGPRYGCAFLIMLSAPTVFCMSFVSDAAGYIAVRFMIGFSLATFV---------SCQYWMSTMFNSQI 183
Cdd:PRK11273 78 FSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQgmgwppcgrTMVHWWSQKERGGI 157
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514995788 184 IGLVNGTAagwgNMGGGatqlIMPLLYEViqraGATPFTAWRIAFFIPGFLHVLMGILVLTLGQDLP 250
Cdd:PRK11273 158 VSVWNCAH----NVGGG----LPPLLFLL----GMAWFNDWHAALYMPAFAAILVALFAFAMMRDTP 212
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
69-430 |
2.91e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.68 E-value: 2.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 69 WVSFFTCFV--STFAAAplVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSAPTVFCMS 146
Cdd:TIGR00881 1 FIGYAAYYLvrKNFALA--MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 147 FVSDAAGYIAVRFMIGFSLAT-FVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGatqLIMPLLYeviqrAGATPFTAWR 225
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMgWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGG---LLPPLVL-----FGIAELYSWH 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 226 IAFFIPGFLHVLMGILVLTLGQDLP-------------DGNLASLQKKGNVAKDKFSnVLWYAVTNYRTWIFVLLYGYSM 292
Cdd:TIGR00881 151 WVFIVPGIIAIIVSLICFLLLRDSPqscglppaeempnEEPDGDAEKKEEELTKKQI-FLQYVLLNKVLWYISLGYVFVY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 293 GVELSTDNVIAEYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASD--VAARYFGMrGRLWTLWILQTFGGVFCMWLG 370
Cdd:TIGR00881 230 VVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDklFNGRRGPL-AVFFMALIIVSLLVYWLNPAA 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514995788 371 KATKLPIAIAAMILFSIGAQA-ACGATFGIIPfisRRSLGIISGLTGAGGNFGSGLTQLVF 430
Cdd:TIGR00881 309 NPLMDLICLFALGFLVYGPQMlIGVIASELAP---KKAAGTAAGFVGFFAYLGGILAGLPL 366
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
125-294 |
3.15e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 49.55 E-value: 3.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 125 LGPRYGCAFLIMLSAPTVFCMSFVSDAAGYIAVRFMIG-FSLATFVSCQYWMSTMFNSQIIGLVNG---TAAGWGNMGGG 200
Cdd:cd17327 68 FPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGlFESGVFPGFILYLGMWYKREEQAKRIAffyAAAGLGSIFGG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 201 ATQlimpllYEVIQRAGATPFTAWRIAFFIPGFLHVLMGILVLTLGQDLPDGN--------------LASLQKKGNVAKD 266
Cdd:cd17327 148 LLA------YGVFKILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAwflteeekelaverLRANQTGKGDQKF 221
|
170 180
....*....|....*....|....*...
gi 514995788 267 KFSNVlWYAVTNYRTWIFVLLYGYSMGV 294
Cdd:cd17327 222 KWKQI-KEAFKDPRTWLLFLFFFCSQIT 248
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
68-389 |
4.58e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.77 E-value: 4.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 68 SWVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAgVTSVS-GSIFSRLVMGAVCDLLGPRYGCAFLIMLSAPTVFCMS 146
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLL-LSALNlGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 147 FVSDAAGYIAVRFMIGFSLATFV-SCQYWMSTMFNSQIIGLVNG---TAAgwgNMGGGATQLIMPLLYEVIqragatpft 222
Cdd:cd17475 80 LVGSYPVLLVLLFLVGAGYGSVQpGGGRAIMRWFPPRERGLAMGirqTGV---PLGGALAAALLPPLALHY--------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 223 AWRIAFFIPGFLHVLMGILVLTLGQDLPDGNLASLQKKGNVAKDKfsnvlwyAVTNYRTWIFVLLYGYSM-GVELSTDNV 301
Cdd:cd17475 148 GWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLK-------EVLRNRDVWLIAIAGALLvAPQFALLTF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 302 IAEYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDvaaRYFGMRGRLWTLWILQTFGGVF-CMWLGKATKLPIAIA 380
Cdd:cd17475 221 LLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSD---RVFGGRRRPVLVITAAIAAAALlVLSLLSPGTPLWLLV 297
|
330
....*....|
gi 514995788 381 A-MILFSIGA 389
Cdd:cd17475 298 LlLILLGLFA 307
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
71-430 |
7.02e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 7.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 71 SFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNA-GVTSVSGsIFSRLVMGAVCDLLGPRYG--------CAFLIMLSAPT 141
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLIlLVARLWD-AITDPLIGALSDRTRTRWGrrrpwiliGAIPLALSFVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 142 VFCMSFVSDAAG--YIAVRFMIGFSLATFVSCQY--WMSTMFNSQIiglVNGTAAGWGNMGGGATQLIMPLL-YEVIQRA 216
Cdd:COG2211 98 LFTAPDLSPTGKliYALVTYLLLGLAYTLVNIPYsaLGAELTPDYE---ERTRLSSWRFAFAGLGGLLASVLpPPLVAAF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 217 GATPFTAWRIAFFIPGFLHVLMGILVLTLGQDLPdgnlaslqkKGNVAKDKFSNVLWYAVTNyRTWIFVLLYGYSMGVEL 296
Cdd:COG2211 175 GGDAALGYRLTALIFAVLGLLAFLLTFFGTKERP---------VPEEEKVSLKESLKALLKN-RPFLLLLLAYLLFFLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 297 STDNVIAEYFY-DRFDLKLHTAGIIAATFGMANLVARPFGGYAsdvaARYFGMRgRLWTLWILQTFGGVFCMWLGKATKL 375
Cdd:COG2211 245 ALVAALLLYYFkYVLGLSAALVGLLLALYFLAALLGAPLWPRL----AKRFGKK-KAFIIGLLLAALGLLLLFFLGPGNL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514995788 376 PIAIAAMILFSIGAQAACGATFGIIPFIS--------RRSLGIISGLTGAGGNFGSGLTQLVF 430
Cdd:COG2211 320 WLLLVLAALAGIGLGAILVLPWAMLADVVdydewktgRRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
72-454 |
1.11e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.60 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 72 FFTCFVSTFAAAPLVPIirDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAF-LIMLSAPTvFCMSFVSD 150
Cdd:cd17316 12 AYDFFLIGFVAPVLAAE--FSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILtLLLFGLAT-LLIGLLPT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 151 AAGYIAVRFMIGFSL-ATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLYEVIqragaTPFTAWRIAFF 229
Cdd:cd17316 89 PILLLVLRFLQGIGIgGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLL-----SGDWGWRILFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 230 IPGFLHVLMGILVLTLGqdlpdgnLASLqkkgnvakdkfsnvlwyavtnyrTWIFVLLYGYSMGVELSTdnviaeYFYDR 309
Cdd:cd17316 164 IGALPALLALLLRRRTL-------LLIL-----------------------LWFFISFGYYGLTTFLPT------YLQTV 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 310 FDLKLHTAGIIAATFGMANLVARPFGGYASDvaaryfgMRGRLWTLWILQTFGGVFCMWLGKATKLPIA--IAAMILFSI 387
Cdd:cd17316 208 LGLSPATSSLYLLLISLGALVGALIAGLLSD-------RIGRKKTLVIGLILSGILALPLFYLLSGSPTllLLLLFILSF 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514995788 388 GAQAACGATFGIIP--FISR-RSLGiiSGLTGAGGNFGSGLTQLVFFS--TTKYSTDTGLFLMGIMIVCCTL 454
Cdd:cd17316 281 FVGGVWGALYAYLAelFPTEvRATG--VGLSYNLGRLGGGGAPPLIALllASTGGTGVPALILALLAIVALI 350
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
69-250 |
2.88e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 46.47 E-value: 2.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 69 WVSFFTCFV---------STFAAAplVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSA 139
Cdd:cd17345 2 WQVFLGIFIgyagyylvrNNFSLA--QPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 140 PTVFCMSFVSDAAGYIAVRFMIGFSLATFVS-----CQYWMSTMFNSQIIGlvnGTAAGWG---NMGGGatqLIMPLLYe 211
Cdd:cd17345 80 IINILIGFVPSATSSVGLMFILLFLNGWFQGmgwppSGRTMVHWFSKKERG---TWTSIWNishNVGGG---LVGPLAG- 152
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 514995788 212 viqrAGATPFTA--WRIAFFIPGFLHVLMGILVLTLGQDLP 250
Cdd:cd17345 153 ----LGLAIFGDgwWRGAFIFPAIIAIIVAVIVLFLGKDTP 189
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
69-425 |
5.89e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.23 E-value: 5.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 69 WVSFFTCFV---STFAAAPLVPIIRDNLNltkVDIGNAG----VTSVSGSIFSrLVMGAVCDLLGPRYGCAFLIMLSAPT 141
Cdd:cd17324 2 LALALAAFAigtTEYVIQGLLPDIARDFG---VSVAQAGllvsAYALGYALGA-LLLGPLSDRIERRRLLLVLLLLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 142 VFCMSFVSDAAGYIAVRFMIGFSLATFVSCQY-WMSTMFNSQIIGLVNGTAAGwGNMGGGATQLIMPLLyeviqragATP 220
Cdd:cd17324 78 NLLAALAPSFALLLLARALAGLAHGGFWAIAAaYAADLVPPEKRGRAIGLVFS-GLTLGLVLGRPLGGL--------LGQ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 221 FTAWRIAFFIPGFLHVLMGILVLTLGQDLPDGNLASLQKKGNVAKDKFSNVLWYAVTNYRTWIFVLLYGYSmgvelstdn 300
Cdd:cd17324 149 LLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYT--------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 301 VIAEYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDvaarYFGMRGRLWTLWILQTFGGVFCMWlgkATKLPIAIA 380
Cdd:cd17324 220 YLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD----RGGRRALLIALLLLAAALLLLTLL---GPSPLLLLV 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 514995788 381 AMILFSIGAQAACGATFGIIPFISRRSLGIISGLTGAGGNFGSGL 425
Cdd:cd17324 293 GLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGAL 337
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
70-461 |
6.53e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.28 E-value: 6.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 70 VSFFtCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSAPTVFCMSFVS 149
Cdd:cd17489 4 ANFF-FFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 150 DAAGYIAVRFMIGFSLATFVSCqywMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLYEVIQRagatpFTAWRIAFF 229
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTA---AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ-----HLGFAVLFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 230 IPGFLHVLMGILVLTLGQDLPdgnlaSLQKKGNVAKDKFSNVLWYAVTNYRTWIFVLLYGYSmgvelSTDNVIAEYFYDR 309
Cdd:cd17489 155 VAAVLALLALLLVFLVKDPPP-----VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYG-----AISTFLPLYAAER 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 310 FdlkLHTAGIIAATFGMANLVARPFGGYASDVaaryfgmRGRLWTLWILQTFGGVFCMWLGKATKLPIAIAAMILFSIG- 388
Cdd:cd17489 225 G---ISNAGLFFTVYAIALLLSRPFSGKLSDR-------KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGf 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514995788 389 --AQAACGATFGIIPFISRRslGIISGLTGAGGNFGSGLTQLVFFSTTKYSTDTGLFLMGIMIVCCTLPVTLVHF 461
Cdd:cd17489 295 glLFPALQALAVDLVPPHRR--GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
69-461 |
1.13e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.15 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 69 WVSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIMLSAPTVFCMSFV 148
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 149 SDAAGYIAVRFMIGFSLATFVSCQY-WMSTMFNSQiiglvNGTAAGWGNMGGGATQLIMPLLYEVIQRAGATpftaWRIA 227
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDTGANtFVGALFEES-----SATRLNVLHGFFGLGALIGPLIATSLLTSELS----WSWA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 228 FFIPGFLHVLMGILVLTLGQDLPDGNLASLQKKGNVAKDKFSnvlwyAVTNYRTWIFVLLYGYSMGVELSTDNVIAEYFY 307
Cdd:cd17333 153 YLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASR-----LLRNPSIILGALALFLYVGAETAFSSWVPSYLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 308 DRFDLKLHTAGIIAATFGMANLVARPFGGYASDvaaryfgmRGRLWTLWILQTFGGV--FCMWLGKATKLPIAIAAMIL- 384
Cdd:cd17333 228 EKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR--------RIKPHTLLVLSGSGALlgLLILLLAPTLVVGLVATALLg 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514995788 385 FSIGAQAACGATFGI--IPFISRRSLGIISGLTGAGGNFGSGLTQLVFFSTTKYSTdtglflMGIMIVCCTLPVTLVHF 461
Cdd:cd17333 300 LFMAALFPTILSLGIsnLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTA------MLLITILYAIIFVLALL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
57-201 |
1.48e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 57 LANPHMRTFHLSWVSFFTCFVSTFAAAPLvpIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPRYGCAFLIM 136
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPL--YLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLL 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514995788 137 LSAPTVFCMSFVSDAAGYIAVRFMIGFSL-ATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGA 201
Cdd:COG2814 282 LLALGLLLLALAGSLWLLLLALFLLGFGFgLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
285-466 |
2.14e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.49 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 285 VLLYGYSMGVELSTDNVIAEYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDvaarYFGMRgrlWTLWILQTFGGV 364
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD----RFGRR---PVLLLGLLLFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 365 FCMWLGKATKLPIAIAAMILFSIGAQAACGATFGIIPFIS-RRSLGIISGLTGAGGNFGSGLTQLV---FFSTTKYSTDT 440
Cdd:cd06174 74 GALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLggiLASSLGFGWRA 153
|
170 180
....*....|....*....|....*.
gi 514995788 441 GLFLMGIMIVCCTLPVTLVHFPQWGS 466
Cdd:cd06174 154 VFLIAAALALLAAILLLLVVPDPPES 179
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
70-234 |
3.02e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.89 E-value: 3.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 70 VSFFTCFVSTFAAAPLVPIIRDNLNLTKVDIGNAGVTSVSGSIFSRLVMGAVCDLLGPR--YGCAFLIMLSAPTVFCMSF 147
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKktLVIGLILSGILALPLFYLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 148 VSDAAGYIAVRFMIGFSLATFVSCQY-WMSTMFNSQIIGLVNGTAAGWGNMGGGATQLIMPLLyeVIQRAGATPFTAWRI 226
Cdd:cd17316 265 SGSPTLLLLLLFILSFFVGGVWGALYaYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL--LASTGGTGVPALILA 342
|
....*...
gi 514995788 227 AFFIPGFL 234
Cdd:cd17316 343 LLAIVALI 350
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
224-403 |
3.13e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.91 E-value: 3.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 224 WRIAFFIPGFLHVLMGILVLTLGQDLPDGNLASLQKKGNVAKDkFSNVLWYAVTNyRTWIFVLLyGYSmGVELSTDNV-- 301
Cdd:cd17328 153 WRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATS-FLADLKALAKN-PSFILSTL-GFT-AVSFVTGALaf 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 302 -IAEYFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDVAARYFGMRGRLWTLWILQT--FGGVFCMWLGKATKLPIA 378
Cdd:cd17328 229 wAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVglLAAAPFLFLALVLALSNL 308
|
170 180
....*....|....*....|....*
gi 514995788 379 IAAMILFSIGAQAACgATFGIIPFI 403
Cdd:cd17328 309 LLAWVLLFLGEFLLS-LNWAPVFAI 332
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
305-425 |
8.05e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 8.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514995788 305 YFYDRFDLKLHTAGIIAATFGMANLVARPFGGYASDvaaryfgMRGRLWTLWILQTFGGVFCMWLGKATKLPIAIAAMIL 384
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLAD-------RKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 514995788 385 FSIG-----AQAAcgatfGIIPFISRRSLGIISGLTGAGGNFGSGL 425
Cdd:cd17478 94 AGIGsaafhPEGA-----RLASQAAGGRRGLAMSIFSVGGNLGFAL 134
|
|
| |
