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Conserved domains on  [gi|514819898|ref|XP_004984641|]
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myb-related protein P [Setaria italica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P_C pfam06640
P protein C-terminus; This family represents the C-terminus of plant P proteins. The maize P ...
 130-364 1.50e-121

P protein C-terminus; This family represents the C-terminus of plant P proteins. The maize P gene is a transcriptional regulator of genes encoding enzymes for flavonoid biosynthesis in the pathway leading to the production of a red phlobaphene pigment, and P proteins are homologous to the DNA-binding domain of myb-like transcription factors. All members of this family contain the pfam00249 domain.


:

Pssm-ID: 429048  Cd Length: 252  Bit Score: 351.23  E-value: 1.50e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898  130 TITIDISKLHSAEKRRGGRTPGRSPKRATTSSGGGGGGSNKAKSKELPDPDSKKPEPESGEAKVASGPVAAAASAASSPR 209
Cdd:pfam06640   1 AIAIDISKLHSAEKRRGGRTPGRSPKRATTSSGGGGGGSNKAKSKELDDPDSKKPEPESGEAKVASGEPAAAASAASSPR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898  210 HSDGARSAVV--DPDQNQPDSSSGAGGGSTPEGPCSEDTTGPLAALDPMEFGGLWEAESEMELLLSSGGVEAGPDPLTGF 287
Cdd:pfam06640  81 HSDGARSAVVdpDPDPNQPDSSSGAGGGSTGEGPCSEDATGPLAALDPIEFGDLWEAESEMDALLSIGGAAADPAPAEGF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898  288 VDAVGEA-GQVDDLL-DMDWDGFAAHIWGDHPTAQVQQQNDDDQSTLLQPDG-PQAAAG----------CNEHQEDE--L 352
Cdd:pfam06640 161 DAAVGEAqAQVDDLFdDMDWDGFAAHIWGDHPTAQVEQQNDDDAQPLLQPAAePQAAAAadvaaagaeaCDEHQEDEheL 240

                         250
                  ....*....|..
gi 514819898  353 ESFATWLLSDSF 364
Cdd:pfam06640 241 EAFATWLLSDSF 252
PLN03091 super family cl33633
hypothetical protein; Provisional
 1-116 3.24e-58

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 195.58  E-value: 3.24e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898   1 MGRAPCCEKVGLKRGRWTAEEDEILANYIAKHGEGSWRSLPKNAGLLRCGKSCRLRWINYLRADVKRGNISKEEEDVIIK 80
Cdd:PLN03091   1 MGRHSCCYKQKLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIE 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 514819898  81 LHATLGNRWSLIASHLPGRTDNEIKNYWNSHLSRQI 116
Cdd:PLN03091  81 LHAVLGNRWSQIAAQLPGRTDNEIKNLWNSCLKKKL 116
 
Name Accession Description Interval E-value
P_C pfam06640
P protein C-terminus; This family represents the C-terminus of plant P proteins. The maize P ...
 130-364 1.50e-121

P protein C-terminus; This family represents the C-terminus of plant P proteins. The maize P gene is a transcriptional regulator of genes encoding enzymes for flavonoid biosynthesis in the pathway leading to the production of a red phlobaphene pigment, and P proteins are homologous to the DNA-binding domain of myb-like transcription factors. All members of this family contain the pfam00249 domain.


Pssm-ID: 429048  Cd Length: 252  Bit Score: 351.23  E-value: 1.50e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898  130 TITIDISKLHSAEKRRGGRTPGRSPKRATTSSGGGGGGSNKAKSKELPDPDSKKPEPESGEAKVASGPVAAAASAASSPR 209
Cdd:pfam06640   1 AIAIDISKLHSAEKRRGGRTPGRSPKRATTSSGGGGGGSNKAKSKELDDPDSKKPEPESGEAKVASGEPAAAASAASSPR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898  210 HSDGARSAVV--DPDQNQPDSSSGAGGGSTPEGPCSEDTTGPLAALDPMEFGGLWEAESEMELLLSSGGVEAGPDPLTGF 287
Cdd:pfam06640  81 HSDGARSAVVdpDPDPNQPDSSSGAGGGSTGEGPCSEDATGPLAALDPIEFGDLWEAESEMDALLSIGGAAADPAPAEGF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898  288 VDAVGEA-GQVDDLL-DMDWDGFAAHIWGDHPTAQVQQQNDDDQSTLLQPDG-PQAAAG----------CNEHQEDE--L 352
Cdd:pfam06640 161 DAAVGEAqAQVDDLFdDMDWDGFAAHIWGDHPTAQVEQQNDDDAQPLLQPAAePQAAAAadvaaagaeaCDEHQEDEheL 240

                         250
                  ....*....|..
gi 514819898  353 ESFATWLLSDSF 364
Cdd:pfam06640 241 EAFATWLLSDSF 252
PLN03091 PLN03091
hypothetical protein; Provisional
 1-116 3.24e-58

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 195.58  E-value: 3.24e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898   1 MGRAPCCEKVGLKRGRWTAEEDEILANYIAKHGEGSWRSLPKNAGLLRCGKSCRLRWINYLRADVKRGNISKEEEDVIIK 80
Cdd:PLN03091   1 MGRHSCCYKQKLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIE 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 514819898  81 LHATLGNRWSLIASHLPGRTDNEIKNYWNSHLSRQI 116
Cdd:PLN03091  81 LHAVLGNRWSQIAAQLPGRTDNEIKNLWNSCLKKKL 116
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 67-112 2.92e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 71.77  E-value: 2.92e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 514819898   67 RGNISKEEEDVIIKLHATLGNRWSLIASHLPGRTDNEIKNYWNSHL 112
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 9-110 4.42e-16

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 79.45  E-value: 4.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898   9 KVGLKRGRWTAEEDEILANYIAKHGEGSWrslPKNAGLL--RCGKSCRLRWINYLRADVKRGNISKEEEDVIIKLHATLG 86
Cdd:COG5147   15 QTKRKGGSWKRTEDEDLKALVKKLGPNNW---SKVASLLisSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELG 91

                         90       100
                 ....*....|....*....|....
gi 514819898  87 NRWSLIASHLPGRTDNEIKNYWNS 110
Cdd:COG5147   92 TQWSTIADYKDRRTAQQCVERYVN 115
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
67-114 1.39e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 61.47  E-value: 1.39e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 514819898    67 RGNISKEEEDVIIKLHATLG-NRWSLIASHLPGRTDNEIKNYWNSHLSR 114
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 71-112 9.36e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 59.13  E-value: 9.36e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 514819898  71 SKEEEDVIIKLHATLG-NRWSLIASHLPGRTDNEIKNYWNSHL 112
Cdd:cd00167    3 TEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
P_C pfam06640
P protein C-terminus; This family represents the C-terminus of plant P proteins. The maize P ...
 130-364 1.50e-121

P protein C-terminus; This family represents the C-terminus of plant P proteins. The maize P gene is a transcriptional regulator of genes encoding enzymes for flavonoid biosynthesis in the pathway leading to the production of a red phlobaphene pigment, and P proteins are homologous to the DNA-binding domain of myb-like transcription factors. All members of this family contain the pfam00249 domain.


Pssm-ID: 429048  Cd Length: 252  Bit Score: 351.23  E-value: 1.50e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898  130 TITIDISKLHSAEKRRGGRTPGRSPKRATTSSGGGGGGSNKAKSKELPDPDSKKPEPESGEAKVASGPVAAAASAASSPR 209
Cdd:pfam06640   1 AIAIDISKLHSAEKRRGGRTPGRSPKRATTSSGGGGGGSNKAKSKELDDPDSKKPEPESGEAKVASGEPAAAASAASSPR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898  210 HSDGARSAVV--DPDQNQPDSSSGAGGGSTPEGPCSEDTTGPLAALDPMEFGGLWEAESEMELLLSSGGVEAGPDPLTGF 287
Cdd:pfam06640  81 HSDGARSAVVdpDPDPNQPDSSSGAGGGSTGEGPCSEDATGPLAALDPIEFGDLWEAESEMDALLSIGGAAADPAPAEGF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898  288 VDAVGEA-GQVDDLL-DMDWDGFAAHIWGDHPTAQVQQQNDDDQSTLLQPDG-PQAAAG----------CNEHQEDE--L 352
Cdd:pfam06640 161 DAAVGEAqAQVDDLFdDMDWDGFAAHIWGDHPTAQVEQQNDDDAQPLLQPAAePQAAAAadvaaagaeaCDEHQEDEheL 240

                         250
                  ....*....|..
gi 514819898  353 ESFATWLLSDSF 364
Cdd:pfam06640 241 EAFATWLLSDSF 252
PLN03091 PLN03091
hypothetical protein; Provisional
 1-116 3.24e-58

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 195.58  E-value: 3.24e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898   1 MGRAPCCEKVGLKRGRWTAEEDEILANYIAKHGEGSWRSLPKNAGLLRCGKSCRLRWINYLRADVKRGNISKEEEDVIIK 80
Cdd:PLN03091   1 MGRHSCCYKQKLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIE 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 514819898  81 LHATLGNRWSLIASHLPGRTDNEIKNYWNSHLSRQI 116
Cdd:PLN03091  81 LHAVLGNRWSQIAAQLPGRTDNEIKNLWNSCLKKKL 116
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 5-147 6.63e-58

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 188.36  E-value: 6.63e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898   5 PCCEKVGLKRGRWTAEEDEILANYIAKHGEGSWRSLPKNAGLLRCGKSCRLRWINYLRADVKRGNISKEEEDVIIKLHAT 84
Cdd:PLN03212  16 PCCTKMGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRL 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514819898  85 LGNRWSLIASHLPGRTDNEIKNYWNSHLSRQIhtyrRTYTAGPDTTITIDISKLHSAEKRRGG 147
Cdd:PLN03212  96 LGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKL----LRQGIDPQTHKPLDANNIHKPEEEVSG 154
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 67-112 2.92e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 71.77  E-value: 2.92e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 514819898   67 RGNISKEEEDVIIKLHATLGNRWSLIASHLPGRTDNEIKNYWNSHL 112
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 9-110 4.42e-16

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 79.45  E-value: 4.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898   9 KVGLKRGRWTAEEDEILANYIAKHGEGSWrslPKNAGLL--RCGKSCRLRWINYLRADVKRGNISKEEEDVIIKLHATLG 86
Cdd:COG5147   15 QTKRKGGSWKRTEDEDLKALVKKLGPNNW---SKVASLLisSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELG 91

                         90       100
                 ....*....|....*....|....
gi 514819898  87 NRWSLIASHLPGRTDNEIKNYWNS 110
Cdd:COG5147   92 TQWSTIADYKDRRTAQQCVERYVN 115
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 14-61 6.17e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.52  E-value: 6.17e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 514819898   14 RGRWTAEEDEILANYIAKHGeGSWRSLPKNAGlLRCGKSCRLRWINYL 61
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLP-GRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
67-114 1.39e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 61.47  E-value: 1.39e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 514819898    67 RGNISKEEEDVIIKLHATLG-NRWSLIASHLPGRTDNEIKNYWNSHLSR 114
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 71-112 9.36e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 59.13  E-value: 9.36e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 514819898  71 SKEEEDVIIKLHATLG-NRWSLIASHLPGRTDNEIKNYWNSHL 112
Cdd:cd00167    3 TEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
14-62 5.02e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 57.23  E-value: 5.02e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 514819898    14 RGRWTAEEDEILANYIAKHGEGSWRSLPKNAGlLRCGKSCRLRWINYLR 62
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 16-61 6.63e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 56.81  E-value: 6.63e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 514819898  16 RWTAEEDEILANYIAKHGEGSWRSLPKNAGlLRCGKSCRLRWINYL 61
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELP-GRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 17-75 1.71e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 56.16  E-value: 1.71e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 514819898   17 WTAEEDEILANYIAKHGeGSWRSLPKNAGLlRCGKSCRLRWINYLRADVKRGNISKEEE 75
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGR-RTPKQCFDRWRRKLNPKISRGPWSKEED 57
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 71-116 1.50e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 50.77  E-value: 1.50e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 514819898   71 SKEEEDVIIKLHATLGNRWSLIASHLPGRTDNEIKNYWNSHLSRQI 116
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKI 47
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 13-100 5.17e-05

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 45.16  E-value: 5.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514819898  13 KRGRWTAEEDEILANYIAKHGeGSWrslpKNAGLLRCGK--SCRLRWINYLR--ADVKRGNISKEEEDVIIKLHATLGN- 87
Cdd:COG5147  290 QRGKWTKEEEQELAKLVVEHG-GSW----TEIGKLLGRMpnDCRDRWRDYVKcgDTLKRNRWSIEEEELLDKVVNEMRLe 364

                         90       100
                 ....*....|....*....|
gi 514819898  88 -------RWSLIASHLPGRT 100
Cdd:COG5147  365 aqqssriLWLLIAQNIRNRL 384
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 16-38 4.50e-03

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 34.85  E-value: 4.50e-03
                         10        20
                 ....*....|....*....|...
gi 514819898  16 RWTAEEDEILANYIAKHGEGSWR 38
Cdd:cd11660    2 KWTDEEDEALVEGVEKYGVGNWA 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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