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Conserved domains on  [gi|51477047|emb|CAH18470|]
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hypothetical protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Folate_carrier super family cl27502
Reduced folate carrier; The reduced folate carrier (a transmembrane glycoprotein) transports ...
 1-40 7.48e-13

Reduced folate carrier; The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy, such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules.


The actual alignment was detected with superfamily member pfam01770:

Pssm-ID: 474932  Cd Length: 412  Bit Score: 64.23  E-value: 7.48e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 51477047     1 MEDYALTFGINPFIALMIQPIVTMTVVDNQGLGLPVDIQH 40
Cdd:pfam01770 371 LERYALVFGINTFVALALQTILTAIVVDKRGLGLDVRPQF 410
 
Name Accession Description Interval E-value
Folate_carrier pfam01770
Reduced folate carrier; The reduced folate carrier (a transmembrane glycoprotein) transports ...
 1-40 7.48e-13

Reduced folate carrier; The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy, such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules.


Pssm-ID: 460318  Cd Length: 412  Bit Score: 64.23  E-value: 7.48e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 51477047     1 MEDYALTFGINPFIALMIQPIVTMTVVDNQGLGLPVDIQH 40
Cdd:pfam01770 371 LERYALVFGINTFVALALQTILTAIVVDKRGLGLDVRPQF 410
rfc TIGR00806
RFC reduced folate carrier; The Reduced Folate Carrier (RFC) Family (TC 2.A.48) Members of the ...
 2-39 8.68e-07

RFC reduced folate carrier; The Reduced Folate Carrier (RFC) Family (TC 2.A.48) Members of the RFC family mediate the uptake of folate, reduce folate, derivatives of reduced folate and the drug, methotrexate. Proteins of the RFC family are so-far restricted to animals. RFC proteins possess 12 putative transmembrane a-helical spanners (TMSs) and evidence for a 12 TMS topology has been published for the human RFC. The RFC transporters appear to transport reduced folate by an energy-dependent, pH-dependent, Na+-independent mechanism. Folate:H+ symport, folate:OH- antiport and folate:anion antiport mechanisms have been proposed, but the energetic mechanism is not well defined. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129888  Cd Length: 511  Bit Score: 46.80  E-value: 8.68e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 51477047     2 EDYALTFGINPFIALMIQPIVTMTVVDNQGLGLPVDIQ 39
Cdd:TIGR00806 385 ELCALVFGINTFVATALKTIITAVVSDKRGLGLQVRKQ 422
 
Name Accession Description Interval E-value
Folate_carrier pfam01770
Reduced folate carrier; The reduced folate carrier (a transmembrane glycoprotein) transports ...
 1-40 7.48e-13

Reduced folate carrier; The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy, such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules.


Pssm-ID: 460318  Cd Length: 412  Bit Score: 64.23  E-value: 7.48e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 51477047     1 MEDYALTFGINPFIALMIQPIVTMTVVDNQGLGLPVDIQH 40
Cdd:pfam01770 371 LERYALVFGINTFVALALQTILTAIVVDKRGLGLDVRPQF 410
rfc TIGR00806
RFC reduced folate carrier; The Reduced Folate Carrier (RFC) Family (TC 2.A.48) Members of the ...
 2-39 8.68e-07

RFC reduced folate carrier; The Reduced Folate Carrier (RFC) Family (TC 2.A.48) Members of the RFC family mediate the uptake of folate, reduce folate, derivatives of reduced folate and the drug, methotrexate. Proteins of the RFC family are so-far restricted to animals. RFC proteins possess 12 putative transmembrane a-helical spanners (TMSs) and evidence for a 12 TMS topology has been published for the human RFC. The RFC transporters appear to transport reduced folate by an energy-dependent, pH-dependent, Na+-independent mechanism. Folate:H+ symport, folate:OH- antiport and folate:anion antiport mechanisms have been proposed, but the energetic mechanism is not well defined. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129888  Cd Length: 511  Bit Score: 46.80  E-value: 8.68e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 51477047     2 EDYALTFGINPFIALMIQPIVTMTVVDNQGLGLPVDIQ 39
Cdd:TIGR00806 385 ELCALVFGINTFVATALKTIITAVVSDKRGLGLQVRKQ 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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