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Conserved domains on  [gi|514694680|ref|XP_004994911|]
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glutaminase [Salpingoeca rosetta]

Protein Classification

glutaminase( domain architecture ID 10523045)

glutaminase catalyzes the conversion from L-glutamine to L-glutamate

CATH:  3.40.710.10|1.10.1500.10
EC:  3.5.1.2
Gene Ontology:  GO:0006541|GO:0004359
PubMed:  16516349
SCOP:  4003774

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glutaminase pfam04960
Glutaminase; This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.
 93-379 1.37e-133

Glutaminase; This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.


:

Pssm-ID: 461499  Cd Length: 283  Bit Score: 389.04  E-value: 1.37e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680   93 GAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVALDLAG-ERVHDHIGHEPSGKRFNA-FE 170
Cdd:pfam04960   1 GKVADYIPELAKVDPDLFGIAICTVDGQVYSAGDADVPFTIQSISKVFTLALALEDLGgEEVFERVGVEPSGDPFNSlVQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  171 LD-ENHKPHNPMINSGAIMASALIRSqfTQKAEPYNALQAFTERAIGkmSPVNFNNSVYLSELGHAARNYALTYFMQEHS 249
Cdd:pfam04960  81 LElENGKPRNPMINAGAIAVTSLIKG--ADPEERFERILDFLRKLAG--RELTIDEEVYLSEKETGDRNRALAYLLKSFG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  250 ELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHAQAALSLMYNCGMYDYSGRFAFEVGIP 329
Cdd:pfam04960 157 NI--ENDVEEVLDLYFRQCSIEVTCRDLAVMGATLANGGVNPITGERVLSPEVVRRVLALMLTCGMYDASGEFAFRVGLP 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 514694680  330 AKSGVSGALFLSVPGKLGIAIYSPRVDALGNTVRGLYVAAQLVRAIpELH 379
Cdd:pfam04960 235 AKSGVGGGILAVVPGKMGIAVFSPPLDEKGNSVRGVKALERLSEEL-GLH 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
405-485 6.75e-11

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 6.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 405 LMQFVAHGDAAKVHELVSNtSVNVNGTNPDGRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPMSEAERHNLQHIL 484
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235


                 .
gi 514694680 485 D 485
Cdd:COG0666  236 K 236
 
Name Accession Description Interval E-value
Glutaminase pfam04960
Glutaminase; This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.
 93-379 1.37e-133

Glutaminase; This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.


Pssm-ID: 461499  Cd Length: 283  Bit Score: 389.04  E-value: 1.37e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680   93 GAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVALDLAG-ERVHDHIGHEPSGKRFNA-FE 170
Cdd:pfam04960   1 GKVADYIPELAKVDPDLFGIAICTVDGQVYSAGDADVPFTIQSISKVFTLALALEDLGgEEVFERVGVEPSGDPFNSlVQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  171 LD-ENHKPHNPMINSGAIMASALIRSqfTQKAEPYNALQAFTERAIGkmSPVNFNNSVYLSELGHAARNYALTYFMQEHS 249
Cdd:pfam04960  81 LElENGKPRNPMINAGAIAVTSLIKG--ADPEERFERILDFLRKLAG--RELTIDEEVYLSEKETGDRNRALAYLLKSFG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  250 ELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHAQAALSLMYNCGMYDYSGRFAFEVGIP 329
Cdd:pfam04960 157 NI--ENDVEEVLDLYFRQCSIEVTCRDLAVMGATLANGGVNPITGERVLSPEVVRRVLALMLTCGMYDASGEFAFRVGLP 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 514694680  330 AKSGVSGALFLSVPGKLGIAIYSPRVDALGNTVRGLYVAAQLVRAIpELH 379
Cdd:pfam04960 235 AKSGVGGGILAVVPGKMGIAVFSPPLDEKGNSVRGVKALERLSEEL-GLH 283
GlsA COG2066
Glutaminase [Amino acid transport and metabolism];
80-381 1.35e-119

Glutaminase [Amino acid transport and metabolism];


Pssm-ID: 441669  Cd Length: 300  Bit Score: 353.97  E-value: 1.35e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  80 LAAIYPRAQ-QVHDGAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVAL-DLAGERVHDHI 157
Cdd:COG2066    1 LEEIYEKVRpYLGEGKVADYIPELAKVDPDLFGIAVVTVDGEVYSAGDADTPFSIQSISKVFTLALALeDLGGEEVWERV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 158 GHEPSGKRFN---AFELdENHKPHNPMINSGAIMASALIRSQFtqKAEPYNALQAFTERAIGKmSPVNFNNSVYLSELGH 234
Cdd:COG2066   81 GVEPSGDPFNsivQLEL-ENGIPRNPMINAGAIVVTSLLPGRS--GDERFERILDFLRRLAGN-RELSVDEEVYASEKAT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 235 AARNYALTYFMQEHSELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHAQAALSLMYNCG 314
Cdd:COG2066  157 GDRNRALAYLLKSFGNL--ENDVEEVLDLYFRQCSIEVTCRDLARMGATLANGGVNPVTGERVISPEVARRVLALMLTCG 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514694680 315 MYDYSGRFAFEVGIPAKSGVSGALFLSVPGKLGIAIYSPRVDALGNTVRGLYVAAQLVRAIpELHVF 381
Cdd:COG2066  235 MYDASGEFAYRVGLPAKSGVGGGIVAVVPGKMGIAVFSPRLDEKGNSVRGVKALERLSTEL-GLSIF 300
PRK00971 PRK00971
glutaminase; Provisional
 67-381 8.01e-99

glutaminase; Provisional


Pssm-ID: 234880  Cd Length: 307  Bit Score: 301.30  E-value: 8.01e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  67 TPVDALVARVQEELAaiyPRAQQvhdGAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVAL 146
Cdd:PRK00971   2 MLMQAILEEILEEVR---PLIGQ---GKVADYIPELAKVDPNKLGIAVCTVDGEVYSAGDADERFSIQSISKVFSLALAL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 147 -DLAGERVHDHIGHEPSGKRFNAFE-LD-ENHKPHNPMINSGAIMASALIRSQFTqkAEPYNALQAFTeRAIGKMSPVNF 223
Cdd:PRK00971  76 qHYGEEEVWQRVGKEPSGDPFNSLVqLElEQGKPRNPMINAGAIVVTDLLQGRLS--EEPCERLLEFV-RQLAGNPDILY 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 224 NNSVYLSELGHAARNYALTYFMQEHSELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHA 303
Cdd:PRK00971 153 DEVVASSELEHADRNAAIAYLMKSFGNI--ENDVETVLDTYFHQCALEMSCVDLARAGLFLANGGVSPHTGERVVSPRQA 230

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514694680 304 QAALSLMYNCGMYDYSGRFAFEVGIPAKSGVSGALFLSVPGKLGIAIYSPRVDALGNTVRGLYVAAQLVRAIpELHVF 381
Cdd:PRK00971 231 RQVNALMLTCGMYDASGEFAYRVGLPAKSGVGGGILAVVPGEMAIAVWSPELDAKGNSLAGTAALERLSQRL-GLSIF 307
Gln_ase TIGR03814
glutaminase A; This family describes the enzyme glutaminase, from a larger family that ...
 76-381 1.55e-96

glutaminase A; This family describes the enzyme glutaminase, from a larger family that includes serine-dependent beta-lactamases and penicillin-binding proteins. Many bacteria have two isozymes. This model is based on selected known glutaminases and their homologs within prokaryotes, with the exclusion of highly-derived (long branch) and architecturally varied homologs, so as to achieve conservative assignments. A sharp drop in scores occurs below 250, and cutoffs are set accordingly. The enzyme converts glutamine to glutamate, with the release of ammonia. Members tend to be described as glutaminase A (glsA), where B (glsB) is unknown and may not be homologous (as in Rhizobium etli). Some species have two isozymes that may both be designated A (GlsA1 and GlsA2). [Energy metabolism, Amino acids and amines]


Pssm-ID: 274797  Cd Length: 300  Bit Score: 295.16  E-value: 1.55e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680   76 VQEELAAIYPRAQQvhdGAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVALDLAG-ERVH 154
Cdd:TIGR03814   1 LEDIVEEARPLIGE---GKVADYIPALAKVDPNQFGIAVVTLDGEVFSAGDADVPFSIQSISKVFTLALALEDLGeDEVW 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  155 DHIGHEPSGKRFN---AFELdENHKPHNPMINSGAIMASALIRSQFTqkAEPYNALQAFTERAIGKMSPVnFNNSVYLSE 231
Cdd:TIGR03814  78 ERVGVEPSGDPFNsivQLEL-EPGKPRNPFINAGAIAVTSLLPGRTS--DEKLERILEFVRKLAGNRSIT-IDEEVAQSE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  232 LGHAARNYALTYFMQEHSELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHAQAALSLMY 311
Cdd:TIGR03814 154 RETGFRNRALAYLLKSFGNL--ENDVEEVLDVYFKQCSIEMTCKDLARAGLFLANGGVNPLTGEQVISAEVAKRINALML 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  312 NCGMYDYSGRFAFEVGIPAKSGVSGALFLSVPGKLGIAIYSPRVDALGNTVRGLYVAAQLVRAIpELHVF 381
Cdd:TIGR03814 232 TCGLYDASGEFAYRVGLPAKSGVGGGILAVVPGKMGIAVWSPALDEAGNSVAGQKALELLSEKL-GLSIF 300
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
405-485 6.75e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 6.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 405 LMQFVAHGDAAKVHELVSNtSVNVNGTNPDGRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPMSEAERHNLQHIL 484
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235


                 .
gi 514694680 485 D 485
Cdd:COG0666  236 K 236
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 401-483 8.83e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.82  E-value: 8.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 401 LHLMLMQFVAHGDAAKVHELVSNTSvNVNGTNPDGRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPMSEAERHNL 480
Cdd:PTZ00322  82 LTVELCQLAASGDAVGARILLTGGA-DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGF 160


                 ...
gi 514694680 481 QHI 483
Cdd:PTZ00322 161 REV 163
Ank_2 pfam12796
Ankyrin repeats (3 copies);
405-479 5.53e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 5.53e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514694680  405 LMQFVAHGDAAKVHELVSNtSVNVNGTNPDGRTALLEALAAGRGDIASYLLAHgADPAVTDHfGNTPMSEAERHN 479
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN-GADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSG 72
 
Name Accession Description Interval E-value
Glutaminase pfam04960
Glutaminase; This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.
 93-379 1.37e-133

Glutaminase; This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.


Pssm-ID: 461499  Cd Length: 283  Bit Score: 389.04  E-value: 1.37e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680   93 GAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVALDLAG-ERVHDHIGHEPSGKRFNA-FE 170
Cdd:pfam04960   1 GKVADYIPELAKVDPDLFGIAICTVDGQVYSAGDADVPFTIQSISKVFTLALALEDLGgEEVFERVGVEPSGDPFNSlVQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  171 LD-ENHKPHNPMINSGAIMASALIRSqfTQKAEPYNALQAFTERAIGkmSPVNFNNSVYLSELGHAARNYALTYFMQEHS 249
Cdd:pfam04960  81 LElENGKPRNPMINAGAIAVTSLIKG--ADPEERFERILDFLRKLAG--RELTIDEEVYLSEKETGDRNRALAYLLKSFG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  250 ELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHAQAALSLMYNCGMYDYSGRFAFEVGIP 329
Cdd:pfam04960 157 NI--ENDVEEVLDLYFRQCSIEVTCRDLAVMGATLANGGVNPITGERVLSPEVVRRVLALMLTCGMYDASGEFAFRVGLP 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 514694680  330 AKSGVSGALFLSVPGKLGIAIYSPRVDALGNTVRGLYVAAQLVRAIpELH 379
Cdd:pfam04960 235 AKSGVGGGILAVVPGKMGIAVFSPPLDEKGNSVRGVKALERLSEEL-GLH 283
GlsA COG2066
Glutaminase [Amino acid transport and metabolism];
80-381 1.35e-119

Glutaminase [Amino acid transport and metabolism];


Pssm-ID: 441669  Cd Length: 300  Bit Score: 353.97  E-value: 1.35e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  80 LAAIYPRAQ-QVHDGAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVAL-DLAGERVHDHI 157
Cdd:COG2066    1 LEEIYEKVRpYLGEGKVADYIPELAKVDPDLFGIAVVTVDGEVYSAGDADTPFSIQSISKVFTLALALeDLGGEEVWERV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 158 GHEPSGKRFN---AFELdENHKPHNPMINSGAIMASALIRSQFtqKAEPYNALQAFTERAIGKmSPVNFNNSVYLSELGH 234
Cdd:COG2066   81 GVEPSGDPFNsivQLEL-ENGIPRNPMINAGAIVVTSLLPGRS--GDERFERILDFLRRLAGN-RELSVDEEVYASEKAT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 235 AARNYALTYFMQEHSELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHAQAALSLMYNCG 314
Cdd:COG2066  157 GDRNRALAYLLKSFGNL--ENDVEEVLDLYFRQCSIEVTCRDLARMGATLANGGVNPVTGERVISPEVARRVLALMLTCG 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514694680 315 MYDYSGRFAFEVGIPAKSGVSGALFLSVPGKLGIAIYSPRVDALGNTVRGLYVAAQLVRAIpELHVF 381
Cdd:COG2066  235 MYDASGEFAYRVGLPAKSGVGGGIVAVVPGKMGIAVFSPRLDEKGNSVRGVKALERLSTEL-GLSIF 300
PRK00971 PRK00971
glutaminase; Provisional
 67-381 8.01e-99

glutaminase; Provisional


Pssm-ID: 234880  Cd Length: 307  Bit Score: 301.30  E-value: 8.01e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  67 TPVDALVARVQEELAaiyPRAQQvhdGAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVAL 146
Cdd:PRK00971   2 MLMQAILEEILEEVR---PLIGQ---GKVADYIPELAKVDPNKLGIAVCTVDGEVYSAGDADERFSIQSISKVFSLALAL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 147 -DLAGERVHDHIGHEPSGKRFNAFE-LD-ENHKPHNPMINSGAIMASALIRSQFTqkAEPYNALQAFTeRAIGKMSPVNF 223
Cdd:PRK00971  76 qHYGEEEVWQRVGKEPSGDPFNSLVqLElEQGKPRNPMINAGAIVVTDLLQGRLS--EEPCERLLEFV-RQLAGNPDILY 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 224 NNSVYLSELGHAARNYALTYFMQEHSELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHA 303
Cdd:PRK00971 153 DEVVASSELEHADRNAAIAYLMKSFGNI--ENDVETVLDTYFHQCALEMSCVDLARAGLFLANGGVSPHTGERVVSPRQA 230

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514694680 304 QAALSLMYNCGMYDYSGRFAFEVGIPAKSGVSGALFLSVPGKLGIAIYSPRVDALGNTVRGLYVAAQLVRAIpELHVF 381
Cdd:PRK00971 231 RQVNALMLTCGMYDASGEFAYRVGLPAKSGVGGGILAVVPGEMAIAVWSPELDAKGNSLAGTAALERLSQRL-GLSIF 307
Gln_ase TIGR03814
glutaminase A; This family describes the enzyme glutaminase, from a larger family that ...
 76-381 1.55e-96

glutaminase A; This family describes the enzyme glutaminase, from a larger family that includes serine-dependent beta-lactamases and penicillin-binding proteins. Many bacteria have two isozymes. This model is based on selected known glutaminases and their homologs within prokaryotes, with the exclusion of highly-derived (long branch) and architecturally varied homologs, so as to achieve conservative assignments. A sharp drop in scores occurs below 250, and cutoffs are set accordingly. The enzyme converts glutamine to glutamate, with the release of ammonia. Members tend to be described as glutaminase A (glsA), where B (glsB) is unknown and may not be homologous (as in Rhizobium etli). Some species have two isozymes that may both be designated A (GlsA1 and GlsA2). [Energy metabolism, Amino acids and amines]


Pssm-ID: 274797  Cd Length: 300  Bit Score: 295.16  E-value: 1.55e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680   76 VQEELAAIYPRAQQvhdGAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVALDLAG-ERVH 154
Cdd:TIGR03814   1 LEDIVEEARPLIGE---GKVADYIPALAKVDPNQFGIAVVTLDGEVFSAGDADVPFSIQSISKVFTLALALEDLGeDEVW 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  155 DHIGHEPSGKRFN---AFELdENHKPHNPMINSGAIMASALIRSQFTqkAEPYNALQAFTERAIGKMSPVnFNNSVYLSE 231
Cdd:TIGR03814  78 ERVGVEPSGDPFNsivQLEL-EPGKPRNPFINAGAIAVTSLLPGRTS--DEKLERILEFVRKLAGNRSIT-IDEEVAQSE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  232 LGHAARNYALTYFMQEHSELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHAQAALSLMY 311
Cdd:TIGR03814 154 RETGFRNRALAYLLKSFGNL--ENDVEEVLDVYFKQCSIEMTCKDLARAGLFLANGGVNPLTGEQVISAEVAKRINALML 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  312 NCGMYDYSGRFAFEVGIPAKSGVSGALFLSVPGKLGIAIYSPRVDALGNTVRGLYVAAQLVRAIpELHVF 381
Cdd:TIGR03814 232 TCGLYDASGEFAYRVGLPAKSGVGGGILAVVPGKMGIAVWSPALDEAGNSVAGQKALELLSEKL-GLSIF 300
PRK12356 PRK12356
glutaminase; Reviewed
 74-389 4.33e-70

glutaminase; Reviewed


Pssm-ID: 237073  Cd Length: 319  Bit Score: 227.54  E-value: 4.33e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  74 ARVQEELAAIYPRAQQVHDGAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVALDLAG-ER 152
Cdd:PRK12356   8 EQLQQAVDQAYAQFKSDTGGKNADYIPALANVPSDLFGVAVVTTDGQVYSAGDSDYRFAIESISKVFTLALALEDVGpQA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 153 VHDHIGHEPSGKRFN---AFELdENHKPHNPMINSGAIMASALIRSqfTQKAEPYNALQAFTERAIGkmSPVNFNNSVYL 229
Cdd:PRK12356  88 VREKIGADPTGLPFNsviAIEL-HGGKPLNPLVNAGAIATTSLVPG--ANSDERWQRILDGQQRFAG--RELALSDEVYQ 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 230 SELGHAARNYALTYFMQEHSELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHAQAALSL 309
Cdd:PRK12356 163 SEQTTNFHNRAIAWLLYSYGRL--YCDPMEACDVYTRQCSTLVTARDLATMGATLAAGGVNPLTGKRVVDADNVPYILAE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 310 MYNCGMYDYSGRFAFEVGIPAKSGVSGALFLSVPGKLGIAIYSPRVDALGNTVRGLYVAAQLVRAIpELHVFSTTRLTHE 389
Cdd:PRK12356 241 MTMEGLYERSGDWAYTVGLPGKSGVGGGILAVVPGKMGIAAFSPPLDSAGNSVRGQKAVAYVADKL-GLNLFKGAPYTEK 319
PRK12357 PRK12357
glutaminase; Reviewed
 92-373 1.24e-60

glutaminase; Reviewed


Pssm-ID: 237074  Cd Length: 326  Bit Score: 203.03  E-value: 1.24e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680  92 DGAQASYIPELEKVNPELFAIALCGPNGHFWSIGDATIPFTLQSCVKPILYNVA-LDLAGERVHDHIGHEPSGKRFNA-- 168
Cdd:PRK12357  30 EGRSASYIPALGEINVSQLGICIVKPDGTMIKSGDWEVPFTLQSISKVISFIAAcLSRGISYVLERVDVEPTGDAFNSii 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 169 -FELDENHKPHNPMINSGAIMASALIRSQF-TQKAEPynaLQAFTERAIGKMSPVNfnNSVYLSELGHAARNYALTYFMQ 246
Cdd:PRK12357 110 rLEIHKPGKPFNPMINAGAITVASLLPGTSvQEKLES---LYVLIEKMIGKRPAIN--EEVFQSEWETAHRNRALAYYLK 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 247 EHSELlkHTSVEEVLHLYFQACSMSTDVRGLAVLAATYAMGGMCPITNERVMDPHHAQAALSLMYNCGMYDYSGRFAFEV 326
Cdd:PRK12357 185 ETGFL--ESDVEETLEVYLKQCSIEVTTEDIALIGLILAHDGYHPIRKEQVIPKEVARLTKALMLTCGMYNASGKFAAFV 262

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514694680 327 GIPAKSGVSGALFLSVPGK----------LGIAIYSPRVDALGNTVRGLYVAAQLVR 373
Cdd:PRK12357 263 GLPAKSGVSGGIMTLVPPKsrkdlpfqdgCGIGIYGPAIDEYGNSLPGIMLLKHIAK 319
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
405-485 6.75e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 6.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 405 LMQFVAHGDAAKVHELVSNtSVNVNGTNPDGRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPMSEAERHNLQHIL 484
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235


                 .
gi 514694680 485 D 485
Cdd:COG0666  236 K 236
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
397-475 2.76e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 2.76e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514694680 397 DTEHLHLMLMQFVAHGDAAKVHELVSNtSVNVNGTNPDGRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPMSEA 475
Cdd:COG0666   83 KDDGGNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
405-479 8.65e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 8.65e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514694680 405 LMQFVAHGDAAKVHELVSNtSVNVNGTNPDGRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPMSEAERHN 479
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLEA-GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG 197
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
404-479 4.56e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.49  E-value: 4.56e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514694680 404 MLMQFVAHGDAAKVHELVSNTSVNVNGTNPDGRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPMSEAERHN 479
Cdd:COG0666   56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 401-483 8.83e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.82  E-value: 8.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 401 LHLMLMQFVAHGDAAKVHELVSNTSvNVNGTNPDGRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPMSEAERHNL 480
Cdd:PTZ00322  82 LTVELCQLAASGDAVGARILLTGGA-DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGF 160


                 ...
gi 514694680 481 QHI 483
Cdd:PTZ00322 161 REV 163
Ank_2 pfam12796
Ankyrin repeats (3 copies);
405-479 5.53e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 5.53e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514694680  405 LMQFVAHGDAAKVHELVSNtSVNVNGTNPDGRTALLEALAAGRGDIASYLLAHgADPAVTDHfGNTPMSEAERHN 479
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN-GADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSG 72
Ank_2 pfam12796
Ankyrin repeats (3 copies);
405-465 7.41e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 7.41e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514694680  405 LMQFVAHGDAAKVHELVSNTSVNVNGtnpDGRTALLEALAAGRGDIASYLLAHGADPAVTD 465
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
405-485 1.15e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.17  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514694680 405 LMQFVAHGDAAKVHELVSNtSVNVNGTNPDGRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPMSEAERHNLQHIL 484
Cdd:COG0666  190 LHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268


                 .
gi 514694680 485 D 485
Cdd:COG0666  269 K 269
PHA03095 PHA03095
ankyrin-like protein; Provisional
 420-485 1.40e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 1.40e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514694680 420 LVSNTSVNVngTNPDGRTALLEAlAAGRGDIA-SYLLAHGADPAVTDHFGNTPMSEAERHNLQHILD 485
Cdd:PHA03095 244 LIAGISINA--RNRYGQTPLHYA-AVFNNPRAcRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_5 pfam13857
Ankyrin repeats (many copies);
420-475 3.45e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 3.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 514694680  420 LVSNTSVNVNGTNPDGRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPMSEA 475
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
435-472 3.23e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 514694680  435 GRTALLEALAAGRGDIASYLLAHGADPAVTDHFGNTPM 472
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETAL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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