NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|514685003|ref|XP_004990081|]
View 

uncharacterized protein PTSG_09657 [Salpingoeca rosetta]

Protein Classification

APOPT family protein( domain architecture ID 10885)

APOPT family protein is a DUF2315 domain-containing protein similar to Caenorhabditis elegans mitochondrial COA8 family protein Y39B6A.34, which may be required for cytochrome c complex (COX) assembly and function, COX being the terminal component of the mitochondrial respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COA8 super family cl10916
Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome ...
 4-123 1.27e-48

Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.


The actual alignment was detected with superfamily member pfam10231:

Pssm-ID: 463011  Cd Length: 119  Bit Score: 152.41  E-value: 1.27e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514685003    4 STRVLAPHPVSNLRRIERVPRADETRAEKRLRLQLDADHEFHQRFWHKNNTDFKQAREAFLEEHREDMSAGRlPAHLMAE 83
Cdd:pfam10231   1 HDWIGPPDPVSNLRPIIYHIPENETPLERQLRELRQETQAWNQEFWTKHNTRFSKEKEEFIESLLKAKGLEE-RAGEMSE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 514685003   84 FYCSFLEAHREDHITYNLEWWGRAARQIPLYVHAYVSRFF 123
Cdd:pfam10231  80 FYKSFLDKNWKRHMNYNKEWYKRNFAILWLAARVALSRFF 119
 
Name Accession Description Interval E-value
COA8 pfam10231
Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome ...
 4-123 1.27e-48

Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.


Pssm-ID: 463011  Cd Length: 119  Bit Score: 152.41  E-value: 1.27e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514685003    4 STRVLAPHPVSNLRRIERVPRADETRAEKRLRLQLDADHEFHQRFWHKNNTDFKQAREAFLEEHREDMSAGRlPAHLMAE 83
Cdd:pfam10231   1 HDWIGPPDPVSNLRPIIYHIPENETPLERQLRELRQETQAWNQEFWTKHNTRFSKEKEEFIESLLKAKGLEE-RAGEMSE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 514685003   84 FYCSFLEAHREDHITYNLEWWGRAARQIPLYVHAYVSRFF 123
Cdd:pfam10231  80 FYKSFLDKNWKRHMNYNKEWYKRNFAILWLAARVALSRFF 119
 
Name Accession Description Interval E-value
COA8 pfam10231
Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome ...
 4-123 1.27e-48

Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.


Pssm-ID: 463011  Cd Length: 119  Bit Score: 152.41  E-value: 1.27e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514685003    4 STRVLAPHPVSNLRRIERVPRADETRAEKRLRLQLDADHEFHQRFWHKNNTDFKQAREAFLEEHREDMSAGRlPAHLMAE 83
Cdd:pfam10231   1 HDWIGPPDPVSNLRPIIYHIPENETPLERQLRELRQETQAWNQEFWTKHNTRFSKEKEEFIESLLKAKGLEE-RAGEMSE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 514685003   84 FYCSFLEAHREDHITYNLEWWGRAARQIPLYVHAYVSRFF 123
Cdd:pfam10231  80 FYKSFLDKNWKRHMNYNKEWYKRNFAILWLAARVALSRFF 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH