NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|514351524|gb|AGO49943|]
View 

Toll-like receptor 7, partial [Philesturnus carunculatus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-228 3.92e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLTHIPPNLSS--TLKELYIYNNMIQEIQEqDLSGLPNLEILDLSGNcprcynapypcipcpksSIQIHS 78
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN-----------------QLTDLP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  79 RAFDSLENLRILRLHSNSLQSIPSSwFRNTKNLKELDLSQNFLmREIGDArfLTHIPSLVQLDLSFNfelkvyspflNLS 158
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----------QLT 241

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351524 159 K--TFSSLANLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKIANLTVFEEFPALKFIDLSVNKI 228
Cdd:COG4886  242 DlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-228 3.92e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLTHIPPNLSS--TLKELYIYNNMIQEIQEqDLSGLPNLEILDLSGNcprcynapypcipcpksSIQIHS 78
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN-----------------QLTDLP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  79 RAFDSLENLRILRLHSNSLQSIPSSwFRNTKNLKELDLSQNFLmREIGDArfLTHIPSLVQLDLSFNfelkvyspflNLS 158
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----------QLT 241

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351524 159 K--TFSSLANLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKIANLTVFEEFPALKFIDLSVNKI 228
Cdd:COG4886  242 DlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1-145 2.59e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 2.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLTHIPpNLSST--LKELYIYNNMIQEIQeqDLSGLPNLEILDLSGNCPRC----YNAP--------YPC 66
Cdd:cd21340   25 NLKVLYLYDNKITKIE-NLEFLtnLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVveglENLTnleelhieNQR 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  67 IPcPKSSIQIHSRAFDSL-ENLRILRLHSNSLQSIpsSWFRNTKNLKELDLSQNFL--MREIGDarFLTHIPSLVQLDLS 143
Cdd:cd21340  102 LP-PGEKLTFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIsdLEELLD--LLSSWPSLRELDLT 176


                 ..
gi 514351524 144 FN 145
Cdd:cd21340  177 GN 178
LRR_8 pfam13855
Leucine rich repeat;
86-145 3.28e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.28e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   86 NLRILRLHSNSLQSIPSSWFRNTKNLKELDLSQNFLmrEIGDARFLTHIPSLVQLDLSFN 145
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-202 1.30e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.93  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLT-HIPPNLSS--TLKELYI-YNNMIQEIQEQdLSGLPNLEILDLsgncprCYNAPYPCIPCpkssiqi 76
Cdd:PLN00113 189 SLEFLTLASNQLVgQIPRELGQmkSLKWIYLgYNNLSGEIPYE-IGGLTSLNHLDL------VYNNLTGPIPS------- 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  77 hsrAFDSLENLRILRLHSNSLQ-SIPSSWFrNTKNLKELDLSQNFLMREIGDarFLTHIPSLVQLDL-SFNFELKVyspf 154
Cdd:PLN00113 255 ---SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPE--LVIQLQNLEILHLfSNNFTGKI---- 324

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 514351524 155 lnlSKTFSSLANLETL-----RLKGYVFKELRAQDlhpllslrNLTMLDLGTN 202
Cdd:PLN00113 325 ---PVALTSLPRLQVLqlwsnKFSGEIPKNLGKHN--------NLTVLDLSTN 366
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-228 3.92e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLTHIPPNLSS--TLKELYIYNNMIQEIQEqDLSGLPNLEILDLSGNcprcynapypcipcpksSIQIHS 78
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN-----------------QLTDLP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  79 RAFDSLENLRILRLHSNSLQSIPSSwFRNTKNLKELDLSQNFLmREIGDArfLTHIPSLVQLDLSFNfelkvyspflNLS 158
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----------QLT 241

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351524 159 K--TFSSLANLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKIANLTVFEEFPALKFIDLSVNKI 228
Cdd:COG4886  242 DlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-228 9.78e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 9.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLTHIPPNLSS--TLKELYIYNNMIQEIQEqDLSGLPNLEILDLSGNcprcynapypcipcpksSIQIHS 78
Cdd:COG4886  137 NLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN-----------------QITDLP 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  79 RAFDSLENLRILRLHSNSLQSIPSSwFRNTKNLKELDLSQNflmrEIGDARFLTHIPSLVQLDLSFNfELKVYSPFLNLS 158
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN-QLTDLPPLANLT 272

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524 159 ktfsslaNLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKIANLTVFEEFPALKFIDLSVNKI 228
Cdd:COG4886  273 -------NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-262 5.92e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLTHIPPNLS--STLKELYIYNNMIQEIQEqDLSGLPNLEILDLSGNcprcynapypcipcpkssiQIHS 78
Cdd:COG4886  160 NLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN-------------------QLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  79 --RAFDSLENLRILRLHSNSLQSIPssWFRNTKNLKELDLSQNflmrEIGDARFLTHIPSLVQLDLSFNFELKVYSPFLN 156
Cdd:COG4886  220 lpEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524 157 LSKTFSSLANLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKIANLTVFEEFPALKFIDLSVNKISPSSGESN 236
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                        250       260
                 ....*....|....*....|....*.
gi 514351524 237 FYGFCSNPGLSVEQYNRQVRQEMHYF 262
Cdd:COG4886  374 LLEATLLTLALLLLTLLLLLLTTTAG 399
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-229 4.71e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 4.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   5 LSLKSNNLTHIPPNLSSTLKELYIYNNMIQEIQEQDLSGLPNLEILDLSGNcprcynapypcipcpkssiqihsRAFDSL 84
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----------------------EELSNL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  85 ENLRILRLHSNSLQSIPSSwFRNTKNLKELDLSQNFLmREIGDArfLTHIPSLVQLDLSFNF------------ELKV-- 150
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQL-TDLPEP--LGNLTNLKSLDLSNNQltdlpeelgnltNLKEld 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524 151 --YSPFLNLSKTFSSLANLETLRLKGYVFKELRAqdlhPLLSLRNLTMLDLGTNfiKIANLTVFEEFPALKFIDLSVNKI 228
Cdd:COG4886  189 lsNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQL 262


                 .
gi 514351524 229 S 229
Cdd:COG4886  263 T 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1-145 2.59e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 2.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLTHIPpNLSST--LKELYIYNNMIQEIQeqDLSGLPNLEILDLSGNCPRC----YNAP--------YPC 66
Cdd:cd21340   25 NLKVLYLYDNKITKIE-NLEFLtnLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVveglENLTnleelhieNQR 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  67 IPcPKSSIQIHSRAFDSL-ENLRILRLHSNSLQSIpsSWFRNTKNLKELDLSQNFL--MREIGDarFLTHIPSLVQLDLS 143
Cdd:cd21340  102 LP-PGEKLTFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIsdLEELLD--LLSSWPSLRELDLT 176


                 ..
gi 514351524 144 FN 145
Cdd:cd21340  177 GN 178
LRR_8 pfam13855
Leucine rich repeat;
86-145 3.28e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.28e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   86 NLRILRLHSNSLQSIPSSWFRNTKNLKELDLSQNFLmrEIGDARFLTHIPSLVQLDLSFN 145
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-202 1.30e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.93  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLT-HIPPNLSS--TLKELYI-YNNMIQEIQEQdLSGLPNLEILDLsgncprCYNAPYPCIPCpkssiqi 76
Cdd:PLN00113 189 SLEFLTLASNQLVgQIPRELGQmkSLKWIYLgYNNLSGEIPYE-IGGLTSLNHLDL------VYNNLTGPIPS------- 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  77 hsrAFDSLENLRILRLHSNSLQ-SIPSSWFrNTKNLKELDLSQNFLMREIGDarFLTHIPSLVQLDL-SFNFELKVyspf 154
Cdd:PLN00113 255 ---SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPE--LVIQLQNLEILHLfSNNFTGKI---- 324

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 514351524 155 lnlSKTFSSLANLETL-----RLKGYVFKELRAQDlhpllslrNLTMLDLGTN 202
Cdd:PLN00113 325 ---PVALTSLPRLQVLqlwsnKFSGEIPKNLGKHN--------NLTVLDLSTN 366
LRR_8 pfam13855
Leucine rich repeat;
1-55 3.65e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 3.65e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 514351524    1 KLAILSLKSNNLTHIPP----NLSStLKELYIYNNMIQEIQEQDLSGLPNLEILDLSGN 55
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgafkGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-229 6.08e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 6.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   2 LAILSLKSNNLT-HIPPNLSS--TLKELYIYNNMIQEIQEQDLSGLPNLEILDLSGNCPRCYNAPYPCIPCPKSSIQIHS 78
Cdd:PLN00113 310 LEILHLFSNNFTgKIPVALTSlpRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFS 389

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  79 RAFDS--------LENLRILRLHSNSLQSIPSSWFRNTKNLKELDLSQNFLMREIGDARFltHIPSLVQLDLSFNfelkv 150
Cdd:PLN00113 390 NSLEGeipkslgaCRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKW--DMPSLQMLSLARN----- 462

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524 151 ySPFLNLSKTFSSlANLETL-----RLKGYV------FKELRAQDL----------HPLLSLRNLTMLDLGTNFIKIANL 209
Cdd:PLN00113 463 -KFFGGLPDSFGS-KRLENLdlsrnQFSGAVprklgsLSELMQLKLsenklsgeipDELSSCKKLVSLDLSHNQLSGQIP 540

                        250       260
                 ....*....|....*....|
gi 514351524 210 TVFEEFPALKFIDLSVNKIS 229
Cdd:PLN00113 541 ASFSEMPVLSQLDLSQNQLS 560
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 82-229 2.47e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  82 DSLENLRILRLHSNSLQSIP----SSWFRNTKNLKELDLSQNflmrEIGD------ARFLTHIPSLVQLDLSFNFELKVY 151
Cdd:cd00116  134 DLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANN----GIGDagiralAEGLKANCNLEVLDLNNNGLTDEG 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524 152 SPFLnlSKTFSSLANLETLRLKGYVFKELRAQDLHPLLSLRNLTM--LDLGTNFIK----IANLTVFEEFPALKFIDLSV 225
Cdd:cd00116  210 ASAL--AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLltLSLSCNDITddgaKDLAEVLAEKESLLELDLRG 287


                 ....
gi 514351524 226 NKIS 229
Cdd:cd00116  288 NKFG 291
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 194-223 6.27e-06

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 42.33  E-value: 6.27e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 514351524  194 LTMLDLGTNFIKIANLTVFEEFPALKFIDL 223
Cdd:pfam18837   1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1-102 3.06e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 3.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLTHIPPNLSSTLKELYIYNNMIQEIQEQdlsgLPN-LEILDLSGNcpRCYNAPYPcIPCPKSSIQIHSR 79
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPAT----LPDtIQEMELSIN--RITELPER-LPSALQSLDLFHN 272

                         90       100
                 ....*....|....*....|....*...
gi 514351524  80 AFDSL-----ENLRILRLHSNSLQSIPS 102
Cdd:PRK15370 273 KISCLpenlpEELRYLSVYDNSIRTLPA 300
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-204 3.10e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   2 LAILSLKSNNLT-HIPPNLSSTLKELYIYNNMIQEIQEQDLSGLPNLEILDLSGNCPRCYNAPYpcipcpkssiqihsra 80
Cdd:PLN00113 120 LRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNS---------------- 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  81 FDSLENLRILRLHSNSLQSIPSSWFRNTKNLKELDLSQNFLMREIGDArfLTHIPSLVQLDLSFNfelkvyspflNLSKT 160
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYN----------NLTGP 251

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 514351524 161 F-SSLANLETLRlkgYVF---KELRAQDLHPLLSLRNLTMLDLGTNFI 204
Cdd:PLN00113 252 IpSSLGNLKNLQ---YLFlyqNKLSGPIPPSIFSLQKLISLDLSDNSL 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-223 3.42e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 3.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   1 KLAILSLKSNNLTHIPPNLS--STLKELYIYNNMIQEIQEqdLSGLPNLEILDLSGNcprcynapypcipcpkssiQIHS 78
Cdd:COG4886  206 NLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN-------------------QLTD 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  79 -RAFDSLENLRILRLHSNSLQSIPSSWFRNTKNLKELDLSQNFLMREIGDARFLTHIPSLVQLDLSFNFELKVYSPFLNL 157
Cdd:COG4886  265 lPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351524 158 SKTFSSLANLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKIANLTVFEEFPALKFIDL 223
Cdd:COG4886  345 SLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-229 1.79e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  16 PPNLSSTLKELYIYNNMIQEIQEQDLSGLPNLEILDLSGNCPRCYNAPYPCIPCPKSSIQIHSRAFDSLENLRILRLHSN 95
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  96 SLQSIPSSWFRNTKNLKELDLSQNflmreigdaRFLTHIPSLVQLDLSFNfelkvysPFLNLSKTFSSLANLETLRLKGY 175
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGN-------QLTDLPEELANLTNLKELDLSNN 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 514351524 176 VFKELRAqdlhPLLSLRNLTMLDLGTNfiKIANLT-VFEEFPALKFIDLSVNKIS 229
Cdd:COG4886  147 QLTDLPE----PLGNLTNLKSLDLSNN--QLTDLPeELGNLTNLKELDLSNNQIT 195
LRR_8 pfam13855
Leucine rich repeat;
21-97 2.35e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351524   21 STLKELYIYNNMIQEIQEQDLSGLPNLEILDLSGNCPRCynapypcipcpkssiqIHSRAFDSLENLRILRLHSNSL 97
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT----------------LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
45-119 2.83e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.83e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351524   45 PNLEILDLSGNcprcynapypcipcpksSIQ-IHSRAFDSLENLRILRLHSNSLQSIPSSWFRNTKNLKELDLSQN 119
Cdd:pfam13855   1 PNLRSLDLSNN-----------------RLTsLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-145 3.24e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   2 LAILSLKSNNLTHIPPNL--SSTLKELYIYNNMIQEIQEQDLSGLPNLEILDLSGNcprcynapypcipcpKSSIQIhSR 79
Cdd:PLN00113 454 LQMLSLARNKFFGGLPDSfgSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN---------------KLSGEI-PD 517

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351524  80 AFDSLENLRILRLHSNSLQ-SIPSSwFRNTKNLKELDLSQNFLMREIgdARFLTHIPSLVQLDLSFN 145
Cdd:PLN00113 518 ELSSCKKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSGEI--PKNLGNVESLVQVNISHN 581
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 5-311 4.76e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 4.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524   5 LSLKSNNLT-HIPPNLS--STLKELYIYNNMIQEIQEQDLSGLPNLEILDLSGNCprcYNAPYPCIPCPKSSIQI-H--- 77
Cdd:PLN00113 241 LDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNS---LSGEIPELVIQLQNLEIlHlfs 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  78 -------SRAFDSLENLRILRLHSNSLQ-SIPSSWFRNTkNLKELDLSQNFLMREIGDArfLTHIPSLVQLDLsFNFELK 149
Cdd:PLN00113 318 nnftgkiPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHN-NLTVLDLSTNNLTGEIPEG--LCSSGNLFKLIL-FSNSLE 393

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524 150 VYSPflnlsKTFSSLANLETLRLKGYVFKELRAQDlhpLLSLRNLTMLDLGTNFIKIANLTVFEEFPALKFIDLSVNKIS 229
Cdd:PLN00113 394 GEIP-----KSLGACRSLRRVRLQDNSFSGELPSE---FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFF 465

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524 230 ----PSSGESNFygfcSNPGLSVEQYNRQVRQEMHYFRYDVY*RSCRSK-----DKEASSYQSLVkedclnygkTLDLSR 300
Cdd:PLN00113 466 gglpDSFGSKRL----ENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKlsgeiPDELSSCKKLV---------SLDLSH 532

                        330
                 ....*....|.
gi 514351524 301 NNVFF*NPSDF 311
Cdd:PLN00113 533 NQLSGQIPASF 543
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 81-229 1.36e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524  81 FDSLENLRILRLHSNSLQSIPSswFRNTKNLKELDLSQNFLmREIGDarfLTHIPSLVQLDLSFNfELKVYSpflNLSKt 160
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQI-EKIEN---LENLVNLKKLYLGGN-RISVVE---GLEN- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351524 161 fssLANLETLRLKGyvfkelraQDLHP----------LLSLRN-LTMLDLGTNfiKIANLTVFEEFPALKFIDLSVNKIS 229
Cdd:cd21340   89 ---LTNLEELHIEN--------QRLPPgekltfdprsLAALSNsLRVLNISGN--NIDSLEPLAPLRNLEQLDASNNQIS 155
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 23-55 4.03e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 4.03e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 514351524   23 LKELYIYNNMIQEIQEqdLSGLPNLEILDLSGN 55
Cdd:pfam12799   3 LEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH