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Conserved domains on  [gi|514351516|gb|AGO49939|]
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Toll-like receptor 7, partial [Cyanoramphus novaezelandiae]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-210 2.60e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   2 STLKELYIYNNKIQVIqEHDLSTLHNLEILDLSGNcprcynapypcipcpksTIEIHSKAFYSLKNLRILRLHSNSIQSI 81
Cdd:COG4886  113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN-----------------QLTDLPEPLGNLTNLKSLDLSNNQLTDL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  82 PSSwFKNLRNLKQLDLSQNfLIKEIGDAqfLKFIPSLVELDLSFNfELKmysptlNLSKSFSSLSNLETLRLRGYVFKEL 161
Cdd:COG4886  175 PEE-LGNLTNLKELDLSNN-QITDLPEP--LGNLTNLEELDLSGN-QLT------DLPEPLANLTNLETLDLSNNQLTDL 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 514351516 162 REgnldpLLSLRNLTVLDLGTNFIKvaDLSVFKKLPSLKLIDLSVNKIS 210
Cdd:COG4886  244 PE-----LGNLTNLEELDLSNNQLT--DLPPLANLTNLKTLDLSNNQLT 285
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-210 2.60e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   2 STLKELYIYNNKIQVIqEHDLSTLHNLEILDLSGNcprcynapypcipcpksTIEIHSKAFYSLKNLRILRLHSNSIQSI 81
Cdd:COG4886  113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN-----------------QLTDLPEPLGNLTNLKSLDLSNNQLTDL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  82 PSSwFKNLRNLKQLDLSQNfLIKEIGDAqfLKFIPSLVELDLSFNfELKmysptlNLSKSFSSLSNLETLRLRGYVFKEL 161
Cdd:COG4886  175 PEE-LGNLTNLKELDLSNN-QITDLPEP--LGNLTNLEELDLSGN-QLT------DLPEPLANLTNLETLDLSNNQLTDL 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 514351516 162 REgnldpLLSLRNLTVLDLGTNFIKvaDLSVFKKLPSLKLIDLSVNKIS 210
Cdd:COG4886  244 PE-----LGNLTNLEELDLSNNQLT--DLPPLANLTNLKTLDLSNNQLT 285
LRR_8 pfam13855
Leucine rich repeat;
67-126 4.40e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 4.40e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   67 NLRILRLHSNSIQSIPSSWFKNLRNLKQLDLSQNfLIKEIGDAQFLKFiPSLVELDLSFN 126
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGL-PSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 4-126 4.03e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   4 LKELYIYNNKIQVIQehDLSTLHNLEILDLSGNCPRC----YNAP--------YPCIPCP-KSTIEIHSkAFYSLKNLRI 70
Cdd:cd21340   48 LTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVveglENLTnleelhieNQRLPPGeKLTFDPRS-LAALSNSLRV 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351516  71 LRLHSNSIQSIpsSWFKNLRNLKQLDLSQNfLIKEIGD-AQFLKFIPSLVELDLSFN 126
Cdd:cd21340  125 LNISGNNIDSL--EPLAPLRNLEQLDASNN-QISDLEElLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 4-210 1.43e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   4 LKELYIYNNKIQVIQEHDLSTLHNLEILDLSGNCprcYNAPYPCIPCPKSTI------------EIhSKAFYSLKNLRIL 71
Cdd:PLN00113 334 LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNN---LTGEIPEGLCSSGNLfklilfsnslegEI-PKSLGACRSLRRV 409

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  72 RLHSNSIQSIPSSWFKNLRNLKQLDLSQNFLIKEIGDAQFLkfIPSLVELDLS---FNFELKMYSPTLNLSK-------- 140
Cdd:PLN00113 410 RLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWD--MPSLQMLSLArnkFFGGLPDSFGSKRLENldlsrnqf 487

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351516 141 ------SFSSLSNLETLRLRGyvfKELREGNLDPLLSLRNLTVLDLGTNFIKVADLSVFKKLPSLKLIDLSVNKIS 210
Cdd:PLN00113 488 sgavprKLGSLSELMQLKLSE---NKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-210 2.60e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   2 STLKELYIYNNKIQVIqEHDLSTLHNLEILDLSGNcprcynapypcipcpksTIEIHSKAFYSLKNLRILRLHSNSIQSI 81
Cdd:COG4886  113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN-----------------QLTDLPEPLGNLTNLKSLDLSNNQLTDL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  82 PSSwFKNLRNLKQLDLSQNfLIKEIGDAqfLKFIPSLVELDLSFNfELKmysptlNLSKSFSSLSNLETLRLRGYVFKEL 161
Cdd:COG4886  175 PEE-LGNLTNLKELDLSNN-QITDLPEP--LGNLTNLEELDLSGN-QLT------DLPEPLANLTNLETLDLSNNQLTDL 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 514351516 162 REgnldpLLSLRNLTVLDLGTNFIKvaDLSVFKKLPSLKLIDLSVNKIS 210
Cdd:COG4886  244 PE-----LGNLTNLEELDLSNNQLT--DLPPLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-218 9.57e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 9.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   4 LKELYIYNNKiqviqehDLSTLHNLEILDLSGNcprcynapypcipcpksTIEIHSKAFYSLKNLRILRLHSNSIQSIPS 83
Cdd:COG4886   98 LTELDLSGNE-------ELSNLTNLESLDLSGN-----------------QLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  84 SwFKNLRNLKQLDLSQNfLIKEIGDAqfLKFIPSLVELDLSFNfelkmysPTLNLSKSFSSLSNLETLRLRGYVFKELRE 163
Cdd:COG4886  154 P-LGNLTNLKSLDLSNN-QLTDLPEE--LGNLTNLKELDLSNN-------QITDLPEPLGNLTNLEELDLSGNQLTDLPE 222

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 514351516 164 gnldPLLSLRNLTVLDLGTNfiKVADLSVFKKLPSLKLIDLSVNKISPSSDESNF 218
Cdd:COG4886  223 ----PLANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLTDLPPLANL 271
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-209 2.74e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 2.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   4 LKELYIYNNKIQVIQEHdLSTLHNLEILDLSGNCprcynapypcipcpkstIEIHSKAFYSLKNLRILRLHSNSIQSIPS 83
Cdd:COG4886  161 LKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ-----------------ITDLPEPLGNLTNLEELDLSGNQLTDLPE 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  84 SwFKNLRNLKQLDLSQNflikEIGDAQFLKFIPSLVELDLSFNfELKMYSPTLNLSksfsslsNLETLRLRGYVFKELRE 163
Cdd:COG4886  223 P-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN-QLTDLPPLANLT-------NLKTLDLSNNQLTDLKL 289

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 514351516 164 GNLDPLLSLRNLTVLDLGTNFIKVADLSVFKKLPSLKLIDLSVNKI 209
Cdd:COG4886  290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-207 1.27e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   2 STLKELYIYNNKIQVIQEhDLSTLHNLEILDLSGNcprcynapypcipcpksTIEIHSKAFYSLKNLRILRLHSNSIQSI 81
Cdd:COG4886  182 TNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN-----------------QLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  82 PssWFKNLRNLKQLDLSQNflikEIGDAQFLKFIPSLVELDLSFNFELKMYSPTL-NLSKSFSSLSNLETLRLRGYVFKE 160
Cdd:COG4886  244 P--ELGNLTNLEELDLSNN----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELeLLLGLNSLLLLLLLLNLLELLILL 317

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 514351516 161 LREGNLDPLLSLRNLTVLDLGTNFIKVADLSVFKKLPSLKLIDLSVN 207
Cdd:COG4886  318 LLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
LRR_8 pfam13855
Leucine rich repeat;
67-126 4.40e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 4.40e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   67 NLRILRLHSNSIQSIPSSWFKNLRNLKQLDLSQNfLIKEIGDAQFLKFiPSLVELDLSFN 126
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGL-PSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 4-126 4.03e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   4 LKELYIYNNKIQVIQehDLSTLHNLEILDLSGNCPRC----YNAP--------YPCIPCP-KSTIEIHSkAFYSLKNLRI 70
Cdd:cd21340   48 LTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVveglENLTnleelhieNQRLPPGeKLTFDPRS-LAALSNSLRV 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351516  71 LRLHSNSIQSIpsSWFKNLRNLKQLDLSQNfLIKEIGD-AQFLKFIPSLVELDLSFN 126
Cdd:cd21340  125 LNISGNNIDSL--EPLAPLRNLEQLDASNN-QISDLEElLDLLSSWPSLRELDLTGN 178
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 175-204 9.45e-08

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 46.96  E-value: 9.45e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 514351516  175 LTVLDLGTNFIKVADLSVFKKLPSLKLIDL 204
Cdd:pfam18837   1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 4-210 1.08e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   4 LKELYIYNNKIQVIQehDLSTLHNLEILDLSGNcprcynapypCIpcpkSTIEihskAFYSLKNLRILRLHSNSIQSIps 83
Cdd:cd21340   26 LKVLYLYDNKITKIE--NLEFLTNLTHLYLQNN----------QI----EKIE----NLENLVNLKKLYLGGNRISVV-- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  84 SWFKNLRNLKQLDLS-QNflikeigdaqflkfipslVELDLSFNFElkmysptlnlSKSFSSLSN-LETLRLRGyvfkeL 161
Cdd:cd21340   84 EGLENLTNLEELHIEnQR------------------LPPGEKLTFD----------PRSLAALSNsLRVLNISG-----N 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 514351516 162 REGNLDPLLSLRNLTVLDLGTNFIKVAD--LSVFKKLPSLKLIDLSVNKIS 210
Cdd:cd21340  131 NIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVC 181
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 62-210 1.32e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  62 FYSLKNLRILRLHSNSIQSIPSswFKNLRNLKQLDLSQNFlIKEIGDAQFLKfipSLVELDLSFNfelkmysptlNLSK- 140
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQ-IEKIENLENLV---NLKKLYLGGN----------RISVv 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351516 141 -SFSSLSNLETLRLRGyvfKELREGN---LDP--LLSLRN-LTVLDLGTNfiKVADLSVFKKLPSLKLIDLSVNKIS 210
Cdd:cd21340   84 eGLENLTNLEELHIEN---QRLPPGEkltFDPrsLAALSNsLRVLNISGN--NIDSLEPLAPLRNLEQLDASNNQIS 155
LRR_8 pfam13855
Leucine rich repeat;
27-100 3.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 3.66e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351516   27 NLEILDLSGNcprcynapypcipcpkSTIEIHSKAFYSLKNLRILRLHSNSIQSIPSSWFKNLRNLKQLDLSQN 100
Cdd:pfam13855   2 NLRSLDLSNN----------------RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 91-209 1.21e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  91 NLKQLDLSQNFLIKEIGD--AQFLKFIPSLVELDLSFNFELKMYSPTLnlSKSFSSLSNLETLRLRGYVFKELREGNL-D 167
Cdd:cd00116  138 ALEKLVLGRNRLEGASCEalAKALRANRDLKELNLANNGIGDAGIRAL--AEGLKANCNLEVLDLNNNGLTDEGASALaE 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 514351516 168 PLLSLRNLTVLDLGTNFIKVADLSVFKK-----LPSLKLIDLSVNKI 209
Cdd:cd00116  216 TLASLKSLEVLNLGDNNLTDAGAAALASallspNISLLTLSLSCNDI 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 4-210 1.43e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   4 LKELYIYNNKIQVIQEHDLSTLHNLEILDLSGNCprcYNAPYPCIPCPKSTI------------EIhSKAFYSLKNLRIL 71
Cdd:PLN00113 334 LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNN---LTGEIPEGLCSSGNLfklilfsnslegEI-PKSLGACRSLRRV 409

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  72 RLHSNSIQSIPSSWFKNLRNLKQLDLSQNFLIKEIGDAQFLkfIPSLVELDLS---FNFELKMYSPTLNLSK-------- 140
Cdd:PLN00113 410 RLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWD--MPSLQMLSLArnkFFGGLPDSFGSKRLENldlsrnqf 487

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351516 141 ------SFSSLSNLETLRLRGyvfKELREGNLDPLLSLRNLTVLDLGTNFIKVADLSVFKKLPSLKLIDLSVNKIS 210
Cdd:PLN00113 488 sgavprKLGSLSELMQLKLSE---NKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 66-108 1.53e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 514351516   66 KNLRILRLHSNSIQSIPSswFKNLRNLKQLDLSQNFLIKEIGD 108
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
LRR_8 pfam13855
Leucine rich repeat;
2-78 1.73e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 1.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351516    2 STLKELYIYNNKIQVIQEHDLSTLHNLEILDLSGNCPRCynapypcipcpkstieIHSKAFYSLKNLRILRLHSNSI 78
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT----------------LSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-183 1.89e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  65 LKNLRILRLHSNSIQ-SIPSSWFkNLRNLKQLDLSQNFLIKEIGDaqflkFIPSLVELDLSFNFELKMyspTLNLSKSFS 143
Cdd:PLN00113 259 LKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPE-----LVIQLQNLEILHLFSNNF---TGKIPVALT 329

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 514351516 144 SLSNLETL-----RLRGYVFKELREGNldpllslrNLTVLDLGTN 183
Cdd:PLN00113 330 SLPRLQVLqlwsnKFSGEIPKNLGKHN--------NLTVLDLSTN 366
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-126 2.63e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   2 STLKELYIYNNKIQV--IQE--HDLSTLHNLEILDLSGNCPRCYNAPYPCIpcpkstieihskAFYSLKNLRILRLHSNS 77
Cdd:cd00116  165 RDLKELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLTDEGASALAE------------TLASLKSLEVLNLGDNN 232

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  78 IQSIPSSWFKN-----LRNLKQLDLSQNflikEIGD------AQFLKFIPSLVELDLSFN 126
Cdd:cd00116  233 LTDAGAAALASallspNISLLTLSLSCN----DITDdgakdlAEVLAEKESLLELDLRGN 288
LRR_8 pfam13855
Leucine rich repeat;
173-210 1.43e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 1.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 514351516  173 RNLTVLDLGTNFIKVADLSVFKKLPSLKLIDLSVNKIS 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-126 3.62e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.11  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516   1 SSTLKELYIYNNKI-----QVIQEHDLSTLHNLEILDLSGNcpRCYNAPypCIPCPKSTIEIHS---------------- 59
Cdd:cd00116  107 SSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRN--RLEGAS--CEALAKALRANRDlkelnlanngigdagi 182

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351516  60 ----KAFYSLKNLRILRLHSNSIQSIPSSW----FKNLRNLKQLDLSQNfLIKEIGDA----QFLKFIPSLVELDLSFN 126
Cdd:cd00116  183 ralaEGLKANCNLEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDN-NLTDAGAAalasALLSPNISLLTLSLSCN 260
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 24-231 5.74e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 5.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516  24 TLHNLEILDLSGNCprcynapypcipcpkSTIEIHSKaFYSLKNLRILRLHSNSIQS-IPSSwFKNLRNLKQLDLSQNFL 102
Cdd:PLN00113 138 SIPNLETLDLSNNM---------------LSGEIPND-IGSFSSLKVLDLGGNVLVGkIPNS-LTNLTSLEFLTLASNQL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351516 103 I----KEIGDAQFLKFI------------------PSLVELDLSFNfelkmySPTLNLSKSFSSLSNLETLrlrgYVFKE 160
Cdd:PLN00113 201 VgqipRELGQMKSLKWIylgynnlsgeipyeigglTSLNHLDLVYN------NLTGPIPSSLGNLKNLQYL----FLYQN 270

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351516 161 LREGNLDP-LLSLRNLTVLDLGTNFIKVADLSVFKKLPSLKLIDLSVNKISPSSDEsnfyGVCSNPRISVEQ 231
Cdd:PLN00113 271 KLSGPIPPsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPV----ALTSLPRLQVLQ 338
PLN03150 PLN03150
hypothetical protein; Provisional
 81-155 6.10e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 37.49  E-value: 6.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351516  81 IPSSWFKnLRNLKQLDLSQNFLIKEIGDAqfLKFIPSLVELDLSFNFelkmysptLNLS--KSFSSLSNLETLRLRG 155
Cdd:PLN03150 434 IPNDISK-LRHLQSINLSGNSIRGNIPPS--LGSITSLEVLDLSYNS--------FNGSipESLGQLTSLRILNLNG 499
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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