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Conserved domains on  [gi|514351502|gb|AGO49932|]
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Toll-like receptor 5, partial [Philesturnus carunculatus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
67-354 9.72e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 9.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  67 NLKNPDDSTFAGLGRSNLNFFDISQGYIFSLNSLVFQSLGSLESLNLFKNKINQIQRQAFFGLGNLKILNLSSNLLGELY 146
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 147 DYTFEGLHSVMYIDLQQ-NHIGIIGDKSFRQLVNLKIIDLRDNAIKRLPP----FPHLTSALLSDNKLMSVADrAITA-- 219
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPEelanLTNLKELDLSNNQLTDLPE-PLGNlt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 220 --THLELERNWLANLGDlyILFQIPDLQYIFLKQNRFSYCvrSANVIENNQLIYMDLGENMLqlvweRDLcLDVFGALPK 297
Cdd:COG4886  160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDL--PEPLGNLTNLEELDLSGNQL-----TDL-PEPLANLTN 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351502 298 LQVLHLNNNYLSALPQeiFRGLTSLKGLNLASNLLSHLSPGLFPQSLTYLNLSGNQL 354
Cdd:COG4886  230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
67-354 9.72e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 9.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  67 NLKNPDDSTFAGLGRSNLNFFDISQGYIFSLNSLVFQSLGSLESLNLFKNKINQIQRQAFFGLGNLKILNLSSNLLGELY 146
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 147 DYTFEGLHSVMYIDLQQ-NHIGIIGDKSFRQLVNLKIIDLRDNAIKRLPP----FPHLTSALLSDNKLMSVADrAITA-- 219
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPEelanLTNLKELDLSNNQLTDLPE-PLGNlt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 220 --THLELERNWLANLGDlyILFQIPDLQYIFLKQNRFSYCvrSANVIENNQLIYMDLGENMLqlvweRDLcLDVFGALPK 297
Cdd:COG4886  160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDL--PEPLGNLTNLEELDLSGNQL-----TDL-PEPLANLTN 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351502 298 LQVLHLNNNYLSALPQeiFRGLTSLKGLNLASNLLSHLSPGLFPQSLTYLNLSGNQL 354
Cdd:COG4886  230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
296-354 2.17e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 2.17e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351502  296 PKLQVLHLNNNYLSALPQEIFRGLTSLKGLNLASNLLSHLSPGLF--PQSLTYLNLSGNQL 354
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
179-354 2.07e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.61  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 179 NLKIIDLRDNAIKRLPP-FPHLTSAL-LSDNKLMSVADRAITATH-LELERNWLANLGDlyilfQIPD-LQYIFLKQNRF 254
Cdd:PRK15370 221 NIKTLYANSNQLTSIPAtLPDTIQEMeLSINRITELPERLPSALQsLDLFHNKISCLPE-----NLPEeLRYLSVYDNSI 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 255 SYC---VRSANV---IENNQLIYM--DLGENMLQLVWERDLCLDVFGALP-KLQVLHLNNNYLSALPQEIFRGLTSlkgL 325
Cdd:PRK15370 296 RTLpahLPSGIThlnVQSNSLTALpeTLPPGLKTLEAGENALTSLPASLPpELQVLDVSKNQITVLPETLPPTITT---L 372

                        170       180
                 ....*....|....*....|....*....
gi 514351502 326 NLASNLLSHLsPGLFPQSLTYLNLSGNQL 354
Cdd:PRK15370 373 DVSRNALTNL-PENLPAALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 289-374 1.21e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 289 LDVFGALPKLQVLHLNNNYLSALpqEIFRGLTSLKGLNLAS-------------NLLSHLSPglfpqSLTYLNLSGNQLF 355
Cdd:cd21340   61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSN-----SLRVLNISGNNID 133

                         90       100
                 ....*....|....*....|
gi 514351502 356 SPEPEVFMT-LSILDITHNN 374
Cdd:cd21340  134 SLEPLAPLRnLEQLDASNNQ 153
LRR smart00370
Leucine-rich repeats, outliers;
295-318 2.97e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.97e-03
                           10        20
                   ....*....|....*....|....
gi 514351502   295 LPKLQVLHLNNNYLSALPQEIFRG 318
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
67-354 9.72e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 9.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  67 NLKNPDDSTFAGLGRSNLNFFDISQGYIFSLNSLVFQSLGSLESLNLFKNKINQIQRQAFFGLGNLKILNLSSNLLGELY 146
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 147 DYTFEGLHSVMYIDLQQ-NHIGIIGDKSFRQLVNLKIIDLRDNAIKRLPP----FPHLTSALLSDNKLMSVADrAITA-- 219
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPEelanLTNLKELDLSNNQLTDLPE-PLGNlt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 220 --THLELERNWLANLGDlyILFQIPDLQYIFLKQNRFSYCvrSANVIENNQLIYMDLGENMLqlvweRDLcLDVFGALPK 297
Cdd:COG4886  160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDL--PEPLGNLTNLEELDLSGNQL-----TDL-PEPLANLTN 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351502 298 LQVLHLNNNYLSALPQeiFRGLTSLKGLNLASNLLSHLSPGLFPQSLTYLNLSGNQL 354
Cdd:COG4886  230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
296-354 2.17e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 2.17e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351502  296 PKLQVLHLNNNYLSALPQEIFRGLTSLKGLNLASNLLSHLSPGLF--PQSLTYLNLSGNQL 354
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
107-166 2.46e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 2.46e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  107 SLESLNLFKNKINQIQRQAFFGLGNLKILNLSSNLLGELYDYTFEGLHSVMYIDLQQNHI 166
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-355 3.53e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 3.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  66 DNLKNPDDSTFAGLGRSNLNFFDISQGYIFSLNSLVFQSLGSLESLNLFKNKinqiqrqAFFGLGNLKILNLSSNLLGEL 145
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 146 yDYTFEGLHSVMYIDLQQNHIGIIGDkSFRQLVNLKIIDLRDNAIKRLPPF----PHLTSALLSDNKLMSVADrAITA-- 219
Cdd:COG4886  129 -PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPE-PLGNlt 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 220 --THLELERNWLANLGDlyILFQIPDLQYIFLKQNRFSYCvrsANVIENNQLIYMDLGENMLQlvwerdlCLDVFGALPK 297
Cdd:COG4886  206 nlEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDL---PELGNLTNLEELDLSNNQLT-------DLPPLANLTN 273

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 514351502 298 LQVLHLNNNYLSALPQEIFRGLTSLKGLNLASNLLSHLSPGLFPQSLTYLNLSGNQLF 355
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR_8 pfam13855
Leucine rich repeat;
131-190 1.11e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.11e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  131 NLKILNLSSNLLGELYDYTFEGLHSVMYIDLQQNHIGIIGDKSFRQLVNLKIIDLRDNAI 190
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
82-142 1.01e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.01e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351502   82 SNLNFFDISQGYIFSLNSLVFQSLGSLESLNLFKNKINQIQRQAFFGLGNLKILNLSSNLL 142
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
179-354 2.07e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.61  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 179 NLKIIDLRDNAIKRLPP-FPHLTSAL-LSDNKLMSVADRAITATH-LELERNWLANLGDlyilfQIPD-LQYIFLKQNRF 254
Cdd:PRK15370 221 NIKTLYANSNQLTSIPAtLPDTIQEMeLSINRITELPERLPSALQsLDLFHNKISCLPE-----NLPEeLRYLSVYDNSI 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 255 SYC---VRSANV---IENNQLIYM--DLGENMLQLVWERDLCLDVFGALP-KLQVLHLNNNYLSALPQEIFRGLTSlkgL 325
Cdd:PRK15370 296 RTLpahLPSGIThlnVQSNSLTALpeTLPPGLKTLEAGENALTSLPASLPpELQVLDVSKNQITVLPETLPPTITT---L 372

                        170       180
                 ....*....|....*....|....*....
gi 514351502 326 NLASNLLSHLsPGLFPQSLTYLNLSGNQL 354
Cdd:PRK15370 373 DVSRNALTNL-PENLPAALQIMQASRNNL 400
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-370 6.05e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 115 KNKINQIQrQAFFGLGNLKILNLSSNLL-GELYDYTFEGLHSVMYIDLQQNHIGiiGDKSFRQLVNLKIIDLRDNAIKRL 193
Cdd:PLN00113  79 KNISGKIS-SAIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGE 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 194 PP-----FPHLTSALLSDNKLMSVADRAITA-THLE---LERNWLANlGDLYILFQIPDLQYIFLKQNRFSYCVRsanvI 264
Cdd:PLN00113 156 IPndigsFSSLKVLDLGGNVLVGKIPNSLTNlTSLEfltLASNQLVG-QIPRELGQMKSLKWIYLGYNNLSGEIP----Y 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 265 ENNQLIYMdlgeNMLQLVWErDLCLDV---FGALPKLQVLHLNNNYLSA-LPQEIFrGLTSLKGLNLASNLLSHLSPGLF 340
Cdd:PLN00113 231 EIGGLTSL----NHLDLVYN-NLTGPIpssLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNSLSGEIPELV 304

                        250       260       270
                 ....*....|....*....|....*....|..
gi 514351502 341 PQ--SLTYLNLSGNQLFSPEPEVFMTLSILDI 370
Cdd:PLN00113 305 IQlqNLEILHLFSNNFTGKIPVALTSLPRLQV 336
LRR_8 pfam13855
Leucine rich repeat;
286-332 6.59e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 6.59e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 514351502  286 DLCLDVFGALPKLQVLHLNNNYLSALPQEIFRGLTSLKGLNLASNLL 332
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 295-373 6.95e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 6.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 295 LPKLQVLHLNNNYLSA-LPQEIFRGLTSLKGLNLASNLLSHLSPGLFPQSLTYLNLSGNQLFSPEPE---VFMTLSILDI 370
Cdd:PLN00113  92 LPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNdigSFSSLKVLDL 171


                 ...
gi 514351502 371 THN 373
Cdd:PLN00113 172 GGN 174
LRR_8 pfam13855
Leucine rich repeat;
155-209 8.94e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 8.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  155 SVMYIDLQQNHIGIIGDKSFRQLVNLKIIDLRDNAIKRLPP-----FPHLTSALLSDNKL 209
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafsgLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 289-374 1.21e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 289 LDVFGALPKLQVLHLNNNYLSALpqEIFRGLTSLKGLNLAS-------------NLLSHLSPglfpqSLTYLNLSGNQLF 355
Cdd:cd21340   61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSN-----SLRVLNISGNNID 133

                         90       100
                 ....*....|....*....|
gi 514351502 356 SPEPEVFMT-LSILDITHNN 374
Cdd:cd21340  134 SLEPLAPLRnLEQLDASNNQ 153
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-374 1.41e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  64 GFDNLKNPDDSTFAGLgrSNLNFFDISQGYIFSLNSLVFQSLGSLESLNLFKNKINQIQRQAFFGLGNLKILNLSSNLL- 142
Cdd:PLN00113 220 GYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLs 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 143 GELYDYTFEgLHSVMYIDLQQNHIGIIGDKSFRQLVNLKIIDLRDNAI-----KRLPPFPHLTSALLSDNKLMSVADRAi 217
Cdd:PLN00113 298 GEIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFsgeipKNLGKHNNLTVLDLSTNNLTGEIPEG- 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 218 tathlelernwLANLGDLY--ILF------QIP-------DLQYIFLKQNRFSYCVRSAnvIENNQLIY-MDLGENMLQ- 280
Cdd:PLN00113 376 -----------LCSSGNLFklILFsnslegEIPkslgacrSLRRVRLQDNSFSGELPSE--FTKLPLVYfLDISNNNLQg 442

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 281 ----LVWErdlcldvfgaLPKLQVLHLN-NNYLSALPQeiFRGLTSLKGLNLASNLLSHLSP---GLFPQsLTYLNLSGN 352
Cdd:PLN00113 443 rinsRKWD----------MPSLQMLSLArNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPrklGSLSE-LMQLKLSEN 509

                        330       340
                 ....*....|....*....|....*
gi 514351502 353 QLFSPEPEVFMT---LSILDITHNN 374
Cdd:PLN00113 510 KLSGEIPDELSSckkLVSLDLSHNQ 534
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 107-188 5.10e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.84  E-value: 5.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  107 SLESLNLFKNkINQIQRQAFFGLGNLKILNLSSNLLgELYDYTFEGLHSVmYIDLQQNhIGIIGDKSFRQLVNLKIIDLR 186
Cdd:pfam13306  12 SLTSITIPSS-LTSIGEYAFSNCTSLKSITLPSSLT-SIGSYAFYNCSLT-SITIPSS-LTSIGEYAFSNCSNLKSITLP 87


                  ..
gi 514351502  187 DN 188
Cdd:pfam13306  88 SN 89
LRR smart00370
Leucine-rich repeats, outliers;
295-318 2.97e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.97e-03
                           10        20
                   ....*....|....*....|....
gi 514351502   295 LPKLQVLHLNNNYLSALPQEIFRG 318
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
295-318 2.97e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.97e-03
                           10        20
                   ....*....|....*....|....
gi 514351502   295 LPKLQVLHLNNNYLSALPQEIFRG 318
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 84-209 3.26e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 3.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  84 LNFFDISQGYIFSLNSLVFQSLGSLESLNLFKNKINQiQRQAFFGLGNLKILNLSSNLLGELYDYTFEGLHSVMYIDLQQ 163
Cdd:PLN00113 430 VYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE 508

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 514351502 164 NHI-GIIGDK--SFRQLVNLkiiDLRDNAIKRLPP-----FPHLTSALLSDNKL 209
Cdd:PLN00113 509 NKLsGEIPDElsSCKKLVSL---DLSHNQLSGQIPasfseMPVLSQLDLSQNQL 559
LRR_9 pfam14580
Leucine-rich repeat;
183-252 4.39e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.82  E-value: 4.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351502  183 IDLRDNAIKRLPPFPHL---TSALLSDNKLMSVA---DRAITATH-LELERNWLANLGDLYILFQIPDLQYIFLKQN 252
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLrrlKTLLLNNNRICRIGeglGEALPNLTeLILTNNNLQELGDLDPLASLKKLTFLSLLRN 123
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-232 5.97e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 5.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502  82 SNLNFFDISQGYIFSLnSLVFQSLGSLESLNLFKNKINQIQrqAFFGLGNLKILNLSSNLLGELYDytFEGLHSVMYIDL 161
Cdd:COG4886  205 TNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDL 279

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351502 162 QQNHIGIIGDKSFRQLVNLKIIDLRDNAIKRLPPFPHLTSALLSDNKLMSVADRAITATHLELERNWLANL 232
Cdd:COG4886  280 SNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 132-354 7.30e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.11  E-value: 7.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 132 LKILNLSSNLLGELYDytfeGLHSVM----------YIDLQQNHIGIIGD---KSFRQLVNLKIIDLRDNAIKRLPpFPH 198
Cdd:cd00116   53 LKELCLSLNETGRIPR----GLQSLLqgltkgcglqELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLGDRG-LRL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 199 LTSALLsdnklmsvaDRAITATHLELERNWLANLG--DLYILFQ-IPDLQYIFLKQNRFSycVRSANVI-----ENNQLI 270
Cdd:cd00116  128 LAKGLK---------DLPPALEKLVLGRNRLEGASceALAKALRaNRDLKELNLANNGIG--DAGIRALaeglkANCNLE 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351502 271 YMDLGENMLQLVWERDLClDVFGALPKLQVLHLNNNYL-----SALPQEIFRGLTSLKGLNLASNLLSHLSPGLFPQ--- 342
Cdd:cd00116  197 VLDLNNNGLTDEGASALA-ETLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAEvla 275

                        250
                 ....*....|....*
gi 514351502 343 ---SLTYLNLSGNQL 354
Cdd:cd00116  276 ekeSLLELDLRGNKF 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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