NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|514351500|gb|AGO49931|]
View 

Toll-like receptor 5, partial [Notiomystis cincta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-327 1.32e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  40 NLKNPDNSTFTGLGRSNLRFLDISDGYIFSLNSLVFQSLGHLESLNLVKNKINQIERKAFFGLGNLKILNLSSNLLGELY 119
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 120 DYTFEGLRSVMYIDLQQ-NHIGIIEDKSFRQLVNLKIIDLRDNAIKRLP----SFPHLTSAFLGDNKLMSLADrAITA-- 192
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQLTDLPE-PLGNlt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 193 --THLELERNWLANLGDlyILFQIPDLQYIFLKQNRFSYcvKSANVRENNQLIYIDLGENMLQLVwerdlcLDVFRALPK 270
Cdd:COG4886  160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL------PEPLANLTN 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351500 271 LQVLHLNNNYLSALPQeiFSGLTSLKGLNLASNLLSHLSPGLFPQSLKYLNLSGNQL 327
Cdd:COG4886  230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-327 1.32e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  40 NLKNPDNSTFTGLGRSNLRFLDISDGYIFSLNSLVFQSLGHLESLNLVKNKINQIERKAFFGLGNLKILNLSSNLLGELY 119
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 120 DYTFEGLRSVMYIDLQQ-NHIGIIEDKSFRQLVNLKIIDLRDNAIKRLP----SFPHLTSAFLGDNKLMSLADrAITA-- 192
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQLTDLPE-PLGNlt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 193 --THLELERNWLANLGDlyILFQIPDLQYIFLKQNRFSYcvKSANVRENNQLIYIDLGENMLQLVwerdlcLDVFRALPK 270
Cdd:COG4886  160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL------PEPLANLTN 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351500 271 LQVLHLNNNYLSALPQeiFSGLTSLKGLNLASNLLSHLSPGLFPQSLKYLNLSGNQL 327
Cdd:COG4886  230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
269-327 1.60e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 1.60e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351500  269 PKLQVLHLNNNYLSALPQEIFSGLTSLKGLNLASNLLSHLSPGLF--PQSLKYLNLSGNQL 327
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
152-327 2.36e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 2.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 152 NLKIIDLRDNAIKRLP-SFPHLTSAF-LGDNKLMSLADRAITATH-LELERNWLANLGDlyilfQIPD-LQYIFLKQNRF 227
Cdd:PRK15370 221 NIKTLYANSNQLTSIPaTLPDTIQEMeLSINRITELPERLPSALQsLDLFHNKISCLPE-----NLPEeLRYLSVYDNSI 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 228 SYC-------VKSANVrENNQLIYI--DLGENMLQLVWERDLCLDVFRALP-KLQVLHLNNNYLSALPQEIFSGLTSlkg 297
Cdd:PRK15370 296 RTLpahlpsgITHLNV-QSNSLTALpeTLPPGLKTLEAGENALTSLPASLPpELQVLDVSKNQITVLPETLPPTITT--- 371

                        170       180       190
                 ....*....|....*....|....*....|
gi 514351500 298 LNLASNLLSHLsPGLFPQSLKYLNLSGNQL 327
Cdd:PRK15370 372 LDVSRNALTNL-PENLPAALQIMQASRNNL 400
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 74-327 5.44e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 5.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  74 VFQSLGHLESLNLVKNKINQIERKAFFGL----GNLKILNLSSNLLGELYDytfeGLRSVMyidlqqnhigiiedKSFRQ 149
Cdd:cd00116   18 LLPKLLCLQVLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPR----GLQSLL--------------QGLTK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 150 LVNLKIIDLRDNAIK-----RLPSFP--------HLTSAFLGDNKLM----SLADRAITATHLELERNWLANLG--DLYI 210
Cdd:cd00116   80 GCGLQELDLSDNALGpdgcgVLESLLrssslqelKLNNNGLGDRGLRllakGLKDLPPALEKLVLGRNRLEGASceALAK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 211 LFQ-IPDLQYIFLKQNRF------SYCVksaNVRENNQLIYIDLGENMLQLVWERDLClDVFRALPKLQVLHLNNNYL-- 281
Cdd:cd00116  160 ALRaNRDLKELNLANNGIgdagirALAE---GLKANCNLEVLDLNNNGLTDEGASALA-ETLASLKSLEVLNLGDNNLtd 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 514351500 282 ---SALPQEIFSGLTSLKGLNLASNLLSHLSPGLFPQ------SLKYLNLSGNQL 327
Cdd:cd00116  236 agaAALASALLSPNISLLTLSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKF 290
LRR smart00370
Leucine-rich repeats, outliers;
268-291 8.13e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 8.13e-03
                           10        20
                   ....*....|....*....|....
gi 514351500   268 LPKLQVLHLNNNYLSALPQEIFSG 291
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-327 1.32e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  40 NLKNPDNSTFTGLGRSNLRFLDISDGYIFSLNSLVFQSLGHLESLNLVKNKINQIERKAFFGLGNLKILNLSSNLLGELY 119
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 120 DYTFEGLRSVMYIDLQQ-NHIGIIEDKSFRQLVNLKIIDLRDNAIKRLP----SFPHLTSAFLGDNKLMSLADrAITA-- 192
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQLTDLPE-PLGNlt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 193 --THLELERNWLANLGDlyILFQIPDLQYIFLKQNRFSYcvKSANVRENNQLIYIDLGENMLQLVwerdlcLDVFRALPK 270
Cdd:COG4886  160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL------PEPLANLTN 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351500 271 LQVLHLNNNYLSALPQeiFSGLTSLKGLNLASNLLSHLSPGLFPQSLKYLNLSGNQL 327
Cdd:COG4886  230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
269-327 1.60e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 1.60e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351500  269 PKLQVLHLNNNYLSALPQEIFSGLTSLKGLNLASNLLSHLSPGLF--PQSLKYLNLSGNQL 327
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-346 4.72e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 4.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  56 NLRFLDISDGYIFSLNSLVFQSLGHLESLNLVKNKINQIERKAFFGLGNLKILNLSSNLLGELYDYTFEGLRSVMYIDLQ 135
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 136 QNHIGIIEDKSFRQLVNLKIIDLRDNaiKRLPSFPHLTSAFLGDNKLMSLADRAITATHLE---LERNWLANLGDlyILF 212
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGN--EELSNLTNLESLDLSGNQLTDLPEELANLTNLKeldLSNNQLTDLPE--PLG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 213 QIPDLQYIFLKQNRFSYCvkSANVRENNQLIYIDLGENMLQlvwerDLcLDVFRALPKLQVLHLNNNYLSALPQEIfSGL 292
Cdd:COG4886  157 NLTNLKSLDLSNNQLTDL--PEELGNLTNLKELDLSNNQIT-----DL-PEPLGNLTNLEELDLSGNQLTDLPEPL-ANL 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 514351500 293 TSLKGLNLASNLLSHLSPGLFPQSLKYLNLSGNQLFSPEPEVFMT-LSILDITHN 346
Cdd:COG4886  228 TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNN 282
LRR_8 pfam13855
Leucine rich repeat;
80-139 5.90e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 5.90e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500   80 HLESLNLVKNKINQIERKAFFGLGNLKILNLSSNLLGELYDYTFEGLRSVMYIDLQQNHI 139
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-344 7.47e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 7.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  39 DNLKNPDNSTFTGLGRSNLRFLDISDGYIFSLNSLVFQSLGHLESLNLVKNKinqierkAFFGLGNLKILNLSSNLLGEL 118
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 119 yDYTFEGLRSVMYIDLQQNHIGIIeDKSFRQLVNLKIIDLRDNAIKRLPSF----PHLTSAFLGDNKLMSLADraitath 194
Cdd:COG4886  129 -PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPE------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 195 lelernwlanlgdlyILFQIPDLQYIFLKQNRFSYcvKSANVRENNQLIYIDLGENMLQlvwerdlCLDVFRALPKLQVL 274
Cdd:COG4886  200 ---------------PLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLT-------DLPELGNLTNLEEL 255

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 275 HLNNNYLSALPQEifSGLTSLKGLNLASNLLSHLSPGLFPQSLKYLNLSGNQLFSPEPEVFMTLSILDIT 344
Cdd:COG4886  256 DLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR_8 pfam13855
Leucine rich repeat;
55-115 1.30e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.30e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351500   55 SNLRFLDISDGYIFSLNSLVFQSLGHLESLNLVKNKINQIERKAFFGLGNLKILNLSSNLL 115
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
104-163 2.30e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 2.30e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  104 NLKILNLSSNLLGELYDYTFEGLRSVMYIDLQQNHIGIIEDKSFRQLVNLKIIDLRDNAI 163
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
152-327 2.36e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 2.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 152 NLKIIDLRDNAIKRLP-SFPHLTSAF-LGDNKLMSLADRAITATH-LELERNWLANLGDlyilfQIPD-LQYIFLKQNRF 227
Cdd:PRK15370 221 NIKTLYANSNQLTSIPaTLPDTIQEMeLSINRITELPERLPSALQsLDLFHNKISCLPE-----NLPEeLRYLSVYDNSI 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 228 SYC-------VKSANVrENNQLIYI--DLGENMLQLVWERDLCLDVFRALP-KLQVLHLNNNYLSALPQEIFSGLTSlkg 297
Cdd:PRK15370 296 RTLpahlpsgITHLNV-QSNSLTALpeTLPPGLKTLEAGENALTSLPASLPpELQVLDVSKNQITVLPETLPPTITT--- 371

                        170       180       190
                 ....*....|....*....|....*....|
gi 514351500 298 LNLASNLLSHLsPGLFPQSLKYLNLSGNQL 327
Cdd:PRK15370 372 LDVSRNALTNL-PENLPAALQIMQASRNNL 400
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-343 3.07e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  80 HLESLNLVKNKINQIERKAFFGLGNLKILNLSSNLL-GELYDYTFEGLRSVMYIDLQQNHI-GIIEDKSfrqLVNLKIID 157
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGS---IPNLETLD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 158 LRDNAI-----KRLPSFPHLTSAFLGDNKLMSLADRAITA-THLE---LERNWLANlGDLYILFQIPDLQYIFLKQNRFS 228
Cdd:PLN00113 147 LSNNMLsgeipNDIGSFSSLKVLDLGGNVLVGKIPNSLTNlTSLEfltLASNQLVG-QIPRELGQMKSLKWIYLGYNNLS 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 229 YCVKSanvrENNQLIYIdlgeNMLQLVWErDLCLDV---FRALPKLQVLHLNNNYLSA-LPQEIFsGLTSLKGLNLASNL 304
Cdd:PLN00113 226 GEIPY----EIGGLTSL----NHLDLVYN-NLTGPIpssLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNS 295

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 514351500 305 LSHLSPGLFPQ--SLKYLNLSGNQLFSPEPEVFMTLSILDI 343
Cdd:PLN00113 296 LSGEIPELVIQlqNLEILHLFSNNFTGKIPVALTSLPRLQV 336
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 268-346 4.10e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 4.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 268 LPKLQVLHLNNNYLSA-LPQEIFSGLTSLKGLNLASNLLSHLSPGLFPQSLKYLNLSGNQLFSPEPE---VFMTLSILDI 343
Cdd:PLN00113  92 LPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNdigSFSSLKVLDL 171


                 ...
gi 514351500 344 THN 346
Cdd:PLN00113 172 GGN 174
LRR_8 pfam13855
Leucine rich repeat;
259-305 7.66e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 7.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 514351500  259 DLCLDVFRALPKLQVLHLNNNYLSALPQEIFSGLTSLKGLNLASNLL 305
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-346 3.17e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 3.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  75 FQSLGHLESLNLVKNKINQIERKAFFGLGNLKILNLSSNLL-GELYDYTFEgLRSVMYIDLQQNHIGIIEDKSFRQLVNL 153
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRL 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 154 KIIDLRDNaikrlpSFPHLTSAFLGDNKLMSLADRAITATHLELERNwLANLGDLY--ILF------QIP-------DLQ 218
Cdd:PLN00113 335 QVLQLWSN------KFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEG-LCSSGNLFklILFsnslegEIPkslgacrSLR 407

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 219 YIFLKQNRFSYCVKSANVREnnQLIY-IDLGENMLQ-----LVWErdlcldvfraLPKLQVLHLN-NNYLSALPQeiFSG 291
Cdd:PLN00113 408 RVRLQDNSFSGELPSEFTKL--PLVYfLDISNNNLQgrinsRKWD----------MPSLQMLSLArNKFFGGLPD--SFG 473

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351500 292 LTSLKGLNLASNLLSHLSP---GLFPQsLKYLNLSGNQLFSPEPEVFMT---LSILDITHN 346
Cdd:PLN00113 474 SKRLENLDLSRNQFSGAVPrklGSLSE-LMQLKLSENKLSGEIPDELSSckkLVSLDLSHN 533
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 74-327 5.44e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 5.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  74 VFQSLGHLESLNLVKNKINQIERKAFFGL----GNLKILNLSSNLLGELYDytfeGLRSVMyidlqqnhigiiedKSFRQ 149
Cdd:cd00116   18 LLPKLLCLQVLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPR----GLQSLL--------------QGLTK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 150 LVNLKIIDLRDNAIK-----RLPSFP--------HLTSAFLGDNKLM----SLADRAITATHLELERNWLANLG--DLYI 210
Cdd:cd00116   80 GCGLQELDLSDNALGpdgcgVLESLLrssslqelKLNNNGLGDRGLRllakGLKDLPPALEKLVLGRNRLEGASceALAK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 211 LFQ-IPDLQYIFLKQNRF------SYCVksaNVRENNQLIYIDLGENMLQLVWERDLClDVFRALPKLQVLHLNNNYL-- 281
Cdd:cd00116  160 ALRaNRDLKELNLANNGIgdagirALAE---GLKANCNLEVLDLNNNGLTDEGASALA-ETLASLKSLEVLNLGDNNLtd 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 514351500 282 ---SALPQEIFSGLTSLKGLNLASNLLSHLSPGLFPQ------SLKYLNLSGNQL 327
Cdd:cd00116  236 agaAALASALLSPNISLLTLSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 262-346 6.49e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 6.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500 262 LDVFRALPKLQVLHLNNNYLSALpqEIFSGLTSLKGLNLAS-------------NLLSHLSPglfpqSLKYLNLSGNQLF 328
Cdd:cd21340   61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSN-----SLRVLNISGNNID 133

                         90
                 ....*....|....*....
gi 514351500 329 SPEPEVFMT-LSILDITHN 346
Cdd:cd21340  134 SLEPLAPLRnLEQLDASNN 152
LRR_8 pfam13855
Leucine rich repeat;
127-182 1.20e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351500  127 RSVMYIDLQQNHIGIIEDKSFRQLVNLKIIDLRDNAIKRLP-----SFPHLTSAFLGDNKL 182
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 59-182 3.16e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  59 FLDISDGYIFSLNSLVFQSLGHLESLNLVKNKINQiERKAFFGLGNLKILNLSSNLLGELYDYTFEGLRSVMYIDLQQNH 138
Cdd:PLN00113 432 FLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK 510

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 514351500 139 I-GIIEDK--SFRQLVNLkiiDLRDNAIK-RLPS----FPHLTSAFLGDNKL 182
Cdd:PLN00113 511 LsGEIPDElsSCKKLVSL---DLSHNQLSgQIPAsfseMPVLSQLDLSQNQL 559
LRR_9 pfam14580
Leucine-rich repeat;
132-225 3.31e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.82  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  132 IDLQQNHIGIIEDKSfRQLVNLKIIDLRDNAIKRLPSFPHL---TSAFLGDNKLMSLA---DRAITATH-LELERNWLAN 204
Cdd:pfam14580  24 LDLRGYKIPIIENLG-ATLDQFDTIDFSDNEIRKLDGFPLLrrlKTLLLNNNRICRIGeglGEALPNLTeLILTNNNLQE 102

                          90       100
                  ....*....|....*....|.
gi 514351500  205 LGDLYILFQIPDLQYIFLKQN 225
Cdd:pfam14580 103 LGDLDPLASLKKLTFLSLLRN 123
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-205 4.11e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500  55 SNLRFLDISDGYIFSLnSLVFQSLGHLESLNLVKNKINQIErkAFFGLGNLKILNLSSNLLGELYDytFEGLRSVMYIDL 134
Cdd:COG4886  205 TNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDL 279

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351500 135 QQNHIGIIEDKSFRQLVNLKIIDLRDNAIKRLPSFPHLTSAFLGDNKLMSLADRAITATHLELERNWLANL 205
Cdd:COG4886  280 SNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 81-161 4.44e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 36.75  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351500   81 LESLNLvKNKINQIERKAFFGLGNLKILNLSSNLLgELYDYTFEG--LRSvmyIDLQQNhIGIIEDKSFRQLVNLKIIDL 158
Cdd:pfam13306  13 LTSITI-PSSLTSIGEYAFSNCTSLKSITLPSSLT-SIGSYAFYNcsLTS---ITIPSS-LTSIGEYAFSNCSNLKSITL 86


                  ...
gi 514351500  159 RDN 161
Cdd:pfam13306  87 PSN 89
LRR smart00370
Leucine-rich repeats, outliers;
268-291 8.13e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 8.13e-03
                           10        20
                   ....*....|....*....|....
gi 514351500   268 LPKLQVLHLNNNYLSALPQEIFSG 291
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
268-291 8.13e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 8.13e-03
                           10        20
                   ....*....|....*....|....
gi 514351500   268 LPKLQVLHLNNNYLSALPQEIFSG 291
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH