|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
69-377 |
1.85e-13 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 71.50 E-value: 1.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 69 DNLKNPDYSTFAGLGRSNLSSLDISRGFILSLKSLVFQSLRNLESLNLFRNKineiqrqAFFGLGNLKILNLSSNLLGEL 148
Cdd:COG4886 56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 149 yDYTFEGLRSVMYIDLQQNHIGMIaDKSFRQLVNLKIIDLRDNAIKILPSfprltsAFLGDNKLmfvsyraitaTHLDLE 228
Cdd:COG4886 129 -PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE------ELGNLTNL----------KELDLS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 229 RNWLANLGDlyILFQIPDLQYIFLKQNRFSycvksanaiennqliymDLGENmlqlvwerdlcldvFGALPKLQVLHLNN 308
Cdd:COG4886 191 NNQITDLPE--PLGNLTNLEELDLSGNQLT-----------------DLPEP--------------LANLTNLETLDLSN 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351498 309 NYLSALPQeiFRGLTSLKSLNLASNLLSHLSPGVFPQSLANLNLSGNQLFSPEPEVFMTLTFLDITHNN 377
Cdd:COG4886 238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
299-357 |
3.87e-12 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 61.00 E-value: 3.87e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351498 299 PKLQVLHLNNNYLSALPQEIFRGLTSLKSLNLASNLLSHLSPGVF--PQSLANLNLSGNQL 357
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
105-378 |
1.79e-07 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 53.31 E-value: 1.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 105 FQSLRNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLL-GELYDYTFeglrsvmyidlqqnhigmiadksfrQLVNL 183
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPELVI-------------------------QLQNL 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 184 KIIDLRDNAI--KI---LPSFPRLTSAFLGDNKLMFVSYRAI----TATHLDLERNWLA--------NLGDLY--ILF-- 242
Cdd:PLN00113 311 EILHLFSNNFtgKIpvaLTSLPRLQVLQLWSNKFSGEIPKNLgkhnNLTVLDLSTNNLTgeipeglcSSGNLFklILFsn 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 243 ----QIP-------DLQYIFLKQNRFSYcvKSANAIENNQLIY-MDLGENMLQ-----LVWErdlcldvfgaLPKLQVLH 305
Cdd:PLN00113 391 slegEIPkslgacrSLRRVRLQDNSFSG--ELPSEFTKLPLVYfLDISNNNLQgrinsRKWD----------MPSLQMLS 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 306 LN-NNYLSALPQeiFRGLTSLKSLNLASNLLSHLSP---GVFPQsLANLNLSGNQLFSPEPEVFMT---LTFLDITHNNF 378
Cdd:PLN00113 459 LArNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPrklGSLSE-LMQLKLSENKLSGEIPDELSSckkLVSLDLSHNQL 535
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
376-415 |
4.74e-05 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 40.49 E-value: 4.74e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 514351498 376 NNFVCDCALKSLLVWLNETNVTLagSQFDRYCVYPPALKG 415
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG 38
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
292-378 |
1.07e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 43.24 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 292 LDVFGALPKLQVLHLNNNYLSALpqEIFRGLTSLKSLNLASNllsHLSPGVF----PQSLAN-------LNLSGNQLFSP 360
Cdd:cd21340 61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQ---RLPPGEKltfdPRSLAAlsnslrvLNISGNNIDSL 135
|
90
....*....|....*....
gi 514351498 361 EPEVFMT-LTFLDITHNNF 378
Cdd:cd21340 136 EPLAPLRnLEQLDASNNQI 154
|
|
| LRR |
smart00370 |
Leucine-rich repeats, outliers; |
298-321 |
2.38e-03 |
|
Leucine-rich repeats, outliers;
Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 35.02 E-value: 2.38e-03
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
351-415 |
2.66e-03 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 40.45 E-value: 2.66e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351498 351 NLSGNQLFSPEPEVF---MTLTFLDITHNNFVCDCALKSLLVWLNETNVTLAGSQfDRYCVYPPALKG 415
Cdd:TIGR00864 1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPE-AALCAGPGALAG 67
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
69-377 |
1.85e-13 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 71.50 E-value: 1.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 69 DNLKNPDYSTFAGLGRSNLSSLDISRGFILSLKSLVFQSLRNLESLNLFRNKineiqrqAFFGLGNLKILNLSSNLLGEL 148
Cdd:COG4886 56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 149 yDYTFEGLRSVMYIDLQQNHIGMIaDKSFRQLVNLKIIDLRDNAIKILPSfprltsAFLGDNKLmfvsyraitaTHLDLE 228
Cdd:COG4886 129 -PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE------ELGNLTNL----------KELDLS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 229 RNWLANLGDlyILFQIPDLQYIFLKQNRFSycvksanaiennqliymDLGENmlqlvwerdlcldvFGALPKLQVLHLNN 308
Cdd:COG4886 191 NNQITDLPE--PLGNLTNLEELDLSGNQLT-----------------DLPEP--------------LANLTNLETLDLSN 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351498 309 NYLSALPQeiFRGLTSLKSLNLASNLLSHLSPGVFPQSLANLNLSGNQLFSPEPEVFMTLTFLDITHNN 377
Cdd:COG4886 238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
299-357 |
3.87e-12 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 61.00 E-value: 3.87e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351498 299 PKLQVLHLNNNYLSALPQEIFRGLTSLKSLNLASNLLSHLSPGVF--PQSLANLNLSGNQL 357
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
86-403 |
4.76e-12 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 67.27 E-value: 4.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 86 NLSSLDISRGFILSLKSLVFQSLRNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLLGELYDYTFEGLRSVMYIDLQ 165
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 166 QNHIGMIADKSFRQLVNLKIIDLRDNaiKILPSFPRLTSAFLGDNKL--MFVSYRAITA-THLDLERNWLANLGDLyiLF 242
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGN--EELSNLTNLESLDLSGNQLtdLPEELANLTNlKELDLSNNQLTDLPEP--LG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 243 QIPDLQYIFLKQNRFSYCVKSANAIENnqLIYMDLGENMLQlvwerDLcLDVFGALPKLQVLHLNNNYLSALPQEIfRGL 322
Cdd:COG4886 157 NLTNLKSLDLSNNQLTDLPEELGNLTN--LKELDLSNNQIT-----DL-PEPLGNLTNLEELDLSGNQLTDLPEPL-ANL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 323 TSLKSLNLASNLLSHLSPGVFPQSLANLNLSGNQLFSPEPEVFMT-LTFLDItHNNFVCDCALKSLLVWLNETNVTLAGS 401
Cdd:COG4886 228 TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDL-SNNQLTDLKLKELELLLGLNSLLLLLL 306
|
..
gi 514351498 402 QF 403
Cdd:COG4886 307 LL 308
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
109-169 |
1.10e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.76 E-value: 1.10e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351498 109 RNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLLGELYDYTFEGLRSVMYIDLQQNHI 169
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
85-145 |
5.11e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.84 E-value: 5.11e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351498 85 SNLSSLDISRGFILSLKSLVFQSLRNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLL 145
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
134-193 |
5.96e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 5.96e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 134 NLKILNLSSNLLGELYDYTFEGLRSVMYIDLQQNHIGMIADKSFRQLVNLKIIDLRDNAI 193
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
105-378 |
1.79e-07 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 53.31 E-value: 1.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 105 FQSLRNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLL-GELYDYTFeglrsvmyidlqqnhigmiadksfrQLVNL 183
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPELVI-------------------------QLQNL 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 184 KIIDLRDNAI--KI---LPSFPRLTSAFLGDNKLMFVSYRAI----TATHLDLERNWLA--------NLGDLY--ILF-- 242
Cdd:PLN00113 311 EILHLFSNNFtgKIpvaLTSLPRLQVLQLWSNKFSGEIPKNLgkhnNLTVLDLSTNNLTgeipeglcSSGNLFklILFsn 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 243 ----QIP-------DLQYIFLKQNRFSYcvKSANAIENNQLIY-MDLGENMLQ-----LVWErdlcldvfgaLPKLQVLH 305
Cdd:PLN00113 391 slegEIPkslgacrSLRRVRLQDNSFSG--ELPSEFTKLPLVYfLDISNNNLQgrinsRKWD----------MPSLQMLS 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 306 LN-NNYLSALPQeiFRGLTSLKSLNLASNLLSHLSP---GVFPQsLANLNLSGNQLFSPEPEVFMT---LTFLDITHNNF 378
Cdd:PLN00113 459 LArNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPrklGSLSE-LMQLKLSENKLSGEIPDELSSckkLVSLDLSHNQL 535
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
128-363 |
1.37e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 50.62 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 128 AFFGLGNLKILNLSSNLL-GELYDYTFEGLRSVMYIDLQQNHI-GMIADKSFRQL---------------------VNLK 184
Cdd:PLN00113 88 AIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLetldlsnnmlsgeipndigsfSSLK 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 185 IIDLRDNAI--KILPSFPRLTSA---FLGDN----------------KLMFVSY------------RAITATHLDLERNW 231
Cdd:PLN00113 168 VLDLGGNVLvgKIPNSLTNLTSLeflTLASNqlvgqiprelgqmkslKWIYLGYnnlsgeipyeigGLTSLNHLDLVYNN 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 232 L-----ANLGDLyilfqiPDLQYIFLKQNRFSYCV-KSANAIENnqLIYMDLGENML-----QLVWErdlcldvfgaLPK 300
Cdd:PLN00113 248 LtgpipSSLGNL------KNLQYLFLYQNKLSGPIpPSIFSLQK--LISLDLSDNSLsgeipELVIQ----------LQN 309
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351498 301 LQVLHLNNNYLSAlpqEIFRGLTS---LKSLNLASNLLShlspGVFPQSLAN------LNLSGNQLFSPEPE 363
Cdd:PLN00113 310 LEILHLFSNNFTG---KIPVALTSlprLQVLQLWSNKFS----GEIPKNLGKhnnltvLDLSTNNLTGEIPE 374
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
50-378 |
1.49e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 50.62 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 50 TQIGSLTFSTHI----------MGSGFGfdNLKNPDY-----STFAG------LGRSNLSSLDISRGFIL-SLKSLVFQs 107
Cdd:PLN00113 230 YEIGGLTSLNHLdlvynnltgpIPSSLG--NLKNLQYlflyqNKLSGpippsiFSLQKLISLDLSDNSLSgEIPELVIQ- 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 108 LRNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLLGELYDYTFEGLRSVMYIDLQQNHI-GMIAD------------ 174
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLtGEIPEglcssgnlfkli 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 175 -----------KSFRQLVNLKIIDLRDNAIKilpsfPRLTSAFLgdnKLMFVSYRAITAThldlerNWLANLGDLYilFQ 243
Cdd:PLN00113 387 lfsnslegeipKSLGACRSLRRVRLQDNSFS-----GELPSEFT---KLPLVYFLDISNN------NLQGRINSRK--WD 450
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 244 IPDLQYIFLKQNRFSYCVksANAIENNQLIYMDLGENMLQLVWERDlcldvFGALPKLQVLHLNNNYLSAlpqEIFRGLT 323
Cdd:PLN00113 451 MPSLQMLSLARNKFFGGL--PDSFGSKRLENLDLSRNQFSGAVPRK-----LGSLSELMQLKLSENKLSG---EIPDELS 520
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351498 324 SLK---SLNLASNLLSHLSPGVFP--QSLANLNLSGNQLFSPEPEVF---MTLTFLDITHNNF 378
Cdd:PLN00113 521 SCKklvSLDLSHNQLSGQIPASFSemPVLSQLDLSQNQLSGEIPKNLgnvESLVQVNISHNHL 583
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
289-335 |
4.77e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.67 E-value: 4.77e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 514351498 289 DLCLDVFGALPKLQVLHLNNNYLSALPQEIFRGLTSLKSLNLASNLL 335
Cdd:pfam13855 15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
298-379 |
9.22e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 47.92 E-value: 9.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 298 LPKLQVLHLNNNYLSA-LPQEIFRGLTSLKSLNLASNLLSHLSPGVFPQSLANLNLSGNQLFSPEPE---VFMTLTFLDI 373
Cdd:PLN00113 92 LPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNdigSFSSLKVLDL 171
|
....*.
gi 514351498 374 THNNFV 379
Cdd:PLN00113 172 GGNVLV 177
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
376-415 |
4.74e-05 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 40.49 E-value: 4.74e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 514351498 376 NNFVCDCALKSLLVWLNETNVTLagSQFDRYCVYPPALKG 415
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG 38
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
292-378 |
1.07e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 43.24 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 292 LDVFGALPKLQVLHLNNNYLSALpqEIFRGLTSLKSLNLASNllsHLSPGVF----PQSLAN-------LNLSGNQLFSP 360
Cdd:cd21340 61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQ---RLPPGEKltfdPRSLAAlsnslrvLNISGNNIDSL 135
|
90
....*....|....*....
gi 514351498 361 EPEVFMT-LTFLDITHNNF 378
Cdd:cd21340 136 EPLAPLRnLEQLDASNNQI 154
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
157-212 |
1.37e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.43 E-value: 1.37e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351498 157 RSVMYIDLQQNHIGMIADKSFRQLVNLKIIDLRDNAIKILP-----SFPRLTSAFLGDNKL 212
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
75-143 |
3.52e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 41.70 E-value: 3.52e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351498 75 DYSTFAGLGRSnLSSLDISRGFILSLKSLVfqSLRNLESLNLFRNKINEIQR--QAFFGLGNLKILNLSSN 143
Cdd:cd21340 111 DPRSLAALSNS-LRVLNISGNNIDSLEPLA--PLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
|
|
| LRR |
smart00370 |
Leucine-rich repeats, outliers; |
298-321 |
2.38e-03 |
|
Leucine-rich repeats, outliers;
Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 35.02 E-value: 2.38e-03
|
| LRR_TYP |
smart00369 |
Leucine-rich repeats, typical (most populated) subfamily; |
298-321 |
2.38e-03 |
|
Leucine-rich repeats, typical (most populated) subfamily;
Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 35.02 E-value: 2.38e-03
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
351-415 |
2.66e-03 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 40.45 E-value: 2.66e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351498 351 NLSGNQLFSPEPEVF---MTLTFLDITHNNFVCDCALKSLLVWLNETNVTLAGSQfDRYCVYPPALKG 415
Cdd:TIGR00864 1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPE-AALCAGPGALAG 67
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
105-210 |
3.17e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 38.61 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 105 FQSLRNLESLNLFRNKINEIQRqaFFGLGNLKILNLSSNLLGELydytfEGL--------------------------RS 158
Cdd:cd21340 42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV-----EGLenltnleelhienqrlppgekltfdpRS 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351498 159 VMYI-------DLQQNHIGMIADksFRQLVNLKIIDLRDNAIK-------ILPSFPRLTSAFLGDN 210
Cdd:cd21340 115 LAALsnslrvlNISGNNIDSLEP--LAPLRNLEQLDASNNQISdleelldLLSSWPSLRELDLTGN 178
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
299-333 |
5.87e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 34.53 E-value: 5.87e-03
10 20 30
....*....|....*....|....*....|....*
gi 514351498 299 PKLQVLHLNNNYLSALPqeIFRGLTSLKSLNLASN 333
Cdd:pfam12799 1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
104-378 |
7.63e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 38.11 E-value: 7.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 104 VFQSLRNLESLNLFRNKINEIQRQAFFGL----GNLKILNLSSNLLGELYDytfeGLRSVM----------YIDLQQNHI 169
Cdd:cd00116 18 LLPKLLCLQVLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPR----GLQSLLqgltkgcglqELDLSDNAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 170 ---GMIADKSFRQLVNLKIIDLRDNAIKILPSfpRLTSAFLGDNKLmfvsyraiTATHLDLERNWLANLG--DLYILFQ- 243
Cdd:cd00116 94 gpdGCGVLESLLRSSSLQELKLNNNGLGDRGL--RLLAKGLKDLPP--------ALEKLVLGRNRLEGASceALAKALRa 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 244 IPDLQYIFLKQNRF------SYCVKSAnaiENNQLIYMDLGENMLQLVWERDLClDVFGALPKLQVLHLNNNYL-----S 312
Cdd:cd00116 164 NRDLKELNLANNGIgdagirALAEGLK---ANCNLEVLDLNNNGLTDEGASALA-ETLASLKSLEVLNLGDNNLtdagaA 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351498 313 ALPQEIFRGLTSLKSLNLASNLLSHLSPGVFPQSLANlnlsgnqlfspepevFMTLTFLDITHNNF 378
Cdd:cd00116 240 ALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAE---------------KESLLELDLRGNKF 290
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
295-354 |
9.79e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 38.26 E-value: 9.79e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351498 295 FGALPKLQVLHLNNNYLSALPQEIFRGLTSLKSLNLASNLLShlspGVFPQSLANLNLSG 354
Cdd:PLN03150 462 LGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS----GRVPAALGGRLLHR 517
|
|
|