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Conserved domains on  [gi|514351496|gb|AGO49929|]
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Toll-like receptor 5, partial [Mohoua ochrocephala]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-357 2.34e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496  69 DNLKNPDYSTFAGLGRSNLSSLDISRGFIFSLKSLVFQSLRNLESLNLFRNKineiqrqAFFGLGNLKILNLSSNLLGEL 148
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 149 yDYTFEGLRSVMYIDLQQNHIGMIaDKSFRQLVNLKIIDLRDNAIKILPSfprltsAFLGDNKLmfvsyraitaTHLDLE 228
Cdd:COG4886  129 -PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE------ELGNLTNL----------KELDLS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 229 RNWLANLGDlyILFQIPDLQYIFLKQNRFSycvksanaiennqliymDLGENmlqlvwerdlcldvFGALPKLQVLHLNN 308
Cdd:COG4886  191 NNQITDLPE--PLGNLTNLEELDLSGNQLT-----------------DLPEP--------------LANLTNLETLDLSN 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 514351496 309 NYLSALPQeiFRGLTSLKSLNLASNLLSHLSPGVFPQSLANLNLSGNQL 357
Cdd:COG4886  238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
376-415 4.74e-05

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 4.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 514351496   376 NNFVCDCALKSLLVWLNETNVTLagSQFDRYCVYPPALKG 415
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG 38
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-357 2.34e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496  69 DNLKNPDYSTFAGLGRSNLSSLDISRGFIFSLKSLVFQSLRNLESLNLFRNKineiqrqAFFGLGNLKILNLSSNLLGEL 148
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 149 yDYTFEGLRSVMYIDLQQNHIGMIaDKSFRQLVNLKIIDLRDNAIKILPSfprltsAFLGDNKLmfvsyraitaTHLDLE 228
Cdd:COG4886  129 -PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE------ELGNLTNL----------KELDLS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 229 RNWLANLGDlyILFQIPDLQYIFLKQNRFSycvksanaiennqliymDLGENmlqlvwerdlcldvFGALPKLQVLHLNN 308
Cdd:COG4886  191 NNQITDLPE--PLGNLTNLEELDLSGNQLT-----------------DLPEP--------------LANLTNLETLDLSN 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 514351496 309 NYLSALPQeiFRGLTSLKSLNLASNLLSHLSPGVFPQSLANLNLSGNQL 357
Cdd:COG4886  238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
299-357 3.34e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 3.34e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351496  299 PKLQVLHLNNNYLSALPQEIFRGLTSLKSLNLASNLLSHLSPGVF--PQSLANLNLSGNQL 357
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 105-378 8.68e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 8.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 105 FQSLRNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLL-GELYDYTFeglrsvmyidlqqnhigmiadksfrQLVNL 183
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPELVI-------------------------QLQNL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 184 KIIDLRDNAI--KI---LPSFPRLTSAFLGDNKLMFVSYRAI----TATHLDLERNWLA--------NLGDLY--ILF-- 242
Cdd:PLN00113 311 EILHLFSNNFtgKIpvaLTSLPRLQVLQLWSNKFSGEIPKNLgkhnNLTVLDLSTNNLTgeipeglcSSGNLFklILFsn 390

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 243 ----QIP-------DLQYIFLKQNRFSYcvKSANAIENNQLIY-MDLGENMLQ-----LVWErdlcldvfgaLPKLQVLH 305
Cdd:PLN00113 391 slegEIPkslgacrSLRRVRLQDNSFSG--ELPSEFTKLPLVYfLDISNNNLQgrinsRKWD----------MPSLQMLS 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 306 LN-NNYLSALPQeiFRGLTSLKSLNLASNLLSHLSP---GVFPQsLANLNLSGNQLFSPEPEVFMT---LT*LDITHNNF 378
Cdd:PLN00113 459 LArNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPrklGSLSE-LMQLKLSENKLSGEIPDELSSckkLVSLDLSHNQL 535
LRRCT smart00082
Leucine rich repeat C-terminal domain;
376-415 4.74e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 4.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 514351496   376 NNFVCDCALKSLLVWLNETNVTLagSQFDRYCVYPPALKG 415
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG 38
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 292-378 1.32e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 292 LDVFGALPKLQVLHLNNNYLSALpqEIFRGLTSLKSLNLASNllsHLSPGVF----PQSLAN-------LNLSGNQLFSP 360
Cdd:cd21340   61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQ---RLPPGEKltfdPRSLAAlsnslrvLNISGNNIDSL 135

                         90
                 ....*....|....*....
gi 514351496 361 EPEVFMT-LT*LDITHNNF 378
Cdd:cd21340  136 EPLAPLRnLEQLDASNNQI 154
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 351-415 1.28e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.22  E-value: 1.28e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351496   351 NLSGNQLFSPEPEVF---MTLT*LDITHNNFVCDCALKSLLVWLNETNVTLAGSQfDRYCVYPPALKG 415
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPE-AALCAGPGALAG 67
LRR smart00370
Leucine-rich repeats, outliers;
298-321 2.27e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.27e-03
                           10        20
                   ....*....|....*....|....
gi 514351496   298 LPKLQVLHLNNNYLSALPQEIFRG 321
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-357 2.34e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496  69 DNLKNPDYSTFAGLGRSNLSSLDISRGFIFSLKSLVFQSLRNLESLNLFRNKineiqrqAFFGLGNLKILNLSSNLLGEL 148
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 149 yDYTFEGLRSVMYIDLQQNHIGMIaDKSFRQLVNLKIIDLRDNAIKILPSfprltsAFLGDNKLmfvsyraitaTHLDLE 228
Cdd:COG4886  129 -PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE------ELGNLTNL----------KELDLS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 229 RNWLANLGDlyILFQIPDLQYIFLKQNRFSycvksanaiennqliymDLGENmlqlvwerdlcldvFGALPKLQVLHLNN 308
Cdd:COG4886  191 NNQITDLPE--PLGNLTNLEELDLSGNQLT-----------------DLPEP--------------LANLTNLETLDLSN 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 514351496 309 NYLSALPQeiFRGLTSLKSLNLASNLLSHLSPGVFPQSLANLNLSGNQL 357
Cdd:COG4886  238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
299-357 3.34e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 3.34e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351496  299 PKLQVLHLNNNYLSALPQEIFRGLTSLKSLNLASNLLSHLSPGVF--PQSLANLNLSGNQL 357
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-403 8.08e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 8.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496  86 NLSSLDISRGFIFSLKSLVFQSLRNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLLGELYDYTFEGLRSVMYIDLQ 165
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 166 QNHIGMIADKSFRQLVNLKIIDLRDNaiKILPSFPRLTSAFLGDNKL--MFVSYRAITA-THLDLERNWLANLGDLyiLF 242
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGN--EELSNLTNLESLDLSGNQLtdLPEELANLTNlKELDLSNNQLTDLPEP--LG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 243 QIPDLQYIFLKQNRFSYCVKSANAIENnqLIYMDLGENMLQlvwerDLcLDVFGALPKLQVLHLNNNYLSALPQEIfRGL 322
Cdd:COG4886  157 NLTNLKSLDLSNNQLTDLPEELGNLTN--LKELDLSNNQIT-----DL-PEPLGNLTNLEELDLSGNQLTDLPEPL-ANL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 323 TSLKSLNLASNLLSHLSPGVFPQSLANLNLSGNQLFSPEPEVFMT-LT*LDItHNNFVCDCALKSLLVWLNETNVTLAGS 401
Cdd:COG4886  228 TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDL-SNNQLTDLKLKELELLLGLNSLLLLLL 306


                 ..
gi 514351496 402 QF 403
Cdd:COG4886  307 LL 308
LRR_8 pfam13855
Leucine rich repeat;
109-169 9.68e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 9.68e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351496  109 RNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLLGELYDYTFEGLRSVMYIDLQQNHI 169
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
85-145 7.79e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 7.79e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351496   85 SNLSSLDISRGFIFSLKSLVFQSLRNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLL 145
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
134-193 5.14e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 5.14e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496  134 NLKILNLSSNLLGELYDYTFEGLRSVMYIDLQQNHIGMIADKSFRQLVNLKIIDLRDNAI 193
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 105-378 8.68e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 8.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 105 FQSLRNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLL-GELYDYTFeglrsvmyidlqqnhigmiadksfrQLVNL 183
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPELVI-------------------------QLQNL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 184 KIIDLRDNAI--KI---LPSFPRLTSAFLGDNKLMFVSYRAI----TATHLDLERNWLA--------NLGDLY--ILF-- 242
Cdd:PLN00113 311 EILHLFSNNFtgKIpvaLTSLPRLQVLQLWSNKFSGEIPKNLgkhnNLTVLDLSTNNLTgeipeglcSSGNLFklILFsn 390

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 243 ----QIP-------DLQYIFLKQNRFSYcvKSANAIENNQLIY-MDLGENMLQ-----LVWErdlcldvfgaLPKLQVLH 305
Cdd:PLN00113 391 slegEIPkslgacrSLRRVRLQDNSFSG--ELPSEFTKLPLVYfLDISNNNLQgrinsRKWD----------MPSLQMLS 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 306 LN-NNYLSALPQeiFRGLTSLKSLNLASNLLSHLSP---GVFPQsLANLNLSGNQLFSPEPEVFMT---LT*LDITHNNF 378
Cdd:PLN00113 459 LArNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPrklGSLSE-LMQLKLSENKLSGEIPDELSSckkLVSLDLSHNQL 535
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-378 6.82e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 6.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496  50 TQIGSLTFSTHI----------MGSGFGfdNLKNPDY-----STFAG------LGRSNLSSLDISRGFIF-SLKSLVFQs 107
Cdd:PLN00113 230 YEIGGLTSLNHLdlvynnltgpIPSSLG--NLKNLQYlflyqNKLSGpippsiFSLQKLISLDLSDNSLSgEIPELVIQ- 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 108 LRNLESLNLFRNKINEIQRQAFFGLGNLKILNLSSNLLGELYDYTFEGLRSVMYIDLQQNHI-GMIAD------------ 174
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLtGEIPEglcssgnlfkli 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 175 -----------KSFRQLVNLKIIDLRDNAIKilpsfPRLTSAFLgdnKLMFVSYRAITAThldlerNWLANLGDLYilFQ 243
Cdd:PLN00113 387 lfsnslegeipKSLGACRSLRRVRLQDNSFS-----GELPSEFT---KLPLVYFLDISNN------NLQGRINSRK--WD 450

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 244 IPDLQYIFLKQNRFSYCVksANAIENNQLIYMDLGENMLQLVWERDlcldvFGALPKLQVLHLNNNYLSAlpqEIFRGLT 323
Cdd:PLN00113 451 MPSLQMLSLARNKFFGGL--PDSFGSKRLENLDLSRNQFSGAVPRK-----LGSLSELMQLKLSENKLSG---EIPDELS 520

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351496 324 SLK---SLNLASNLLSHLSPGVFP--QSLANLNLSGNQLFSPEPEVF---MTLT*LDITHNNF 378
Cdd:PLN00113 521 SCKklvSLDLSHNQLSGQIPASFSemPVLSQLDLSQNQLSGEIPKNLgnvESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 128-363 1.22e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 128 AFFGLGNLKILNLSSNLL-GELYDYTFEGLRSVMYIDLQQNHI-GMIADKSFRQL---------------------VNLK 184
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLetldlsnnmlsgeipndigsfSSLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 185 IIDLRDNAI--KILPSFPRLTSA---FLGDN----------------KLMFVSY------------RAITATHLDLERNW 231
Cdd:PLN00113 168 VLDLGGNVLvgKIPNSLTNLTSLeflTLASNqlvgqiprelgqmkslKWIYLGYnnlsgeipyeigGLTSLNHLDLVYNN 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 232 L-----ANLGDLyilfqiPDLQYIFLKQNRFSYCV-KSANAIENnqLIYMDLGENML-----QLVWErdlcldvfgaLPK 300
Cdd:PLN00113 248 LtgpipSSLGNL------KNLQYLFLYQNKLSGPIpPSIFSLQK--LISLDLSDNSLsgeipELVIQ----------LQN 309

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351496 301 LQVLHLNNNYLSAlpqEIFRGLTS---LKSLNLASNLLShlspGVFPQSLAN------LNLSGNQLFSPEPE 363
Cdd:PLN00113 310 LEILHLFSNNFTG---KIPVALTSlprLQVLQLWSNKFS----GEIPKNLGKhnnltvLDLSTNNLTGEIPE 374
LRR_8 pfam13855
Leucine rich repeat;
289-335 4.37e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 4.37e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 514351496  289 DLCLDVFGALPKLQVLHLNNNYLSALPQEIFRGLTSLKSLNLASNLL 335
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
376-415 4.74e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 4.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 514351496   376 NNFVCDCALKSLLVWLNETNVTLagSQFDRYCVYPPALKG 415
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG 38
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 298-379 5.04e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 5.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 298 LPKLQVLHLNNNYLSA-LPQEIFRGLTSLKSLNLASNLLSHLSPGVFPQSLANLNLSGNQLFSPEPE---VFMTLT*LDI 373
Cdd:PLN00113  92 LPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNdigSFSSLKVLDL 171


                 ....*.
gi 514351496 374 THNNFV 379
Cdd:PLN00113 172 GGNVLV 177
LRR_8 pfam13855
Leucine rich repeat;
157-212 1.26e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351496  157 RSVMYIDLQQNHIGMIADKSFRQLVNLKIIDLRDNAIKILP-----SFPRLTSAFLGDNKL 212
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 292-378 1.32e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 292 LDVFGALPKLQVLHLNNNYLSALpqEIFRGLTSLKSLNLASNllsHLSPGVF----PQSLAN-------LNLSGNQLFSP 360
Cdd:cd21340   61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQ---RLPPGEKltfdPRSLAAlsnslrvLNISGNNIDSL 135

                         90
                 ....*....|....*....
gi 514351496 361 EPEVFMT-LT*LDITHNNF 378
Cdd:cd21340  136 EPLAPLRnLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-143 4.16e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 4.16e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351496  75 DYSTFAGLGRSnLSSLDISRGFIFSLKSLVfqSLRNLESLNLFRNKINEIQR--QAFFGLGNLKILNLSSN 143
Cdd:cd21340  111 DPRSLAALSNS-LRVLNISGNNIDSLEPLA--PLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 351-415 1.28e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.22  E-value: 1.28e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351496   351 NLSGNQLFSPEPEVF---MTLT*LDITHNNFVCDCALKSLLVWLNETNVTLAGSQfDRYCVYPPALKG 415
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPE-AALCAGPGALAG 67
LRR smart00370
Leucine-rich repeats, outliers;
298-321 2.27e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.27e-03
                           10        20
                   ....*....|....*....|....
gi 514351496   298 LPKLQVLHLNNNYLSALPQEIFRG 321
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
298-321 2.27e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.27e-03
                           10        20
                   ....*....|....*....|....
gi 514351496   298 LPKLQVLHLNNNYLSALPQEIFRG 321
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 105-210 2.84e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 2.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 105 FQSLRNLESLNLFRNKINEIQRqaFFGLGNLKILNLSSNLLGELydytfEGL--------------------------RS 158
Cdd:cd21340   42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV-----EGLenltnleelhienqrlppgekltfdpRS 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351496 159 VMYI-------DLQQNHIGMIADksFRQLVNLKIIDLRDNAIK-------ILPSFPRLTSAFLGDN 210
Cdd:cd21340  115 LAALsnslrvlNISGNNIDSLEP--LAPLRNLEQLDASNNQISdleelldLLSSWPSLRELDLTGN 178
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 299-333 5.65e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 5.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 514351496  299 PKLQVLHLNNNYLSALPqeIFRGLTSLKSLNLASN 333
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
PLN03150 PLN03150
hypothetical protein; Provisional
 295-354 9.79e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.26  E-value: 9.79e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351496 295 FGALPKLQVLHLNNNYLSALPQEIFRGLTSLKSLNLASNLLShlspGVFPQSLANLNLSG 354
Cdd:PLN03150 462 LGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS----GRVPAALGGRLLHR 517
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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