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Conserved domains on  [gi|514351494|gb|AGO49928|]
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Toll-like receptor 5, partial [Cyanoramphus novaezelandiae]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
17-304 1.43e-10

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  17 NLKNPDQDTFAGLARSDLRLLDISNGYIFSLKSLIFQSLGSLESLNLFKNKINEIQRQAFFGLRNLKILNLSSNLLGELY 96
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  97 DYTFTGLHSVMYIDLQQ-NHIGIVQEKSFSNLVSLKIIDLRDNAIKKLP----SFPHLTSAFLGDNKLMSIAS--KTLAA 169
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQLTDLPEplGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 170 -TYLELERNWLANLGDlyILFKVPDVQYIFLKQNRFSYcvKNDNIIKNQQLIYMDLGENMLQLVwerglcLDVFHGLSKL 248
Cdd:COG4886  161 lKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL------PEPLANLTNL 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 514351494 249 QVLHLNNNYLSALPQevFRGLTSLKRLNLASNLLSHLSPGIFPQSLTNLNLSGNQL 304
Cdd:COG4886  231 ETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-304 1.43e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  17 NLKNPDQDTFAGLARSDLRLLDISNGYIFSLKSLIFQSLGSLESLNLFKNKINEIQRQAFFGLRNLKILNLSSNLLGELY 96
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  97 DYTFTGLHSVMYIDLQQ-NHIGIVQEKSFSNLVSLKIIDLRDNAIKKLP----SFPHLTSAFLGDNKLMSIAS--KTLAA 169
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQLTDLPEplGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 170 -TYLELERNWLANLGDlyILFKVPDVQYIFLKQNRFSYcvKNDNIIKNQQLIYMDLGENMLQLVwerglcLDVFHGLSKL 248
Cdd:COG4886  161 lKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL------PEPLANLTNL 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 514351494 249 QVLHLNNNYLSALPQevFRGLTSLKRLNLASNLLSHLSPGIFPQSLTNLNLSGNQL 304
Cdd:COG4886  231 ETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
246-304 2.27e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 2.27e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351494  246 SKLQVLHLNNNYLSALPQEVFRGLTSLKRLNLASNLLSHLSPGIF--PQSLTNLNLSGNQL 304
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-310 3.41e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 3.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  75 AFFGLRNLKILNLSSNLL-GELYDYTFTGLHSVMYIDLQQNHI-GIVQEKSFSNL---------------------VSLK 131
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLetldlsnnmlsgeipndigsfSSLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 132 IIDLRDNA--------IKKLPSFPHLTSA---------------------FLGDNKLMSIASKTL----AATYLELERNW 178
Cdd:PLN00113 168 VLDLGGNVlvgkipnsLTNLTSLEFLTLAsnqlvgqiprelgqmkslkwiYLGYNNLSGEIPYEIggltSLNHLDLVYNN 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 179 L-----ANLGDLyilfkvPDVQYIFLKQNRFSYCVKNdNIIKNQQLIYMDLGENMLQlvwerGLCLDVFHGLSKLQVLHL 253
Cdd:PLN00113 248 LtgpipSSLGNL------KNLQYLFLYQNKLSGPIPP-SIFSLQKLISLDLSDNSLS-----GEIPELVIQLQNLEILHL 315

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351494 254 -NNNYLSALPqevfRGLTSLKR---LNLASNLLSHLSPGIFPQ--SLTNLNLSGNQLFSPDPE 310
Cdd:PLN00113 316 fSNNFTGKIP----VALTSLPRlqvLQLWSNKFSGEIPKNLGKhnNLTVLDLSTNNLTGEIPE 374
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-90 4.60e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 4.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351494  22 DQDTFAGLARSdLRLLDISNGYIFSLKSLifQSLGSLESLNLFKNKINEIQR--QAFFGLRNLKILNLSSN 90
Cdd:cd21340  111 DPRSLAALSNS-LRVLNISGNNIDSLEPL--APLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-304 1.43e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  17 NLKNPDQDTFAGLARSDLRLLDISNGYIFSLKSLIFQSLGSLESLNLFKNKINEIQRQAFFGLRNLKILNLSSNLLGELY 96
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  97 DYTFTGLHSVMYIDLQQ-NHIGIVQEKSFSNLVSLKIIDLRDNAIKKLP----SFPHLTSAFLGDNKLMSIAS--KTLAA 169
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQLTDLPEplGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 170 -TYLELERNWLANLGDlyILFKVPDVQYIFLKQNRFSYcvKNDNIIKNQQLIYMDLGENMLQLVwerglcLDVFHGLSKL 248
Cdd:COG4886  161 lKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL------PEPLANLTNL 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 514351494 249 QVLHLNNNYLSALPQevFRGLTSLKRLNLASNLLSHLSPGIFPQSLTNLNLSGNQL 304
Cdd:COG4886  231 ETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
246-304 2.27e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 2.27e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351494  246 SKLQVLHLNNNYLSALPQEVFRGLTSLKRLNLASNLLSHLSPGIF--PQSLTNLNLSGNQL 304
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
57-116 9.36e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 9.36e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494   57 SLESLNLFKNKINEIQRQAFFGLRNLKILNLSSNLLGELYDYTFTGLHSVMYIDLQQNHI 116
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
80-140 3.20e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.20e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351494   80 RNLKILNLSSNLLGELYDYTFTGLHSVMYIDLQQNHIGIVQEKSFSNLVSLKIIDLRDNAI 140
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-321 3.43e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 3.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  16 DNLKNPDQDTFAGLARSDLRLLDISNGYIFSLKSLIFQSLGSLESLNLFKNKineiqrqAFFGLRNLKILNLSSNLLGEL 95
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  96 yDYTFTGLHSVMYIDLQQNHIGIVQEkSFSNLVSLKIIDLRDNAIKKLPSF----PHLTSAFLGDNKLMSIaSKTLAA-- 169
Cdd:COG4886  129 -PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDL-PEPLGNlt 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 170 --TYLELERNWLANLGDlyilfkvpdvqyiflkqnrfsycvkndNIIKNQQLIYMDLGENMLQlvwerglCLDVFHGLSK 247
Cdd:COG4886  206 nlEELDLSGNQLTDLPE---------------------------PLANLTNLETLDLSNNQLT-------DLPELGNLTN 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351494 248 LQVLHLNNNYLSALPQEVfrGLTSLKRLNLASNLLSHLSPGIFPQSLTNLNLSGNQLFSPDPELFMTLSILDIT 321
Cdd:COG4886  252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-282 5.63e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 5.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  34 LRLLDISNGYIFSLKSLIFQsLGSLESLNLFKNKINEIQrQAFFGLRNLKILNLSSNLLGELyDYTFTGLHSVMYIDLQQ 113
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 114 NHIGIVqeKSFSNLVSLKIIDLRDNAIKKLPS---FPHLTSAFLGDNKLMSIASKTLAATYLELERNWLANLGDLYILFK 190
Cdd:COG4886  238 NQLTDL--PELGNLTNLEELDLSNNQLTDLPPlanLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 191 VPDVQYIFLKQNRFSYCVKNDNIIKNQQLIYMDLGENMLQLVWERGLCLDVFHGLSKLQVLHLNNNYLSALPQEVFRGLT 270
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395

                        250
                 ....*....|..
gi 514351494 271 SLKRLNLASNLL 282
Cdd:COG4886  396 TTAGVLLLTLAL 407
LRR_8 pfam13855
Leucine rich repeat;
34-92 7.03e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 7.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 514351494   34 LRLLDISNGYIFSLKSLIFQSLGSLESLNLFKNKINEIQRQAFFGLRNLKILNLSSNLL 92
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-310 3.41e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 3.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  75 AFFGLRNLKILNLSSNLL-GELYDYTFTGLHSVMYIDLQQNHI-GIVQEKSFSNL---------------------VSLK 131
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLetldlsnnmlsgeipndigsfSSLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 132 IIDLRDNA--------IKKLPSFPHLTSA---------------------FLGDNKLMSIASKTL----AATYLELERNW 178
Cdd:PLN00113 168 VLDLGGNVlvgkipnsLTNLTSLEFLTLAsnqlvgqiprelgqmkslkwiYLGYNNLSGEIPYEIggltSLNHLDLVYNN 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 179 L-----ANLGDLyilfkvPDVQYIFLKQNRFSYCVKNdNIIKNQQLIYMDLGENMLQlvwerGLCLDVFHGLSKLQVLHL 253
Cdd:PLN00113 248 LtgpipSSLGNL------KNLQYLFLYQNKLSGPIPP-SIFSLQKLISLDLSDNSLS-----GEIPELVIQLQNLEILHL 315

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351494 254 -NNNYLSALPqevfRGLTSLKR---LNLASNLLSHLSPGIFPQ--SLTNLNLSGNQLFSPDPE 310
Cdd:PLN00113 316 fSNNFTGKIP----VALTSLPRlqvLQLWSNKFSGEIPKNLGKhnNLTVLDLSTNNLTGEIPE 374
LRR_8 pfam13855
Leucine rich repeat;
236-282 1.68e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.68e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 514351494  236 GLCLDVFHGLSKLQVLHLNNNYLSALPQEVFRGLTSLKRLNLASNLL 282
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
135-323 4.92e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 4.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 135 LRDNAIKKLPSFPH--LTSAFLGDNKLMSIASkTLAATY--LELERNWLANLGDlyilfKVPD-VQYIFLKQNRFSyCVK 209
Cdd:PRK15370 206 LDNNELKSLPENLQgnIKTLYANSNQLTSIPA-TLPDTIqeMELSINRITELPE-----RLPSaLQSLDLFHNKIS-CLP 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 210 nDNIikNQQLIYMDLGENMLQLVWErglcldvfHGLSKLQVLHLNNNYLSALPQEVFRGLtslKRLNLASNLLSHLsPGI 289
Cdd:PRK15370 279 -ENL--PEELRYLSVYDNSIRTLPA--------HLPSGITHLNVQSNSLTALPETLPPGL---KTLEAGENALTSL-PAS 343

                        170       180       190
                 ....*....|....*....|....*....|....
gi 514351494 290 FPQSLTNLNLSGNQLFSPDPELFMTLSILDITHN 323
Cdd:PRK15370 344 LPPELQVLDVSKNQITVLPETLPPTITTLDVSRN 377
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-323 1.07e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  52 FQSLGSLESLNLFKNKINEIQRQAFFGLRNLKILNLSSNLL-GE---------------LYDYTFTG--------LHSVM 107
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEipelviqlqnleilhLFSNNFTGkipvaltsLPRLQ 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 108 YIDLQQNHIGIVQEKSFSNLVSLKIIDLRDNAIK-KLP----SFPHLTSAFLGDNKLMSIASKTLAAT----YLELERNW 178
Cdd:PLN00113 336 VLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPeglcSSGNLFKLILFSNSLEGEIPKSLGACrslrRVRLQDNS 415

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 179 LAnlGDLYILF-KVPDVQYIFLKQNRFSYCVkNDNIIKNQQLIYMDLGENMLQlvwerGLCLDVFhGLSKLQVLHLNNNY 257
Cdd:PLN00113 416 FS--GELPSEFtKLPLVYFLDISNNNLQGRI-NSRKWDMPSLQMLSLARNKFF-----GGLPDSF-GSKRLENLDLSRNQ 486

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351494 258 LSALPQEVFRGLTSLKRLNLASNLLSHLSPGIFP--QSLTNLNLSGNQLFSPDPELFM---TLSILDITHN 323
Cdd:PLN00113 487 FSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSscKKLVSLDLSHNQLSGQIPASFSempVLSQLDLSQN 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-90 4.60e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 4.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351494  22 DQDTFAGLARSdLRLLDISNGYIFSLKSLifQSLGSLESLNLFKNKINEIQR--QAFFGLRNLKILNLSSN 90
Cdd:cd21340  111 DPRSLAALSNS-LRVLNISGNNIDSLEPL--APLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 241-323 4.20e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 4.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 241 VFHGLSKLQVLHLNNNYLSA-LPQEVFRGLTSLKRLNLASNLLSHLSPGIFPQSLTNLNLSGNQLFSPDPE---LFMTLS 316
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNdigSFSSLK 167


                 ....*..
gi 514351494 317 ILDITHN 323
Cdd:PLN00113 168 VLDLGGN 174
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 239-324 2.04e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494 239 LDVFHGLSKLQVLHLNNNYLSALpqEVFRGLTSLKRLNLAS-------------NLLSHLSPgifpqSLTNLNLSGNQLF 305
Cdd:cd21340   61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSN-----SLRVLNISGNNID 133

                         90       100
                 ....*....|....*....|
gi 514351494 306 SPDP-ELFMTLSILDITHNN 324
Cdd:cd21340  134 SLEPlAPLRNLEQLDASNNQ 153
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 17-142 2.79e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351494  17 NLKNPDQDTFAGLARS--DLRLLDISNGYI----FSLKSLIFQSLGSLESLNLFKNKINEIQRQAFFG----LRNLKILN 86
Cdd:cd00116  148 RLEGASCEALAKALRAnrDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLN 227

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514351494  87 LSSNLLG-----ELYDYTFTGLHSVMYIDLQQNHIGIVQEKSFS----NLVSLKIIDLRDNAIKK 142
Cdd:cd00116  228 LGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGE 292
PLN03150 PLN03150
hypothetical protein; Provisional
 211-288 8.19e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 37.87  E-value: 8.19e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351494 211 DNIIKNQQLIYMDLGENMLqlvweRGLCLDVFHGLSKLQVLHLNNNYLSALPQEVFRGLTSLKRLNLASNLLSHLSPG 288
Cdd:PLN03150 436 NDISKLRHLQSINLSGNSI-----RGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPA 508
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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