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Conserved domains on  [gi|514351488|gb|AGO49925|]
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Toll-like receptor 5, partial [Callaeas wilsoni]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-356 3.71e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 3.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488  69 NLKGPDDSTFAGLERSNLKFFDISQGYIFSLNSLVF*SLGSLESLNLFKNKINQIQRRAFFGLGNLKILNLSSNLLGELY 148
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 149 DYTFEGLHSVMYIDLQQ-NHIGMIGDKSFRQLVNLKIIDLRDNAVKRLP----SFPHLTSALLGDNKLMSVADrAITA-- 221
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQLTDLPE-PLGNlt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 222 --THL*LERNWLANLGDlyILFQIPDLQYIFLKQNRFSYCvrSANVIENNQLIYMDLGENMLqlvweRDLcLDVFGALPK 299
Cdd:COG4886  160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDL--PEPLGNLTNLEELDLSGNQL-----TDL-PEPLANLTN 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351488 300 LQVLHLNNNYLSALPQeiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 356
Cdd:COG4886  230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
375-414 2.52e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 2.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 514351488   375 NNYVCDCGLKSLLVWLNETNVTLagSQPDRYCVYPPALKG 414
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG 38
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-356 3.71e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 3.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488  69 NLKGPDDSTFAGLERSNLKFFDISQGYIFSLNSLVF*SLGSLESLNLFKNKINQIQRRAFFGLGNLKILNLSSNLLGELY 148
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 149 DYTFEGLHSVMYIDLQQ-NHIGMIGDKSFRQLVNLKIIDLRDNAVKRLP----SFPHLTSALLGDNKLMSVADrAITA-- 221
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQLTDLPE-PLGNlt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 222 --THL*LERNWLANLGDlyILFQIPDLQYIFLKQNRFSYCvrSANVIENNQLIYMDLGENMLqlvweRDLcLDVFGALPK 299
Cdd:COG4886  160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDL--PEPLGNLTNLEELDLSGNQL-----TDL-PEPLANLTN 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351488 300 LQVLHLNNNYLSALPQeiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 356
Cdd:COG4886  230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
298-356 4.21e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 4.21e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351488  298 PKLQVLHLNNNYLSALPQEIFRGLTSLKRLNLASNLLSHLSPGLF--PQSLTNLNLSGNQL 356
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 127-406 4.71e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 4.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 127 AFFGLGNLKILNLSSNLL-GELYDYTFEGLHSVMYIDLQQNHigMIGDKSFRQLVNLKIIDLRDNAV-----KRLPSFPH 200
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNN--FTGSIPRGSIPNLETLDLSNNMLsgeipNDIGSFSS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 201 LTSALLGDNKLMSVADRAITATH----L*LERNWLANlGDLYILFQIPDLQYIFLKQNRFSYCVRsanvIENNQLIYMdl 276
Cdd:PLN00113 166 LKVLDLGGNVLVGKIPNSLTNLTslefLTLASNQLVG-QIPRELGQMKSLKWIYLGYNNLSGEIP----YEIGGLTSL-- 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 277 geNMLQLVWErDLCLDV---FGALPKLQVLHLNNNYLSA-LPQEIFrGLTSLKRLNLASNLLSHLSPGLFPQ--SLTNLN 350
Cdd:PLN00113 239 --NHLDLVYN-NLTGPIpssLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQlqNLEILH 314

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351488 351 LSGNQLFSPEPEVFMT---LSILDITHNNYV----CDCGLKSLLVWLNETNVTLAGSQPDRYC 406
Cdd:PLN00113 315 LFSNNFTGKIPVALTSlprLQVLQLWSNKFSgeipKNLGKHNNLTVLDLSTNNLTGEIPEGLC 377
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 291-376 2.16e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 291 LDVFGALPKLQVLHLNNNYLSALpqEIFRGLTSLKRLNLAS-------------NLLSHLSPglfpqSLTNLNLSGNQLF 357
Cdd:cd21340   61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSN-----SLRVLNISGNNID 133

                         90       100
                 ....*....|....*....|
gi 514351488 358 SPEPEVFMT-LSILDITHNN 376
Cdd:cd21340  134 SLEPLAPLRnLEQLDASNNQ 153
LRRCT smart00082
Leucine rich repeat C-terminal domain;
375-414 2.52e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 2.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 514351488   375 NNYVCDCGLKSLLVWLNETNVTLagSQPDRYCVYPPALKG 414
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG 38
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 350-414 4.60e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 4.60e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351488   350 NLSGNQLFSPEPEVF---MTLSILDITHNNYVCDCGLKSLLVWLNETNVTLAgsQPD-RYCVYPPALKG 414
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVR--QPEaALCAGPGALAG 67
LRR smart00370
Leucine-rich repeats, outliers;
297-320 2.95e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.95e-03
                           10        20
                   ....*....|....*....|....
gi 514351488   297 LPKLQVLHLNNNYLSALPQEIFRG 320
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-356 3.71e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 3.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488  69 NLKGPDDSTFAGLERSNLKFFDISQGYIFSLNSLVF*SLGSLESLNLFKNKINQIQRRAFFGLGNLKILNLSSNLLGELY 148
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 149 DYTFEGLHSVMYIDLQQ-NHIGMIGDKSFRQLVNLKIIDLRDNAVKRLP----SFPHLTSALLGDNKLMSVADrAITA-- 221
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQLTDLPE-PLGNlt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 222 --THL*LERNWLANLGDlyILFQIPDLQYIFLKQNRFSYCvrSANVIENNQLIYMDLGENMLqlvweRDLcLDVFGALPK 299
Cdd:COG4886  160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDL--PEPLGNLTNLEELDLSGNQL-----TDL-PEPLANLTN 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351488 300 LQVLHLNNNYLSALPQeiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 356
Cdd:COG4886  230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
298-356 4.21e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 4.21e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351488  298 PKLQVLHLNNNYLSALPQEIFRGLTSLKRLNLASNLLSHLSPGLF--PQSLTNLNLSGNQL 356
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-401 4.90e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 4.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488  85 NLKFFDISQGYIFSLNSLVF*SLGSLESLNLFKNKINQIQRRAFFGLGNLKILNLSSNLLGELYDYTFEGLHSVMYIDLQ 164
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 165 QNHIGMIGDKSFRQLVNLKIIDLRDNavKRLPSFPHLTSALLGDNKLMSVADrAITA----THL*LERNWLANLGDLyiL 240
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGN--EELSNLTNLESLDLSGNQLTDLPE-ELANltnlKELDLSNNQLTDLPEP--L 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 241 FQIPDLQYIFLKQNRFSYCvrSANVIENNQLIYMDLGENMLQlvwerDLcLDVFGALPKLQVLHLNNNYLSALPQEIfRG 320
Cdd:COG4886  156 GNLTNLKSLDLSNNQLTDL--PEELGNLTNLKELDLSNNQIT-----DL-PEPLGNLTNLEELDLSGNQLTDLPEPL-AN 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 321 LTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQLFSPEPEVFMT-LSILDItHNNYVCDCGLKSLLVWLNETNVTLAG 399
Cdd:COG4886  227 LTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDL-SNNQLTDLKLKELELLLGLNSLLLLL 305


                 ..
gi 514351488 400 SQ 401
Cdd:COG4886  306 LL 307
LRR_8 pfam13855
Leucine rich repeat;
109-168 3.24e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 3.24e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488  109 SLESLNLFKNKINQIQRRAFFGLGNLKILNLSSNLLGELYDYTFEGLHSVMYIDLQQNHI 168
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-357 1.84e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 1.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488  74 DDSTFAGLERSNLKFFDISQGYIFSLNSLVF*SLGSLESLNLFKNKinqiqrrAFFGLGNLKILNLSSNLLGELyDYTFE 153
Cdd:COG4886   62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 154 GLHSVMYIDLQQNHIGMIGDkSFRQLVNLKIIDLRDNAVKRLPSF----PHLTSALLGDNKLMSVADrAITA----THL* 225
Cdd:COG4886  134 NLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPE-PLGNltnlEELD 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 226 LERNWLANLGDlyILFQIPDLQYIFLKQNRFSYCvrsANVIENNQLIYMDLGENMLQlvwerdlCLDVFGALPKLQVLHL 305
Cdd:COG4886  212 LSGNQLTDLPE--PLANLTNLETLDLSNNQLTDL---PELGNLTNLEELDLSNNQLT-------DLPPLANLTNLKTLDL 279

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 514351488 306 NNNYLSALPQEIFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQLF 357
Cdd:COG4886  280 SNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR_8 pfam13855
Leucine rich repeat;
133-190 1.31e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.31e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 514351488  133 NLKILNLSSNLLGELYDYTFEGLHSVMYIDLQQNHIGMIGDKSFRQLVNLKIIDLRDN 190
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
84-144 4.94e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 4.94e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351488   84 SNLKFFDISQGYIFSLNSLVF*SLGSLESLNLFKNKINQIQRRAFFGLGNLKILNLSSNLL 144
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 127-406 4.71e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 4.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 127 AFFGLGNLKILNLSSNLL-GELYDYTFEGLHSVMYIDLQQNHigMIGDKSFRQLVNLKIIDLRDNAV-----KRLPSFPH 200
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNN--FTGSIPRGSIPNLETLDLSNNMLsgeipNDIGSFSS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 201 LTSALLGDNKLMSVADRAITATH----L*LERNWLANlGDLYILFQIPDLQYIFLKQNRFSYCVRsanvIENNQLIYMdl 276
Cdd:PLN00113 166 LKVLDLGGNVLVGKIPNSLTNLTslefLTLASNQLVG-QIPRELGQMKSLKWIYLGYNNLSGEIP----YEIGGLTSL-- 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 277 geNMLQLVWErDLCLDV---FGALPKLQVLHLNNNYLSA-LPQEIFrGLTSLKRLNLASNLLSHLSPGLFPQ--SLTNLN 350
Cdd:PLN00113 239 --NHLDLVYN-NLTGPIpssLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQlqNLEILH 314

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351488 351 LSGNQLFSPEPEVFMT---LSILDITHNNYV----CDCGLKSLLVWLNETNVTLAGSQPDRYC 406
Cdd:PLN00113 315 LFSNNFTGKIPVALTSlprLQVLQLWSNKFSgeipKNLGKHNNLTVLDLSTNNLTGEIPEGLC 377
LRR_8 pfam13855
Leucine rich repeat;
288-334 1.14e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 514351488  288 DLCLDVFGALPKLQVLHLNNNYLSALPQEIFRGLTSLKRLNLASNLL 334
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-376 3.61e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 3.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488  66 GFDNLKGPDDSTFAGLerSNLKFFDISQGyifSLNSLVF*SLGSLESLN---LFKNKINQIQRRAFFGLGNLKILNLSSN 142
Cdd:PLN00113 220 GYNNLSGEIPYEIGGL--TSLNHLDLVYN---NLTGPIPSSLGNLKNLQylfLYQNKLSGPIPPSIFSLQKLISLDLSDN 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 143 LL-GELYDYTFEgLHSVMYIDLQQNHIGMIGDKSFRQLVNLKIIDLRDNavkrlpSFPHLTSALLGDNKLMSVADRAITA 221
Cdd:PLN00113 295 SLsGEIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN------KFSGEIPKNLGKHNNLTVLDLSTNN 367

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 222 THL*LERNwLANLGDLY--ILF------QIP-------DLQYIFLKQNRFSYCVRSAnvIENNQLIY-MDLGENMLQ--- 282
Cdd:PLN00113 368 LTGEIPEG-LCSSGNLFklILFsnslegEIPkslgacrSLRRVRLQDNSFSGELPSE--FTKLPLVYfLDISNNNLQgri 444

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 283 --LVWErdlcldvfgaLPKLQVLHLN-NNYLSALPQeiFRGLTSLKRLNLASNLLSHLSP---GLFPQsLTNLNLSGNQL 356
Cdd:PLN00113 445 nsRKWD----------MPSLQMLSLArNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPrklGSLSE-LMQLKLSENKL 511

                        330       340
                 ....*....|....*....|...
gi 514351488 357 FSPEPEVFMT---LSILDITHNN 376
Cdd:PLN00113 512 SGEIPDELSSckkLVSLDLSHNQ 534
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 291-376 2.16e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 291 LDVFGALPKLQVLHLNNNYLSALpqEIFRGLTSLKRLNLAS-------------NLLSHLSPglfpqSLTNLNLSGNQLF 357
Cdd:cd21340   61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSN-----SLRVLNISGNNID 133

                         90       100
                 ....*....|....*....|
gi 514351488 358 SPEPEVFMT-LSILDITHNN 376
Cdd:cd21340  134 SLEPLAPLRnLEQLDASNNQ 153
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 134-356 2.30e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 134 LKILNLSSNLLGELYDytfeGLHSVMyidlqqnhigmigdKSFRQLVNLKIIDLRDNAVkrLPSFPHLTSALLgdnklms 213
Cdd:cd00116   53 LKELCLSLNETGRIPR----GLQSLL--------------QGLTKGCGLQELDLSDNAL--GPDGCGVLESLL------- 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 214 vadRAITATHL*LERNWLAN---------LGDLYilfqiPDLQYIFLKQNRFSY--CVRSANV-IENNQLIYMDLGENML 281
Cdd:cd00116  106 ---RSSSLQELKLNNNGLGDrglrllakgLKDLP-----PALEKLVLGRNRLEGasCEALAKAlRANRDLKELNLANNGI 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 282 QLVWERDLCLDvFGALPKLQVLHLNNNYL-----SALpQEIFRGLTSLKRLNLASNLL-----SHLSPGL--FPQSLTNL 349
Cdd:cd00116  178 GDAGIRALAEG-LKANCNLEVLDLNNNGLtdegaSAL-AETLASLKSLEVLNLGDNNLtdagaAALASALlsPNISLLTL 255


                 ....*..
gi 514351488 350 NLSGNQL 356
Cdd:cd00116  256 SLSCNDI 262
LRRCT smart00082
Leucine rich repeat C-terminal domain;
375-414 2.52e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 2.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 514351488   375 NNYVCDCGLKSLLVWLNETNVTLagSQPDRYCVYPPALKG 414
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG 38
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 350-414 4.60e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 4.60e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351488   350 NLSGNQLFSPEPEVF---MTLSILDITHNNYVCDCGLKSLLVWLNETNVTLAgsQPD-RYCVYPPALKG 414
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVR--QPEaALCAGPGALAG 67
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 155-354 1.20e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 155 LHSVMYIDLQQNHIGMIGDksFRQLVNLKIIDLRDNAVKRLPSFPHLTsallgdnKLmsvadraitaTHL*LERNW---L 231
Cdd:cd21340    1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIENLEFLT-------NL----------THLYLQNNQiekI 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 232 ANLGDLyilfqiPDLQYIFLKQNRFSycvrsanVIEN----NQLIYMDLGENMLQLvwERDLCLD---VFGALPKLQVLH 304
Cdd:cd21340   62 ENLENL------VNLKKLYLGGNRIS-------VVEGlenlTNLEELHIENQRLPP--GEKLTFDprsLAALSNSLRVLN 126

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 514351488 305 LNNNYLSALpqEIFRGLTSLKRLNLASNLLSHLSP--GLFPQ--SLTNLNLSGN 354
Cdd:cd21340  127 ISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSwpSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 67-377 1.35e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488  67 FDNLKGPDDSTFAGLerSNLKFFDISQGY--------IFSLNSLV----------------F*SLGSLESLNLFKNKINQ 122
Cdd:PLN00113 245 YNNLTGPIPSSLGNL--KNLQYLFLYQNKlsgpippsIFSLQKLIsldlsdnslsgeipelVIQLQNLEILHLFSNNFTG 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 123 IQRRAFFGLGNLKILNLSSNLLGELYDYTFEGLHSVMYIDLQQNHI-GMIGDKSFRQLVNLKII----DLRDNAVKRLPS 197
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLtGEIPEGLCSSGNLFKLIlfsnSLEGEIPKSLGA 402

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 198 FPHLTSALLGDNKLMSVADRAITATHL*L-----ERNWLANLGDLYilFQIPDLQYIFLKQNRFSYCVrsANVIENNQLI 272
Cdd:PLN00113 403 CRSLRRVRLQDNSFSGELPSEFTKLPLVYfldisNNNLQGRINSRK--WDMPSLQMLSLARNKFFGGL--PDSFGSKRLE 478

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488 273 YMDLGENMLQLVWERDlcldvFGALPKLQVLHLNNNYLSAlpqEIFRGLTSLKR---LNLASNLLSHLSPGLFP--QSLT 347
Cdd:PLN00113 479 NLDLSRNQFSGAVPRK-----LGSLSELMQLKLSENKLSG---EIPDELSSCKKlvsLDLSHNQLSGQIPASFSemPVLS 550

                        330       340       350
                 ....*....|....*....|....*....|...
gi 514351488 348 NLNLSGNQLFSPEPEVF---MTLSILDITHNNY 377
Cdd:PLN00113 551 QLDLSQNQLSGEIPKNLgnvESLVQVNISHNHL 583
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 109-190 2.35e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.91  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488  109 SLESLNLFKNkINQIQRRAFFGLGNLKILNLSSNLLgELYDYTFEGLHSVmYIDLQQNhIGMIGDKSFRQLVNLKIIDLR 188
Cdd:pfam13306  12 SLTSITIPSS-LTSIGEYAFSNCTSLKSITLPSSLT-SIGSYAFYNCSLT-SITIPSS-LTSIGEYAFSNCSNLKSITLP 87


                  ..
gi 514351488  189 DN 190
Cdd:pfam13306  88 SN 89
LRR_8 pfam13855
Leucine rich repeat;
157-211 2.95e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351488  157 SVMYIDLQQNHIGMIGDKSFRQLVNLKIIDLRDNAVKRLP-----SFPHLTSALLGDNKL 211
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPSLRYLDLSGNRL 61
LRR smart00370
Leucine-rich repeats, outliers;
297-320 2.95e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.95e-03
                           10        20
                   ....*....|....*....|....
gi 514351488   297 LPKLQVLHLNNNYLSALPQEIFRG 320
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
297-320 2.95e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.95e-03
                           10        20
                   ....*....|....*....|....
gi 514351488   297 LPKLQVLHLNNNYLSALPQEIFRG 320
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PLN03150 PLN03150
hypothetical protein; Provisional
 294-340 3.79e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.41  E-value: 3.79e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 514351488 294 FGALPKLQVLHLNNNYLSALPQEIFRGLTSLKRLNLASNLLSHLSPG 340
Cdd:PLN03150 462 LGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPA 508
LRR_9 pfam14580
Leucine-rich repeat;
185-254 5.05e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.82  E-value: 5.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351488  185 IDLRDNAVKRLPSFPHL---TSALLGDNKLMSVA---DRAITATH-L*LERNWLANLGDLYILFQIPDLQYIFLKQN 254
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLrrlKTLLLNNNRICRIGeglGEALPNLTeLILTNNNLQELGDLDPLASLKKLTFLSLLRN 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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