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Conserved domains on  [gi|514351486|gb|AGO49924|]
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Toll-like receptor 5, partial [Apteryx mantelli mantelli]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-352 3.31e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 3.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486  64 DNLKNPDENTFTGLAGSDLRLLDIS*GYIFSLNPFVFQSLGKLELLNLYSNKinqiqrqAFFGLGNLKTLNVSSNLLGEL 143
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 144 yDYTFEGLHSVMHIDLQQNHIGIIGqKSFSRLVNLEIIDLRDNAIKKLPSfpyvttAFLGDNKLmsvvdraiaaTYLDLE 223
Cdd:COG4886  129 -PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE------ELGNLTNL----------KELDLS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 224 RNWLANLGDlyILFQVPDLQYIFLkqnrfsycvkrvnviENNQIIYIDlgenmlqlvwerdlclDVFRALSKLQVLHLNN 303
Cdd:COG4886  191 NNQITDLPE--PLGNLTNLEELDL---------------SGNQLTDLP----------------EPLANLTNLETLDLSN 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 514351486 304 NYLSALPQevFRGLTSLQRLNLASNLLSHLSPGIFPQSLTNLNLSGNQL 352
Cdd:COG4886  238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
371-409 2.68e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 2.68e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 514351486   371 NKYVCDCTLKSLLVWLNETNVTLagSQSDRYCLYPPALQ 409
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLR 37
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-352 3.31e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 3.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486  64 DNLKNPDENTFTGLAGSDLRLLDIS*GYIFSLNPFVFQSLGKLELLNLYSNKinqiqrqAFFGLGNLKTLNVSSNLLGEL 143
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 144 yDYTFEGLHSVMHIDLQQNHIGIIGqKSFSRLVNLEIIDLRDNAIKKLPSfpyvttAFLGDNKLmsvvdraiaaTYLDLE 223
Cdd:COG4886  129 -PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE------ELGNLTNL----------KELDLS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 224 RNWLANLGDlyILFQVPDLQYIFLkqnrfsycvkrvnviENNQIIYIDlgenmlqlvwerdlclDVFRALSKLQVLHLNN 303
Cdd:COG4886  191 NNQITDLPE--PLGNLTNLEELDL---------------SGNQLTDLP----------------EPLANLTNLETLDLSN 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 514351486 304 NYLSALPQevFRGLTSLQRLNLASNLLSHLSPGIFPQSLTNLNLSGNQL 352
Cdd:COG4886  238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
294-352 1.34e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.34e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351486  294 SKLQVLHLNNNYLSALPQEVFRGLTSLQRLNLASNLLSHLSPGIF--PQSLTNLNLSGNQL 352
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 130-372 2.59e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 130 LKTLNVSSNLLGELYDytfeGLHSVM----------HIDLQQNHIGIIGQ---KSFSRLVNLEIIDLRDNAIKKLPsfpy 196
Cdd:cd00116   53 LKELCLSLNETGRIPR----GLQSLLqgltkgcglqELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLGDRG---- 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 197 vtTAFLGDnklmSVVDRAIAATYLDLERNWLANLG--DLYILFQV-PDLQYIFLKQNrfsycvkrvnviennqiiyiDLG 273
Cdd:cd00116  125 --LRLLAK----GLKDLPPALEKLVLGRNRLEGASceALAKALRAnRDLKELNLANN--------------------GIG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 274 ENMLQLvwerdLCLDvFRALSKLQVLHLNNNYL-----SALpQEVFRGLTSLQRLNLASNLL-----SHLSPGI--FPQS 341
Cdd:cd00116  179 DAGIRA-----LAEG-LKANCNLEVLDLNNNGLtdegaSAL-AETLASLKSLEVLNLGDNNLtdagaAALASALlsPNIS 251

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 514351486 342 LTNLNLSGN--------QLFSPEPEiFMTLSVLDITHNK 372
Cdd:cd00116  252 LLTLSLSCNditddgakDLAEVLAE-KESLLELDLRGNK 289
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-358 2.89e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 2.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 123 AFFGLGNLKTLNVSSNLL-GELYDYTFEGLHSVMHIDLQQNHI-GIIGQKSFSRL---------------------VNLE 179
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLetldlsnnmlsgeipndigsfSSLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 180 IIDLRDNA--------IKKLPSFPYVTTA---------------------FLGDNKLMSVVDRAI----AATYLDLERNW 226
Cdd:PLN00113 168 VLDLGGNVlvgkipnsLTNLTSLEFLTLAsnqlvgqiprelgqmkslkwiYLGYNNLSGEIPYEIggltSLNHLDLVYNN 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 227 L-----ANLGDLyilfqvPDLQYIFLKQNRFSYCVKRvNVIENNQIIYIDLGENML-----QLVWErdlcldvfraLSKL 296
Cdd:PLN00113 248 LtgpipSSLGNL------KNLQYLFLYQNKLSGPIPP-SIFSLQKLISLDLSDNSLsgeipELVIQ----------LQNL 310

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351486 297 QVLHL-NNNYLSALPqevfRGLTSLQR---LNLASNLLSHLSPGIFPQ--SLTNLNLSGNQLFSPEPE 358
Cdd:PLN00113 311 EILHLfSNNFTGKIP----VALTSLPRlqvLQLWSNKFSGEIPKNLGKhnNLTVLDLSTNNLTGEIPE 374
LRRCT smart00082
Leucine rich repeat C-terminal domain;
371-409 2.68e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 2.68e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 514351486   371 NKYVCDCTLKSLLVWLNETNVTLagSQSDRYCLYPPALQ 409
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLR 37
LRR smart00370
Leucine-rich repeats, outliers;
293-316 5.87e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 5.87e-03
                           10        20
                   ....*....|....*....|....
gi 514351486   293 LSKLQVLHLNNNYLSALPQEVFRG 316
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-352 3.31e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 3.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486  64 DNLKNPDENTFTGLAGSDLRLLDIS*GYIFSLNPFVFQSLGKLELLNLYSNKinqiqrqAFFGLGNLKTLNVSSNLLGEL 143
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 144 yDYTFEGLHSVMHIDLQQNHIGIIGqKSFSRLVNLEIIDLRDNAIKKLPSfpyvttAFLGDNKLmsvvdraiaaTYLDLE 223
Cdd:COG4886  129 -PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE------ELGNLTNL----------KELDLS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 224 RNWLANLGDlyILFQVPDLQYIFLkqnrfsycvkrvnviENNQIIYIDlgenmlqlvwerdlclDVFRALSKLQVLHLNN 303
Cdd:COG4886  191 NNQITDLPE--PLGNLTNLEELDL---------------SGNQLTDLP----------------EPLANLTNLETLDLSN 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 514351486 304 NYLSALPQevFRGLTSLQRLNLASNLLSHLSPGIFPQSLTNLNLSGNQL 352
Cdd:COG4886  238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
294-352 1.34e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.34e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351486  294 SKLQVLHLNNNYLSALPQEVFRGLTSLQRLNLASNLLSHLSPGIF--PQSLTNLNLSGNQL 352
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
82-140 2.69e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 2.69e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 514351486   82 LRLLDIS*GYIFSLNPFVFQSLGKLELLNLYSNKINQIQRQAFFGLGNLKTLNVSSNLL 140
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
129-188 8.63e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 8.63e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486  129 NLKTLNVSSNLLGELYDYTFEGLHSVMHIDLQQNHIGIIGQKSFSRLVNLEIIDLRDNAI 188
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
105-164 1.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.24e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486  105 KLELLNLYSNKINQIQRQAFFGLGNLKTLNVSSNLLGELYDYTFEGLHSVMHIDLQQNHI 164
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
284-330 4.74e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 4.74e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 514351486  284 DLCLDVFRALSKLQVLHLNNNYLSALPQEVFRGLTSLQRLNLASNLL 330
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 130-372 2.59e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 130 LKTLNVSSNLLGELYDytfeGLHSVM----------HIDLQQNHIGIIGQ---KSFSRLVNLEIIDLRDNAIKKLPsfpy 196
Cdd:cd00116   53 LKELCLSLNETGRIPR----GLQSLLqgltkgcglqELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLGDRG---- 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 197 vtTAFLGDnklmSVVDRAIAATYLDLERNWLANLG--DLYILFQV-PDLQYIFLKQNrfsycvkrvnviennqiiyiDLG 273
Cdd:cd00116  125 --LRLLAK----GLKDLPPALEKLVLGRNRLEGASceALAKALRAnRDLKELNLANN--------------------GIG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 274 ENMLQLvwerdLCLDvFRALSKLQVLHLNNNYL-----SALpQEVFRGLTSLQRLNLASNLL-----SHLSPGI--FPQS 341
Cdd:cd00116  179 DAGIRA-----LAEG-LKANCNLEVLDLNNNGLtdegaSAL-AETLASLKSLEVLNLGDNNLtdagaAALASALlsPNIS 251

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 514351486 342 LTNLNLSGN--------QLFSPEPEiFMTLSVLDITHNK 372
Cdd:cd00116  252 LLTLSLSCNditddgakDLAEVLAE-KESLLELDLRGNK 289
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-358 2.89e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 2.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 123 AFFGLGNLKTLNVSSNLL-GELYDYTFEGLHSVMHIDLQQNHI-GIIGQKSFSRL---------------------VNLE 179
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLetldlsnnmlsgeipndigsfSSLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 180 IIDLRDNA--------IKKLPSFPYVTTA---------------------FLGDNKLMSVVDRAI----AATYLDLERNW 226
Cdd:PLN00113 168 VLDLGGNVlvgkipnsLTNLTSLEFLTLAsnqlvgqiprelgqmkslkwiYLGYNNLSGEIPYEIggltSLNHLDLVYNN 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 227 L-----ANLGDLyilfqvPDLQYIFLKQNRFSYCVKRvNVIENNQIIYIDLGENML-----QLVWErdlcldvfraLSKL 296
Cdd:PLN00113 248 LtgpipSSLGNL------KNLQYLFLYQNKLSGPIPP-SIFSLQKLISLDLSDNSLsgeipELVIQ----------LQNL 310

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351486 297 QVLHL-NNNYLSALPqevfRGLTSLQR---LNLASNLLSHLSPGIFPQ--SLTNLNLSGNQLFSPEPE 358
Cdd:PLN00113 311 EILHLfSNNFTGKIP----VALTSLPRlqvLQLWSNKFSGEIPKNLGKhnNLTVLDLSTNNLTGEIPE 374
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-372 4.87e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 4.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486  62 GFDNLKNPDENTFTGLagSDLRLLDIS*GYIFSLNPFVFQSLGKLELLNLYSNKINQIQRQAFFGLGNLKTLNVSSNLL- 140
Cdd:PLN00113 220 GYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLs 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 141 GELYDytfeglhsvMHIDLQqnhigiigqksfsrlvNLEIIDLRDNAIK-KLP----SFPYVTTAFLGDNKLMSVVDRAI 215
Cdd:PLN00113 298 GEIPE---------LVIQLQ----------------NLEILHLFSNNFTgKIPvaltSLPRLQVLQLWSNKFSGEIPKNL 352

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 216 AA----TYLDLERNWLA--------NLGDLY--ILF------QVP-------DLQYIFLKQNRFSYCVKRvNVIENNQII 268
Cdd:PLN00113 353 GKhnnlTVLDLSTNNLTgeipeglcSSGNLFklILFsnslegEIPkslgacrSLRRVRLQDNSFSGELPS-EFTKLPLVY 431

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 269 YIDLGENMLQ-----LVWErdlcldvfraLSKLQVLHLN-NNYLSALPQevFRGLTSLQRLNLASNLLSHLSP---GIFP 339
Cdd:PLN00113 432 FLDISNNNLQgrinsRKWD----------MPSLQMLSLArNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPrklGSLS 499

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 514351486 340 QsLTNLNLSGNQLFSPEPEIFMT---LSVLDITHNK 372
Cdd:PLN00113 500 E-LMQLKLSENKLSGEIPDELSSckkLVSLDLSHNQ 534
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-372 7.65e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 7.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486  80 SDLRLLDIS*GYIFSLNPFVFQSLGKLELLNLYSNK-INQIQRQaffgLGNLKTLNV----SSNLLGELyDYTFEGLHSV 154
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQlVGQIPRE----LGQMKSLKWiylgYNNLSGEI-PYEIGGLTSL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 155 MHIDLQQNHigIIGQ--KSFSRLVNLEIIDLRDNAIkklpSFPYVTTAFlGDNKLMSvvdraiaatyLDLERNWL----- 227
Cdd:PLN00113 239 NHLDLVYNN--LTGPipSSLGNLKNLQYLFLYQNKL----SGPIPPSIF-SLQKLIS----------LDLSDNSLsgeip 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 228 ---ANLGDLYILF---------------QVPDLQYIFLKQNRFSYCVKRvNVIENNQIIYIDLGENMLQLVWERDLC--- 286
Cdd:PLN00113 302 elvIQLQNLEILHlfsnnftgkipvaltSLPRLQVLQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNLTGEIPEGLCssg 380

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 287 ----LDVFR------------ALSKLQVLHLNNNYLSA-LPQEVFR-----------------------GLTSLQRLNLA 326
Cdd:PLN00113 381 nlfkLILFSnslegeipkslgACRSLRRVRLQDNSFSGeLPSEFTKlplvyfldisnnnlqgrinsrkwDMPSLQMLSLA 460

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 514351486 327 SNLLSHLSPGIF-PQSLTNLNLSGNQLFSPEPEIFMTLSV---LDITHNK 372
Cdd:PLN00113 461 RNKFFGGLPDSFgSKRLENLDLSRNQFSGAVPRKLGSLSElmqLKLSENK 510
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 264-372 3.50e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 264 NNQIIYIDLGENM-----LQLVWERDLCLDVFRALSKLQVLHLNNNYLSALpqEVFRGLTSLQRLNLAS----------- 327
Cdd:cd21340   33 DNKITKIENLEFLtnlthLYLQNNQIEKIENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltf 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 514351486 328 --NLLSHLSPgifpqSLTNLNLSGNQLFSPEP-EIFMTLSVLDITHNK 372
Cdd:cd21340  111 dpRSLAALSN-----SLRVLNISGNNIDSLEPlAPLRNLEQLDASNNQ 153
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 265-371 6.61e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 6.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 265 NQIIYIDL-GENMlqlvwERDLCLDVFRaLSKLQVLHLNNNYLSA-LPQEVFRGLTSLQRLNLASNLLSHLSPGIFPQSL 342
Cdd:PLN00113  69 SRVVSIDLsGKNI-----SGKISSAIFR-LPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNL 142

                         90       100       110
                 ....*....|....*....|....*....|..
gi 514351486 343 TNLNLSGNQLFSPEPE---IFMTLSVLDITHN 371
Cdd:PLN00113 143 ETLDLSNNMLSGEIPNdigSFSSLKVLDLGGN 174
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 151-350 1.10e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 151 LHSVMHIDLQQNHIGIIGqkSFSRLVNLEIIDLRDNAIKK---LPSFPYVTTAFLGDNKL--MSVVDRAIAATYLDLERN 225
Cdd:cd21340    1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKienLEFLTNLTHLYLQNNQIekIENLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486 226 WLANLGDLYILFQVPDLQyiflkqnrfsycvkrvnvIENNQIiyiDLGENmlqlvwerdLCLDVF--RALSK-LQVLHLN 302
Cdd:cd21340   79 RISVVEGLENLTNLEELH------------------IENQRL---PPGEK---------LTFDPRslAALSNsLRVLNIS 128

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 514351486 303 NNYLSALpqEVFRGLTSLQRLNLASNLLSHLSP--GIFPQ--SLTNLNLSGN 350
Cdd:cd21340  129 GNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSwpSLRELDLTGN 178
LRRCT smart00082
Leucine rich repeat C-terminal domain;
371-409 2.68e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 2.68e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 514351486   371 NKYVCDCTLKSLLVWLNETNVTLagSQSDRYCLYPPALQ 409
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLR 37
LRR smart00370
Leucine-rich repeats, outliers;
293-316 5.87e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 5.87e-03
                           10        20
                   ....*....|....*....|....
gi 514351486   293 LSKLQVLHLNNNYLSALPQEVFRG 316
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
293-316 5.87e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 5.87e-03
                           10        20
                   ....*....|....*....|....
gi 514351486   293 LSKLQVLHLNNNYLSALPQEVFRG 316
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 80-190 6.17e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.49  E-value: 6.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351486  80 SDLRLLDIS*GyifSLNPFVFQSLGK-------LELLNLYSNKINQIQRQAFFG----LGNLKTLNVSSNLLG-----EL 143
Cdd:cd00116  165 RDLKELNLANN---GIGDAGIRALAEglkancnLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTdagaaAL 241

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 514351486 144 YDYTFEGLHSVMHIDLQQNHIGIIGQKSFSRL----VNLEIIDLRDNAIKK 190
Cdd:cd00116  242 ASALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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