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Conserved domains on  [gi|514351434|gb|AGO49898|]
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Toll-like receptor 2B, partial [Cyanoramphus novaezelandiae]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-317 1.66e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 1.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434   1 PAETQLLRVMSNSFANKISFKEALITDATVPEIVSII*DMPKLEE*ELID*RLMGTGRWKMQIH*NQSQT*K**TI*KLS 80
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434  81 IEQFYLFTDLQ*VZGL***-------------LTKVTVENTKVFLVPCRLSQ*LRSLEYLDLSSNLLGD*SLEhsacQGG 147
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTELdlsgneelsnltnLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEP----LGN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 148 WPSLQTLNLSQNSLSDLGMT*KSLSHLRHLILldiSQNNFGDIPDVCEWPKTLKYLNLSRTQIPKVTTCIP--PTLEVLD 225
Cdd:COG4886  158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDL---SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 226 VSANNLKEFG--LQLPFLKELYLTRNQLKTLPDAAPIPNLVAMSVRRNKLNSFSKAELESFKHMELLDASDNNFICSCEF 303
Cdd:COG4886  235 LSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        330
                 ....*....|....
gi 514351434 304 LSFIHHQAGLAPVL 317
Cdd:COG4886  315 ILLLLLTTLLLLLL 328
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
295-348 4.97e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.79  E-value: 4.97e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 514351434   295 NNFICSCEFLSFIHHQagLAPVLVGWP*KYVCDSPLAVRGaQVGAVHLSLMECH 348
Cdd:smart00082   1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-317 1.66e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 1.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434   1 PAETQLLRVMSNSFANKISFKEALITDATVPEIVSII*DMPKLEE*ELID*RLMGTGRWKMQIH*NQSQT*K**TI*KLS 80
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434  81 IEQFYLFTDLQ*VZGL***-------------LTKVTVENTKVFLVPCRLSQ*LRSLEYLDLSSNLLGD*SLEhsacQGG 147
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTELdlsgneelsnltnLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEP----LGN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 148 WPSLQTLNLSQNSLSDLGMT*KSLSHLRHLILldiSQNNFGDIPDVCEWPKTLKYLNLSRTQIPKVTTCIP--PTLEVLD 225
Cdd:COG4886  158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDL---SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 226 VSANNLKEFG--LQLPFLKELYLTRNQLKTLPDAAPIPNLVAMSVRRNKLNSFSKAELESFKHMELLDASDNNFICSCEF 303
Cdd:COG4886  235 LSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        330
                 ....*....|....
gi 514351434 304 LSFIHHQAGLAPVL 317
Cdd:COG4886  315 ILLLLLTTLLLLLL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 149-225 1.39e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 149 PSLQTLNLSQNSLSDLgmt*KSLSHLRHLILLDISQNNFGDIPDVCE----WPKtLKYLNLS---RTQIPK-----VTTC 216
Cdd:cd21340  120 NSLRVLNISGNNIDSL----EPLAPLRNLEQLDASNNQISDLEELLDllssWPS-LRELDLTgnpVCKKPKyrdkiILAS 194


                 ....*....
gi 514351434 217 ipPTLEVLD 225
Cdd:cd21340  195 --KSLEVLD 201
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-259 2.43e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 2.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434  28 ATVPE-IVSII*DMPKLEE*elID*RLMGTGRwkmQIH*NQSQT*K**TI*KLSIEQFYLFTD--LQ*VZGL***LTKVT 104
Cdd:PRK15370 195 ACIPEqITTLILDNNELKS---LPENLQGNIK---TLYANSNQLTSIPATLPDTIQEMELSINriTELPERLPSALQSLD 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 105 VENTKVFLVPCRLSQ*LRsleYLDLSSNLLgd*slehSACQGGWPS-LQTLNLSQNSLSDLGMT*KSlshlrHLILLDIS 183
Cdd:PRK15370 269 LFHNKISCLPENLPEELR---YLSVYDNSI-------RTLPAHLPSgITHLNVQSNSLTALPETLPP-----GLKTLEAG 333

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351434 184 QNNFGDIPDvcEWPKTLKYLNLSRTQIPKVTTCIPPTLEVLDVSANNLKEFGLQLP-FLKELYLTRNQLKTLPDAAP 259
Cdd:PRK15370 334 ENALTSLPA--SLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPaALQIMQASRNNLVRLPESLP 408
LRR_8 pfam13855
Leucine rich repeat;
122-187 2.77e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.77e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351434  122 RSLEYLDLSSNLLgd*SLEHSACQGgWPSLQTLNLSQNSLSDLGMt*KSLSHLRHLILLDISQNNF 187
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKG-LSNLKVLDLSNNLLTTLSP--GAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
295-348 4.97e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.79  E-value: 4.97e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 514351434   295 NNFICSCEFLSFIHHQagLAPVLVGWP*KYVCDSPLAVRGaQVGAVHLSLMECH 348
Cdd:smart00082   1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-317 1.66e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 1.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434   1 PAETQLLRVMSNSFANKISFKEALITDATVPEIVSII*DMPKLEE*ELID*RLMGTGRWKMQIH*NQSQT*K**TI*KLS 80
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434  81 IEQFYLFTDLQ*VZGL***-------------LTKVTVENTKVFLVPCRLSQ*LRSLEYLDLSSNLLGD*SLEhsacQGG 147
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTELdlsgneelsnltnLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEP----LGN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 148 WPSLQTLNLSQNSLSDLGMT*KSLSHLRHLILldiSQNNFGDIPDVCEWPKTLKYLNLSRTQIPKVTTCIP--PTLEVLD 225
Cdd:COG4886  158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDL---SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 226 VSANNLKEFG--LQLPFLKELYLTRNQLKTLPDAAPIPNLVAMSVRRNKLNSFSKAELESFKHMELLDASDNNFICSCEF 303
Cdd:COG4886  235 LSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        330
                 ....*....|....
gi 514351434 304 LSFIHHQAGLAPVL 317
Cdd:COG4886  315 ILLLLLTTLLLLLL 328
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-298 7.29e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 7.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 100 LTKVTVENTKVFLVPCRLSQ*LRSLEYLDLSSNLLGD*SLEhsacQGGWPSLQTLNLSQNSLSDLGmt*KSLSHLRHLIL 179
Cdd:COG4886  138 LKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPEE----LGNLTNLKELDLSNNQITDLP---EPLGNLTNLEE 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 180 LDISQNNFGDIPDVCEWPKTLKYLNLSRTQIpkvtTCIP-----PTLEVLDVSANNLKEFG--LQLPFLKELYLTRNQLK 252
Cdd:COG4886  210 LDLSGNQLTDLPEPLANLTNLETLDLSNNQL----TDLPelgnlTNLEELDLSNNQLTDLPplANLTNLKTLDLSNNQLT 285

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 514351434 253 TLPDAAPIPNLVAMSVRRNKLNSFSKAELESFKHMELLDASDNNFI 298
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 149-225 1.39e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 149 PSLQTLNLSQNSLSDLgmt*KSLSHLRHLILLDISQNNFGDIPDVCE----WPKtLKYLNLS---RTQIPK-----VTTC 216
Cdd:cd21340  120 NSLRVLNISGNNIDSL----EPLAPLRNLEQLDASNNQISDLEELLDllssWPS-LRELDLTgnpVCKKPKyrdkiILAS 194


                 ....*....
gi 514351434 217 ipPTLEVLD 225
Cdd:cd21340  195 --KSLEVLD 201
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-259 2.43e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 2.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434  28 ATVPE-IVSII*DMPKLEE*elID*RLMGTGRwkmQIH*NQSQT*K**TI*KLSIEQFYLFTD--LQ*VZGL***LTKVT 104
Cdd:PRK15370 195 ACIPEqITTLILDNNELKS---LPENLQGNIK---TLYANSNQLTSIPATLPDTIQEMELSINriTELPERLPSALQSLD 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 105 VENTKVFLVPCRLSQ*LRsleYLDLSSNLLgd*slehSACQGGWPS-LQTLNLSQNSLSDLGMT*KSlshlrHLILLDIS 183
Cdd:PRK15370 269 LFHNKISCLPENLPEELR---YLSVYDNSI-------RTLPAHLPSgITHLNVQSNSLTALPETLPP-----GLKTLEAG 333

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351434 184 QNNFGDIPDvcEWPKTLKYLNLSRTQIPKVTTCIPPTLEVLDVSANNLKEFGLQLP-FLKELYLTRNQLKTLPDAAP 259
Cdd:PRK15370 334 ENALTSLPA--SLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPaALQIMQASRNNLVRLPESLP 408
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
153-299 8.23e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 8.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 153 TLNLSQNSLSDLGMT*KSlshlrHLILLDISQNNFGDIPDVCewPKTLKYLNLSRTQIPKVTTCIPPTLEVLDVSANNLK 232
Cdd:PRK15370 203 TLILDNNELKSLPENLQG-----NIKTLYANSNQLTSIPATL--PDTIQEMELSINRITELPERLPSALQSLDLFHNKIS 275

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351434 233 EFGLQLP-FLKELYLTRNQLKTLPDAAPiPNLVAMSVRRNKLnSFSKAELESfkHMELLDASDNNFIC 299
Cdd:PRK15370 276 CLPENLPeELRYLSVYDNSIRTLPAHLP-SGITHLNVQSNSL-TALPETLPP--GLKTLEAGENALTS 339
LRR_8 pfam13855
Leucine rich repeat;
122-187 2.77e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.77e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351434  122 RSLEYLDLSSNLLgd*SLEHSACQGgWPSLQTLNLSQNSLSDLGMt*KSLSHLRHLILLDISQNNF 187
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKG-LSNLKVLDLSNNLLTTLSP--GAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 123-254 2.97e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 123 SLEYLDLSSNLLGD*SLEHSAC--QGGWPSLQTLNLSQNSLSDLGMT--*KSLSHLRHLILLDISQNNFGD--IPDVCE- 195
Cdd:cd00116  109 SLQELKLNNNGLGDRGLRLLAKglKDLPPALEKLVLGRNRLEGASCEalAKALRANRDLKELNLANNGIGDagIRALAEg 188

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351434 196 --WPKTLKYLNLSRTQIpkvtTCI-----------PPTLEVLDVSANNLKEFGLQlPFLKELYLTRNQLKTL 254
Cdd:cd00116  189 lkANCNLEVLDLNNNGL----TDEgasalaetlasLKSLEVLNLGDNNLTDAGAA-ALASALLSPNISLLTL 255
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 119-254 3.81e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 3.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 119 Q*LRSLEYLDLSSNLLGD*SLEHsACQGG--WPSLQTLNLSQNSLSDLGMT*KS--LSHLRHLILLDISQNNFGD--IPD 192
Cdd:cd00116  162 RANRDLKELNLANNGIGDAGIRA-LAEGLkaNCNLEVLDLNNNGLTDEGASALAetLASLKSLEVLNLGDNNLTDagAAA 240

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351434 193 VCE----WPKTLKYLNLSRTQIP-----KVTTCIP--PTLEVLDVSANNLKEFGLQLPFLkELYLTRNQLKTL 254
Cdd:cd00116  241 LASallsPNISLLTLSLSCNDITddgakDLAEVLAekESLLELDLRGNKFGEEGAQLLAE-SLLEPGNELESL 312
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 121-296 1.02e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 121 LRSLEYLDLSSN-LLGD*SLEhsacQGGWPSLQTLNLSQNSLSdlGMT*KSLSHLRHLILLDISQNNF-GDIPDVCEWPK 198
Cdd:PLN00113 187 LTSLEFLTLASNqLVGQIPRE----LGQMKSLKWIYLGYNNLS--GEIPYEIGGLTSLNHLDLVYNNLtGPIPSSLGNLK 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 199 TLKYLNLSRTqipKVTTCIPPT------LEVLDVSANNLK----EFGLQLPFLKELYLTRNQLK-TLPDA-APIPNLVAM 266
Cdd:PLN00113 261 NLQYLFLYQN---KLSGPIPPSifslqkLISLDLSDNSLSgeipELVIQLQNLEILHLFSNNFTgKIPVAlTSLPRLQVL 337

                        170       180       190
                 ....*....|....*....|....*....|
gi 514351434 267 SVRRNKLNSFSKAELESFKHMELLDASDNN 296
Cdd:PLN00113 338 QLWSNKFSGEIPKNLGKHNNLTVLDLSTNN 367
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 113-297 1.30e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 113 VPCRLSQ*LRSLEYLDLS-SNLLGD--*SLehsacqGGWPSLQTLNLSQNSLSdlGMT*KSLSHLRHLILLDISQNNF-G 188
Cdd:PLN00113 228 IPYEIGG-LTSLNHLDLVyNNLTGPipSSL------GNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLsG 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 189 DIPDVCEWPKTLKYLNLSRT----QIPKVTTCIP-----------------------PTLEVLDVSANNLKEfglQLP-- 239
Cdd:PLN00113 299 EIPELVIQLQNLEILHLFSNnftgKIPVALTSLPrlqvlqlwsnkfsgeipknlgkhNNLTVLDLSTNNLTG---EIPeg 375

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 240 -----FLKELYLTRNQLKtlpdaAPIPNLVAM--SVRRNKL--NSFSKAELESFKHMEL---LDASDNNF 297
Cdd:PLN00113 376 lcssgNLFKLILFSNSLE-----GEIPKSLGAcrSLRRVRLqdNSFSGELPSEFTKLPLvyfLDISNNNL 440
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 121-297 2.47e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 2.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 121 LRSLEYLDL-SSNLLGD*SLEHSACqggwPSLQTLNLSQNSLSdlGMT*KSLSHLRHLILLDISQNNF-GDIPD-VCEWP 197
Cdd:PLN00113 307 LQNLEILHLfSNNFTGKIPVALTSL----PRLQVLQLWSNKFS--GEIPKNLGKHNNLTVLDLSTNNLtGEIPEgLCSSG 380

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 198 KTLKYLNLSRT---QIPK-VTTC----------------IP------PTLEVLDVSANNLK----EFGLQLPFLKELYLT 247
Cdd:PLN00113 381 NLFKLILFSNSlegEIPKsLGACrslrrvrlqdnsfsgeLPseftklPLVYFLDISNNNLQgrinSRKWDMPSLQMLSLA 460

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514351434 248 RNQ-LKTLPD-------------------AAP-----IPNLVAMSVRRNKLNSFSKAELESFKHMELLDASDNNF 297
Cdd:PLN00113 461 RNKfFGGLPDsfgskrlenldlsrnqfsgAVPrklgsLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR_8 pfam13855
Leucine rich repeat;
149-210 7.02e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 7.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351434  149 PSLQTLNLSQNSLSDLGMt*KSLSHLRHLILLDISQNNFGDI-PDVCEWPKTLKYLNLSRTQI 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD--GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 119-292 2.20e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.24  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 119 Q*LRSLEYLDLSSNLLGD*SLEH--SACQGGwPSLQTLNLSQNSLSDLGMT*--KSLSHLRHLILLDISQNNFGD----- 189
Cdd:COG5238  233 KGNKSLTTLDLSNNQIGDEGVIAlaEALKNN-TTVETLYLSGNQIGAEGAIAlaKALQGNTTLTSLDLSVNRIGDegaia 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 190 IPDVCEWPKTLKYLNLSRTQIpKVTTCIP--------PTLEVLDVSANNLKEFG-------LQL-PFLKELYLTRNQLKT 253
Cdd:COG5238  312 LAEGLQGNKTLHTLNLAYNGI-GAQGAIAlakalqenTTLHSLDLSDNQIGDEGaialakyLEGnTTLRELNLGKNNIGK 390

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 514351434 254 LPDAAPIPNLVAMSVRRNKLNSFSKAELESFKHMELLDA 292
Cdd:COG5238  391 QGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLER 429
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 130-295 2.57e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 130 SSNLLGD*SLEHSACQggwpSLQTLNLSQNSLSdlGMT*KSLSHLRHLILLDISQNNFGDIPDVCEWPKT-LKYLNLSRT 208
Cdd:PLN00113 389 SNSLEGEIPKSLGACR----SLRRVRLQDNSFS--GELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPsLQMLSLARN 462

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 209 qipKVTTCIPPT-----LEVLDVSANNLKE-----FGlQLPFLKELYLTRNQLK-TLPDA-APIPNLVAMSVRRNKLNSF 276
Cdd:PLN00113 463 ---KFFGGLPDSfgskrLENLDLSRNQFSGavprkLG-SLSELMQLKLSENKLSgEIPDElSSCKKLVSLDLSHNQLSGQ 538

                        170
                 ....*....|....*....
gi 514351434 277 SKAELESFKHMELLDASDN 295
Cdd:PLN00113 539 IPASFSEMPVLSQLDLSQN 557
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 93-213 2.86e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434  93 VZGL***LTKVTVENTKvflvpcRLSQ*LR---SLEYLDLSSNLLGD*-------SLEHSAcqggwpSLQTLNLSQNSLS 162
Cdd:COG5238  266 VETLYLSGNQIGAEGAI------ALAKALQgntTLTSLDLSVNRIGDEgaialaeGLQGNK------TLHTLNLAYNGIG 333

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 514351434 163 DLGMT*--KSLSHLRHLILLDISQNNFGDI--PDVCEWPK---TLKYLNLSRTQIPKV 213
Cdd:COG5238  334 AQGAIAlaKALQENTTLHSLDLSDNQIGDEgaIALAKYLEgntTLRELNLGKNNIGKQ 391
LRRCT smart00082
Leucine rich repeat C-terminal domain;
295-348 4.97e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.79  E-value: 4.97e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 514351434   295 NNFICSCEFLSFIHHQagLAPVLVGWP*KYVCDSPLAVRGaQVGAVHLSLMECH 348
Cdd:smart00082   1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
241-297 8.04e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 8.04e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 514351434  241 LKELYLTRNQLKTLPDAAPI--PNLVAMSVRRNKLNSFSKAELESFKHMELLDASDNNF 297
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
149-287 9.77e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.30  E-value: 9.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 149 PSLQTLNLSQNSLSDLGMT*KSLSHL--------------RHLILLDISQNNFGDIPDVCEWPKTLKYLNLSRTQIPkvt 214
Cdd:PRK15387 302 PGLQELSVSDNQLASLPALPSELCKLwaynnqltslptlpSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLP--- 378

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351434 215 tCIPPTLEVLDVSANNLKEFGLQLPFLKELYLTRNQLKTLPdaaPIPN-LVAMSVRRNKLNSFSkaelESFKHM 287
Cdd:PRK15387 379 -ALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLP---MLPSgLLSLSVYRNQLTRLP----ESLIHL 444
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 124-297 2.90e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 124 LEYLDLSSNLLgd*SLEHSACQGGWPSLQTLNLSQNSLsdLGMT*KSLSHLRHLILLDISQNNF-GDIPDVCEWPKTLK- 201
Cdd:PLN00113 142 LETLDLSNNML---SGEIPNDIGSFSSLKVLDLGGNVL--VGKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKw 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351434 202 ----YLNLS---RTQIPKVTtcippTLEVLDVSANNL-----KEFGlQLPFLKELYLTRNQLktlpdAAPIP-------N 262
Cdd:PLN00113 217 iylgYNNLSgeiPYEIGGLT-----SLNHLDLVYNNLtgpipSSLG-NLKNLQYLFLYQNKL-----SGPIPpsifslqK 285

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 514351434 263 LVAMSVRRNKLNSFSKAELESFKHMELLDASDNNF 297
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF 320
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 149-186 5.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 5.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 514351434  149 PSLQTLNLSQNSLSDLGmt*kSLSHLRHLILLDISQNN 186
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP----PLAKLPNLETLDLSGNN 34
LRR_8 pfam13855
Leucine rich repeat;
219-273 9.72e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 9.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351434  219 PTLEVLDVSANNL----KEFGLQLPFLKELYLTRNQLKTLPDAA--PIPNLVAMSVRRNKL 273
Cdd:pfam13855   1 PNLRSLDLSNNRLtsldDGAFKGLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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