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Conserved domains on  [gi|514351400|gb|AGO49881|]
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Toll-like receptor 1LA, partial [Notiomystis cincta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
135-311 1.71e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 1.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 135 QYLNFSHNALTDeLFQNCSTLRDLKLLILQKNKFESLSKVsfmTSLMKSLKYLDMSNNLLRHEGAGVQcqWAESLAELDL 214
Cdd:COG4886  116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLTDLPEELG--NLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 215 SSNQLAD--AVFSCLPaNVRKLGLRNNHISSVPRGMVELSSLQELNLASNRLADLPACSGFASLQVLNVEMNSI--LTPS 290
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLtdLPPL 268

                        170       180
                 ....*....|....*....|.
gi 514351400 291 ADFfqscPRVRELQAGHNPFK 311
Cdd:COG4886  269 ANL----TNLKTLDLSNNQLT 285
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
308-360 1.13e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 1.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 514351400   308 NPFKCSCELQAFIGLERraGGKLFGWPAAYVCEYPQGLRGtELKDFHLSQLAC 360
Cdd:smart00082   1 NPFICDCELRWLLRWLQ--ANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
135-311 1.71e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 1.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 135 QYLNFSHNALTDeLFQNCSTLRDLKLLILQKNKFESLSKVsfmTSLMKSLKYLDMSNNLLRHEGAGVQcqWAESLAELDL 214
Cdd:COG4886  116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLTDLPEELG--NLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 215 SSNQLAD--AVFSCLPaNVRKLGLRNNHISSVPRGMVELSSLQELNLASNRLADLPACSGFASLQVLNVEMNSI--LTPS 290
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLtdLPPL 268

                        170       180
                 ....*....|....*....|.
gi 514351400 291 ADFfqscPRVRELQAGHNPFK 311
Cdd:COG4886  269 ANL----TNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 114-308 1.02e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 114 NLTIYD-------AYMPHMLCpNRTSSFQYLNFShNALTDELFQNCSTLRDLKLLILQKNKFESLSKVSFMTslMKSLKY 186
Cdd:PLN00113 357 NLTVLDlstnnltGEIPEGLC-SSGNLFKLILFS-NSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTK--LPLVYF 432

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 187 LDMSNNLLrhEGAGVQCQW-AESLAELDLSSNQLadavFSCLP-----ANVRKLGLRNNHIS-SVPRGMVELSSLQELNL 259
Cdd:PLN00113 433 LDISNNNL--QGRINSRKWdMPSLQMLSLARNKF----FGGLPdsfgsKRLENLDLSRNQFSgAVPRKLGSLSELMQLKL 506

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 514351400 260 ASNRLA-----DLPACSGFASlqvLNVEMNSILTPSADFFQSCPRVRELQAGHN 308
Cdd:PLN00113 507 SENKLSgeipdELSSCKKLVS---LDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 137-310 6.41e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 6.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 137 LNFSHNALTD-ELFQNCstlRDLKLLILQKNKFESLSKVSFMTSL------------------MKSLKYLDMSNNLLRH- 196
Cdd:cd21340    7 LYLNDKNITKiDNLSLC---KNLKVLYLYDNKITKIENLEFLTNLthlylqnnqiekienlenLVNLKKLYLGGNRISVv 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 197 EGagVQCQwaESLAELDLSSNQLAdavfsclpanvrklglRNNHISSVPRGMVELS-SLQELNLASNRLADLPACSGFAS 275
Cdd:cd21340   84 EG--LENL--TNLEELHIENQRLP----------------PGEKLTFDPRSLAALSnSLRVLNISGNNIDSLEPLAPLRN 143

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 514351400 276 LQVLNVEMNSI--LTPSADFFQSCPRVRELQAGHNPF 310
Cdd:cd21340  144 LEQLDASNNQIsdLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
158-219 3.25e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 3.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351400  158 LKLLILQKNKFESLSKVSFMTslMKSLKYLDMSNNLLRH--EGAGVQCqwaESLAELDLSSNQL 219
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKG--LSNLKVLDLSNNLLTTlsPGAFSGL---PSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
308-360 1.13e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 1.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 514351400   308 NPFKCSCELQAFIGLERraGGKLFGWPAAYVCEYPQGLRGtELKDFHLSQLAC 360
Cdd:smart00082   1 NPFICDCELRWLLRWLQ--ANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
135-311 1.71e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 1.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 135 QYLNFSHNALTDeLFQNCSTLRDLKLLILQKNKFESLSKVsfmTSLMKSLKYLDMSNNLLRHEGAGVQcqWAESLAELDL 214
Cdd:COG4886  116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLTDLPEELG--NLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 215 SSNQLAD--AVFSCLPaNVRKLGLRNNHISSVPRGMVELSSLQELNLASNRLADLPACSGFASLQVLNVEMNSI--LTPS 290
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLtdLPPL 268

                        170       180
                 ....*....|....*....|.
gi 514351400 291 ADFfqscPRVRELQAGHNPFK 311
Cdd:COG4886  269 ANL----TNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
110-311 3.83e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 3.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 110 MNIANLTIYDAYMPHMLCPNRTSSFQYLNFSHNALTDELFQNCSTLRDLKLLILQKNKFESLSKVSFMTSLMKSLKYLDM 189
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 190 SNNLLrhEGAGVQCQWAESLAELDLSSNqlaDAVFSClpANVRKLGLRNNHISSVPRGMVELSSLQELNLASNRLADLPA 269
Cdd:COG4886   81 LLSLL--LLGLTDLGDLTNLTELDLSGN---EELSNL--TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 514351400 270 -CSGFASLQVLNVEMNSILT-PSAdfFQSCPRVRELQAGHNPFK 311
Cdd:COG4886  154 pLGNLTNLKSLDLSNNQLTDlPEE--LGNLTNLKELDLSNNQIT 195
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 114-308 1.02e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 114 NLTIYD-------AYMPHMLCpNRTSSFQYLNFShNALTDELFQNCSTLRDLKLLILQKNKFESLSKVSFMTslMKSLKY 186
Cdd:PLN00113 357 NLTVLDlstnnltGEIPEGLC-SSGNLFKLILFS-NSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTK--LPLVYF 432

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 187 LDMSNNLLrhEGAGVQCQW-AESLAELDLSSNQLadavFSCLP-----ANVRKLGLRNNHIS-SVPRGMVELSSLQELNL 259
Cdd:PLN00113 433 LDISNNNL--QGRINSRKWdMPSLQMLSLARNKF----FGGLPdsfgsKRLENLDLSRNQFSgAVPRKLGSLSELMQLKL 506

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 514351400 260 ASNRLA-----DLPACSGFASlqvLNVEMNSILTPSADFFQSCPRVRELQAGHN 308
Cdd:PLN00113 507 SENKLSgeipdELSSCKKLVS---LDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 137-310 6.41e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 6.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 137 LNFSHNALTD-ELFQNCstlRDLKLLILQKNKFESLSKVSFMTSL------------------MKSLKYLDMSNNLLRH- 196
Cdd:cd21340    7 LYLNDKNITKiDNLSLC---KNLKVLYLYDNKITKIENLEFLTNLthlylqnnqiekienlenLVNLKKLYLGGNRISVv 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 197 EGagVQCQwaESLAELDLSSNQLAdavfsclpanvrklglRNNHISSVPRGMVELS-SLQELNLASNRLADLPACSGFAS 275
Cdd:cd21340   84 EG--LENL--TNLEELHIENQRLP----------------PGEKLTFDPRSLAALSnSLRVLNISGNNIDSLEPLAPLRN 143

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 514351400 276 LQVLNVEMNSI--LTPSADFFQSCPRVRELQAGHNPF 310
Cdd:cd21340  144 LEQLDASNNQIsdLEELLDLLSSWPSLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
135-288 8.93e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 8.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 135 QYLNFSHNALTDeLFQNCSTLRDLKLLILQKNKFESLSKVsfmTSLMKSLKYLDMSNNLLRHEGAGVQCQwaeSLAELDL 214
Cdd:COG4886  185 KELDLSNNQITD-LPEPLGNLTNLEELDLSGNQLTDLPEP---LANLTNLETLDLSNNQLTDLPELGNLT---NLEELDL 257

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351400 215 SSNQLADAVFSCLPANVRKLGLRNNHISSvprgmVELSSLQELNLASNRLADLPACSGFASLQVLNVEMNSILT 288
Cdd:COG4886  258 SNNQLTDLPPLANLTNLKTLDLSNNQLTD-----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR_8 pfam13855
Leucine rich repeat;
158-219 3.25e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 3.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351400  158 LKLLILQKNKFESLSKVSFMTslMKSLKYLDMSNNLLRH--EGAGVQCqwaESLAELDLSSNQL 219
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKG--LSNLKVLDLSNNLLTTlsPGAFSGL---PSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 124-308 3.35e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 3.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 124 HMLCPNRTSSFQYLNFSHNALTDE--------LFQNCStlrdLKLLILQKNKFESLSKVSF--MTSLMKSLKYLDMSNNL 193
Cdd:COG5238  172 SMAKALQNNSVETVYLGCNQIGDEgieelaeaLTQNTT----VTTLWLKRNPIGDEGAEILaeALKGNKSLTTLDLSNNQ 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 194 LRHEGAgvqCQWAESLAE------LDLSSNQL----ADAVFSCLPAN--VRKLGLRNNHISSvpRGMVEL-------SSL 254
Cdd:COG5238  248 IGDEGV---IALAEALKNnttvetLYLSGNQIgaegAIALAKALQGNttLTSLDLSVNRIGD--EGAIALaeglqgnKTL 322

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351400 255 QELNLASNRLADLPACSGFASLQV------LNVEMNSILTPSAD----FFQSCPRVRELQAGHN 308
Cdd:COG5238  323 HTLNLAYNGIGAQGAIALAKALQEnttlhsLDLSDNQIGDEGAIalakYLEGNTTLRELNLGKN 386
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 130-292 9.44e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 9.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 130 RTSSFQYLNFSHNALTDE-LFQNCSTLRDLKL----LILQKNKFESLSkvsfMTSLMK------SLKYLDMSNNLLRHEG 198
Cdd:cd00116  106 RSSSLQELKLNNNGLGDRgLRLLAKGLKDLPPalekLVLGRNRLEGAS----CEALAKalranrDLKELNLANNGIGDAG 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 199 AGVQCQ---WAESLAELDLSSNQLADAVFSCL------PANVRKLGLRNNHISSVprGMVEL--------SSLQELNLAS 261
Cdd:cd00116  182 IRALAEglkANCNLEVLDLNNNGLTDEGASALaetlasLKSLEVLNLGDNNLTDA--GAAALasallspnISLLTLSLSC 259

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 514351400 262 NRLADLPA------CSGFASLQVLNVEMNSILTPSAD 292
Cdd:cd00116  260 NDITDDGAkdlaevLAEKESLLELDLRGNKFGEEGAQ 296
LRR_8 pfam13855
Leucine rich repeat;
208-264 1.08e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351400  208 SLAELDLSSNQL---ADAVFSCLPaNVRKLGLRNNHISSV-PRGMVELSSLQELNLASNRL 264
Cdd:pfam13855   2 NLRSLDLSNNRLtslDDGAFKGLS-NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
308-360 1.13e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 1.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 514351400   308 NPFKCSCELQAFIGLERraGGKLFGWPAAYVCEYPQGLRGtELKDFHLSQLAC 360
Cdd:smart00082   1 NPFICDCELRWLLRWLQ--ANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
132-293 1.55e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 132 SSFQYLNFSHNALTDeLFQNCSTLRDLKLLILQKNKFESLSKVSFMTslmkSLKYLDMSNNLLRHEGAGVQCQwaeSLAE 211
Cdd:COG4886  205 TNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLTDLPELGNLT----NLEELDLSNNQLTDLPPLANLT---NLKT 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 212 LDLSSNQLADAVFSCLPA-NVRKLGLRNNHISSVPRGMVELSSLQELNLASNRLADLPACSGFASLQVLNVEMNSILTPS 290
Cdd:COG4886  277 LDLSNNQLTDLKLKELELlLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356


                 ...
gi 514351400 291 ADF 293
Cdd:COG4886  357 NLL 359
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
209-268 3.31e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.84  E-value: 3.31e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 209 LAELDLSSNQLADavFSCLPANVRKLGLRNNHISSVPrgmVELSSLQELNLASNRLADLP 268
Cdd:PRK15387 304 LQELSVSDNQLAS--LPALPSELCKLWAYNNQLTSLP---TLPSGLQELSVSDNQLASLP 358
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 182-301 6.20e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 6.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 182 KSLKYLDMSNNLLRHEGAGVQCQWAE---SLAELDLSSNQL----ADAVFSCLPAN--VRKLGLRNNHISSvpRGMVEL- 251
Cdd:COG5238  292 TTLTSLDLSVNRIGDEGAIALAEGLQgnkTLHTLNLAYNGIgaqgAIALAKALQENttLHSLDLSDNQIGD--EGAIALa 369

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351400 252 ------SSLQELNLASNRLADLPACSGFASLQV-----LNVEMNSILT-PSADFFQSCPRVR 301
Cdd:COG5238  370 kylegnTTLRELNLGKNNIGKQGAEALIDALQTnrlhtLILDGNLIGAeAQQRLEQLLERIK 431
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
209-286 7.16e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.69  E-value: 7.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 209 LAELDLSSNQLADavFSCLPANVRKLGLRNNHISSVP---RGMVEL--------------SSLQELNLASNRLADLPAC- 270
Cdd:PRK15387 344 LQELSVSDNQLAS--LPTLPSELYKLWAYNNRLTSLPalpSGLKELivsgnrltslpvlpSELKELMVSGNRLTSLPMLp 421

                         90
                 ....*....|....*.
gi 514351400 271 SGFASLQVLNVEMNSI 286
Cdd:PRK15387 422 SGLLSLSVYRNQLTRL 437
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 253-293 1.24e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 514351400  253 SLQELNLASNRLADLPACSGFASLQVLNVEMNSILTPSADF 293
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITDLSDL 42
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 137-310 1.56e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 137 LNFSHNALTDELFQNCSTLRDLKLLILQKNKFESLSKVSfMTSLMK-----------------------SLKYLDMSNNL 193
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA-LTSLPRlqvlqlwsnkfsgeipknlgkhnNLTVLDLSTNN 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 194 LRHEGAGVQCQwAESLAELDLSSNQLADAVFSCLPA--NVRKLGLRNNHIS-SVPRGMVELSSLQELNLASNRLA----- 265
Cdd:PLN00113 368 LTGEIPEGLCS-SGNLFKLILFSNSLEGEIPKSLGAcrSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrins 446

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 514351400 266 ---DLPacsgfaSLQVLNVEMNSILTPSADFFQScPRVRELQAGHNPF 310
Cdd:PLN00113 447 rkwDMP------SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQF 487
LRR_8 pfam13855
Leucine rich repeat;
135-194 2.13e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351400  135 QYLNFSHNALT---DELFQNcstLRDLKLLILQKNKFESLSKVSFmtSLMKSLKYLDMSNNLL 194
Cdd:pfam13855   4 RSLDLSNNRLTsldDGAFKG---LSNLKVLDLSNNLLTTLSPGAF--SGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 136-284 2.18e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 136 YLNFSHNALTDELFQNCSTLRDLKLLILQKNKFESLSKVSFMTslmKSLKYLDMSNNLLrhegAGVQCQWAESLAE---L 212
Cdd:PLN00113 432 FLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS---KRLENLDLSRNQF----SGAVPRKLGSLSElmqL 504

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351400 213 DLSSNQLA----DAVFSClpANVRKLGLRNNHIS-SVPRGMVELSSLQELNLASNRLA-DLPACSG-FASLQVLNVEMN 284
Cdd:PLN00113 505 KLSENKLSgeipDELSSC--KKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGnVESLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 133-192 2.60e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 2.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351400 133 SFQYLNFSHNALTDelFQNCSTLRDLKLLILQKNKFESLSKVSFMTSLMKSLKYLDMSNN 192
Cdd:cd21340  121 SLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
252-310 3.59e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 3.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351400  252 SSLQELNLASNRLADLP--ACSGFASLQVLNVEMNSILTPSADFFQSCPRVRELQAGHNPF 310
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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