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Conserved domains on  [gi|511333626|gb|EGF86672|]
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hypothetical protein HMPREF0433_01376 [Gemella sanguinis M325]

Protein Classification

regulatory protein RecX( domain architecture ID 4708)

regulatory protein RecX modulates RecA activities (both recombinase and coprotease) through direct physical interaction

CATH:  1.10.10.10
Gene Ontology:  GO:0006282
PubMed:  18650935

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
recX super family cl00936
recombination regulator RecX; Reviewed
1-167 3.58e-37

recombination regulator RecX; Reviewed


The actual alignment was detected with superfamily member PRK14135:

Pssm-ID: 470000 [Multi-domain]  Cd Length: 263  Bit Score: 129.18  E-value: 3.58e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626   1 MQVTNITKLKVKYKIELDNGKHFYVSEDTIIKYGLIKKIELTKEQLKEILAHESVESAYSKVVHYLQYGLRTKQEIKDYL 80
Cdd:PRK14135   2 TKITVQKKNKERYNIFLDEKYAFSVDEDTLVKFMLKKGKELDEEDLEEIQYADQVSKGKNLALYYLSYQMRTEKEVRDYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626  81 IKKEIAPKVIDEVIEKLVEIGYLNDEHYVEAAVTDYFNLNLKGPYWIKRKLQEKDLDKDAIDNYIAKIcTEEAMIEMLYK 160
Cdd:PRK14135  82 KKHEISEEIISEVIDKLKEEKYIDDKEYAESYVRTNINTGDKGPRVIKQKLLQKGIEDEIIEEALSEY-TEEDQIEVAQK 160

                 ....*..
gi 511333626 161 IIEREFK 167
Cdd:PRK14135 161 LAEKLLK 167
 
Name Accession Description Interval E-value
recX PRK14135
recombination regulator RecX; Provisional
1-167 3.58e-37

recombination regulator RecX; Provisional


Pssm-ID: 237619 [Multi-domain]  Cd Length: 263  Bit Score: 129.18  E-value: 3.58e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626   1 MQVTNITKLKVKYKIELDNGKHFYVSEDTIIKYGLIKKIELTKEQLKEILAHESVESAYSKVVHYLQYGLRTKQEIKDYL 80
Cdd:PRK14135   2 TKITVQKKNKERYNIFLDEKYAFSVDEDTLVKFMLKKGKELDEEDLEEIQYADQVSKGKNLALYYLSYQMRTEKEVRDYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626  81 IKKEIAPKVIDEVIEKLVEIGYLNDEHYVEAAVTDYFNLNLKGPYWIKRKLQEKDLDKDAIDNYIAKIcTEEAMIEMLYK 160
Cdd:PRK14135  82 KKHEISEEIISEVIDKLKEEKYIDDKEYAESYVRTNINTGDKGPRVIKQKLLQKGIEDEIIEEALSEY-TEEDQIEVAQK 160

                 ....*..
gi 511333626 161 IIEREFK 167
Cdd:PRK14135 161 LAEKLLK 167
RecX COG2137
SOS response regulatory protein OraA/RecX, interacts with RecA [Posttranslational modification, ...
53-172 1.59e-25

SOS response regulatory protein OraA/RecX, interacts with RecA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441740 [Multi-domain]  Cd Length: 154  Bit Score: 96.01  E-value: 1.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626  53 ESVESAYSKVVHYLQYGLRTKQEIKDYLIKKEIAPKVIDEVIEKLVEIGYLNDEHYVEAAVTDYFNLNLKGPYWIKRKLQ 132
Cdd:COG2137    3 DTEKKARNRALRLLARRERSRKELRRKLARKGFDEEEIEEVLDRLKEEGYLDDERFAESYVRSRLRRKGYGPRRIRQELR 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 511333626 133 EKDLDKDAIDNYIAKIcTEEAMIEMLYKIIEREFKVRREA 172
Cdd:COG2137   83 QKGIDEELIEEALEEL-DEEDELEAARELARKKFGSLKPL 121
RecX pfam02631
RecX family; RecX is a putative bacterial regulatory protein. The gene encoding RecX is found ...
80-167 7.15e-14

RecX family; RecX is a putative bacterial regulatory protein. The gene encoding RecX is found downstream of recA, and is thought to interact with the RecA protein.


Pssm-ID: 460631 [Multi-domain]  Cd Length: 123  Bit Score: 64.92  E-value: 7.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626   80 LIKKEIAPKVIDEVIEKLVEIGYLNDEHYVEAAVTDYFNLNLKGPYWIKRKLQEKDLDKDAIDNYIAKICTEEamiEMLY 159
Cdd:pfam02631   1 LRKKGFSEEVIEEVLDRLKELGYLDDARFAESFVRSRARTRGKGPRRIRQELRQKGVDEEIIEEALEEFDEEE---QIAR 77

                  ....*...
gi 511333626  160 KIIEREFK 167
Cdd:pfam02631  78 ELAEKKFK 85
 
Name Accession Description Interval E-value
recX PRK14135
recombination regulator RecX; Provisional
1-167 3.58e-37

recombination regulator RecX; Provisional


Pssm-ID: 237619 [Multi-domain]  Cd Length: 263  Bit Score: 129.18  E-value: 3.58e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626   1 MQVTNITKLKVKYKIELDNGKHFYVSEDTIIKYGLIKKIELTKEQLKEILAHESVESAYSKVVHYLQYGLRTKQEIKDYL 80
Cdd:PRK14135   2 TKITVQKKNKERYNIFLDEKYAFSVDEDTLVKFMLKKGKELDEEDLEEIQYADQVSKGKNLALYYLSYQMRTEKEVRDYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626  81 IKKEIAPKVIDEVIEKLVEIGYLNDEHYVEAAVTDYFNLNLKGPYWIKRKLQEKDLDKDAIDNYIAKIcTEEAMIEMLYK 160
Cdd:PRK14135  82 KKHEISEEIISEVIDKLKEEKYIDDKEYAESYVRTNINTGDKGPRVIKQKLLQKGIEDEIIEEALSEY-TEEDQIEVAQK 160

                 ....*..
gi 511333626 161 IIEREFK 167
Cdd:PRK14135 161 LAEKLLK 167
RecX COG2137
SOS response regulatory protein OraA/RecX, interacts with RecA [Posttranslational modification, ...
53-172 1.59e-25

SOS response regulatory protein OraA/RecX, interacts with RecA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441740 [Multi-domain]  Cd Length: 154  Bit Score: 96.01  E-value: 1.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626  53 ESVESAYSKVVHYLQYGLRTKQEIKDYLIKKEIAPKVIDEVIEKLVEIGYLNDEHYVEAAVTDYFNLNLKGPYWIKRKLQ 132
Cdd:COG2137    3 DTEKKARNRALRLLARRERSRKELRRKLARKGFDEEEIEEVLDRLKEEGYLDDERFAESYVRSRLRRKGYGPRRIRQELR 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 511333626 133 EKDLDKDAIDNYIAKIcTEEAMIEMLYKIIEREFKVRREA 172
Cdd:COG2137   83 QKGIDEELIEEALEEL-DEEDELEAARELARKKFGSLKPL 121
RecX pfam02631
RecX family; RecX is a putative bacterial regulatory protein. The gene encoding RecX is found ...
80-167 7.15e-14

RecX family; RecX is a putative bacterial regulatory protein. The gene encoding RecX is found downstream of recA, and is thought to interact with the RecA protein.


Pssm-ID: 460631 [Multi-domain]  Cd Length: 123  Bit Score: 64.92  E-value: 7.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626   80 LIKKEIAPKVIDEVIEKLVEIGYLNDEHYVEAAVTDYFNLNLKGPYWIKRKLQEKDLDKDAIDNYIAKICTEEamiEMLY 159
Cdd:pfam02631   1 LRKKGFSEEVIEEVLDRLKELGYLDDARFAESFVRSRARTRGKGPRRIRQELRQKGVDEEIIEEALEEFDEEE---QIAR 77

                  ....*...
gi 511333626  160 KIIEREFK 167
Cdd:pfam02631  78 ELAEKKFK 85
recX PRK00117
recombination regulator RecX; Reviewed
50-142 9.55e-09

recombination regulator RecX; Reviewed


Pssm-ID: 234646 [Multi-domain]  Cd Length: 157  Bit Score: 52.20  E-value: 9.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626  50 LAHESVESAYSKVVHYLQYGL----RTKQEIKDYLIKKEIAPKVIDEVIEKLVEIGYLNDEHYVEAAVTDYfNLNLKGPY 125
Cdd:PRK00117   1 LEDTARRRMYASARARALRLLarreHSRAELRRKLAAKGFSEEVIEAVLDRLKEEGLLDDERFAESFVRSR-ARKGYGPR 79
                         90
                 ....*....|....*..
gi 511333626 126 WIKRKLQEKDLDKDAID 142
Cdd:PRK00117  80 RIRQELRQKGVDREIIE 96
recX PRK14134
recombination regulator RecX; Provisional
6-168 2.11e-06

recombination regulator RecX; Provisional


Pssm-ID: 184530 [Multi-domain]  Cd Length: 283  Bit Score: 46.72  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626   6 ITKLKVKYK------IELDNGKHFYVSEDTIIKYGLIKKIELTKEQLKEILAHESVESAYSKVVHYLQYGLRTKQEIKDY 79
Cdd:PRK14134   5 ITKIEVQKRnkdrvnVYIDEEFAFACSAELVYYHNLKKGKVIDVNSLNDIIKEDNYIKCKGYALKYIEKSYKTEKQIKEK 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511333626  80 LIKKEIAPKVIDEVIEKLVEIGYLNDEHYVEAAVTDyfNLNLKGPYWIKRKLQEKDLDKDAIDNYIAKIcTEEAMIEMLY 159
Cdd:PRK14134  85 LYLKEYDEDAVNRVIRFLKEYNFIDDDKYCDMYIRE--KINSYGRNKIKYTLLNKGIKENIIIEKINNI-DEEKEKKVAY 161

                 ....*....
gi 511333626 160 KIIEREFKV 168
Cdd:PRK14134 162 KLAEKKYKI 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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