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Conserved domains on  [gi|510951775|gb|AGN55414|]
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early growth response 3, partial [Tydemania navigatoris]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 1-97 1.94e-14

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


:

Pssm-ID: 463400  Cd Length: 104  Bit Score: 67.55  E-value: 1.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510951775    1 KFAFDTPPSGGIggsgWCSDNNIISLVSaGILGVSPSPGTVTTQTSSSAAS-----------MGGQTSDMEQVYGPPlPA 69
Cdd:pfam11928   2 KFSIDPQYPGGG----SLWPEGLISLVS-GLVGMANPPSSSSSSSPSSSSSpnssgplctmsCSVQSSEMEHIYSAP-PP 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 510951775   70 Y--STCSDLYQDQVSFHHSPaTSTALAYPS 97
Cdd:pfam11928  76 YpsSGCGDLYQDPSAFLSTP-SGPPLAYPP 104
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-250 3.80e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 3.80e-05
                          10        20
                  ....*....|....*....|....*.
gi 510951775  225 ELTRHLRIHTGHKPFQCRICMRSFSR 250
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
205-266 2.32e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 2.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 510951775 205 HERPHACPaeNCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKP 266
Cdd:COG5048   30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPS 91
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 1-97 1.94e-14

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 67.55  E-value: 1.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510951775    1 KFAFDTPPSGGIggsgWCSDNNIISLVSaGILGVSPSPGTVTTQTSSSAAS-----------MGGQTSDMEQVYGPPlPA 69
Cdd:pfam11928   2 KFSIDPQYPGGG----SLWPEGLISLVS-GLVGMANPPSSSSSSSPSSSSSpnssgplctmsCSVQSSEMEHIYSAP-PP 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 510951775   70 Y--STCSDLYQDQVSFHHSPaTSTALAYPS 97
Cdd:pfam11928  76 YpsSGCGDLYQDPSAFLSTP-SGPPLAYPP 104
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-250 3.80e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 3.80e-05
                          10        20
                  ....*....|....*....|....*.
gi 510951775  225 ELTRHLRIHTGHKPFQCRICMRSFSR 250
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-266 2.32e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 2.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 510951775 205 HERPHACPaeNCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKP 266
Cdd:COG5048   30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPS 91
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 1-97 1.94e-14

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 67.55  E-value: 1.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510951775    1 KFAFDTPPSGGIggsgWCSDNNIISLVSaGILGVSPSPGTVTTQTSSSAAS-----------MGGQTSDMEQVYGPPlPA 69
Cdd:pfam11928   2 KFSIDPQYPGGG----SLWPEGLISLVS-GLVGMANPPSSSSSSSPSSSSSpnssgplctmsCSVQSSEMEHIYSAP-PP 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 510951775   70 Y--STCSDLYQDQVSFHHSPaTSTALAYPS 97
Cdd:pfam11928  76 YpsSGCGDLYQDPSAFLSTP-SGPPLAYPP 104
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-250 3.80e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 3.80e-05
                          10        20
                  ....*....|....*....|....*.
gi 510951775  225 ELTRHLRIHTGHKPFQCRICMRSFSR 250
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 239-261 1.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|...
gi 510951775  239 FQCRICMRSFSRSDHLTTHIRTH 261
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-266 2.32e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 2.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 510951775 205 HERPHACPaeNCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKP 266
Cdd:COG5048   30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPS 91
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 194-262 6.00e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 37.78  E-value: 6.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510951775 194 KYPNRPSKTpVHERPHACPAENCDRRFSRSDELTRHlRIHtGH---------------------KPFQCRICMRSFSRSD 252
Cdd:COG5189  336 DTPSRMLKV-KDGKPYKCPVEGCNKKYKNQNGLKYH-MLH-GHqnqklhenpspekmnifsakdKPYRCEVCDKRYKNLN 412

                         90
                 ....*....|
gi 510951775 253 HLTTHiRTHT 262
Cdd:COG5189  413 GLKYH-RKHS 421
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 239-261 8.50e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 33.00  E-value: 8.50e-03
                          10        20
                  ....*....|....*....|...
gi 510951775  239 FQCRICMRSFSRSDHLTTHIRTH 261
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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