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Conserved domains on  [gi|50980309|ref|NP_115551|]
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U3 small nucleolar RNA-associated protein 15 homolog isoform 1 [Homo sapiens]

Protein Classification

U3 small nucleolar RNA-associated protein 15( domain architecture ID 11456900)

U3 small nucleolar RNA-associated protein 15 is involved in nucleolar processing of pre-18S ribosomal RNA

Gene Ontology:  GO:0042274|GO:0006364|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 343-490 4.31e-63

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


:

Pssm-ID: 462782  Cd Length: 146  Bit Score: 202.33  E-value: 4.31e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309   343 NYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTctIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVL 422
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50980309   423 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 490
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 6.92e-57

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 6.92e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  39 GAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQF 118
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 119 EGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFITGSYDHTVKMFDART 196
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 197 SESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKV 274
Cdd:COG2319 236 GKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270
                ....*....|....*....|....*....|....
gi 50980309 275 YSTTSYKVVHSFD-YAASILSLALAHEDETIVVG 307
Cdd:COG2319 315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 343-490 4.31e-63

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 202.33  E-value: 4.31e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309   343 NYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTctIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVL 422
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50980309   423 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 490
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 6.92e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 6.92e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  39 GAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQF 118
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 119 EGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFITGSYDHTVKMFDART 196
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 197 SESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKV 274
Cdd:COG2319 236 GKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270
                ....*....|....*....|....*....|....
gi 50980309 275 YSTTSYKVVHSFD-YAASILSLALAHEDETIVVG 307
Cdd:COG2319 315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-306 1.41e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.74  E-value: 1.41e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  39 GAVSKVDFSPQPpyNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLR 116
Cdd:cd00200  10 GGVTCVAFSPDG--KLLATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 117 QFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKlNPDLFITGSYDHTVKMFDART 196
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 197 SESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKV 274
Cdd:cd00200 167 GKCVATLTgHTGEVNSVAFSPDGEKLLSSSSdGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                       250       260       270
                ....*....|....*....|....*....|...
gi 50980309 275 YSTTSYKVVHSFD-YAASILSLALaHEDETIVV 306
Cdd:cd00200 246 WDLRTGECVQTLSgHTNSVTSLAW-SPDGKRLA 277
PTZ00421 PTZ00421
coronin; Provisional
 91-236 5.15e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 58.37  E-value: 5.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309   91 DGRLLVAGSEDGGVQLFDI-------SGRAPLRQFEGHTKAVHTVDFTADKYHVVSGAD-DYTVKLWDIPNSKEILTFKE 162
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKC 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  163 HSDYVrCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVES--VLLFPSGGLLVSAG-----GRYVKVWDML 235
Cdd:PTZ00421 167 HSDQI-TSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGcsksqQRQIMLWDTR 245


                 .
gi 50980309  236 K 236
Cdd:PTZ00421 246 K 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-150 1.20e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.20e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 50980309    114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
114-150 2.04e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 50980309   114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 343-490 4.31e-63

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 202.33  E-value: 4.31e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309   343 NYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTctIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVL 422
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50980309   423 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 490
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 6.92e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 6.92e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  39 GAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQF 118
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 119 EGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFITGSYDHTVKMFDART 196
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 197 SESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKV 274
Cdd:COG2319 236 GKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270
                ....*....|....*....|....*....|....
gi 50980309 275 YSTTSYKVVHSFD-YAASILSLALAHEDETIVVG 307
Cdd:COG2319 315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 1.16e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 1.16e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  39 GAVSKVDFSPQPpyNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLR 116
Cdd:COG2319 121 GAVRSVAFSPDG--KTLASGSAdgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 117 QFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCgCAskLNPD--LFITGSYDHTVKMFDA 194
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS-VA--FSPDgrLLASGSADGTVRLWDL 275

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 195 RTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKV 272
Cdd:COG2319 276 ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDdGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 50980309 273 KVYSTTSYKVVHSF-DYAASILSLALAHEDETIVVG 307
Cdd:COG2319 355 RLWDLATGELLRTLtGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
39-279 2.23e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.80  E-value: 2.23e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  39 GAVSKVDFSPQPpyNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLR 116
Cdd:COG2319 163 GAVTSVAFSPDG--KLLASGSDdgTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 117 QFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFITGSYDHTVKMFDA 194
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PDgkLLASGSDDGTVRLWDL 317

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 195 RTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKV 272
Cdd:COG2319 318 ATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDdGTVRLWD-LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396


                ....*..
gi 50980309 273 KVYSTTS 279
Cdd:COG2319 397 RLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
38-315 2.62e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.11  E-value: 2.62e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  38 FGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQ 117
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 118 FEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCgCAskLNPD--LFITGSYDHTVKMFDAR 195
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS-VA--FSPDgkLLASGSDDGTVRLWDLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 196 TSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVK 273
Cdd:COG2319 193 TGKLLRTLTgHTGAVRSVAFSPDGKLLASGSAdGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 50980309 274 VYSTTSYKVVHSFD-YAASILSLALAHEDETIVVGMTNGILSV 315
Cdd:COG2319 272 LWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRL 314
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-306 1.41e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.74  E-value: 1.41e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  39 GAVSKVDFSPQPpyNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLR 116
Cdd:cd00200  10 GGVTCVAFSPDG--KLLATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 117 QFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKlNPDLFITGSYDHTVKMFDART 196
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 197 SESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKV 274
Cdd:cd00200 167 GKCVATLTgHTGEVNSVAFSPDGEKLLSSSSdGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                       250       260       270
                ....*....|....*....|....*....|...
gi 50980309 275 YSTTSYKVVHSFD-YAASILSLALaHEDETIVV 306
Cdd:cd00200 246 WDLRTGECVQTLSgHTNSVTSLAW-SPDGKRLA 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-315 1.72e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 163.66  E-value: 1.72e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  72 PIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI 151
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 152 PNSKEILTFKEHSDYVRCgCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYV 229
Cdd:cd00200  81 ETGECVRTLTGHTSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQdGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 230 KVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDY-AASILSLALAHEDETIVVGM 308
Cdd:cd00200 160 KLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGS 238


                ....*..
gi 50980309 309 TNGILSV 315
Cdd:cd00200 239 EDGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-276 1.53e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.35  E-value: 1.53e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  39 GAVSKVDFSPQppYNYAVTASS----RIHIYGrySQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAP 114
Cdd:cd00200  52 GPVRDVAASAD--GTYLASGSSdktiRLWDLE--TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 115 LRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKlNPDLFITGSYDHTVKMFDA 194
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDL 206

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 195 RTSESVLS-VEHGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKV 272
Cdd:cd00200 207 STGKCLGTlRGHENGVNSVAFSPDGYLLASGSEdGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                ....
gi 50980309 273 KVYS 276
Cdd:cd00200 286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
45-315 2.12e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.45  E-value: 2.12e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  45 DFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKA 124
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 125 VHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFITGSYDHTVKMFDARTSESVLS 202
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS---PDgkTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 203 VE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSY 280
Cdd:COG2319 158 LTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 50980309 281 KVVHSFD-YAASILSLALAHEDETIVVGMTNGILSV 315
Cdd:COG2319 237 KLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-193 7.72e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 7.72e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  26 WNNyKTPVQIKEF----GAVSKVDFSPQPPYnyaVTASSR---IHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAG 98
Cdd:cd00200 120 WDV-ETGKCLTTLrghtDWVNSVAFSPDGTF---VASSSQdgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  99 SEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPD 178
Cdd:cd00200 196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275

                       170
                ....*....|....*
gi 50980309 179 LfITGSYDHTVKMFD 193
Cdd:cd00200 276 L-ASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 91-236 5.15e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 58.37  E-value: 5.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309   91 DGRLLVAGSEDGGVQLFDI-------SGRAPLRQFEGHTKAVHTVDFTADKYHVVSGAD-DYTVKLWDIPNSKEILTFKE 162
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKC 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  163 HSDYVrCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVES--VLLFPSGGLLVSAG-----GRYVKVWDML 235
Cdd:PTZ00421 167 HSDQI-TSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGcsksqQRQIMLWDTR 245


                 .
gi 50980309  236 K 236
Cdd:PTZ00421 246 K 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-150 1.20e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.20e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 50980309    114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-276 1.79e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.79e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 50980309    238 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 276
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
114-150 2.04e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 50980309   114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
238-276 4.48e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.48e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 50980309   238 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 276
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 85-318 1.52e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309   85 CA-TFRQDGRLLVAGSEDGGVQLFDIS-----GRA---PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSK 155
Cdd:PLN00181 487 CAiGFDRDGEFFATAGVNKKIKIFECEsiikdGRDihyPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQ 566

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  156 EILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVlLFPSG---GLLVSAGGRYVKVW 232
Cdd:PLN00181 567 LVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCV-QFPSEsgrSLAFGSADHKVYYY 645

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  233 DMLKGGQLLVSLKNHHKTVTCLCLSSSGQrLLSGSLDRKVKVY------STTSYKVVHSFDYAASILS-LALAHEDETIV 305
Cdd:PLN00181 646 DLRNPKLPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWdlsmsiSGINETPLHSFMGHTNVKNfVGLSVSDGYIA 724

                        250
                 ....*....|...
gi 50980309  306 VGMTNGILSVKHR 318
Cdd:PLN00181 725 TGSETNEVFVYHK 737
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-193 1.25e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.25e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 50980309    153 NSKEILTFKEHSDYVRCGCASKlNPDLFITGSYDHTVKMFD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
154-193 1.75e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 50980309   154 SKEILTFKEHSDYVRCgCASKLNPDLFITGSYDHTVKMFD 193
Cdd:pfam00400   1 GKLLKTLEGHTGSVTS-LAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 69-108 4.75e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 50980309     69 SQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFD 108
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
179-306 1.20e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.45  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 179 LFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLL--VSAGGRYVKVWDmLKGGQLLVSLKNhHKTVTCLCL 256
Cdd:COG3391  82 LYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLyvADSGNGRVSVID-TATGKVVATIPV-GAGPHGIAV 159

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 50980309 257 SSSGQRLLSGSLDRK-----VKVYSTTSYKVVHSFDYAASILSLALAHEDETIVV 306
Cdd:COG3391 160 DPDGKRLYVANSGSNtvsviVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYV 214
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 94-320 1.38e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.83  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309    94 LLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI----PNSKEILTFKE------- 162
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrSSEKRSRNTQTefprkdh 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309   163 ------------HSDYVRCGCASkLNPDLFITGSYDHTVKMFDARTSESVLSVEHgqpvesvllfPSG----GLLVSAGG 226
Cdd:pfam20426 176 viaetpfhilcgHDDIITCLYVS-VELDIVISGSKDGTCIFHTLREGRYVRSIRH----------PSGcplsKLVASRHG 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309   227 RYVKVWDM--------LKGGQLLVSLKNHHktVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAA-SILSLAL 297
Cdd:pfam20426 245 RIVLYADDdlslhlysINGKHIASSESNGR--LNCIELSSCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGkIITSLTV 322

                         250       260
                  ....*....|....*....|....*....
gi 50980309   298 AHEdETIVVGMTNGILSV------KHRKS 320
Cdd:pfam20426 323 TPE-ECFLAGTKDGSLLVysienpQLRKA 350
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
38-229 1.85e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 1.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  38 FGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLL-VAGSEDGGVQLFDISGRAPLR 116
Cdd:COG3391  25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309 117 QFEGHTKAvHTVDFTADKYHV-VSGADDYTVKLWDIPNSKEILTFKEHSDYVrcGCAskLNPD---LFITGSYDHT---- 188
Cdd:COG3391 105 TIPVGGGP-RGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPVGAGPH--GIA--VDPDgkrLYVANSGSNTvsvi 179

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 50980309 189 VKMFDARTSESVLSVEHG-QPVesvllfpsgGLLVSAGGRYV 229
Cdd:COG3391 180 VSVIDTATGKVVATIPVGgGPV---------GVAVSPDGRRL 212
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
55-196 2.66e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 2.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50980309  55 AVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHtKAVHTVDFTAD- 133
Cdd:COG3391  85 ANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVDPDg 163

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50980309 134 KYHVVSGADDYT----VKLWDIPNSKEILTFKEHSDyvrcGCASKLNPD---LFITGSY-------DHTVKMFDART 196
Cdd:COG3391 164 KRLYVANSGSNTvsviVSVIDTATGKVVATIPVGGG----PVGVAVSPDgrrLYVANRGsntsnggSNTVSVIDLAT 236
WD40 pfam00400
WD domain, G-beta repeat;
71-108 4.83e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 50980309    71 EPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFD 108
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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