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Conserved domains on  [gi|50949358|emb|CAB66853|]
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hypothetical protein, partial [Homo sapiens]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-251 1.50e-160

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 466.71  E-value: 1.50e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358     1 PANPITVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFD 80
Cdd:pfam12534  87 PSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFD 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358    81 SPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEGSLVNSQSLKSIPEKFVVD-KSTAGALDKKEGEQAK 152
Cdd:pfam12534 167 SPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKKEGEQAK 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   153 ALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKL 232
Cdd:pfam12534 247 ALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKL 326

                         250
                  ....*....|....*....
gi 50949358   233 SFCYLCFVSIYGLTCLYTL 251
Cdd:pfam12534 327 LVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-685 1.68e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 1.68e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 495 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 574
Cdd:COG4886  89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 575 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 654
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190
                ....*....|....*....|....*....|.
gi 50949358 655 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 685
Cdd:COG4886 241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 425-535 4.18e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 425 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 500
Cdd:cd21340  66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 50949358 501 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 535
Cdd:cd21340 141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-251 1.50e-160

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 466.71  E-value: 1.50e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358     1 PANPITVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFD 80
Cdd:pfam12534  87 PSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFD 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358    81 SPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEGSLVNSQSLKSIPEKFVVD-KSTAGALDKKEGEQAK 152
Cdd:pfam12534 167 SPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKKEGEQAK 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   153 ALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKL 232
Cdd:pfam12534 247 ALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKL 326

                         250
                  ....*....|....*....
gi 50949358   233 SFCYLCFVSIYGLTCLYTL 251
Cdd:pfam12534 327 LVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-685 1.68e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 1.68e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 495 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 574
Cdd:COG4886  89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 575 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 654
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190
                ....*....|....*....|....*....|.
gi 50949358 655 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 685
Cdd:COG4886 241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 498-677 4.74e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 4.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 498 LKKMTNLTeleLVHCDLERIPhaVFSLL-SLQELDLKENNLKSIEeivSFQHLRKLTVLKLWHNSITYIpEHIKKLTSLE 576
Cdd:cd21340   1 LKRITHLY---LNDKNITKID--NLSLCkNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLK 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 577 RLSFSHNKIEVLpSHLFLCNKIRYLDLSYNDIrfiPPE----------IGVLQSLQYFSITCNKVESLpDELYFCKKLKT 646
Cdd:cd21340  72 KLYLGGNRISVV-EGLENLTNLEELHIENQRL---PPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQ 146

                       170       180       190
                ....*....|....*....|....*....|....
gi 50949358 647 LKIGKN---SLSVLSPKIGNLLFLSYLDVKGNHF 677
Cdd:cd21340 147 LDASNNqisDLEELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 354-690 3.62e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 3.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  354 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELSLHQ--CSVKIHSAALSFLKenlkVLSVKFDDMR---ELPPWMY 424
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYLFLYQnkLSGPIPPSIFSLQK----LISLDLSDNSlsgEIPELVI 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  425 GLRNLEELYLvgsLSHDISRNVTlESLRDLKSLKILSIKSN--VSKIPQavvdvssHLQKmciHNDGTKLVMLNN----- 497
Cdd:PLN00113 306 QLQNLEILHL---FSNNFTGKIP-VALTSLPRLQVLQLWSNkfSGEIPK-------NLGK---HNNLTVLDLSTNnltge 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  498 ----LKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKK 571
Cdd:PLN00113 372 ipegLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD 450

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  572 LTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELYFCKKLKTLKI 649
Cdd:PLN00113 451 MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDL 530

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 50949358  650 GKNSLSVLSP-KIGNLLFLSYLDVKGNHFE-ILPPELGDCRAL 690
Cdd:PLN00113 531 SHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
LRR_8 pfam13855
Leucine rich repeat;
550-608 2.45e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.45e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50949358   550 RKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKIEVLPSHLFLC-NKIRYLDLSYNDI 608
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 425-535 4.18e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 425 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 500
Cdd:cd21340  66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 50949358 501 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 535
Cdd:cd21340 141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 338-646 8.45e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.47  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   338 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSvkihsaalsflkenlkvlsvkfdDMR 417
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCS-----------------------SLV 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   418 ELPPWMYGLRNLEELylvgslshDISRNVTLESLR---DLKSLKILSIkSNVSKIpQAVVDVSSHLQKMCIhnDGTKLVM 494
Cdd:PLN03210  672 ELPSSIQYLNKLEDL--------DMSRCENLEILPtgiNLKSLYRLNL-SGCSRL-KSFPDISTNISWLDL--DETAIEE 739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   495 LNNLKKMTNLTELELVHCDLERIPHAVFSLL--------SLQELDLkeNNLKSIEEI-VSFQHLRKLTVLKLWH-NSITY 564
Cdd:PLN03210  740 FPSNLRLENLDELILCEMKSEKLWERVQPLTplmtmlspSLTRLFL--SDIPSLVELpSSIQNLHKLEHLEIENcINLET 817

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   565 IPEHIkKLTSLERLSFSH-NKIEVLPShlfLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS-ITCNKVESLPDELYFCK 642
Cdd:PLN03210  818 LPTGI-NLESLESLDLSGcSRLRTFPD---ISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDmNGCNNLQRVSLNISKLK 893


                  ....
gi 50949358   643 KLKT 646
Cdd:PLN03210  894 HLET 897
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-251 1.50e-160

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 466.71  E-value: 1.50e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358     1 PANPITVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFD 80
Cdd:pfam12534  87 PSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFD 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358    81 SPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEGSLVNSQSLKSIPEKFVVD-KSTAGALDKKEGEQAK 152
Cdd:pfam12534 167 SPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKKEGEQAK 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   153 ALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKL 232
Cdd:pfam12534 247 ALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKL 326

                         250
                  ....*....|....*....
gi 50949358   233 SFCYLCFVSIYGLTCLYTL 251
Cdd:pfam12534 327 LVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-685 1.68e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 1.68e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 495 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 574
Cdd:COG4886  89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 575 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 654
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190
                ....*....|....*....|....*....|.
gi 50949358 655 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 685
Cdd:COG4886 241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
428-692 3.51e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.89  E-value: 3.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 428 NLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTEL 507
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 508 ELVHCDLerIPHAVFSLLSLQELDLKENNlksieeivSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEV 587
Cdd:COG4886  81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 588 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 667
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                       250       260
                ....*....|....*....|....*
gi 50949358 668 SYLDVKGNHFEILpPELGDCRALKR 692
Cdd:COG4886 231 ETLDLSNNQLTDL-PELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
311-684 2.34e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 2.34e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 311 NKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQC 390
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 391 SVKIHSAALSFLKENLKVLSVKFDDMRELppwmYGLRNLEELYLVGSLSHDISrnvtlESLRDLKSLKILSIKSN-VSKI 469
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEEL----SNLTNLESLDLSGNQLTDLP-----EELANLTNLKELDLSNNqLTDL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 470 PqavvdvsshlqkmcihndgtklvmlNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEivSFQHL 549
Cdd:COG4886 152 P-------------------------EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNL 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 550 RKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPShLFLCNKIRYLDLSYNDIRFIPPEIGvLQSLQYFSITCN 629
Cdd:COG4886 205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNN 282

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 50949358 630 KVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPEL 684
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
269-671 2.28e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 2.28e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 269 QETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSG 348
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 349 LPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKeNLKVLSVKFDDMRELPPWMYGLRN 428
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 429 LEELYLVGSLSHDISrnvtlESLRDLKSLKILSIKSN-VSKIPQAvvdvsshlqkmcihndgtklvmlnnLKKMTNLTEL 507
Cdd:COG4886 161 LKSLDLSNNQLTDLP-----EELGNLTNLKELDLSNNqITDLPEP-------------------------LGNLTNLEEL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 508 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIvsfQHLRKLTVLKLWHNSITYIPEhIKKLTSLERLSFSHNKIEV 587
Cdd:COG4886 211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 588 LP-SHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLF 666
Cdd:COG4886 287 LKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366


                ....*
gi 50949358 667 LSYLD 671
Cdd:COG4886 367 LTLGL 371
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 498-677 4.74e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 4.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 498 LKKMTNLTeleLVHCDLERIPhaVFSLL-SLQELDLKENNLKSIEeivSFQHLRKLTVLKLWHNSITYIpEHIKKLTSLE 576
Cdd:cd21340   1 LKRITHLY---LNDKNITKID--NLSLCkNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLK 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 577 RLSFSHNKIEVLpSHLFLCNKIRYLDLSYNDIrfiPPE----------IGVLQSLQYFSITCNKVESLpDELYFCKKLKT 646
Cdd:cd21340  72 KLYLGGNRISVV-EGLENLTNLEELHIENQRL---PPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQ 146

                       170       180       190
                ....*....|....*....|....*....|....
gi 50949358 647 LKIGKN---SLSVLSPKIGNLLFLSYLDVKGNHF 677
Cdd:cd21340 147 LDASNNqisDLEELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 354-690 3.62e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 3.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  354 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELSLHQ--CSVKIHSAALSFLKenlkVLSVKFDDMR---ELPPWMY 424
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYLFLYQnkLSGPIPPSIFSLQK----LISLDLSDNSlsgEIPELVI 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  425 GLRNLEELYLvgsLSHDISRNVTlESLRDLKSLKILSIKSN--VSKIPQavvdvssHLQKmciHNDGTKLVMLNN----- 497
Cdd:PLN00113 306 QLQNLEILHL---FSNNFTGKIP-VALTSLPRLQVLQLWSNkfSGEIPK-------NLGK---HNNLTVLDLSTNnltge 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  498 ----LKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKK 571
Cdd:PLN00113 372 ipegLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD 450

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  572 LTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELYFCKKLKTLKI 649
Cdd:PLN00113 451 MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDL 530

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 50949358  650 GKNSLSVLSP-KIGNLLFLSYLDVKGNHFE-ILPPELGDCRAL 690
Cdd:PLN00113 531 SHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 456-708 1.70e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 1.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  456 SLKILSIKSNV--SKIPQAVVDVSShLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDL 532
Cdd:PLN00113 165 SLKVLDLGGNVlvGKIPNSLTNLTS-LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  533 KENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKKLTSLERLSFSHNKIE-VLPSHLFLCNKIRYLDLSYNDIR- 609
Cdd:PLN00113 244 VYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTg 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  610 FIPPEIGVLQSLQYFSITCNKVE-SLPDELYFCKKLKTLKIGKNSLSVLSPKI----GNL----LFLSYLDVKgnhfeiL 680
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGlcssGNLfkliLFSNSLEGE------I 396

                        250       260
                 ....*....|....*....|....*...
gi 50949358  681 PPELGDCRALKRAGLvVEDALFETLPSD 708
Cdd:PLN00113 397 PKSLGACRSLRRVRL-QDNSFSGELPSE 423
LRR_8 pfam13855
Leucine rich repeat;
550-608 2.45e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.45e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50949358   550 RKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKIEVLPSHLFLC-NKIRYLDLSYNDI 608
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
494-714 4.48e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.63  E-value: 4.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  494 MLNNLKKmtNLTELELVHCDLERIPHAVFSllSLQELDLKENNLKSIEEIVSfQHLRKLTVLKlwhNSITYIPEHIKKlt 573
Cdd:PRK15370 172 MRDCLKN--NKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQ-GNIKTLYANS---NQLTSIPATLPD-- 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  574 SLERLSFSHNKIEVLPSHLflcnkiryldlsyndirfipPeigvlQSLQYFSITCNKVESLPDELyfCKKLKTLKIGKNS 653
Cdd:PRK15370 242 TIQEMELSINRITELPERL--------------------P-----SALQSLDLFHNKISCLPENL--PEELRYLSVYDNS 294

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50949358  654 LSVLSPKIGNllFLSYLDVKGNHFEILPPELgdcrALKRAGLVVEDALFETLPSDVREQMK 714
Cdd:PRK15370 295 IRTLPAHLPS--GITHLNVQSNSLTALPETL----PPGLKTLEAGENALTSLPASLPPELQ 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 516-691 4.57e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 4.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  516 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEhiKKLTSLERLSFSHNKIE-VLPSHLF 593
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  594 LCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNK-VESLPDELYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYL 670
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYeIGGLTSLNHL 241

                        170       180
                 ....*....|....*....|..
gi 50949358  671 D-VKGNHFEILPPELGDCRALK 691
Cdd:PLN00113 242 DlVYNNLTGPIPSSLGNLKNLQ 263
LRR_8 pfam13855
Leucine rich repeat;
502-562 1.43e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.43e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50949358   502 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWHNSI 562
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
526-585 5.52e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50949358   526 SLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKI 585
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 426-600 1.01e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 426 LRNLEELYLvgslSH-DISRnvtLESLRDLKSLKILsiksnvskipqavvdvssHLQKMCIhndgtklVMLNNLKKMTNL 504
Cdd:cd21340  45 LTNLTHLYL----QNnQIEK---IENLENLVNLKKL------------------YLGGNRI-------SVVEGLENLTNL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 505 TELelvHCDLERI---------PHAVFSLL-SLQELDLKENNLKSIEEivsFQHLRKLTVLKLWHNSITYIPE---HIKK 571
Cdd:cd21340  93 EEL---HIENQRLppgekltfdPRSLAALSnSLRVLNISGNNIDSLEP---LAPLRNLEQLDASNNQISDLEElldLLSS 166

                       170       180
                ....*....|....*....|....*....
gi 50949358 572 LTSLERLSFSHNKIevlpshlflCNKIRY 600
Cdd:cd21340 167 WPSLRELDLTGNPV---------CKKPKY 186
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
362-638 1.37e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  362 LKLEIIKNVMIPATIAQ------LDNLQELSLHQCsvkihsaalsfLKENLKVLSVKFDDMRELPPWMYGlrNLEELylv 435
Cdd:PRK15370 183 LRLKILGLTTIPACIPEqittliLDNNELKSLPEN-----------LQGNIKTLYANSNQLTSIPATLPD--TIQEM--- 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  436 gslshDISRNVTLESLRDLKS-LKILSIKSN-VSKIPQAVVDvssHLQKMCIHNdgtklvmlNNLKKMTnltelelvhcd 513
Cdd:PRK15370 247 -----ELSINRITELPERLPSaLQSLDLFHNkISCLPENLPE---ELRYLSVYD--------NSIRTLP----------- 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358  514 lERIPHavfsllSLQELDLKENNLKSIEEIVSFQhlrkLTVLKLWHNSITYIPEHIKKltSLERLSFSHNKIEVLPSHlf 593
Cdd:PRK15370 300 -AHLPS------GITHLNVQSNSLTALPETLPPG----LKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLPET-- 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 50949358  594 LCNKIRYLDLSYNDIRFIPPEIGVlqSLQYFSITCNKVESLPDEL 638
Cdd:PRK15370 365 LPPTITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRLPESL 407
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 495-656 3.43e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.17  E-value: 3.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 495 LNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL--KSIEEIVS-FQHLRKLTVLKLWHNSIT-----YIP 566
Cdd:COG5238 178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIGdegviALA 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 567 EHIKKLTSLERLSFSHNKIEV-----LPSHLFLCNKIRYLDLSYNDIRFiPPEIGVLQSLQ-----------YFSITCNK 630
Cdd:COG5238 258 EALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQgnktlhtlnlaYNGIGAQG 336

                       170       180
                ....*....|....*....|....*.
gi 50949358 631 VESLPDELYFCKKLKTLKIGKNSLSV 656
Cdd:COG5238 337 AIALAKALQENTTLHSLDLSDNQIGD 362
PLN03150 PLN03150
hypothetical protein; Provisional
 517-583 4.38e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 4.38e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50949358  517 IPHAVFSLLSLQELDLKENNLKSieEI-VSFQHLRKLTVLKLWHNSIT-YIPEHIKKLTSLERLSFSHN 583
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
619-677 2.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50949358   619 QSLQYFSITCNKVESLPDE-LYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYLDVKGNHF 677
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 425-535 4.18e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 425 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 500
Cdd:cd21340  66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 50949358 501 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 535
Cdd:cd21340 141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 338-646 8.45e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.47  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   338 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSvkihsaalsflkenlkvlsvkfdDMR 417
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCS-----------------------SLV 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   418 ELPPWMYGLRNLEELylvgslshDISRNVTLESLR---DLKSLKILSIkSNVSKIpQAVVDVSSHLQKMCIhnDGTKLVM 494
Cdd:PLN03210  672 ELPSSIQYLNKLEDL--------DMSRCENLEILPtgiNLKSLYRLNL-SGCSRL-KSFPDISTNISWLDL--DETAIEE 739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   495 LNNLKKMTNLTELELVHCDLERIPHAVFSLL--------SLQELDLkeNNLKSIEEI-VSFQHLRKLTVLKLWH-NSITY 564
Cdd:PLN03210  740 FPSNLRLENLDELILCEMKSEKLWERVQPLTplmtmlspSLTRLFL--SDIPSLVELpSSIQNLHKLEHLEIENcINLET 817

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358   565 IPEHIkKLTSLERLSFSH-NKIEVLPShlfLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS-ITCNKVESLPDELYFCK 642
Cdd:PLN03210  818 LPTGI-NLESLESLDLSGcSRLRTFPD---ISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDmNGCNNLQRVSLNISKLK 893


                  ....
gi 50949358   643 KLKT 646
Cdd:PLN03210  894 HLET 897
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 496-609 9.93e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 9.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50949358 496 NNLKKMTNLTELELVHCDL-ERIPHAVFSLL----SLQELDLKENNLKSIEEIVSFQHL---RKLTVLKLWHNSIT---- 563
Cdd:COG5238 286 KALQGNTTLTSLDLSVNRIgDEGAIALAEGLqgnkTLHTLNLAYNGIGAQGAIALAKALqenTTLHSLDLSDNQIGdega 365

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 50949358 564 -YIPEHIKKLTSLERLSFSHNKI-----EVLPSHLfLCNKIRYLDLSYNDIR 609
Cdd:COG5238 366 iALAKYLEGNTTLRELNLGKNNIgkqgaEALIDAL-QTNRLHTLILDGNLIG 416
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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