NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|508715643|gb|EOY07540|]
View 

Transducin/WD40 repeat-like superfamily protein, putative [Theobroma cacao]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 399-732 2.18e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 2.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  399 LCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWEVQECEVMSMSEG-SLTPGNLtplhpslsssplhpslsMSQDQS 477
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDV-----------------AASADG 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  478 GLLEAVGNlhekkkkgkgssskkGNQIpdyvhvpeTVFSLSD-KPVCSFKGHLDDVLDLSWSRSQQ-LLSSSMDKTVRLW 555
Cdd:cd00200    64 TYLASGSS---------------DKTI--------RLWDLETgECVRTLTGHTSYVSSVAFSPDGRiLSSSSRDKTIKVW 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  556 DLESKSCLKLF-AHNDYVTCIHFNPmDDDYFISGSLDAKVRIWNIPDRQVVDWTDLHEMA-TSACYTPDGQGAIIGSHKG 633
Cdd:cd00200   121 DVETGKCLTTLrGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEvNSVAFSPDGEKLLSSSSDG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  634 TCRMYSTKDYKLTQleqiTIQtkkkAHAKKITGFQFcpiNPSEVLITSA--DSRIRI--LDGSEVIYKFKGfrNTSSQIS 709
Cdd:cd00200   200 TIKLWDLSTGKCLG----TLR----GHENGVNSVAF---SPDGYLLASGseDGTIRVwdLRTGECVQTLSG--HTNSVTS 266

                         330       340
                  ....*....|....*....|...
gi 508715643  710 ASFTSDGKYIVSASEDSQVFVWR 732
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 399-732 2.18e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 2.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  399 LCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWEVQECEVMSMSEG-SLTPGNLtplhpslsssplhpslsMSQDQS 477
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDV-----------------AASADG 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  478 GLLEAVGNlhekkkkgkgssskkGNQIpdyvhvpeTVFSLSD-KPVCSFKGHLDDVLDLSWSRSQQ-LLSSSMDKTVRLW 555
Cdd:cd00200    64 TYLASGSS---------------DKTI--------RLWDLETgECVRTLTGHTSYVSSVAFSPDGRiLSSSSRDKTIKVW 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  556 DLESKSCLKLF-AHNDYVTCIHFNPmDDDYFISGSLDAKVRIWNIPDRQVVDWTDLHEMA-TSACYTPDGQGAIIGSHKG 633
Cdd:cd00200   121 DVETGKCLTTLrGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEvNSVAFSPDGEKLLSSSSDG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  634 TCRMYSTKDYKLTQleqiTIQtkkkAHAKKITGFQFcpiNPSEVLITSA--DSRIRI--LDGSEVIYKFKGfrNTSSQIS 709
Cdd:cd00200   200 TIKLWDLSTGKCLG----TLR----GHENGVNSVAF---SPDGYLLASGseDGTIRVwdLRTGECVQTLSG--HTNSVTS 266

                         330       340
                  ....*....|....*....|...
gi 508715643  710 ASFTSDGKYIVSASEDSQVFVWR 732
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
393-732 1.61e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  393 ELSALHLCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWEVQECEVM-SMSEGSLTPGNLTplhpslsssplhpsls 471
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLrTLTGHSGAVTSVA---------------- 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  472 MSQDqsGLLEAVGNlhekkkkgkgssskKGNQIpdyvhvpeTVFSLSD-KPVCSFKGHLDDVLDLSW-----------Sr 539
Cdd:COG2319   170 FSPD--GKLLASGS--------------DDGTV--------RLWDLATgKLLRTLTGHTGAVRSVAFspdgkllasgsA- 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  540 sqqllsssmDKTVRLWDLESKSCLKLFA-HNDYVTCIHFNPmDDDYFISGSLDAKVRIWNIPDRQVVDWTDLHEMA-TSA 617
Cdd:COG2319   225 ---------DGTVRLWDLATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGvNSV 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  618 CYTPDGQGAIIGSHKGTCRMYSTKDYKLTQleqiTIqtkkKAHAKKITGFQFCPiNPSEVLITSADSRIRI--LDGSEVI 695
Cdd:COG2319   295 AFSPDGKLLASGSDDGTVRLWDLATGKLLR----TL----TGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELL 365

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 508715643  696 YKFKGFRNTSSqiSASFTSDGKYIVSASEDSQVFVWR 732
Cdd:COG2319   366 RTLTGHTGAVT--SVAFSPDGRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 398-435 1.70e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.70e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 508715643    398 HLCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWE 435
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
559-598 6.75e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 6.75e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 508715643   559 SKSCLKLFAHNDYVTCIHFNPmDDDYFISGSLDAKVRIWN 598
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 549-731 1.81e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  549 DKTVRLWDL-ESKSCLKLFAHNDYVTCIHFNPMDDDYFISGSLDAKVRIWNIpdRQVVDWTDLHEMATSACY---TPDGQ 624
Cdd:PLN00181  554 EGVVQVWDVaRSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI--NQGVSIGTIKTKANICCVqfpSESGR 631

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  625 GAIIGSHKGTCRMYSTKDYKLTQLEQItiqtkkkAHAKKITGFQFcpINPSEVLITSADSRIRILDGSEVI--------Y 696
Cdd:PLN00181  632 SLAFGSADHKVYYYDLRNPKLPLCTMI-------GHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLSMSIsginetplH 702

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 508715643  697 KFKGFRNTSSQISASfTSDGkYIVSASEDSQVFVW 731
Cdd:PLN00181  703 SFMGHTNVKNFVGLS-VSDG-YIATGSETNEVFVY 735
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 399-732 2.18e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 2.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  399 LCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWEVQECEVMSMSEG-SLTPGNLtplhpslsssplhpslsMSQDQS 477
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDV-----------------AASADG 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  478 GLLEAVGNlhekkkkgkgssskkGNQIpdyvhvpeTVFSLSD-KPVCSFKGHLDDVLDLSWSRSQQ-LLSSSMDKTVRLW 555
Cdd:cd00200    64 TYLASGSS---------------DKTI--------RLWDLETgECVRTLTGHTSYVSSVAFSPDGRiLSSSSRDKTIKVW 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  556 DLESKSCLKLF-AHNDYVTCIHFNPmDDDYFISGSLDAKVRIWNIPDRQVVDWTDLHEMA-TSACYTPDGQGAIIGSHKG 633
Cdd:cd00200   121 DVETGKCLTTLrGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEvNSVAFSPDGEKLLSSSSDG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  634 TCRMYSTKDYKLTQleqiTIQtkkkAHAKKITGFQFcpiNPSEVLITSA--DSRIRI--LDGSEVIYKFKGfrNTSSQIS 709
Cdd:cd00200   200 TIKLWDLSTGKCLG----TLR----GHENGVNSVAF---SPDGYLLASGseDGTIRVwdLRTGECVQTLSG--HTNSVTS 266

                         330       340
                  ....*....|....*....|...
gi 508715643  710 ASFTSDGKYIVSASEDSQVFVWR 732
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
393-732 1.61e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  393 ELSALHLCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWEVQECEVM-SMSEGSLTPGNLTplhpslsssplhpsls 471
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLrTLTGHSGAVTSVA---------------- 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  472 MSQDqsGLLEAVGNlhekkkkgkgssskKGNQIpdyvhvpeTVFSLSD-KPVCSFKGHLDDVLDLSW-----------Sr 539
Cdd:COG2319   170 FSPD--GKLLASGS--------------DDGTV--------RLWDLATgKLLRTLTGHTGAVRSVAFspdgkllasgsA- 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  540 sqqllsssmDKTVRLWDLESKSCLKLFA-HNDYVTCIHFNPmDDDYFISGSLDAKVRIWNIPDRQVVDWTDLHEMA-TSA 617
Cdd:COG2319   225 ---------DGTVRLWDLATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGvNSV 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  618 CYTPDGQGAIIGSHKGTCRMYSTKDYKLTQleqiTIqtkkKAHAKKITGFQFCPiNPSEVLITSADSRIRI--LDGSEVI 695
Cdd:COG2319   295 AFSPDGKLLASGSDDGTVRLWDLATGKLLR----TL----TGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELL 365

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 508715643  696 YKFKGFRNTSSqiSASFTSDGKYIVSASEDSQVFVWR 732
Cdd:COG2319   366 RTLTGHTGAVT--SVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 394-688 6.17e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 6.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  394 LSALHLCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWEVQecevmsmsegsltpgnltplhpslsssplhpslsms 473
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE------------------------------------ 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  474 qdqsglleavgnlhekkkkgkgssskkgnqipdyvhvpetvfslSDKPVCSFKGHLDDVLDLSWSRSQQL-LSSSMDKTV 552
Cdd:cd00200   124 --------------------------------------------TGKCLTTLRGHTDWVNSVAFSPDGTFvASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  553 RLWDLESKSCLKLF-AHNDYVTCIHFNPmDDDYFISGSLDAKVRIWNIPDRQVVDWTDLHEMA-TSACYTPDGQGAIIGS 630
Cdd:cd00200   160 KLWDLRTGKCVATLtGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGvNSVAFSPDGYLLASGS 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 508715643  631 HKGTCRMYSTKDYKLTQleqiTIQtkkkAHAKKITGFQFCPINPseVLIT-SADSRIRI 688
Cdd:cd00200   239 EDGTIRVWDLRTGECVQ----TLS----GHTNSVTSLAWSPDGK--RLASgSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 521-734 3.45e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 3.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  521 PVCSFKGHLDDVLDLSWSRSQQL-LSSSMDKTVRLWDLESKSCLK----------------------------------- 564
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLlATGSGDGTIKVWDLETGELLRtlkghtgpvrdvaasadgtylasgssdktirlwdl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  565 --------LFAHNDYVTCIHFNPmDDDYFISGSLDAKVRIWNIPDRQVVDWTDLHEMA-TSACYTPDGQGAIIGSHKGTC 635
Cdd:cd00200    81 etgecvrtLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWvNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  636 RMYSTKDYKLTQleqiTIqtkkKAHAKKITGFQFCPINpSEVLITSADSRIRI--LDGSEVIYKFKGFRNTSSqiSASFT 713
Cdd:cd00200   160 KLWDLRTGKCVA----TL----TGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLwdLSTGKCLGTLRGHENGVN--SVAFS 228

                         250       260
                  ....*....|....*....|.
gi 508715643  714 SDGKYIVSASEDSQVFVWRYD 734
Cdd:cd00200   229 PDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
401-601 7.24e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 7.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  401 QEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWEVQecevmsmsegsltpgnltplhpslsssplhpslsmsqdqsgll 480
Cdd:COG2319   282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA------------------------------------------- 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  481 eavgnlhekkkkgkgssskkgnqipdyvhvpetvfslSDKPVCSFKGHLDDVLDLSWSRSQQL-LSSSMDKTVRLWDLES 559
Cdd:COG2319   319 -------------------------------------TGKLLRTLTGHTGAVRSVAFSPDGKTlASGSDDGTVRLWDLAT 361

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 508715643  560 KSCLK-LFAHNDYVTCIHFNPmDDDYFISGSLDAKVRIWNIPD 601
Cdd:COG2319   362 GELLRtLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
549-732 2.43e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 2.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  549 DKTVRLWDLESKSCLK-LFAHNDYVTCIHFNPmDDDYFISGSLDAKVRIWNIPDRQVVDWTDLHEMA-TSACYTPDGQGA 626
Cdd:COG2319    57 DLTLLLLDAAAGALLAtLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAvRSVAFSPDGKTL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  627 IIGSHKGTCRMYSTKDYKLTQleqiTIqtkkKAHAKKITgfqfcpinpsevlitsadsririldgseviykfkgfrntss 706
Cdd:COG2319   136 ASGSADGTVRLWDLATGKLLR----TL----TGHSGAVT----------------------------------------- 166

                         170       180
                  ....*....|....*....|....*.
gi 508715643  707 qiSASFTSDGKYIVSASEDSQVFVWR 732
Cdd:COG2319   167 --SVAFSPDGKLLASGSDDGTVRLWD 190
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 398-435 1.70e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.70e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 508715643    398 HLCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWE 435
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 560-598 2.13e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 2.13e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 508715643    560 KSCLKLFAHNDYVTCIHFNPmDDDYFISGSLDAKVRIWN 598
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
559-598 6.75e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 6.75e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 508715643   559 SKSCLKLFAHNDYVTCIHFNPmDDDYFISGSLDAKVRIWN 598
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
399-435 1.34e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 1.34e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 508715643   399 LCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWE 435
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 393-444 2.02e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 2.02e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 508715643  393 ELSALHLCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWEVQECEVMSM 444
Cdd:cd00200   205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
393-437 3.48e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 3.48e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 508715643  393 ELSALHLCQEIQAHEGSIWTIRFSTDTRFLASAGEDKIIHVWEVQ 437
Cdd:COG2319   358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 549-731 1.81e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  549 DKTVRLWDL-ESKSCLKLFAHNDYVTCIHFNPMDDDYFISGSLDAKVRIWNIpdRQVVDWTDLHEMATSACY---TPDGQ 624
Cdd:PLN00181  554 EGVVQVWDVaRSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI--NQGVSIGTIKTKANICCVqfpSESGR 631

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  625 GAIIGSHKGTCRMYSTKDYKLTQLEQItiqtkkkAHAKKITGFQFcpINPSEVLITSADSRIRILDGSEVI--------Y 696
Cdd:PLN00181  632 SLAFGSADHKVYYYDLRNPKLPLCTMI-------GHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLSMSIsginetplH 702

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 508715643  697 KFKGFRNTSSQISASfTSDGkYIVSASEDSQVFVW 731
Cdd:PLN00181  703 SFMGHTNVKNFVGLS-VSDG-YIATGSETNEVFVY 735
PTZ00420 PTZ00420
coronin; Provisional
 521-603 9.38e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 9.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508715643  521 PVCSFKGHLDDVLDLSWSR--SQQLLSSSMDKTVRLWDL----ESKSCLK-----LFAHNDYVTCIHFNPMDddYFI--S 587
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIphndESVKEIKdpqciLKGHKKKISIIDWNPMN--YYImcS 143

                          90
                  ....*....|....*.
gi 508715643  588 GSLDAKVRIWNIPDRQ 603
Cdd:PTZ00420  144 SGFDSFVNIWDIENEK 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH