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Conserved domains on  [gi|507979012|ref|XP_004693362|]
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PREDICTED: nuclear pore complex protein Nup153 [Condylura cristata]

Protein Classification

zinc finger Ran-binding domain-containing protein( domain architecture ID 13755470)

zinc finger Ran-binding domain-containing protein similar to Arabidopsis thaliana chloroplastic zinc finger protein VAR3, which is involved in C-to-U editing of chloroplastic RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 114-617 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


:

Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 653.11  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   114 PSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 193
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   194 DKDIAVSKNTSVPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 273
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   274 VRQPKLRNTPYQAPVRRQMKAKQLSSQSYGVTSSTARRILQSLEKMSSPLADAKRIPS-VASPLNSPLDRSGIGTsTDFQ 352
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPStVSSPLSSPLDRSDLDI-TNFQ 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   353 AKREKVDSQYPPVQRLMTPKPVSIAANRTVYFKPSLTPSGELRKTNQRIDKKHSTG--YENNMQNREQRESGY-YPNFSM 429
Cdd:pfam08604  239 SKRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRETevRQSPEQAVEPSESSLsYPKFST 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   430 SAANGLSSGVGSGGGKMRRERTHFVASKPPEEEEME-VPVLPKISLPITSSALPTFNFSSSVIT-TSSSPVSPSQSLTNK 507
Cdd:pfam08604  319 PASNSLSSGGNGGGGKMRRERGRRPSSKPAEEDEVVeVPVLPKISLPISTASLPTFNFSSPTSStSSSSPPSVTKSAENK 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   508 VQMTSPNSTGSPMFRFSSPIVKSTEADVLPP-SSIGFTFSVPVAKTAELSGSSsiSEPTTSSLRQDITVVNSATSKKSQD 586
Cdd:pfam08604  399 AQKQPPSTSGSPAFTFSSPIVKSTEASVPPPsPSIGFTFSVPVAKTAELSGSS--GTSVVSVVSTETTTVNSTSNKKEEE 476

                          490       500       510
                   ....*....|....*....|....*....|.
gi 507979012   587 EDCDGPFRPAKILKEGSVLDILKNPGFVSPK 617
Cdd:pfam08604  477 EEFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1381-1467 4.04e-19

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


:

Pssm-ID: 371156  Cd Length: 86  Bit Score: 83.19  E-value: 4.04e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012  1381 PNSSSVFQFGSSSTNFNFANNSTSGVFTFGANPSTPAAPAQPSSSGGFPFSQSSAAFTVGSNGKNMFsssgtSVSGRKIK 1460
Cdd:pfam10599    5 PDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSNMF-----SVSGRKIA 79


                   ....*..
gi 507979012  1461 TAVRRKK 1467
Cdd:pfam10599   80 QMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
844-873 8.86e-10

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 55.05  E-value: 8.86e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 507979012   844 PEGSWDCEVCLVQNKADSTKCVACESEKPG 873
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
716-744 1.70e-09

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 54.28  E-value: 1.70e-09
                           10        20
                   ....*....|....*....|....*....
gi 507979012   716 VGTWDCDTCLVQNKPEAIKCVACETPKPG 744
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
786-815 6.11e-08

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 49.66  E-value: 6.11e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 507979012   786 PVGSWECPVCCVCNNAEDNKCVSCMSEKPG 815
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
650-680 3.39e-07

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.39e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 507979012   650 KAGSlWQCHVCLVQNKVTDNKCSACQATKLP 680
Cdd:pfam00641    1 REGD-WDCSKCLVQNFATSTKCVACQAPKPD 30
PPE super family cl35037
PPE-repeat protein [Function unknown];
1209-1420 4.09e-03

PPE-repeat protein [Function unknown];


The actual alignment was detected with superfamily member COG5651:

Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 41.42  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012 1209 TSSSAPVTAFVFGqASNPVSSSAFGNSAECSTSQSLLFPPESKPATTSSSGTTVTPFVFGPGANSSNTAASGFSFGATTA 1288
Cdd:COG5651   175 TNPGGLLGAQNAG-SGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAAGAAAAAAAAAAAAGA 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012 1289 SSSAGSSFVFGTAPSAPAASPAFGANQTPTFGQSQGVSQPNSQGFGAISSTATLFSAGSQPAPPTFGAVSSSSQPPVFGQ 1368
Cdd:COG5651   254 GASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAGAALGAGAA 333

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 507979012 1369 QPSQSAFGSGTAPNSSSVFQFGSSSTNFNFANNSTSGVFTFGANPSTPAAPA 1420
Cdd:COG5651   334 AAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAAA 385
 
Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 114-617 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 653.11  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   114 PSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 193
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   194 DKDIAVSKNTSVPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 273
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   274 VRQPKLRNTPYQAPVRRQMKAKQLSSQSYGVTSSTARRILQSLEKMSSPLADAKRIPS-VASPLNSPLDRSGIGTsTDFQ 352
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPStVSSPLSSPLDRSDLDI-TNFQ 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   353 AKREKVDSQYPPVQRLMTPKPVSIAANRTVYFKPSLTPSGELRKTNQRIDKKHSTG--YENNMQNREQRESGY-YPNFSM 429
Cdd:pfam08604  239 SKRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRETevRQSPEQAVEPSESSLsYPKFST 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   430 SAANGLSSGVGSGGGKMRRERTHFVASKPPEEEEME-VPVLPKISLPITSSALPTFNFSSSVIT-TSSSPVSPSQSLTNK 507
Cdd:pfam08604  319 PASNSLSSGGNGGGGKMRRERGRRPSSKPAEEDEVVeVPVLPKISLPISTASLPTFNFSSPTSStSSSSPPSVTKSAENK 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   508 VQMTSPNSTGSPMFRFSSPIVKSTEADVLPP-SSIGFTFSVPVAKTAELSGSSsiSEPTTSSLRQDITVVNSATSKKSQD 586
Cdd:pfam08604  399 AQKQPPSTSGSPAFTFSSPIVKSTEASVPPPsPSIGFTFSVPVAKTAELSGSS--GTSVVSVVSTETTTVNSTSNKKEEE 476

                          490       500       510
                   ....*....|....*....|....*....|.
gi 507979012   587 EDCDGPFRPAKILKEGSVLDILKNPGFVSPK 617
Cdd:pfam08604  477 EEFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1381-1467 4.04e-19

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


Pssm-ID: 371156  Cd Length: 86  Bit Score: 83.19  E-value: 4.04e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012  1381 PNSSSVFQFGSSSTNFNFANNSTSGVFTFGANPSTPAAPAQPSSSGGFPFSQSSAAFTVGSNGKNMFsssgtSVSGRKIK 1460
Cdd:pfam10599    5 PDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSNMF-----SVSGRKIA 79


                   ....*..
gi 507979012  1461 TAVRRKK 1467
Cdd:pfam10599   80 QMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
844-873 8.86e-10

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 55.05  E-value: 8.86e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 507979012   844 PEGSWDCEVCLVQNKADSTKCVACESEKPG 873
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
716-744 1.70e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 54.28  E-value: 1.70e-09
                           10        20
                   ....*....|....*....|....*....
gi 507979012   716 VGTWDCDTCLVQNKPEAIKCVACETPKPG 744
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
786-815 6.11e-08

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 49.66  E-value: 6.11e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 507979012   786 PVGSWECPVCCVCNNAEDNKCVSCMSEKPG 815
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
650-680 3.39e-07

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.39e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 507979012   650 KAGSlWQCHVCLVQNKVTDNKCSACQATKLP 680
Cdd:pfam00641    1 REGD-WDCSKCLVQNFATSTKCVACQAPKPD 30
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 717-741 6.75e-06

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 43.85  E-value: 6.75e-06
                            10        20
                    ....*....|....*....|....*
gi 507979012    717 GTWDCDTCLVQNKPEAIKCVACETP 741
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 846-868 1.83e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 42.69  E-value: 1.83e-05
                            10        20
                    ....*....|....*....|...
gi 507979012    846 GSWDCEVCLVQNKADSTKCVACE 868
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACG 23
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 655-676 1.62e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.99  E-value: 1.62e-04
                            10        20
                    ....*....|....*....|..
gi 507979012    655 WQCHVCLVQNKVTDNKCSACQA 676
Cdd:smart00547    3 WECPACTFLNFASRSKCFACGA 24
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 788-809 1.01e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 37.68  E-value: 1.01e-03
                            10        20
                    ....*....|....*....|..
gi 507979012    788 GSWECPVCCVCNNAEDNKCVSC 809
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFAC 22
PPE COG5651
PPE-repeat protein [Function unknown];
1209-1420 4.09e-03

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 41.42  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012 1209 TSSSAPVTAFVFGqASNPVSSSAFGNSAECSTSQSLLFPPESKPATTSSSGTTVTPFVFGPGANSSNTAASGFSFGATTA 1288
Cdd:COG5651   175 TNPGGLLGAQNAG-SGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAAGAAAAAAAAAAAAGA 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012 1289 SSSAGSSFVFGTAPSAPAASPAFGANQTPTFGQSQGVSQPNSQGFGAISSTATLFSAGSQPAPPTFGAVSSSSQPPVFGQ 1368
Cdd:COG5651   254 GASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAGAALGAGAA 333

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 507979012 1369 QPSQSAFGSGTAPNSSSVFQFGSSSTNFNFANNSTSGVFTFGANPSTPAAPA 1420
Cdd:COG5651   334 AAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAAA 385
 
Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 114-617 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 653.11  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   114 PSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 193
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   194 DKDIAVSKNTSVPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 273
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   274 VRQPKLRNTPYQAPVRRQMKAKQLSSQSYGVTSSTARRILQSLEKMSSPLADAKRIPS-VASPLNSPLDRSGIGTsTDFQ 352
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPStVSSPLSSPLDRSDLDI-TNFQ 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   353 AKREKVDSQYPPVQRLMTPKPVSIAANRTVYFKPSLTPSGELRKTNQRIDKKHSTG--YENNMQNREQRESGY-YPNFSM 429
Cdd:pfam08604  239 SKRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRETevRQSPEQAVEPSESSLsYPKFST 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   430 SAANGLSSGVGSGGGKMRRERTHFVASKPPEEEEME-VPVLPKISLPITSSALPTFNFSSSVIT-TSSSPVSPSQSLTNK 507
Cdd:pfam08604  319 PASNSLSSGGNGGGGKMRRERGRRPSSKPAEEDEVVeVPVLPKISLPISTASLPTFNFSSPTSStSSSSPPSVTKSAENK 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012   508 VQMTSPNSTGSPMFRFSSPIVKSTEADVLPP-SSIGFTFSVPVAKTAELSGSSsiSEPTTSSLRQDITVVNSATSKKSQD 586
Cdd:pfam08604  399 AQKQPPSTSGSPAFTFSSPIVKSTEASVPPPsPSIGFTFSVPVAKTAELSGSS--GTSVVSVVSTETTTVNSTSNKKEEE 476

                          490       500       510
                   ....*....|....*....|....*....|.
gi 507979012   587 EDCDGPFRPAKILKEGSVLDILKNPGFVSPK 617
Cdd:pfam08604  477 EEFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1381-1467 4.04e-19

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


Pssm-ID: 371156  Cd Length: 86  Bit Score: 83.19  E-value: 4.04e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012  1381 PNSSSVFQFGSSSTNFNFANNSTSGVFTFGANPSTPAAPAQPSSSGGFPFSQSSAAFTVGSNGKNMFsssgtSVSGRKIK 1460
Cdd:pfam10599    5 PDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSNMF-----SVSGRKIA 79


                   ....*..
gi 507979012  1461 TAVRRKK 1467
Cdd:pfam10599   80 QMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
844-873 8.86e-10

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 55.05  E-value: 8.86e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 507979012   844 PEGSWDCEVCLVQNKADSTKCVACESEKPG 873
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
716-744 1.70e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 54.28  E-value: 1.70e-09
                           10        20
                   ....*....|....*....|....*....
gi 507979012   716 VGTWDCDTCLVQNKPEAIKCVACETPKPG 744
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
786-815 6.11e-08

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 49.66  E-value: 6.11e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 507979012   786 PVGSWECPVCCVCNNAEDNKCVSCMSEKPG 815
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
650-680 3.39e-07

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.39e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 507979012   650 KAGSlWQCHVCLVQNKVTDNKCSACQATKLP 680
Cdd:pfam00641    1 REGD-WDCSKCLVQNFATSTKCVACQAPKPD 30
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 717-741 6.75e-06

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 43.85  E-value: 6.75e-06
                            10        20
                    ....*....|....*....|....*
gi 507979012    717 GTWDCDTCLVQNKPEAIKCVACETP 741
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 846-868 1.83e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 42.69  E-value: 1.83e-05
                            10        20
                    ....*....|....*....|...
gi 507979012    846 GSWDCEVCLVQNKADSTKCVACE 868
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACG 23
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 655-676 1.62e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.99  E-value: 1.62e-04
                            10        20
                    ....*....|....*....|..
gi 507979012    655 WQCHVCLVQNKVTDNKCSACQA 676
Cdd:smart00547    3 WECPACTFLNFASRSKCFACGA 24
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 788-809 1.01e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 37.68  E-value: 1.01e-03
                            10        20
                    ....*....|....*....|..
gi 507979012    788 GSWECPVCCVCNNAEDNKCVSC 809
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFAC 22
PPE COG5651
PPE-repeat protein [Function unknown];
1209-1420 4.09e-03

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 41.42  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012 1209 TSSSAPVTAFVFGqASNPVSSSAFGNSAECSTSQSLLFPPESKPATTSSSGTTVTPFVFGPGANSSNTAASGFSFGATTA 1288
Cdd:COG5651   175 TNPGGLLGAQNAG-SGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAAGAAAAAAAAAAAAGA 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012 1289 SSSAGSSFVFGTAPSAPAASPAFGANQTPTFGQSQGVSQPNSQGFGAISSTATLFSAGSQPAPPTFGAVSSSSQPPVFGQ 1368
Cdd:COG5651   254 GASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAGAALGAGAA 333

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 507979012 1369 QPSQSAFGSGTAPNSSSVFQFGSSSTNFNFANNSTSGVFTFGANPSTPAAPA 1420
Cdd:COG5651   334 AAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAAA 385
PPE COG5651
PPE-repeat protein [Function unknown];
1269-1456 6.87e-03

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 40.65  E-value: 6.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012 1269 PGANSSN-TAASGFSFGATTASSSAGSSFVFGTAPSAPAASPAFGANQTPTFGQSQGVSQPNSQGFGAISSTATLFSAGS 1347
Cdd:COG5651   177 PGGLLGAqNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAAGAAAAAAAAAAAAGAGAS 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507979012 1348 QPAPPTFGAVSSSSQPPVFGQQPSQSAFGSGTAPnSSSVFQFGSSSTNFNFANNSTSGVFTFGANPSTPAAPAQPSSSGG 1427
Cdd:COG5651   257 AALASLAATLLNASSLGLAATAASSAATNLGLAG-SPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAGAALGAGAAAA 335

                         170       180
                  ....*....|....*....|....*....
gi 507979012 1428 FPFSQSSAAFTVGSNGKNMFSSSGTSVSG 1456
Cdd:COG5651   336 AAGAAAGAGAAAAAAAGGAGGGGGGALGA 364
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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