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Conserved domains on  [gi|506279494|ref|WP_015799269|]
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NADP-dependent isocitrate dehydrogenase [Acidimicrobium ferrooxidans]

Protein Classification

NADP-dependent isocitrate dehydrogenase( domain architecture ID 10001701)

NADP-dependent isocitrate dehydrogenase catalyzes the conversion of isocitrate to 2-oxoglutarate in an NADP-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 9-400 0e+00

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


:

Pssm-ID: 440304  Cd Length: 409  Bit Score: 667.97  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   9 ADGRLIVGDEVIIPYIEGDGTGVDIWPAARTVFDAALA-AHG--RRVEWREVLAGEKAFRETGSWLPDETLSVFREYLVG 85
Cdd:COG0538    9 EDGKLKVPDNPIIPFIEGDGIGPEITRAIWKVIDAAVEkAYGgkRDIEWKEVDAGEKARDETGDWLPDETAEAIKEYGVG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  86 IKGPLTTPVGGGIRSLNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVYAGLEVQAGSEEARALREF 165
Cdd:COG0538   89 IKGPLTTPVGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAGSPEALKLIFF 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 166 LAERFGWE---LGADAGIGIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFRAWGYELVREEFADVAV 242
Cdd:COG0538  169 LEDEMGVTvirFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEEFGDKFI 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 243 GWDD----CGGDPGDKLLVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINYVTGhGIFE 318
Cdd:COG0538  249 TEGPwekyKGPKPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGG-AEFE 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 319 ATHGTAPKYAGKDMVNPGSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFARLRDGATKVSTSEFGHAVAERI 398
Cdd:COG0538  328 ATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTYDLARLMEGATELSTSEFGDAIIENL 407


                 ..
gi 506279494 399 RR 400
Cdd:COG0538  408 DK 409
 
Name Accession Description Interval E-value
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 9-400 0e+00

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 667.97  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   9 ADGRLIVGDEVIIPYIEGDGTGVDIWPAARTVFDAALA-AHG--RRVEWREVLAGEKAFRETGSWLPDETLSVFREYLVG 85
Cdd:COG0538    9 EDGKLKVPDNPIIPFIEGDGIGPEITRAIWKVIDAAVEkAYGgkRDIEWKEVDAGEKARDETGDWLPDETAEAIKEYGVG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  86 IKGPLTTPVGGGIRSLNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVYAGLEVQAGSEEARALREF 165
Cdd:COG0538   89 IKGPLTTPVGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAGSPEALKLIFF 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 166 LAERFGWE---LGADAGIGIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFRAWGYELVREEFADVAV 242
Cdd:COG0538  169 LEDEMGVTvirFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEEFGDKFI 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 243 GWDD----CGGDPGDKLLVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINYVTGhGIFE 318
Cdd:COG0538  249 TEGPwekyKGPKPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGG-AEFE 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 319 ATHGTAPKYAGKDMVNPGSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFARLRDGATKVSTSEFGHAVAERI 398
Cdd:COG0538  328 ATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTYDLARLMEGATELSTSEFGDAIIENL 407


                 ..
gi 506279494 399 RR 400
Cdd:COG0538  408 DK 409
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 10-394 0e+00

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 645.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  10 DGRLIVGDEVIIPYIEGDGTGVDIWPAARTVFDAALA-AHG--RRVEWREVLAGEKAFRETGS--WLPDETLSVFREYLV 84
Cdd:PRK07006  11 NGKLNVPNNPIIPFIEGDGIGPDITPAMLKVVDAAVEkAYKgeRKISWMEIYAGEKATKVYGEdvWLPEETLDLIREYRV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  85 GIKGPLTTPVGGGIRSLNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVYAGLEVQAGSEEARALRE 164
Cdd:PRK07006  91 AIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKAGSAEAKKVIK 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 165 FLAErfgwELGAD-------AGIGIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFRAWGYELVREEF 237
Cdd:PRK07006 171 FLQE----EMGVKkirfpetSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEEF 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 238 ADVAVGWD--DCGGDP--GDKLLVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyvTG 313
Cdd:PRK07006 247 GDELIDGGpwDKIKNPetGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN--DG 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 314 HGIFEATHGTAPKYAGKDMVNPGSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFARLRDGATKVSTSEFGHA 393
Cdd:PRK07006 325 HAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTVTYDFARLMEGATEVKCSEFGDA 404


                 .
gi 506279494 394 V 394
Cdd:PRK07006 405 L 405
prok_nadp_idh TIGR00183
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent ...
 10-396 0e+00

isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. [Energy metabolism, TCA cycle]


Pssm-ID: 272948  Cd Length: 416  Bit Score: 595.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   10 DGRLIVGDEVIIPYIEGDGTGVDIWPAARTVFDAALAAHG---RRVEWREVLAGEKAFRETGS--WLPDETLSVFREYLV 84
Cdd:TIGR00183  18 NGKLNVPNNPIIPYIEGDGIGVDVTPAAIKVLDAAVEKAYkgeKKIVWFEVYAGEKAYQLYGQdqWLPADTLDAIKEYRV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   85 GIKGPLTTPVGGGIRSLNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVYAGLEVQAGSEEARALRE 164
Cdd:TIGR00183  98 AIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYKGVPSPVKHPEKVDMVIFRENTEDIYAGIEWAEGSEEAKKLIR 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  165 FLAERFGWE---LGADAGIGIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFRAWGYELVREEFADVA 241
Cdd:TIGR00183 178 FLQNELGVKkirFPEDSGIGIKPISEEGTKRLVRAAIEYAIENDRKSVTLVHKGNIMKFTEGAFRDWGYELAKKEFGAEC 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  242 VG---WDDCGG-DPGDKLLVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINYVTGhgIF 317
Cdd:TIGR00183 258 ITwglWDKYKNpNPGKEIVIKDRIADAFLQQILTRPDEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIGDEIG--IF 335

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 506279494  318 EATHGTAPKYAGKDMVNPGSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFARLRDGATKVSTSEFGHAVAE 396
Cdd:TIGR00183 336 EATHGTAPKYAGQDKVNPGSIILSGEMMLEHMGWKEAADLIKKAMEKAIASKIVTYDFARLMDGAKEVKCSEFAEAIIE 414
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
20-394 3.90e-116

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 342.35  E-value: 3.90e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   20 IIPYIEGDGTGVDIWPAARTVFDAALAAHGRRVEWREVLAGEKAFRETGSWLPDETLSVFREYLVGIKGPLTTPVG--GG 97
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWdpAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   98 IRSLN--VALRQLLDLYVCLRPVRWF--EGVPSPVR-HPEWVDMVIFRENTEDVYAGLE-VQAGSEEARAlreflaerfg 171
Cdd:pfam00180  81 VRPENglLALRKELGLFANLRPAKVFppLGDASPLKnEVEGVDIVIVRELTGGIYFGIEkGIKGSGNEVA---------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  172 welgadagIGIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGafraWGY---ELVREEFADVAvgwddcg 248
Cdd:pfam00180 151 --------VDTKLYSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL----WRKivtEVAKAEYPDVE------- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  249 gdpgdkllVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINYvTGHGIFEATHGTAPKYA 328
Cdd:pfam00180 212 --------LEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGA-NGFGIFEPVHGSAPDIA 282

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506279494  329 GKDMVNPGSVILSGVLMFEY-LGWNDVADAIVDALERTIAEGIVTYDFARLrdgATKVSTSEFGHAV 394
Cdd:pfam00180 283 GKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKVLESGIRTGDLAGS---ATYVSTSEFGEAV 346
 
Name Accession Description Interval E-value
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 9-400 0e+00

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 667.97  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   9 ADGRLIVGDEVIIPYIEGDGTGVDIWPAARTVFDAALA-AHG--RRVEWREVLAGEKAFRETGSWLPDETLSVFREYLVG 85
Cdd:COG0538    9 EDGKLKVPDNPIIPFIEGDGIGPEITRAIWKVIDAAVEkAYGgkRDIEWKEVDAGEKARDETGDWLPDETAEAIKEYGVG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  86 IKGPLTTPVGGGIRSLNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVYAGLEVQAGSEEARALREF 165
Cdd:COG0538   89 IKGPLTTPVGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAGSPEALKLIFF 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 166 LAERFGWE---LGADAGIGIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFRAWGYELVREEFADVAV 242
Cdd:COG0538  169 LEDEMGVTvirFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEEFGDKFI 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 243 GWDD----CGGDPGDKLLVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINYVTGhGIFE 318
Cdd:COG0538  249 TEGPwekyKGPKPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGG-AEFE 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 319 ATHGTAPKYAGKDMVNPGSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFARLRDGATKVSTSEFGHAVAERI 398
Cdd:COG0538  328 ATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTYDLARLMEGATELSTSEFGDAIIENL 407


                 ..
gi 506279494 399 RR 400
Cdd:COG0538  408 DK 409
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 10-394 0e+00

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 645.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  10 DGRLIVGDEVIIPYIEGDGTGVDIWPAARTVFDAALA-AHG--RRVEWREVLAGEKAFRETGS--WLPDETLSVFREYLV 84
Cdd:PRK07006  11 NGKLNVPNNPIIPFIEGDGIGPDITPAMLKVVDAAVEkAYKgeRKISWMEIYAGEKATKVYGEdvWLPEETLDLIREYRV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  85 GIKGPLTTPVGGGIRSLNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVYAGLEVQAGSEEARALRE 164
Cdd:PRK07006  91 AIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKAGSAEAKKVIK 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 165 FLAErfgwELGAD-------AGIGIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFRAWGYELVREEF 237
Cdd:PRK07006 171 FLQE----EMGVKkirfpetSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEEF 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 238 ADVAVGWD--DCGGDP--GDKLLVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyvTG 313
Cdd:PRK07006 247 GDELIDGGpwDKIKNPetGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN--DG 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 314 HGIFEATHGTAPKYAGKDMVNPGSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFARLRDGATKVSTSEFGHA 393
Cdd:PRK07006 325 HAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTVTYDFARLMEGATEVKCSEFGDA 404


                 .
gi 506279494 394 V 394
Cdd:PRK07006 405 L 405
prok_nadp_idh TIGR00183
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent ...
 10-396 0e+00

isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. [Energy metabolism, TCA cycle]


Pssm-ID: 272948  Cd Length: 416  Bit Score: 595.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   10 DGRLIVGDEVIIPYIEGDGTGVDIWPAARTVFDAALAAHG---RRVEWREVLAGEKAFRETGS--WLPDETLSVFREYLV 84
Cdd:TIGR00183  18 NGKLNVPNNPIIPYIEGDGIGVDVTPAAIKVLDAAVEKAYkgeKKIVWFEVYAGEKAYQLYGQdqWLPADTLDAIKEYRV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   85 GIKGPLTTPVGGGIRSLNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVYAGLEVQAGSEEARALRE 164
Cdd:TIGR00183  98 AIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYKGVPSPVKHPEKVDMVIFRENTEDIYAGIEWAEGSEEAKKLIR 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  165 FLAERFGWE---LGADAGIGIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFRAWGYELVREEFADVA 241
Cdd:TIGR00183 178 FLQNELGVKkirFPEDSGIGIKPISEEGTKRLVRAAIEYAIENDRKSVTLVHKGNIMKFTEGAFRDWGYELAKKEFGAEC 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  242 VG---WDDCGG-DPGDKLLVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINYVTGhgIF 317
Cdd:TIGR00183 258 ITwglWDKYKNpNPGKEIVIKDRIADAFLQQILTRPDEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIGDEIG--IF 335

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 506279494  318 EATHGTAPKYAGKDMVNPGSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFARLRDGATKVSTSEFGHAVAE 396
Cdd:TIGR00183 336 EATHGTAPKYAGQDKVNPGSIILSGEMMLEHMGWKEAADLIKKAMEKAIASKIVTYDFARLMDGAKEVKCSEFAEAIIE 414
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
10-397 3.14e-164

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 469.58  E-value: 3.14e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  10 DGRLIVGDEVIIPYIEGDGTGVDIWPAARTVFDAALA-AHG--RRVEWREVLAGEKAFRETGS--WLPDETLSVFREYLV 84
Cdd:PRK07362  20 NGKPVVPDNPIIPFIRGDGTGVDIWPATQKVLDAAVAkAYGgeRKINWFKVYAGDEACDLYGTyqYLPEDTLEAIREYGV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  85 GIKGPLTTPVGGGIRSLNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVYAGLEVQAGSEEARALRE 164
Cdd:PRK07362 100 AIKGPLTTPIGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIYMGIEWEAGDEIGDKLIK 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 165 FLAERF---GWELGA-----DAGIGIKPVSAHGSKRLIRAAIRYA--LDHHRRSVTLVHKGNIQKFTEGAFRAWGYELVR 234
Cdd:PRK07362 180 HLNEEVipaSPELGKrqiplGSGIGIKPVSKTGSQRHIRRAIEHAlrLPGDKRHVTLVHKGNIMKYTEGAFRDWGYELAT 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 235 EEFADVAV----GW--DDCGGDPG----------------------------------------------DKLLVKDAIA 262
Cdd:PRK07362 260 TEFRDECVtereSWilSNKEKNPNisiednarmiepgydsltpekkaaicaevkevldsiwsshgngkwkEKVLVDDRIA 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 263 DNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyvTGHGIFEATHGTAPKYAGKDMVNPGSVILSG 342
Cdd:PRK07362 340 DSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIG--DNAAIFEATHGTAPKHAGLDRINPGSVILSG 417

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 506279494 343 VLMFEYLGWNDVADAIVDALERTIAEGIVTYDFARLRDGATK-VSTSEFGHAVAER 397
Cdd:PRK07362 418 VMMLEYLGWQEAADLITKGLSAAIANKQVTYDLARLMEPPVDpLSCSEFAEAIISH 473
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
10-398 1.87e-144

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 416.93  E-value: 1.87e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  10 DGRLIVGDEVIIPYIEGDGTGVDIWPAARTVFDAALA-AHG--RRVEWREVLAGEKAFRETGSWLPDETLSVFREYLVGI 86
Cdd:PRK06451  15 NGKWIVPKKPIILYVEGDGIGPEITHAAMKVINKAVEkAYGsdREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  87 KGPLTTPVGGGIRSLNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVYAGLEVQAGSEEARALREFL 166
Cdd:PRK06451  95 KGPLETPIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPLKNPEKIDLIIFRENTDDLYRGIEYPYDSEEAKKIRDFL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 167 AERFGWELGADAGIGIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFRAWGYELVREEFADVAVGWDD 246
Cdd:PRK06451 175 RKELGVEVEDDTGIGIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVALKEFRDYVVTEEE 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 247 C-----GGDPGDKLLVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINYvTGhGIFEATH 321
Cdd:PRK06451 255 VtknynGVPPSGKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGD-TG-GMFEAIH 332

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506279494 322 GTAPKYAGKDMVNPGSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFARLRdGATKVSTSEFGHAVAERI 398
Cdd:PRK06451 333 GTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKVTQDLARFM-GVRALSTTEYTDELISII 408
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
20-394 3.90e-116

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 342.35  E-value: 3.90e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   20 IIPYIEGDGTGVDIWPAARTVFDAALAAHGRRVEWREVLAGEKAFRETGSWLPDETLSVFREYLVGIKGPLTTPVG--GG 97
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWdpAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494   98 IRSLN--VALRQLLDLYVCLRPVRWF--EGVPSPVR-HPEWVDMVIFRENTEDVYAGLE-VQAGSEEARAlreflaerfg 171
Cdd:pfam00180  81 VRPENglLALRKELGLFANLRPAKVFppLGDASPLKnEVEGVDIVIVRELTGGIYFGIEkGIKGSGNEVA---------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  172 welgadagIGIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGafraWGY---ELVREEFADVAvgwddcg 248
Cdd:pfam00180 151 --------VDTKLYSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL----WRKivtEVAKAEYPDVE------- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  249 gdpgdkllVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINYvTGHGIFEATHGTAPKYA 328
Cdd:pfam00180 212 --------LEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGA-NGFGIFEPVHGSAPDIA 282

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506279494  329 GKDMVNPGSVILSGVLMFEY-LGWNDVADAIVDALERTIAEGIVTYDFARLrdgATKVSTSEFGHAV 394
Cdd:pfam00180 283 GKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKVLESGIRTGDLAGS---ATYVSTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 24-398 2.58e-112

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 332.36  E-value: 2.58e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  24 IEGDGTGVDIWPAARTVFDAALAAHGRRVEWREVLAGEKAFRETGSWLPDETLSVFREYLVGIKGPLTTPV---GGGIRS 100
Cdd:COG0473    7 LPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKwddGVRPES 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 101 LNVALRQLLDLYVCLRPVRWFEGVPSPVRH--PEWVDMVIFRENTEDVYAGLEvqagseearalreflaERFGWELGADA 178
Cdd:COG0473   87 GLLALRKELDLYANLRPAKLYPGLPSPLKPeiVEGIDLVIVRENTEGLYFGIG----------------GRIGTGTGEEV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 179 GIGIKPVSAHGSKRLIRAAIRYALDHhRRSVTLVHKGNIQKFTEGAFRawgyELVRE---EFADVAVgwddcggdpgDKL 255
Cdd:COG0473  151 AIDTRVYTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWR----EVVREvakEYPDVEL----------DHM 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 256 LVkdaiaDNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyVTGHGIFEATHGTAPKYAGKDMVNP 335
Cdd:COG0473  216 YV-----DAAAMQLVRNPEQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIG-DEGKALFEPVHGSAPDIAGKGIANP 289

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 506279494 336 GSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFarlrdgATKVSTSEFGHAVAERI 398
Cdd:COG0473  290 IATILSAAMMLRHLGEEEAADAIEAAVEKVLAEGVRTPDL------GGKAGTSEMGDAIIAAL 346
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
24-398 1.14e-83

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 263.68  E-value: 1.14e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  24 IEGDGTGVDIWPAARTVFDAAlaahGRRVEWREVLAGEKAF-RETGSWLPDETLSVFREYLVGIKGPLTTPVGGGIRSLN 102
Cdd:PRK09222  10 AYGDGIGPEIMEAVLKILEAA----GAPLEIETIEIGEKVYkKGWTSGISPSAWESIRRTKVLLKAPITTPQGGGYKSLN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 103 VALRQLLDLYVCLRPVR-WFEGVPSPvrHPEwVDMVIFRENTEDVYAGLEVQAGSEEARALreflaerfgwelgadagig 181
Cdd:PRK09222  86 VTLRKTLGLYANVRPCVsYHPFVETK--HPN-LDVVIIRENEEDLYAGIEHRQTPDVYQCL------------------- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 182 iKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFRAwGYELVREEFADV-AVGWddcggdpgdkllvkda 260
Cdd:PRK09222 144 -KLISRPGSEKIIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHK-VFDEIAKEYPDIeAEHY---------------- 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 261 IADNAFQQVLTRPRDYDVIATTNLNGDYLSDaLAAQV-GGIGIAPGGNInyvtGHG--IFEATHGTAPKYAGKDMVNPGS 337
Cdd:PRK09222 206 IVDIGAARLATNPENFDVIVTPNLYGDILSD-IAAEIsGSVGLAGSANI----GEEyaMFEAVHGSAPDIAGKNIANPSG 280

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 506279494 338 VILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFARLRDGATKVSTSEFGHAVAERI 398
Cdd:PRK09222 281 LLNAAVMMLVHIGQFDIAELIENAWLKTLEDGIHTADIYNEGVSKKKVGTKEFAEAVIENL 341
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 21-398 3.65e-73

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 231.92  E-value: 3.65e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  21 IPYIEGDGTGVDIWPAARTVFDAAlaahGRRVEWREVLAGEKAFRETGSWLPDETLSVFREYLVGIKGPLTTPVGGGIRS 100
Cdd:PRK08997   5 ITVIPGDGIGPSIIDATLKILDKL----GCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEGFTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 101 LNVALRQLLDLYVCLRPVRWFEGVPSpvRHpEWVDMVIFRENTEDVYAGL--EVQAGSEEARALREflaerfgwelgada 178
Cdd:PRK08997  81 INVTLRKKFDLYANVRPVLSFPGTKA--RY-DNIDIITVRENTEGMYSGEgqTVSEDGETAEATSI-------------- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 179 gigikpVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFRAWGYElVREEFADVAvgwddcggdpgdkllVK 258
Cdd:PRK08997 144 ------ITRKGAERIVRFAYELARKEGRKKVTAVHKANIMKSTSGLFLKVARE-VALRYPDIE---------------FE 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 259 DAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyvTGHGIFEATHGTAPKYAGKDMVNPGSV 338
Cdd:PRK08997 202 EMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVGGLGMAPGANIG--RDAAIFEAVHGSAPDIAGKNLANPTSV 279

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 339 ILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTydfarLRDGATKVSTSEFGHAVAERI 398
Cdd:PRK08997 280 ILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRT-----TRDLGGTHGTTDFTQAVIDRL 334
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 21-398 2.73e-68

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 219.23  E-value: 2.73e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  21 IPYIEGDGTGVDIWPAARTVfdaaLAAHGRRVEWREVLAGEKAFRETGSWLPDETLSVFREylvgIKGPLTTPVGGGIRS 100
Cdd:PRK14025   4 ICVIEGDGIGKEVVPAALHV----LEATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKE----ADAVLFGAAGETAAD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 101 LNVALRQLLDLYVCLRPVRWFEGVPSpvRHPEwVDMVIFRENTEDVYAGLEVQAGSEEARALReflaerfgwelgadagi 180
Cdd:PRK14025  76 VIVKLRRILDTYANVRPVKSYKGVKC--LYPD-IDYVIVRENTEGLYKGIEAEIADGVTVATR----------------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 181 gikPVSAHGSKRLIRAAIRYALDHH----RRSVTLVHKGNIQKFTEGAFRawgyelvrEEFADVAVGWDDcggdpgdkLL 256
Cdd:PRK14025 136 ---VITRKASERIFRFAFEMAKRRKkmgkEGKVTCAHKANVLKKTDGLFK--------KTFYEVAKEYPD--------IK 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 257 VKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyvTGHGIFEATHGTAPKYAGKDMVNPG 336
Cdd:PRK14025 197 AEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIG--DKYGLFEPVHGSAPDIAGKGIANPT 274

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506279494 337 SVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTYDFarlrdGATkVSTSEFGHAVAERI 398
Cdd:PRK14025 275 ATILTAVLMLRHLGENEEADKVEKALEEVLALGLTTPDL-----GGN-LSTMEMAEEVAKRV 330
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 26-398 1.14e-61

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 203.57  E-value: 1.14e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  26 GDGTGVDIWPAARTVFDAAlaahGRRVEWREVLAGEKAFRETGSWLPDETLSVFREYLVGIKGPLTTPVGGGIRSLNVAL 105
Cdd:PLN00118  49 GDGIGPEIAESVKQVFTAA----GVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 106 RQLLDLYVCLRPVRWFEGVPSpvRHPEwVDMVIFRENTEDVYAGLEVQAgseeARALREflaerfgwelgadagiGIKPV 185
Cdd:PLN00118 125 RKELGLYANVRPCYSLPGYKT--RYDD-VDLVTIRENTEGEYSGLEHQV----VRGVVE----------------SLKII 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 186 SAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFrawgYELVREefadVAVGWDDcggdpgdkLLVKDAIADNA 265
Cdd:PLN00118 182 TRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLF----LKCCRE----VAEKYPE--------IVYEEVIIDNC 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 266 FQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyVTGHGIFEATHGTAPKYAGKDMVNPGSVILSGVLM 345
Cdd:PLN00118 246 CMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIG-ENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMM 324

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 506279494 346 FEYLGWNDVADAIVDALERTIAEGivTYdfaRLRDGATKVSTSEFGHAVAERI 398
Cdd:PLN00118 325 LRHLKLNEQAEQIHNAILNTIAEG--KY---RTADLGGSSTTTDFTKAICDHL 372
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 24-398 6.10e-57

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 190.14  E-value: 6.10e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  24 IEGDGTGVDIWPAARTVFDAALAAhGRRVEWREVLAGEKAFRETGSWLPDETLSVFREY---LVGIKGPLTTPVGGGIRS 100
Cdd:PRK03437  10 IPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGARRYLRTGETLPDSVLAELRQHdaiLLGAIGDPSVPSGVLERG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 101 LNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVYAGL--EVQAGSEEARALREFLAERFGWElgada 178
Cdd:PRK03437  89 LLLKLRFALDHYVNLRPSKLYPGVTSPLAGPGDIDFVVVREGTEGPYTGNggALRVGTPHEVATEVSVNTAFGVE----- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 179 gigikpvsahgskRLIRAAIRYALDHHRRSVTLVHKGNIQKFtegAFRAWG--YELVREEFADVAVgwDDCGGDPGDKLL 256
Cdd:PRK03437 164 -------------RVVRDAFERAQKRPRKHLTLVHKTNVLTF---AGDLWQrtVDEVAAEYPDVTV--DYQHVDAATIFM 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 257 VKDaiadnafqqvltrPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINYV-TGHGIFEATHGTAPKYAGKDMVNP 335
Cdd:PRK03437 226 VTD-------------PSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTgTNPSMFEPVHGSAPDIAGQGIADP 292

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 506279494 336 GSVILSGVLMFEYLGWNDVADAIVDALERTIAEgivtydfarlrDGATKVSTSEFGHAVAERI 398
Cdd:PRK03437 293 TAAILSVALLLDHLGEEDAAARIEAAVEADLAE-----------RGKMGRSTAEVGDRIAARL 344
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 19-401 2.59e-52

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 178.37  E-value: 2.59e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  19 VIIPyieGDGTGVDIWPAARTVFDAALAAHGRRVEWREVLAGEKAFRETGSWLPDETLSVFREY---LVG-IKGPLTTPV 94
Cdd:PRK00772   6 AVLP---GDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAAdavLLGaVGGPKWDNL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  95 GGGIRSLN--VALRQLLDLYVCLRPVRWFEGV--PSPVRhPEWV---DMVIFRENTEDVYAGlevqagseEARALREFLA 167
Cdd:PRK00772  83 PPDVRPERglLALRKELGLFANLRPAKLYPGLadASPLK-PEIVaglDILIVRELTGGIYFG--------EPRGREGLGG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 168 ERFGWElgadagigIKPVSAHGSKRLIRAAIRYALDhhRRS-VTLVHKGNIQKftegAFRAWgYELVRE---EFADVAVg 243
Cdd:PRK00772 154 EERAFD--------TMVYTREEIERIARVAFELARK--RRKkVTSVDKANVLE----SSRLW-REVVTEvakEYPDVEL- 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 244 wddcggdpgDKLLVkdaiaDNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyVTGHGIFEATHGT 323
Cdd:PRK00772 218 ---------SHMYV-----DNAAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLG-ESGPGLYEPIHGS 282

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 506279494 324 APKYAGKDMVNPGSVILSGVLMFEY-LGWNDVADAIVDALERTIAEGIVTYDfarLRDGATKVSTSEFGHAVAERIRRG 401
Cdd:PRK00772 283 APDIAGKGIANPIATILSAAMMLRYsLGLEEAADAIEAAVEKVLAQGYRTAD---IAEGGGKVSTSEMGDAILAALAEG 358
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 24-394 1.43e-45

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 160.80  E-value: 1.43e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  24 IEGDGTGVDIWPAARTVFDAALAAhgrrVEWR--EVLAGEKAfretgswLPDETLSVFREYLVGIKGPLTTPVGGGIRSL 101
Cdd:PLN00123  36 IPGDGIGPLVTGAVEQVMEAMHAP----VYFEryEVHGDMKK-------VPEEVLESIRRNKVCLKGGLATPVGGGVSSL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 102 NVALRQLLDLYVCLrpVRWFEGVPSPVRHpEWVDMVIFRENTEDVYAGL--EVQAGSEEAralreflaerfgwelgadag 179
Cdd:PLN00123 105 NVQLRKELDLFASL--VNCFNLPGLPTRH-ENVDIVVIRENTEGEYSGLehEVVPGVVES-------------------- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 180 igIKPVSAHGSKRLIRAAIRYALDHHRRSVTLVHKGNIQKFTEGAFrawgYELVREefadVAVGWddcggdPGDKLlvKD 259
Cdd:PLN00123 162 --LKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF----LESCRE----VAKKY------PGIKY--NE 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 260 AIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyvTGHGIFE--ATHGTA--PKYAGKDMVNP 335
Cdd:PLN00123 224 IIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG--ADHAVFEqgASAGNVgnEKLVEQKKANP 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 506279494 336 GSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIvtydfARLRDGATKVSTSEFGHAV 394
Cdd:PLN00123 302 VALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGK-----YRTKDLGGSSTTQEVVDAV 355
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 21-400 6.08e-42

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 151.03  E-value: 6.08e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  21 IPYIEGDGTGVDIWPAARTVFDAALAAHGR-RVEWREVLAGEKAFRETGSWLPD---ETLSVFREYLVGIKG-PLTTPVG 95
Cdd:PRK08194   6 IAVIPGDGVGKEVVPAAVRVLKAVAEVHGGlKFEFTEFPWSCEYYLEHGEMMPEdglEQLKQFDAIFLGAVGnPKLVPDH 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  96 GGIRSLNVALRQLLDLYVCLRPVRWFEGVPSPVRHPEWVDMVIFRENTEDVY--AGLEVQAGSEEaralreflaerfgwe 173
Cdd:PRK08194  86 ISLWGLLIKIRREFEQVINIRPAKQLRGIKSPLANPKDFDLLVVRENSEGEYseVGGRIHRGEDE--------------- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 174 lgadagIGIKpvSAHGSKRLIRAAIRYALD---HHRRSVTLVHKGNIQKFTEGAFRawgyelvrEEFADVAVGWDDCGGD 250
Cdd:PRK08194 151 ------IAIQ--NAVFTRKGTERAMRYAFElaaKRRKHVTSATKSNGIVHSMPFWD--------EVFQEVGKDYPEIETD 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 251 pgdkLLVKDAIAdnAFqqVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyVTGH--GIFEATHGTAPKYA 328
Cdd:PRK08194 215 ----SQHIDALA--AF--FVTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANIN-VNGKypSMFEPVHGSAPDIA 285

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506279494 329 GKDMVNPGSVILSGVLMFEYLGWNDVADAIVDALERTIAEGIVTydfarlRDGATKVSTSEFGHAVAERIRR 400
Cdd:PRK08194 286 GKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVIEDVTEDGIKT------PDIGGRATTDEVTDEIISRLKK 351
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 21-369 8.43e-21

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 93.60  E-value: 8.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494  21 IPYIEGDGTGVDIWPAARTVFDAALAAHGRRVEWREVLAGEKAFRETGSWLPDETLSVFREYlvgiKGPLTTPVGGGIRS 100
Cdd:PLN02329  49 IALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQS----DAILLGAIGGYKWD 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 101 LN----------VALRQLLDLYVCLRPV----RWFEGVPSPVRHPEWVDMVIFRENTEDVYAGlevqagseEARALREFl 166
Cdd:PLN02329 125 KNekhlrpemalFYLRRDLKVFANLRPAtvlpQLVDASTLKKEVAEGVDMMIVRELTGGIYFG--------EPRGITIN- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 167 aerfgwELGADAGIGIKPVSAHGSKRLIRAAIRYAlDHHRRSVTLVHKGNIQKftegAFRAWgyelvREEFADVAVGWDD 246
Cdd:PLN02329 196 ------ENGEEVGVSTEIYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLD----ASILW-----RKRVTALASEYPD 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506279494 247 cggdpgdkLLVKDAIADNAFQQVLTRPRDYDVIATTNLNGDYLSDALAAQVGGIGIAPGGNINyVTGHGIFEATHGTAPK 326
Cdd:PLN02329 260 --------VELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLG-ESGPGLFEPIHGSAPD 330

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 506279494 327 YAGKDMVNPGSVILSGVLMFEY-LGWNDVA----DAIVDALERTIAEG 369
Cdd:PLN02329 331 IAGQDKANPLATILSAAMLLKYgLGEEKAAkrieDAVVDALNKGFRTG 378
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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