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Conserved domains on  [gi|506267873|ref|WP_015787648|]
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antibiotic biosynthesis monooxygenase [Saccharomonospora viridis]

Protein Classification

antibiotic biosynthesis monooxygenase family protein( domain architecture ID 10006366)

antibiotic biosynthesis monooxygenase family protein may be involved in the biosynthesis of several antibiotics; similar to Streptomyces tetracenomycin-F1 monooxygenase and deoxynogalonate monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  31399587
SCOP:  4001439

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 5-99 2.41e-17

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


:

Pssm-ID: 441901  Cd Length: 98  Bit Score: 70.41  E-value: 2.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506267873   5 IRVLVYYRC--DDEAKIRDAYHVVSPRLSQVPGLLNNELLASTHDPNSYIVLSEWTDRETHRRWEQSQEHLEQTAPLQPY 82
Cdd:COG2329    2 IVVINRFRVkpGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKGREI 81

                         90
                 ....*....|....*..
gi 506267873  83 LDnqLPMSFGIYEVKAS 99
Cdd:COG2329   82 LA--GPPRVEHYEVVAE 96
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 5-99 2.41e-17

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 70.41  E-value: 2.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506267873   5 IRVLVYYRC--DDEAKIRDAYHVVSPRLSQVPGLLNNELLASTHDPNSYIVLSEWTDRETHRRWEQSQEHLEQTAPLQPY 82
Cdd:COG2329    2 IVVINRFRVkpGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKGREI 81

                         90
                 ....*....|....*..
gi 506267873  83 LDnqLPMSFGIYEVKAS 99
Cdd:COG2329   82 LA--GPPRVEHYEVVAE 96
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 5-74 8.61e-08

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 45.34  E-value: 8.61e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506267873    5 IRVLVYYRC--DDEAKIRDAYHVVSPRLSQVPGLLNNELLASTHDPNSYIVLSEWTDRETHRRWEQSQEHLE 74
Cdd:pfam03992   1 IVVVAEIRVkpGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKA 72
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 5-99 2.41e-17

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 70.41  E-value: 2.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506267873   5 IRVLVYYRC--DDEAKIRDAYHVVSPRLSQVPGLLNNELLASTHDPNSYIVLSEWTDRETHRRWEQSQEHLEQTAPLQPY 82
Cdd:COG2329    2 IVVINRFRVkpGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKGREI 81

                         90
                 ....*....|....*..
gi 506267873  83 LDnqLPMSFGIYEVKAS 99
Cdd:COG2329   82 LA--GPPRVEHYEVVAE 96
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 5-74 8.61e-08

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 45.34  E-value: 8.61e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506267873    5 IRVLVYYRC--DDEAKIRDAYHVVSPRLSQVPGLLNNELLASTHDPNSYIVLSEWTDRETHRRWEQSQEHLE 74
Cdd:pfam03992   1 IVVVAEIRVkpGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKA 72
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
5-79 7.69e-07

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 43.40  E-value: 7.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506267873   5 IRVLVYYRC--DDEAKIRDAYHVVSPRLSQVPGLLNNELLASTHDPNSYIVLSEWTDRE---THRRWEQSQEHLEQTAPL 79
Cdd:COG1359    1 ITVIAKLTVkpGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAaleAHLASPHFKAFLAALAPL 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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