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Conserved domains on  [gi|505359298|ref|WP_015546400|]
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MULTISPECIES: GNAT family N-acetyltransferase [Bacteroidales]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 12153134)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  10940244|9175471|15581578
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 28-141 5.96e-32

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 110.05  E-value: 5.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298   28 DFTQEGIETFKSFVYDTSLMNTLD-----IYGAFDNHLLIGIIGVhQERQHISLFFVLPHYHQQGIGKSLFDYMMSNC-- 100
Cdd:pfam13673   4 DYSEEGIETFYEFISPEALRERIDqgeyfFFVAFEGGQIVGVIAL-RDRGHISLLFVDPDYQGQGIGKALLEAVEDYAek 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 505359298  101 ---NFTYITVNSSTYAETFYTSLGFKKVGEKEINKGIVSIPMKR 141
Cdd:pfam13673  83 dgiKLSELTVNASPYAVPFYEKLGFRATGPEQEFNGIRFVPMEK 126
 
Name Accession Description Interval E-value
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 28-141 5.96e-32

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 110.05  E-value: 5.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298   28 DFTQEGIETFKSFVYDTSLMNTLD-----IYGAFDNHLLIGIIGVhQERQHISLFFVLPHYHQQGIGKSLFDYMMSNC-- 100
Cdd:pfam13673   4 DYSEEGIETFYEFISPEALRERIDqgeyfFFVAFEGGQIVGVIAL-RDRGHISLLFVDPDYQGQGIGKALLEAVEDYAek 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 505359298  101 ---NFTYITVNSSTYAETFYTSLGFKKVGEKEINKGIVSIPMKR 141
Cdd:pfam13673  83 dgiKLSELTVNASPYAVPFYEKLGFRATGPEQEFNGIRFVPMEK 126
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
53-143 5.13e-14

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 64.05  E-value: 5.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298  53 YGAFDNHLLIG---IIGVHQERQHISLFFVLPHYHQQGIGKSLFDYMMSNC---NFTYITVNSSTYAETFYTSLGFKKVG 126
Cdd:COG2153   37 LLAYDDGELVAtarLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEArerGARRIVLSAQAHAVGFYEKLGFVPVG 116

                         90
                 ....*....|....*..
gi 505359298 127 EKEINKGIVSIPMKRNI 143
Cdd:COG2153  117 EEFLEAGIPHIDMRKPL 133
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 52-97 1.82e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.65  E-value: 1.82e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 505359298  52 IYGAFDNHLLIGIIGVHQERQ-----HISLFFVLPHYHQQGIGKSLFDYMM 97
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSggdtaYIGDLAVLPEYRGKGIGSALLEAAE 51
PRK09831 PRK09831
GNAT family N-acetyltransferase;
73-130 2.80e-05

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 41.48  E-value: 2.80e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 505359298  73 HISLFFVLPHYHQQGIGKSLFDYMMSncNFTYITVNSSTYAETFYTSLGFKKVGEKEI 130
Cdd:PRK09831  74 YIDMLFVDPEYTRRGVASALLKPLIK--SESELTVDASITAKPFFERYGFQTVKQQRV 129
Spm_actase_Thplmales NF041158
spermidine N(1)-acetyltransferase;
2-93 5.87e-03

spermidine N(1)-acetyltransferase;


Pssm-ID: 469070  Cd Length: 115  Bit Score: 34.52  E-value: 5.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298   2 IRKLTQEEYNNAADLSYQVYMECGRNDFTQEGIETFKSFVYDTS-LMN-------TLDI--YGAFDNHLLIGII--GVHQ 69
Cdd:NF041158   4 IRKLSAEDVDALIEVARESWKWTYRDIYSNEFIESWISEKYSKEkLLNeiirsqsNLDIifLGAFVNSALIGFIelKIIA 83

                         90       100
                 ....*....|....*....|....
gi 505359298  70 ERQHISLFFVLPHYHQQGIGKSLF 93
Cdd:NF041158  84 DKAELLRLYLKPEYTHRGIGKLLL 107
 
Name Accession Description Interval E-value
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 28-141 5.96e-32

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 110.05  E-value: 5.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298   28 DFTQEGIETFKSFVYDTSLMNTLD-----IYGAFDNHLLIGIIGVhQERQHISLFFVLPHYHQQGIGKSLFDYMMSNC-- 100
Cdd:pfam13673   4 DYSEEGIETFYEFISPEALRERIDqgeyfFFVAFEGGQIVGVIAL-RDRGHISLLFVDPDYQGQGIGKALLEAVEDYAek 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 505359298  101 ---NFTYITVNSSTYAETFYTSLGFKKVGEKEINKGIVSIPMKR 141
Cdd:pfam13673  83 dgiKLSELTVNASPYAVPFYEKLGFRATGPEQEFNGIRFVPMEK 126
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
53-143 5.13e-14

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 64.05  E-value: 5.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298  53 YGAFDNHLLIG---IIGVHQERQHISLFFVLPHYHQQGIGKSLFDYMMSNC---NFTYITVNSSTYAETFYTSLGFKKVG 126
Cdd:COG2153   37 LLAYDDGELVAtarLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEArerGARRIVLSAQAHAVGFYEKLGFVPVG 116

                         90
                 ....*....|....*..
gi 505359298 127 EKEINKGIVSIPMKRNI 143
Cdd:COG2153  117 EEFLEAGIPHIDMRKPL 133
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 63-143 3.67e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 53.12  E-value: 3.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298  63 GIIGVHQERQ----HISLFFVLPHYHQQGIGKSLFDYMMS-----NCNFTYITVNSS-TYAETFYTSLGFKKVGEKEINK 132
Cdd:COG0456    1 GFALLGLVDGgdeaEIEDLAVDPEYRGRGIGRALLEAALErarerGARRLRLEVREDnEAAIALYEKLGFEEVGERPNYY 80

                         90
                 ....*....|.
gi 505359298 133 GIVSIPMKRNI 143
Cdd:COG0456   81 GDDALVMEKEL 91
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 51-143 1.18e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 52.69  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298  51 DIYGAFDNHLLIGIIGVHQ---ERQHISLFFVLPHYHQQGIGKSLFDYMMSNC---NFTYITVNSSTYAETFYTSLGFKK 124
Cdd:COG1246   29 EFWVAEEDGEIVGCAALHPldeDLAELRSLAVHPDYRGRGIGRRLLEALLAEArelGLKRLFLLTTSAAIHFYEKLGFEE 108

                         90       100
                 ....*....|....*....|...
gi 505359298 125 VGEKEINKGIV----SIPMKRNI 143
Cdd:COG1246  109 IDKEDLPYAKVwqrdSVVMEKDL 131
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
2-141 3.14e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 52.01  E-value: 3.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298   2 IRKLTQEEYNNAADLSYQVYMECGRNDFTQ---EGIETFKSFVydtslmntldiygAFDNHLLIGIIGV-------HQER 71
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFGPGREAELVDrlrEDPAAGLSLV-------------AEDDGEIVGHVALspvdidgEGPA 67

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505359298  72 QHISLFFVLPHYHQQGIGKSLFDYMMSNC---NFTYITVNSSTYAETFYTSLGFKKVGEKEINKGIVSIPMKR 141
Cdd:COG3153   68 LLLGPLAVDPEYRGQGIGRALMRAALEAArerGARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPDEVFLAK 140
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 52-124 6.26e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 49.76  E-value: 6.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298   52 IYGAFDNHLLIGIIGVHQERQHISL----FFVLPHYHQQGIGKSLFDYMM---SNCNFTYITVNSSTYAETFYTSLGFKK 124
Cdd:pfam13508   5 FFVAEDDGKIVGFAALLPLDDEGALaelrLAVHPEYRGQGIGRALLEAAEaaaKEGGIKLLELETTNRAAAFYEKLGFEE 84
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 61-127 4.63e-08

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 48.51  E-value: 4.63e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505359298  61 LIGIIGVHQ---ERQHISLFFVLPHYHQQGIGKSLFDYMMSNC---NFTYITVNSSTY---AETFYTSLGFKKVGE 127
Cdd:COG0454   45 PIGFAGLRRlddKVLELKRLYVLPEYRGKGIGKALLEALLEWArerGCTALELDTLDGnpaAIRFYERLGFKEIER 120
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 52-97 1.82e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.65  E-value: 1.82e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 505359298  52 IYGAFDNHLLIGIIGVHQERQ-----HISLFFVLPHYHQQGIGKSLFDYMM 97
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSggdtaYIGDLAVLPEYRGKGIGSALLEAAE 51
PRK09831 PRK09831
GNAT family N-acetyltransferase;
73-130 2.80e-05

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 41.48  E-value: 2.80e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 505359298  73 HISLFFVLPHYHQQGIGKSLFDYMMSncNFTYITVNSSTYAETFYTSLGFKKVGEKEI 130
Cdd:PRK09831  74 YIDMLFVDPEYTRRGVASALLKPLIK--SESELTVDASITAKPFFERYGFQTVKQQRV 129
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 18-122 5.81e-05

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 40.19  E-value: 5.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298   18 YQVYMECGRNDFTQEGIETFKSFVYDTSLMntldIYGAFDNHLLIGIIGVHQERQ-----HISLFFVLPHYHQQGIGKSL 92
Cdd:pfam00583   5 YELLSEEFPEPWPDEPLDLLEDWDEDASEG----FFVAEEDGELVGFASLSIIDDeppvgEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 505359298   93 FDYMM-----SNCNFTYITV-NSSTYAETFYTSLGF 122
Cdd:pfam00583  81 LQALLewareRGCERIFLEVaADNLAAIALYEKLGF 116
PRK10562 PRK10562
putative acetyltransferase; Provisional
 61-127 6.44e-04

putative acetyltransferase; Provisional


Pssm-ID: 236715 [Multi-domain]  Cd Length: 145  Bit Score: 37.74  E-value: 6.44e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505359298  61 LIGIIGVHQERqHISLFFVLPHYHQQGIGKSLFDYMMSNCNFTYITV-NSSTYAETFYTSLGFKKVGE 127
Cdd:PRK10562  59 LLGFVSVLEGR-FVGALFVAPKAVRRGIGKALMQHVQQRYPHLSLEVyQKNQRAVNFYHAQGFRIVDS 125
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
77-127 1.39e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 36.90  E-value: 1.39e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 505359298  77 FFVLPHYHQQGIGKSLFDYMMSNC---NFTYI---TVNSSTYAETFYTSLGFKKVGE 127
Cdd:COG1247   86 IYVDPDARGRGIGRALLEALIERArarGYRRLvavVLADNEASIALYEKLGFEEVGT 142
Spm_actase_Thplmales NF041158
spermidine N(1)-acetyltransferase;
2-93 5.87e-03

spermidine N(1)-acetyltransferase;


Pssm-ID: 469070  Cd Length: 115  Bit Score: 34.52  E-value: 5.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505359298   2 IRKLTQEEYNNAADLSYQVYMECGRNDFTQEGIETFKSFVYDTS-LMN-------TLDI--YGAFDNHLLIGII--GVHQ 69
Cdd:NF041158   4 IRKLSAEDVDALIEVARESWKWTYRDIYSNEFIESWISEKYSKEkLLNeiirsqsNLDIifLGAFVNSALIGFIelKIIA 83

                         90       100
                 ....*....|....*....|....
gi 505359298  70 ERQHISLFFVLPHYHQQGIGKSLF 93
Cdd:NF041158  84 DKAELLRLYLKPEYTHRGIGKLLL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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