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Conserved domains on  [gi|50510701|dbj|BAD32336|]
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mKIAA0908 protein, partial [Mus musculus]

Protein Classification

prenylcysteine oxidase family protein( domain architecture ID 10602892)

prenylcysteine oxidase family protein similar to Arabidopsis thaliana farnesylcysteine lyase that cleaves specifically the thioether bond of S-farnesyl-L-cysteine and has no activity with S-geranylgeranyl-L-cysteine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prenylcys_lyase pfam07156
Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are ...
 124-490 0e+00

Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps.


:

Pssm-ID: 462104 [Multi-domain]  Cd Length: 364  Bit Score: 637.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   124 FEESSWFVINVIKLVWRYGFQSLRMHMWVEDLLDKFMRIYRYQSHDYAFSSVEKLMHAIGGDDYVRLLNQTLRENLKKAG 203
Cdd:pfam07156   1 FEESSWSWINLAKLLWRYGFSPLRMQMWVEDILDKFMRIYEYQAHGYAFSSVEELLHALGGDGFLNLTNQTLEEALLKAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   204 FSETFLNEMIAPVMKVNYGQSTDINAFVGAVSLTAADSNLWAVEGGNKIVCSGLLQASSSNLISGSVMSIEEktrtKQTG 283
Cdd:pfam07156  81 FSQLFINEIVQAVTRVNYGQSVNINGFVGAVSLAGAQSGLWAVEGGNKLVCSGLLKASKANLINGTVTSIEL----KQSG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   284 NPTKMYEVVYKTGSETHSDFYDIVLVAAPLNRKMSNITFRNFDPPIEEFNDPYQQLVTTFIKGELNSTLFSSRPKDQFGL 363
Cdd:pfam07156 157 GSTSLYEVTYKTESGTHSDLYDIVVIATPLHRKMSNITFDNFSPPIPEFPGPYQHTVATLVHGRLNPSYFGLPDPSLFPL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   364 SAILVTDDSDMFINSLSIVASVRQKEGP-PPAVDGMHVWKTFSRDILTKEQISKLFLSYDYAVRKPWLSYPHYEPPQKCP 442
Cdd:pfam07156 237 ATILTTDNPSLFINSISSVSPVNISDNPrRKPPKEAAVWKIFSPEPLSKEQLKSLFSSYDSVQEKDWLAYPHYSPPETFP 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 50510701   443 SIILHDRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQ 490
Cdd:pfam07156 317 PFILHDGLYYLNGIEWAASAMEMSAIAAKNVALLAYHRWYGNTDKIDQ 364
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
35-102 3.28e-12

NAD(P)-binding Rossmann-like domain;


:

Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 61.78  E-value: 3.28e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701    35 IVGAGIGGTSSAYYLRKkfgKDVKIDVFE-REEVGGRLATLKVQGHDYEAGGSVIHPLN-LHMKRFVKEL 102
Cdd:pfam13450   1 IVGAGLAGLVAAALLAK---RGFRVLVLEkRDRLGGNAYSYRVPGYVFDYGAHIFHGSDePNVRDLLDEL 67
 
Name Accession Description Interval E-value
Prenylcys_lyase pfam07156
Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are ...
 124-490 0e+00

Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps.


Pssm-ID: 462104 [Multi-domain]  Cd Length: 364  Bit Score: 637.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   124 FEESSWFVINVIKLVWRYGFQSLRMHMWVEDLLDKFMRIYRYQSHDYAFSSVEKLMHAIGGDDYVRLLNQTLRENLKKAG 203
Cdd:pfam07156   1 FEESSWSWINLAKLLWRYGFSPLRMQMWVEDILDKFMRIYEYQAHGYAFSSVEELLHALGGDGFLNLTNQTLEEALLKAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   204 FSETFLNEMIAPVMKVNYGQSTDINAFVGAVSLTAADSNLWAVEGGNKIVCSGLLQASSSNLISGSVMSIEEktrtKQTG 283
Cdd:pfam07156  81 FSQLFINEIVQAVTRVNYGQSVNINGFVGAVSLAGAQSGLWAVEGGNKLVCSGLLKASKANLINGTVTSIEL----KQSG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   284 NPTKMYEVVYKTGSETHSDFYDIVLVAAPLNRKMSNITFRNFDPPIEEFNDPYQQLVTTFIKGELNSTLFSSRPKDQFGL 363
Cdd:pfam07156 157 GSTSLYEVTYKTESGTHSDLYDIVVIATPLHRKMSNITFDNFSPPIPEFPGPYQHTVATLVHGRLNPSYFGLPDPSLFPL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   364 SAILVTDDSDMFINSLSIVASVRQKEGP-PPAVDGMHVWKTFSRDILTKEQISKLFLSYDYAVRKPWLSYPHYEPPQKCP 442
Cdd:pfam07156 237 ATILTTDNPSLFINSISSVSPVNISDNPrRKPPKEAAVWKIFSPEPLSKEQLKSLFSSYDSVQEKDWLAYPHYSPPETFP 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 50510701   443 SIILHDRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQ 490
Cdd:pfam07156 317 PFILHDGLYYLNGIEWAASAMEMSAIAAKNVALLAYHRWYGNTDKIDQ 364
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
27-340 2.78e-13

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 71.49  E-value: 2.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701  27 RAPPNRIAIVGAGIGGTSSAYYLRKKfGKDVKidVFE-REEVGGRLATLKVQGHDY--EAGGSVIHPLNLHMKRFVKELG 103
Cdd:COG1231   4 RARGKDVVIVGAGLAGLAAARELRKA-GLDVT--VLEaRDRVGGRVWTLRFGDDGLyaELGAMRIPPSHTNLLALARELG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701 104 LSSVP---ASGGLVGVYNGKSLVFEESSWFVINviklvwrygfqslrmhmwVEDLLDKFMRiyryqshdYAFSSVEKLMH 180
Cdd:COG1231  81 LPLEPfpnENGNALLYLGGKRVRAGEIAADLRG------------------VAELLAKLLR--------ALAAALDPWAH 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701 181 AIGGDDyvrllNQTLRENLKKAGFSETfLNEMIAPVMKVNYGQSTDINAFVGAVSLTAA---DSNLWAVEGGNKIVCSGL 257
Cdd:COG1231 135 PAAELD-----RESLAEWLRRNGASPS-ARRLLGLLGAGEYGADPDELSLLDLLRYAASaggGAQQFRIVGGMDQLPRAL 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701 258 LQASSSNLISGS-VMSIEektrtkQTGNPtkmYEVVYKTGSETHSDFydiVLVAAPLNrKMSNITfrnFDPPieeFNDPY 336
Cdd:COG1231 209 AAELGDRIRLGApVTRIR------QDGDG---VTVTTDDGGTVRADA---VIVTVPPS-VLRRIE---FDPP---LPAAK 269


                ....
gi 50510701 337 QQLV 340
Cdd:COG1231 270 RAAI 273
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
35-102 3.28e-12

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 61.78  E-value: 3.28e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701    35 IVGAGIGGTSSAYYLRKkfgKDVKIDVFE-REEVGGRLATLKVQGHDYEAGGSVIHPLN-LHMKRFVKEL 102
Cdd:pfam13450   1 IVGAGLAGLVAAALLAK---RGFRVLVLEkRDRLGGNAYSYRVPGYVFDYGAHIFHGSDePNVRDLLDEL 67
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 32-104 4.45e-12

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 67.94  E-value: 4.45e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50510701  32 RIAIVGAGIGGTSSAYYLRKkfgKDVKIDVFEREE-VGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGL 104
Cdd:COG1232   3 RVAVIGGGIAGLTAAYRLAK---AGHEVTVLEASDrVGGLIRTVEVDGFRIDRGPHSFLTRDPEVLELLRELGL 73
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 32-124 3.55e-10

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 61.79  E-value: 3.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   32 RIAIVGAGIGGTSSAYYLRKKFGkDVKIDVFEREE-VGGRLATLKVQGHDYEAGGS---VIHPlnlHMKRFVKELGLssv 107
Cdd:PRK11883   2 KVAIIGGGITGLSAAYRLHKKGP-DADITLLEASDrLGGKIQTVRKDGFPIELGPEsflARKP---SAPALVKELGL--- 74

                         90
                 ....*....|....*..
gi 50510701  108 paSGGLVGVYNGKSLVF 124
Cdd:PRK11883  75 --EDELVANTTGQSYIY 89
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 29-110 7.89e-08

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 54.46  E-value: 7.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701    29 PPNRIAIVGAGIGGTSSAYYLRKKF-GKDVKIDVFEREE-VGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSS 106
Cdd:TIGR00562   1 GKKHVVIIGGGISGLCAAYYLEKEIpELPVELTLVEASDrVGGKIQTVKEDGYLIERGPDSFLERKKSAPDLVKDLGLEH 80


                  ....
gi 50510701   107 VPAS 110
Cdd:TIGR00562  81 VLVS 84
 
Name Accession Description Interval E-value
Prenylcys_lyase pfam07156
Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are ...
 124-490 0e+00

Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps.


Pssm-ID: 462104 [Multi-domain]  Cd Length: 364  Bit Score: 637.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   124 FEESSWFVINVIKLVWRYGFQSLRMHMWVEDLLDKFMRIYRYQSHDYAFSSVEKLMHAIGGDDYVRLLNQTLRENLKKAG 203
Cdd:pfam07156   1 FEESSWSWINLAKLLWRYGFSPLRMQMWVEDILDKFMRIYEYQAHGYAFSSVEELLHALGGDGFLNLTNQTLEEALLKAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   204 FSETFLNEMIAPVMKVNYGQSTDINAFVGAVSLTAADSNLWAVEGGNKIVCSGLLQASSSNLISGSVMSIEEktrtKQTG 283
Cdd:pfam07156  81 FSQLFINEIVQAVTRVNYGQSVNINGFVGAVSLAGAQSGLWAVEGGNKLVCSGLLKASKANLINGTVTSIEL----KQSG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   284 NPTKMYEVVYKTGSETHSDFYDIVLVAAPLNRKMSNITFRNFDPPIEEFNDPYQQLVTTFIKGELNSTLFSSRPKDQFGL 363
Cdd:pfam07156 157 GSTSLYEVTYKTESGTHSDLYDIVVIATPLHRKMSNITFDNFSPPIPEFPGPYQHTVATLVHGRLNPSYFGLPDPSLFPL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   364 SAILVTDDSDMFINSLSIVASVRQKEGP-PPAVDGMHVWKTFSRDILTKEQISKLFLSYDYAVRKPWLSYPHYEPPQKCP 442
Cdd:pfam07156 237 ATILTTDNPSLFINSISSVSPVNISDNPrRKPPKEAAVWKIFSPEPLSKEQLKSLFSSYDSVQEKDWLAYPHYSPPETFP 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 50510701   443 SIILHDRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQ 490
Cdd:pfam07156 317 PFILHDGLYYLNGIEWAASAMEMSAIAAKNVALLAYHRWYGNTDKIDQ 364
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
27-340 2.78e-13

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 71.49  E-value: 2.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701  27 RAPPNRIAIVGAGIGGTSSAYYLRKKfGKDVKidVFE-REEVGGRLATLKVQGHDY--EAGGSVIHPLNLHMKRFVKELG 103
Cdd:COG1231   4 RARGKDVVIVGAGLAGLAAARELRKA-GLDVT--VLEaRDRVGGRVWTLRFGDDGLyaELGAMRIPPSHTNLLALARELG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701 104 LSSVP---ASGGLVGVYNGKSLVFEESSWFVINviklvwrygfqslrmhmwVEDLLDKFMRiyryqshdYAFSSVEKLMH 180
Cdd:COG1231  81 LPLEPfpnENGNALLYLGGKRVRAGEIAADLRG------------------VAELLAKLLR--------ALAAALDPWAH 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701 181 AIGGDDyvrllNQTLRENLKKAGFSETfLNEMIAPVMKVNYGQSTDINAFVGAVSLTAA---DSNLWAVEGGNKIVCSGL 257
Cdd:COG1231 135 PAAELD-----RESLAEWLRRNGASPS-ARRLLGLLGAGEYGADPDELSLLDLLRYAASaggGAQQFRIVGGMDQLPRAL 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701 258 LQASSSNLISGS-VMSIEektrtkQTGNPtkmYEVVYKTGSETHSDFydiVLVAAPLNrKMSNITfrnFDPPieeFNDPY 336
Cdd:COG1231 209 AAELGDRIRLGApVTRIR------QDGDG---VTVTTDDGGTVRADA---VIVTVPPS-VLRRIE---FDPP---LPAAK 269


                ....
gi 50510701 337 QQLV 340
Cdd:COG1231 270 RAAI 273
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
35-102 3.28e-12

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 61.78  E-value: 3.28e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701    35 IVGAGIGGTSSAYYLRKkfgKDVKIDVFE-REEVGGRLATLKVQGHDYEAGGSVIHPLN-LHMKRFVKEL 102
Cdd:pfam13450   1 IVGAGLAGLVAAALLAK---RGFRVLVLEkRDRLGGNAYSYRVPGYVFDYGAHIFHGSDePNVRDLLDEL 67
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 32-104 4.45e-12

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 67.94  E-value: 4.45e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50510701  32 RIAIVGAGIGGTSSAYYLRKkfgKDVKIDVFEREE-VGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGL 104
Cdd:COG1232   3 RVAVIGGGIAGLTAAYRLAK---AGHEVTVLEASDrVGGLIRTVEVDGFRIDRGPHSFLTRDPEVLELLRELGL 73
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 32-124 3.55e-10

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 61.79  E-value: 3.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   32 RIAIVGAGIGGTSSAYYLRKKFGkDVKIDVFEREE-VGGRLATLKVQGHDYEAGGS---VIHPlnlHMKRFVKELGLssv 107
Cdd:PRK11883   2 KVAIIGGGITGLSAAYRLHKKGP-DADITLLEASDrLGGKIQTVRKDGFPIELGPEsflARKP---SAPALVKELGL--- 74

                         90
                 ....*....|....*..
gi 50510701  108 paSGGLVGVYNGKSLVF 124
Cdd:PRK11883  75 --EDELVANTTGQSYIY 89
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 40-323 1.46e-09

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 60.20  E-value: 1.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701    40 IGGTSSAYYLrKKFGKDVKidVFE-REEVGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSSVpasgglvgvyn 118
Cdd:pfam01593   1 LAGLAAAREL-LRAGHDVT--VLEaRDRVGGRIRTVRDDGFLIELGAMWFHGAQPPLLALLKELGLEDR----------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   119 gksLVFEESSWFVINVIKLVWRYGFQSLRMHMWVEDLLDKFMRIYRYQSHDYAFssvekLMHAIGGDDYVRLLNQTLRE- 197
Cdd:pfam01593  67 ---LVLPDPAPFYTVLFAGGRRYPGDFRRVPAGWEGLLEFGRLLSIPEKLRLGL-----AALASDALDEFDLDDFSLAEs 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   198 --NLKKAGFSE-TFLNEMIAPVMKVNYGQSTDINAFVGAVSLTAADSN-LWAVEG--GNKIVCSGLLQASSSNL---ISG 268
Cdd:pfam01593 139 llFLGRRGPGDvEVWDRLIDPELFAALPFASGAFAGDPSELSAGLALPlLWALLGegGSLLLPRGGLGALPDALaaqLLG 218

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 50510701   269 SVMSIEEK-TRTKQTGNptkMYEVVYKTGSETHSDFydiVLVAAPLnRKMSNITFR 323
Cdd:pfam01593 219 GDVRLNTRvRSIDREGD---GVTVTLTDGEVIEADA---VIVTVPL-GVLKRILFT 267
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 32-105 1.57e-09

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 59.86  E-value: 1.57e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50510701  32 RIAIVGAGIGGTSSAYYLRKKfGKDVkiDVFER-EEVGGRLATLKVQGHDYEAGGSViHPLNLHMKRFVKELGLS 105
Cdd:COG1233   5 DVVVIGAGIGGLAAAALLARA-GYRV--TVLEKnDTPGGRARTFERPGFRFDVGPSV-LTMPGVLERLFRELGLE 75
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 29-110 7.89e-08

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 54.46  E-value: 7.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701    29 PPNRIAIVGAGIGGTSSAYYLRKKF-GKDVKIDVFEREE-VGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSS 106
Cdd:TIGR00562   1 GKKHVVIIGGGISGLCAAYYLEKEIpELPVELTLVEASDrVGGKIQTVKEDGYLIERGPDSFLERKKSAPDLVKDLGLEH 80


                  ....
gi 50510701   107 VPAS 110
Cdd:TIGR00562  81 VLVS 84
PRK07233 PRK07233
hypothetical protein; Provisional
 32-106 2.46e-06

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 49.89  E-value: 2.46e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50510701   32 RIAIVGAGIGGTSSAYYLRKKfGKDVkiDVFER-EEVGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSS 106
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKR-GHEV--TVFEAdDQLGGLAASFEFGGLPIERFYHHIFKSDEALLELLDELGLED 73
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
32-216 8.53e-06

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 48.19  E-value: 8.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701  32 RIAIVGAGIGGTSSAYYLRKKFgkdvKIDVFEREE-VGGRLATlkvqgHDYEAGGSVIH-------------PlnlHMKR 97
Cdd:COG2907   5 RIAVIGSGISGLTAAWLLSRRH----DVTLFEANDrLGGHTHT-----VDVDLDGRTVPvdtgfivfnertyP---NLTA 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701  98 FVKELGLSSVP---------ASGGLvgVYNGKSL--VFEESSwfviNVIKLvwRYgfqsLRMhmwVEDLLdkfmRIYRyQ 166
Cdd:COG2907  73 LFAELGVPTQPsdmsfsvslDGGGL--EYAGSNLngLFAQRR----NLLRP--RF----WRM---LRDIL----RFNR-E 132

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 50510701 167 SHDYAfssveklmhAIGGDDyvrllNQTLRENLKKAGFSETFLNEMIAPV 216
Cdd:COG2907 133 APALL---------EAGSDD-----DLTLGEFLDRNGYSEAFRDHYLLPM 168
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
29-78 1.65e-05

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 46.80  E-value: 1.65e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 50510701  29 PPNRIAIVGAGIGGTSSAYYLRKkfgKDVKIDVFER-EEVGGRLATLKVQG 78
Cdd:COG3380   2 SMPDIAIIGAGIAGLAAARALQD---AGHEVTVFEKsRGVGGRMATRRLDG 49
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
32-102 1.69e-05

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 46.82  E-value: 1.69e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50510701  32 RIAIVGAGIGGTSSAYYLRKKfGKDVKidVFEREEVG----GRLATLkVQGHDYEAGGSVIHPLNLHMKRFVKEL 102
Cdd:COG0665   4 DVVVIGGGIAGLSTAYHLARR-GLDVT--VLERGRPGsgasGRNAGQ-LRPGLAALADRALVRLAREALDLWREL 74
PLN02576 PLN02576
protoporphyrinogen oxidase
 28-81 2.41e-05

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 46.93  E-value: 2.41e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 50510701   28 APPNRIAIVGAGIGGTSSAYYLRKKFGkdVKIDVFE-REEVGGRLATlkVQGHDY 81
Cdd:PLN02576  10 ASSKDVAVVGAGVSGLAAAYALASKHG--VNVLVTEaRDRVGGNITS--VSEDGF 60
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 25-69 1.24e-04

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 44.36  E-value: 1.24e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 50510701  25 EPRAPPN--RIAIVGAGIGGTSSAYYLRKKfGkdVKIDVFER-EEVGG 69
Cdd:COG0493 114 PPPAPRTgkKVAVVGSGPAGLAAAYQLARA-G--HEVTVFEAlDKPGG 158
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 32-102 2.45e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 43.16  E-value: 2.45e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50510701    32 RIAIVGAGIGGTSSAYYLRKKfGKDVkiDVFEREEVGGRLATLK----VQGHDYEAGGSVIHPLNLHMKRFVKEL 102
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARR-GLSV--TLLERGDDPGSGASGRnaglIHPGLRYLEPSELARLALEALDLWEEL 72
PRK06753 PRK06753
hypothetical protein; Provisional
 31-94 4.07e-04

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 42.75  E-value: 4.07e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50510701   31 NRIAIVGAGIGGTSSAYYLRKKfGKDVKidVFEREEvggrlaTLKVQGHDYEAGGSVIHPLNLH 94
Cdd:PRK06753   1 MKIAIIGAGIGGLTAAALLQEQ-GHEVK--VFEKNE------SVKEVGAGIGIGDNVIKKLGNH 55
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 25-69 4.28e-04

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 42.94  E-value: 4.28e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 50510701   25 EPRAPPN--RIAIVGAGIGGTSSAYYLRKKfGKDVKIdvFE-REEVGG 69
Cdd:PRK12771 130 PAPAPDTgkRVAVIGGGPAGLSAAYHLRRM-GHAVTI--FEaGPKLGG 174
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 26-69 5.94e-04

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 42.09  E-value: 5.94e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 50510701   26 PRAPPN--RIAIVGAGIGGTSSAYYLRKKfGKDVkiDVFE-REEVGG 69
Cdd:PRK11749 134 KRAPKTgkKVAVIGAGPAGLTAAHRLARK-GYDV--TIFEaRDKAGG 177
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
29-70 9.20e-04

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 41.86  E-value: 9.20e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 50510701  29 PPNRIAIVGAGIGGTSSAYYLRKKFGKDVKIDVFEREEVGGR 70
Cdd:COG4529   4 ARKRIAIIGGGASGTALAIHLLRRAPEPLRITLFEPRPELGR 45
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 32-69 1.10e-03

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 41.39  E-value: 1.10e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 50510701  32 RIAIVGAGIGGTSSAYYLRKKfGKDVkiDVFER-EEVGG 69
Cdd:COG2072   8 DVVVIGAGQAGLAAAYHLRRA-GIDF--VVLEKaDDVGG 43
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
33-81 1.35e-03

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 40.87  E-value: 1.35e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 50510701  33 IAIVGAGIGGTSSAYYLRKkFGKDVKidVFEREEVGGRLATLKvQGHDY 81
Cdd:COG0492   3 VVIIGAGPAGLTAAIYAAR-AGLKTL--VIEGGEPGGQLATTK-EIENY 47
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
32-59 1.39e-03

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 40.89  E-value: 1.39e-03
                        10        20
                ....*....|....*....|....*...
gi 50510701  32 RIAIVGAGIGGTSSAYYLRKKFGKDVKI 59
Cdd:COG1252   3 RIVIVGGGFAGLEAARRLRKKLGGDAEV 30
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 29-92 1.44e-03

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 41.52  E-value: 1.44e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50510701   29 PPNrIAIVGAGIGGTSSAyylRKKFGKDVKIDVFE-REEVGGRLATLKVQGHDYEA----GGSVIHPLN 92
Cdd:PLN02328 238 PAN-VVVVGAGLAGLVAA---RQLLSMGFKVVVLEgRARPGGRVKTMKMKGDGVVAaadlGGSVLTGIN 302
PRK12416 PRK12416
protoporphyrinogen oxidase; Provisional
 33-126 1.58e-03

protoporphyrinogen oxidase; Provisional


Pssm-ID: 183516  Cd Length: 463  Bit Score: 40.97  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50510701   33 IAIVGAGIGGTSSAYYLrKKFGKDVKID----VFEREEV-GGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSSV 107
Cdd:PRK12416   4 VVVIGGGITGLSTMFYL-EKLKKDYNIDlnliLVEKEEYlGGKIHSVEEKDFIMESGADSIVARNEHVMPLVKDLNLEEE 82

                         90       100
                 ....*....|....*....|.
gi 50510701  108 PasgglvgVYN--GKSLVFEE 126
Cdd:PRK12416  83 M-------VYNetGISYIYSD 96
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 22-69 2.38e-03

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 40.48  E-value: 2.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 50510701   22 ASAEPRAPP------NRIAIVGAGIGGTSSAYYLRKKfGKDVKIdvFEREEVGG 69
Cdd:PRK12814 179 ESAERYIPErapksgKKVAIIGAGPAGLTAAYYLLRK-GHDVTI--FDANEQAG 229
PLN02568 PLN02568
polyamine oxidase
 32-89 2.75e-03

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 40.20  E-value: 2.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50510701   32 RIAIVGAGIGGTSSAY--YLRKKFGKDVKIDVFER-EEVGGRLATLKVQGHDYEAGGSVIH 89
Cdd:PLN02568   7 RIVIIGAGMAGLTAANklYTSSAANDMFELTVVEGgDRIGGRINTSEFGGERIEMGATWIH 67
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
34-72 6.01e-03

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 37.64  E-value: 6.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 50510701    34 AIVGAGIGGTSSAYYL-RKKFGKDVKIDVFEREEVGGRLA 72
Cdd:pfam13454   1 AIVGGGPSGLALLERLlARAPKRPLEITLFDPSPPGAGGV 40
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 32-103 9.98e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 38.07  E-value: 9.98e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50510701    32 RIAIVGAGIGGTSSAYYLRKkfgKDVKIDVFEREE--VGGRLATLKVQGHDYEAGGSVIHPLNL--HMKRFVKELG 103
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQ---LGGKVTLIEDEGtcPYGGCVLSKALLGAAEAPEIASLWADLykRKEEVVKKLN 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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