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Conserved domains on  [gi|505033343|ref|WP_015220445|]
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type II toxin-antitoxin system YhaV family toxin [Cyanobacterium aponinum]

Protein Classification

type II toxin-antitoxin system YhaV family toxin( domain architecture ID 10569416)

type II toxin-antitoxin (TA) system YhaV family toxin similar to Escherichia coli YhaV, which acts as a transcription factor and is the toxin component of the YhaV/PrlF TA system; YhaV causes reversible bacteriostasis that is counteracted by PrlF

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Toxin_YhaV pfam11663
Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible ...
 11-145 4.53e-65

Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity.


:

Pssm-ID: 431989  Cd Length: 138  Bit Score: 194.79  E-value: 4.53e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505033343   11 IYFHPLFYQQWLELVNRVKYLKQRSaPENFVTHPDVKLLKALDQGIKDKIPKDPFASYFALKKPLQ-KYSRLKKMGLPSR 89
Cdd:pfam11663   1 LFAHPLFLEQLEELIAAVERLKAKD-PEDYVKHPAVKLLAAINKLIFDKIPQDPTASEYRQGGTLGpKYKHWFRAKFGQR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 505033343   90 YRLFFRVFKEANTIIILWLG---FPRKERDKKDCYKVFSKMVINGNFPEDIASFLDLAN 145
Cdd:pfam11663  80 YRLFFRYFSESKIIVYAWVNdenTLRKYGSKTDAYAVFTKMLERGNPPDDWDALLKEAK 138
 
Name Accession Description Interval E-value
Toxin_YhaV pfam11663
Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible ...
 11-145 4.53e-65

Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity.


Pssm-ID: 431989  Cd Length: 138  Bit Score: 194.79  E-value: 4.53e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505033343   11 IYFHPLFYQQWLELVNRVKYLKQRSaPENFVTHPDVKLLKALDQGIKDKIPKDPFASYFALKKPLQ-KYSRLKKMGLPSR 89
Cdd:pfam11663   1 LFAHPLFLEQLEELIAAVERLKAKD-PEDYVKHPAVKLLAAINKLIFDKIPQDPTASEYRQGGTLGpKYKHWFRAKFGQR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 505033343   90 YRLFFRVFKEANTIIILWLG---FPRKERDKKDCYKVFSKMVINGNFPEDIASFLDLAN 145
Cdd:pfam11663  80 YRLFFRYFSESKIIVYAWVNdenTLRKYGSKTDAYAVFTKMLERGNPPDDWDALLKEAK 138
 
Name Accession Description Interval E-value
Toxin_YhaV pfam11663
Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible ...
 11-145 4.53e-65

Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity.


Pssm-ID: 431989  Cd Length: 138  Bit Score: 194.79  E-value: 4.53e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505033343   11 IYFHPLFYQQWLELVNRVKYLKQRSaPENFVTHPDVKLLKALDQGIKDKIPKDPFASYFALKKPLQ-KYSRLKKMGLPSR 89
Cdd:pfam11663   1 LFAHPLFLEQLEELIAAVERLKAKD-PEDYVKHPAVKLLAAINKLIFDKIPQDPTASEYRQGGTLGpKYKHWFRAKFGQR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 505033343   90 YRLFFRVFKEANTIIILWLG---FPRKERDKKDCYKVFSKMVINGNFPEDIASFLDLAN 145
Cdd:pfam11663  80 YRLFFRYFSESKIIVYAWVNdenTLRKYGSKTDAYAVFTKMLERGNPPDDWDALLKEAK 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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