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Conserved domains on  [gi|504446805|ref|WP_014633907|]
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MULTISPECIES: tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE [Streptococcus]

Protein Classification

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE( domain architecture ID 10002738)

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB

Gene Symbol:  tsaE
Gene Ontology:  GO:0002949|GO:0005524
PubMed:  36362385

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 6-144 5.22e-52

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440565  Cd Length: 146  Bit Score: 161.80  E-value: 5.22e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504446805   6 NEEELISIGQKLGRLLDSGDIIVLSGDLGAGKTTLTKGIAKGLDISQMIKSPTYTIVREYE-GRLPLYHLDVYRIGDDPD 84
Cdd:COG0802    3 SEEETEALGARLAALLKPGDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYElGRLPLYHFDLYRLEDPEE 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504446805  85 SIDL--DDFLYGEGVTIIEWGELLDESLLGDYLLISISHHGD-GRQLLFESFGPRSKEIQEEM 144
Cdd:COG0802   83 LEDLglEEYLDGDGVCLIEWPERIEGLLPEDDLEITIEYLGEdGRRITLTAHGPRGERLLEAL 145
 
Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 6-144 5.22e-52

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440565  Cd Length: 146  Bit Score: 161.80  E-value: 5.22e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504446805   6 NEEELISIGQKLGRLLDSGDIIVLSGDLGAGKTTLTKGIAKGLDISQMIKSPTYTIVREYE-GRLPLYHLDVYRIGDDPD 84
Cdd:COG0802    3 SEEETEALGARLAALLKPGDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYElGRLPLYHFDLYRLEDPEE 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504446805  85 SIDL--DDFLYGEGVTIIEWGELLDESLLGDYLLISISHHGD-GRQLLFESFGPRSKEIQEEM 144
Cdd:COG0802   83 LEDLglEEYLDGDGVCLIEWPERIEGLLPEDDLEITIEYLGEdGRRITLTAHGPRGERLLEAL 145
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
 4-126 2.44e-48

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 151.82  E-value: 2.44e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504446805    4 SQNEEELISIGQKLGRLLDSGDIIVLSGDLGAGKTTLTKGIAKGLDISQMIKSPTYTIVREYE-GRLPLYHLDVYRIGDD 82
Cdd:pfam02367   1 LNSEEETEALGKRLAALLKPGDVILLSGDLGAGKTTFTRGLARGLGVTGPVTSPTFTLVNEYEgGGLPLYHFDLYRLEDP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 504446805   83 PDSID--LDDFLYGEGVTIIEWGELLDESLLGDYLLISISHHGDGR 126
Cdd:pfam02367  81 EELEDlgLEDYFDGDGVCLIEWPERIEELLPEDDLDIEIEREGEEG 126
T6A_YjeE TIGR00150
tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a ...
 7-130 1.23e-33

tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a four-gene system responsible for the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have (weak) ATPase activity. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129254  Cd Length: 133  Bit Score: 114.85  E-value: 1.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504446805    7 EEELISIGQKLGRLLDSGDIIVLSGDLGAGKTTLTKGIAKGLDISQMIKSPTYTIVREY-EGRLPLYHLDVYRIGDDP-- 83
Cdd:TIGR00150   5 EKAMDKFGKAFAKPLDFGTVVLLKGDLGAGKTTLVQGLLQGLGIQGNVTSPTFTLVNEYnEGNLMVYHFDLYRLADPEel 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 504446805   84 DSIDLDDFLYGEGVTIIEWGELLDESLLGDYLLISISHHGDGRQLLF 130
Cdd:TIGR00150  85 ELMGLEDYFEGDGICLVEWPEEGLEILPDYDLQIKIDYVGDGREIEL 131
PRK10646 PRK10646
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;
6-79 7.27e-15

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;


Pssm-ID: 182615  Cd Length: 153  Bit Score: 67.10  E-value: 7.27e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504446805   6 NEEELISIGQKLGRLLDSGDIIVLSGDLGAGKTTLTKGIAKGLDISQMIKSPTYTIVREYE-GRLPLYHLDVYRI 79
Cdd:PRK10646  10 DEQATLDLGARVAKACDGATVIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTlDNLMVYHFDLYRL 84
 
Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 6-144 5.22e-52

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440565  Cd Length: 146  Bit Score: 161.80  E-value: 5.22e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504446805   6 NEEELISIGQKLGRLLDSGDIIVLSGDLGAGKTTLTKGIAKGLDISQMIKSPTYTIVREYE-GRLPLYHLDVYRIGDDPD 84
Cdd:COG0802    3 SEEETEALGARLAALLKPGDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYElGRLPLYHFDLYRLEDPEE 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504446805  85 SIDL--DDFLYGEGVTIIEWGELLDESLLGDYLLISISHHGD-GRQLLFESFGPRSKEIQEEM 144
Cdd:COG0802   83 LEDLglEEYLDGDGVCLIEWPERIEGLLPEDDLEITIEYLGEdGRRITLTAHGPRGERLLEAL 145
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
 4-126 2.44e-48

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 151.82  E-value: 2.44e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504446805    4 SQNEEELISIGQKLGRLLDSGDIIVLSGDLGAGKTTLTKGIAKGLDISQMIKSPTYTIVREYE-GRLPLYHLDVYRIGDD 82
Cdd:pfam02367   1 LNSEEETEALGKRLAALLKPGDVILLSGDLGAGKTTFTRGLARGLGVTGPVTSPTFTLVNEYEgGGLPLYHFDLYRLEDP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 504446805   83 PDSID--LDDFLYGEGVTIIEWGELLDESLLGDYLLISISHHGDGR 126
Cdd:pfam02367  81 EELEDlgLEDYFDGDGVCLIEWPERIEELLPEDDLDIEIEREGEEG 126
T6A_YjeE TIGR00150
tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a ...
 7-130 1.23e-33

tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a four-gene system responsible for the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have (weak) ATPase activity. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129254  Cd Length: 133  Bit Score: 114.85  E-value: 1.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504446805    7 EEELISIGQKLGRLLDSGDIIVLSGDLGAGKTTLTKGIAKGLDISQMIKSPTYTIVREY-EGRLPLYHLDVYRIGDDP-- 83
Cdd:TIGR00150   5 EKAMDKFGKAFAKPLDFGTVVLLKGDLGAGKTTLVQGLLQGLGIQGNVTSPTFTLVNEYnEGNLMVYHFDLYRLADPEel 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 504446805   84 DSIDLDDFLYGEGVTIIEWGELLDESLLGDYLLISISHHGDGRQLLF 130
Cdd:TIGR00150  85 ELMGLEDYFEGDGICLVEWPEEGLEILPDYDLQIKIDYVGDGREIEL 131
PRK10646 PRK10646
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;
6-79 7.27e-15

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;


Pssm-ID: 182615  Cd Length: 153  Bit Score: 67.10  E-value: 7.27e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504446805   6 NEEELISIGQKLGRLLDSGDIIVLSGDLGAGKTTLTKGIAKGLDISQMIKSPTYTIVREYE-GRLPLYHLDVYRI 79
Cdd:PRK10646  10 DEQATLDLGARVAKACDGATVIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTlDNLMVYHFDLYRL 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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