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Conserved domains on  [gi|504383313|ref|WP_014570415|]
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MULTISPECIES: transporter [Lactococcus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ABC-2_lan_permease_NisG-like cd21810
lantibiotic immunity ABC transporter NisG family permease (also called ABC-2 transporter NisG ...
 2-209 2.25e-69

lantibiotic immunity ABC transporter NisG family permease (also called ABC-2 transporter NisG family permease) subunit, and similar proteins; This subfamily contains lantibiotic ABC transporter permease subunits NisG and NsuG, which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to the lantibiotic nisin. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. In Lactococcus lactis and Streptococcus uberis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG. In Streptococcus uberis, similar proteins provide self-protection against the pore-forming lantibiotic nisin U. This subfamily contains the NisG and NsuG permease subunits that transport nisin to the surface and expel it from the membrane.


:

Pssm-ID: 409635  Cd Length: 211  Bit Score: 210.94  E-value: 2.25e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313   2 IRSECLKLKNSLGFYLVFLFTLLELLTVPIYLAFGRSHVSMTDLSLMIFLFFPLLVTILSILIFEQESLANRFQEINVNK 81
Cdd:cd21810    1 LKSELLKLKNSYALYLILGFSLLELLTIPIYLAFVNNSVSLENIIFLPMLGYCLLTSILSILLFEQEEKANHFQNIRSEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313  82 KSSRIWLSKLIVVDFLLFFPSAMIWIITGVSQAVGQQGMMIATASWLMAIFLNHFHLLLTFIINRGGSMIIAIIEILLII 161
Cdd:cd21810   81 NSSRIWLAKLIVVDLLLFLPTVFLWLVIGVELNNLSYGLYVGLASWLLLIFLNHFHMLLSLILGKGGNLIIAFVECLFII 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 504383313 162 FASNKVLLAAYWCPIALPVNFMITG---RCAYLIAAVGWIVLSTIILVALS 209
Cdd:cd21810  161 FASNKVFLNAYWCPIALPVNFILTIgkrDLNYLLALIGWIVLLTIINLVLL 211
 
Name Accession Description Interval E-value
ABC-2_lan_permease_NisG-like cd21810
lantibiotic immunity ABC transporter NisG family permease (also called ABC-2 transporter NisG ...
 2-209 2.25e-69

lantibiotic immunity ABC transporter NisG family permease (also called ABC-2 transporter NisG family permease) subunit, and similar proteins; This subfamily contains lantibiotic ABC transporter permease subunits NisG and NsuG, which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to the lantibiotic nisin. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. In Lactococcus lactis and Streptococcus uberis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG. In Streptococcus uberis, similar proteins provide self-protection against the pore-forming lantibiotic nisin U. This subfamily contains the NisG and NsuG permease subunits that transport nisin to the surface and expel it from the membrane.


Pssm-ID: 409635  Cd Length: 211  Bit Score: 210.94  E-value: 2.25e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313   2 IRSECLKLKNSLGFYLVFLFTLLELLTVPIYLAFGRSHVSMTDLSLMIFLFFPLLVTILSILIFEQESLANRFQEINVNK 81
Cdd:cd21810    1 LKSELLKLKNSYALYLILGFSLLELLTIPIYLAFVNNSVSLENIIFLPMLGYCLLTSILSILLFEQEEKANHFQNIRSEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313  82 KSSRIWLSKLIVVDFLLFFPSAMIWIITGVSQAVGQQGMMIATASWLMAIFLNHFHLLLTFIINRGGSMIIAIIEILLII 161
Cdd:cd21810   81 NSSRIWLAKLIVVDLLLFLPTVFLWLVIGVELNNLSYGLYVGLASWLLLIFLNHFHMLLSLILGKGGNLIIAFVECLFII 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 504383313 162 FASNKVLLAAYWCPIALPVNFMITG---RCAYLIAAVGWIVLSTIILVALS 209
Cdd:cd21810  161 FASNKVFLNAYWCPIALPVNFILTIgkrDLNYLLALIGWIVLLTIINLVLL 211
EfiE COG4200
Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];
2-208 4.07e-03

Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];


Pssm-ID: 443354 [Multi-domain]  Cd Length: 250  Bit Score: 37.24  E-value: 4.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313   2 IRSECLKLKNSLGFY-------LVFLFTLLELLTVPIYLAFGRSHVSMTDL-----SLMIFLFFPLLVTILSILIFEQES 69
Cdd:COG4200    6 LRAELLKLKRSLIWLlvlllplLSALLGLFNYLLNYEILQPYNDGDGWLSLwtqsfLFWSFFFLPLLIALLASLLARLEH 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313  70 LANRFQEINVNKKS-SRIWLSKLIVVDFLLFFPSAMIWIITGVSQAVGQQGMMI--------ATASWLMAIFLNHFHLLL 140
Cdd:COG4200   86 KNGNWKQLLTLPVSrAKLYLAKLLVVALLLLLSQLLFFVLYLLSGLLLGLSGSIpwgellkwLLLGWLASLPLIALQLWL 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504383313 141 TFII-NRGGSMIIAIIEILLIIFASNKVLLAAYWCPIALPVNFMITGRCAYLIAAVGWIVLSTIILVAL 208
Cdd:COG4200  166 SLRFrSFAAPVGIGIVGTIAGLLASVTGSGLGYYYPWSLPVLGMRSNGLGDLSSVSLVLFLLVSLLYFV 234
 
Name Accession Description Interval E-value
ABC-2_lan_permease_NisG-like cd21810
lantibiotic immunity ABC transporter NisG family permease (also called ABC-2 transporter NisG ...
 2-209 2.25e-69

lantibiotic immunity ABC transporter NisG family permease (also called ABC-2 transporter NisG family permease) subunit, and similar proteins; This subfamily contains lantibiotic ABC transporter permease subunits NisG and NsuG, which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to the lantibiotic nisin. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. In Lactococcus lactis and Streptococcus uberis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG. In Streptococcus uberis, similar proteins provide self-protection against the pore-forming lantibiotic nisin U. This subfamily contains the NisG and NsuG permease subunits that transport nisin to the surface and expel it from the membrane.


Pssm-ID: 409635  Cd Length: 211  Bit Score: 210.94  E-value: 2.25e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313   2 IRSECLKLKNSLGFYLVFLFTLLELLTVPIYLAFGRSHVSMTDLSLMIFLFFPLLVTILSILIFEQESLANRFQEINVNK 81
Cdd:cd21810    1 LKSELLKLKNSYALYLILGFSLLELLTIPIYLAFVNNSVSLENIIFLPMLGYCLLTSILSILLFEQEEKANHFQNIRSEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313  82 KSSRIWLSKLIVVDFLLFFPSAMIWIITGVSQAVGQQGMMIATASWLMAIFLNHFHLLLTFIINRGGSMIIAIIEILLII 161
Cdd:cd21810   81 NSSRIWLAKLIVVDLLLFLPTVFLWLVIGVELNNLSYGLYVGLASWLLLIFLNHFHMLLSLILGKGGNLIIAFVECLFII 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 504383313 162 FASNKVLLAAYWCPIALPVNFMITG---RCAYLIAAVGWIVLSTIILVALS 209
Cdd:cd21810  161 FASNKVFLNAYWCPIALPVNFILTIgkrDLNYLLALIGWIVLLTIINLVLL 211
ABC-2_lan_permease cd21503
lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit; ...
 4-208 6.01e-18

lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit; This family contains lantibiotic ABC transporter permease subunits which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to type-A lantibiotics. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Lactococcus lactis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG subunits. This family includes the Lactococcus lactis NisG permease subunit that transports nisin to the surface and expels it from the membrane. This family also includes the lantibiotic ABC transporter permease subunits EpiE, MutE, MutG, and SlvE. Self-protection of the epidermin-producing strain Staphylococcus epidermidis Tu3298 against the pore-forming lantibiotic epidermin is mediated by an ABC transporter composed of the EpiF, EpiE, and EpiG proteins. In the mutacin I-producing strain Streptococcus mutans CH43, self-immunity against mutacin I is mediated by proteins MutF, MutE, and MutG, while in salivaricin D-producing strain Streptococcus salivarius 5M6c, mediation is via ABC transporter proteins SlvF, SlvE, and SlvG.


Pssm-ID: 409631  Cd Length: 221  Bit Score: 78.88  E-value: 6.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313   4 SECLKLKNSLGFYLVFLFTLLELLTVPIYLAFGRS--HVSMTDLSLMIFLFFPLLVTILSILIFEQESLANRFQEINVNK 81
Cdd:cd21503    1 SEWLKTKRTPFRVLLILFPILFALILSLYIGFTNSlkGVSIFSFFTIYNILLPFLISLLIPLLYEQEEQAGNFQNILRSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313  82 KSS-RIWLSKLI-------VVDFLLFFPSAMIWIITGVSQAV--GQQGMMIATASWLMAIFLNHFHLLLTFIINRGGsMI 151
Cdd:cd21503   81 HSRkKIFLSKFLfitllllLVILLLSLPFILIWLITGIGNITiiLFLLTLIGTITSLPIIPLYQFLSLKYNTGGSIG-IG 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504383313 152 IAIIEILLIIFASNKVLLAAYWCPIALPVNFMIT-----GRCAYLIAAVGWIVLSTIILVAL 208
Cdd:cd21503  160 IFFTLAAILFGTTNLGEGIWYLIPFTWPIKLTFIlfstnVQGNNSLLLLGLFILSSVLLLAV 221
EfiE COG4200
Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];
2-208 4.07e-03

Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];


Pssm-ID: 443354 [Multi-domain]  Cd Length: 250  Bit Score: 37.24  E-value: 4.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313   2 IRSECLKLKNSLGFY-------LVFLFTLLELLTVPIYLAFGRSHVSMTDL-----SLMIFLFFPLLVTILSILIFEQES 69
Cdd:COG4200    6 LRAELLKLKRSLIWLlvlllplLSALLGLFNYLLNYEILQPYNDGDGWLSLwtqsfLFWSFFFLPLLIALLASLLARLEH 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504383313  70 LANRFQEINVNKKS-SRIWLSKLIVVDFLLFFPSAMIWIITGVSQAVGQQGMMI--------ATASWLMAIFLNHFHLLL 140
Cdd:COG4200   86 KNGNWKQLLTLPVSrAKLYLAKLLVVALLLLLSQLLFFVLYLLSGLLLGLSGSIpwgellkwLLLGWLASLPLIALQLWL 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504383313 141 TFII-NRGGSMIIAIIEILLIIFASNKVLLAAYWCPIALPVNFMITGRCAYLIAAVGWIVLSTIILVAL 208
Cdd:COG4200  166 SLRFrSFAAPVGIGIVGTIAGLLASVTGSGLGYYYPWSLPVLGMRSNGLGDLSSVSLVLFLLVSLLYFV 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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