NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|504376216|ref|WP_014563318|]
View 

amino acid ABC transporter permease [Lactobacillus helveticus]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 13-219 1.25e-56

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 179.12  E-value: 1.25e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  13 SNFDRLLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPrSLHINWPGT 92
Cdd:COG0765   10 DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLP-LLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  93 WMAVLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLISV 172
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGV 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 504376216 173 MDVINVGQQIIEANNQkfptgVFWVYGLIFFFYFILDYPLSVWAKSL 219
Cdd:COG0765  169 PELTRAAQQIASRTFR-----PFEVYLVAALIYLVLTLPLSLLARRL 210
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 13-219 1.25e-56

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 179.12  E-value: 1.25e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  13 SNFDRLLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPrSLHINWPGT 92
Cdd:COG0765   10 DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLP-LLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  93 WMAVLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLISV 172
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGV 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 504376216 173 MDVINVGQQIIEANNQkfptgVFWVYGLIFFFYFILDYPLSVWAKSL 219
Cdd:COG0765  169 PELTRAAQQIASRTFR-----PFEVYLVAALIYLVLTLPLSLLARRL 210
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 18-186 6.71e-23

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 92.04  E-value: 6.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  18 LLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRSL-HINWPGTWMAV 96
Cdd:PRK09494  15 LLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFnDLRIDPFTAAV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  97 LAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLISVMDVI 176
Cdd:PRK09494  95 VTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELT 174

                        170
                 ....*....|
gi 504376216 177 NVGQQIIEAN 186
Cdd:PRK09494 175 RQGQEIIAGN 184
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 18-214 2.14e-19

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 82.59  E-value: 2.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216   18 LLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRsLHINWPGTWMAVL 97
Cdd:TIGR03004   7 LLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPL-IGLSLDPVTTGVM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216   98 AFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLISVMDVIN 177
Cdd:TIGR03004  86 VLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTF 165

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 504376216  178 VGQQIieaNNQKFPTGVfwVYGLIFFFYFILDYPLSV 214
Cdd:TIGR03004 166 AAQSI---RNLTLDTLS--IFAITLLCYFVMALIIML 197
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 22-207 7.04e-15

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.00  E-value: 7.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  22 LWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRSLHINWPG--TWMAVLAF 99
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPglGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216 100 SLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLISVMDVINVG 179
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180
                 ....*....|....*....|....*...
gi 504376216 180 QQIIEANNQKFPTGVFWVYGLIFFFYFI 207
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 36-219 2.53e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 43.44  E-value: 2.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216   36 GLLIGTVFGVlrtMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRSlhINWPGTWMAVLAFSLWVAAEFSDIVRGAL 115
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILS--ILGHGILPAIILALLGWAGYARLIRRAAL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  116 QSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSIlmLISVMDVINVGQQIIEANNQKFPTGVF 195
Cdd:pfam00528  76 RSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVL--LEFLGSWPGLGLLLIEAILGYDYPEIQ 153

                         170       180
                  ....*....|....*....|....
gi 504376216  196 WVYGLIFFFYFILDYPLSVWAKSL 219
Cdd:pfam00528 154 GPVLAAALILLLLNLLVDILQRLL 177
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 13-219 1.25e-56

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 179.12  E-value: 1.25e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  13 SNFDRLLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPrSLHINWPGT 92
Cdd:COG0765   10 DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLP-LLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  93 WMAVLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLISV 172
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGV 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 504376216 173 MDVINVGQQIIEANNQkfptgVFWVYGLIFFFYFILDYPLSVWAKSL 219
Cdd:COG0765  169 PELTRAAQQIASRTFR-----PFEVYLVAALIYLVLTLPLSLLARRL 210
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 18-186 6.71e-23

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 92.04  E-value: 6.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  18 LLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRSL-HINWPGTWMAV 96
Cdd:PRK09494  15 LLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFnDLRIDPFTAAV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  97 LAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLISVMDVI 176
Cdd:PRK09494  95 VTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELT 174

                        170
                 ....*....|
gi 504376216 177 NVGQQIIEAN 186
Cdd:PRK09494 175 RQGQEIIAGN 184
artM PRK11122
arginine ABC transporter permease ArtM;
18-203 3.26e-20

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 85.01  E-value: 3.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  18 LLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYY---ILPRSLHINWPGTWM 94
Cdd:PRK11122   8 LLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYgpgQFPWLQEYPWLWHLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  95 ------AVLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLfLYVLLPQAFKLELPATINLATRVIKTTSILM 168
Cdd:PRK11122  88 sqpwlcAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQT-LRILLPYAFKRALSSYSNEVVLVFKSTSLAY 166

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 504376216 169 LISVMDVINVGQQIieaNNQKFPTGVFWVYGLIFF 203
Cdd:PRK11122 167 TITLMDVMGYSQLL---YGRTYDVMVFGAAGIIYL 198
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 18-214 2.14e-19

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 82.59  E-value: 2.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216   18 LLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRsLHINWPGTWMAVL 97
Cdd:TIGR03004   7 LLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPL-IGLSLDPVTTGVM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216   98 AFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLISVMDVIN 177
Cdd:TIGR03004  86 VLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTF 165

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 504376216  178 VGQQIieaNNQKFPTGVfwVYGLIFFFYFILDYPLSV 214
Cdd:TIGR03004 166 AAQSI---RNLTLDTLS--IFAITLLCYFVMALIIML 197
PRK15100 PRK15100
cystine ABC transporter permease;
18-182 1.68e-18

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 80.56  E-value: 1.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  18 LLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRsLHINWPGTWMAVL 97
Cdd:PRK15100  15 LLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQ-FGIELDPIPAAMI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  98 AFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLISVMDVIN 177
Cdd:PRK15100  94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFR 173


                 ....*
gi 504376216 178 VGQQI 182
Cdd:PRK15100 174 QAQLI 178
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 14-113 7.07e-17

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 72.95  E-value: 7.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216   14 NFDRLLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRsLHINWPGTW 93
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPL-IGIRLSPLT 79

                          90       100
                  ....*....|....*....|
gi 504376216   94 MAVLAFSLWVAAEFSDIVRG 113
Cdd:TIGR01726  80 AAVIALTLFYGAYLAEIFRG 99
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
23-190 3.91e-16

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 74.33  E-value: 3.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  23 WTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYY--------------------ILP 82
Cdd:PRK11123  12 GMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFgssqllltlsdgftlnlgfvQIP 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  83 RSLHINW---PGTWMAVLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATR 159
Cdd:PRK11123  92 VQMDIENfevSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLV 171

                        170       180       190
                 ....*....|....*....|....*....|.
gi 504376216 160 VIKTTSILMLISVMDVINVGQQIIEANNQKF 190
Cdd:PRK11123 172 LLKDTALVSLISVNDLMLQTKSIATRTQEPF 202
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
18-186 3.07e-15

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 71.78  E-value: 3.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  18 LLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRSLHINW---PGTWM 94
Cdd:PRK15107  16 LLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLglsPKTDI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  95 ----AVLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLI 170
Cdd:PRK15107  96 rlisAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVL 175

                        170
                 ....*....|....*.
gi 504376216 171 SVMDVINVGQQIIEAN 186
Cdd:PRK15107 176 SLADFFRTASTIGERD 191
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 22-207 7.04e-15

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.00  E-value: 7.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  22 LWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRSLHINWPG--TWMAVLAF 99
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPglGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216 100 SLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILMLISVMDVINVG 179
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180
                 ....*....|....*....|....*...
gi 504376216 180 QQIIEANNQKFPTGVFWVYGLIFFFYFI 207
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
PRK15069 PRK15069
histidine ABC transporter permease HisM;
19-216 2.14e-12

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 63.92  E-value: 2.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  19 LVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLyLVYYILPRSLHINWPGTWM---- 94
Cdd:PRK15069  20 FTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQL-LVFYTGMYSLEIVRGTDLLdaff 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  95 ------AVLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSILM 168
Cdd:PRK15069  99 rsglncTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAF 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 504376216 169 LISVMDVINVGQQIIEANNQKFPTgvfwvYGLIFFFYFILDYPLsVWA 216
Cdd:PRK15069 179 TATVPDILKIARDINSATYQPFQA-----FGIAAVLYLIISFVL-ISL 220
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 13-178 1.27e-08

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 54.00  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  13 SNFDRLLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFR-----------------ILPS----- 70
Cdd:COG4597   83 TYGRAFLVGLLNTLLVAVLGIVLATILGFLVGIARLSSNWLVSKLATVYVEIFRniplllqiffwyfavleALPSprqsl 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  71 ------------------------------------------------------------------VVLLYLVYYILPRS 84
Cdd:COG4597  163 slfdgvflnnrglylpapvfepgfgwvlaallaaivaafvlrrwarrrqeatgqrfpvwwislallVGLPLLAFLLLGAP 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  85 LHINWP---------GT-----WMA-VLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLE 149
Cdd:COG4597  243 LSLDYPelkgfnfrgGLtlspeFVAlLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVI 322

                        250       260
                 ....*....|....*....|....*....
gi 504376216 150 LPATINLATRVIKTTSILMLISVMDVINV 178
Cdd:COG4597  323 IPPLTSQYLNLTKNSSLAVAIGYPDLVSV 351
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
18-215 2.49e-08

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 52.49  E-value: 2.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  18 LLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRSLH----------I 87
Cdd:PRK15135   9 ILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNsvtealgvgqI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  88 NWPGTWMAVLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSIL 167
Cdd:PRK15135  89 DIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALV 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 504376216 168 MLISVMDVINVGQQIIEANNQKFPTGVfwVYGLIFFFYFILDYPLSVW 215
Cdd:PRK15135 169 SLLGLEDVVKATQLAGKSTWEPFYFAI--VCGVIYLVFTTVSNGVLLW 214
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 9-145 6.90e-06

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 45.52  E-value: 6.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216   9 LFSGSNFDRLLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMpNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRSlhiN 88
Cdd:COG0600   50 LVELLASGELWEHLLASLLRVLLGFALAALLGVPLGLLLGL-SRLLRRLLDPLLVFLRPIPPLALAPLLILWFGIG---E 125

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 504376216  89 WPGTWMAVLA--FSLWVAaefsdiVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQA 145
Cdd:COG0600  126 ASKIFVIFLGafFPILLN------TAAGVRSVDPELLELARSLGASRWQILRKVVLPAA 178
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 36-219 2.53e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 43.44  E-value: 2.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216   36 GLLIGTVFGVlrtMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRSlhINWPGTWMAVLAFSLWVAAEFSDIVRGAL 115
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILS--ILGHGILPAIILALLGWAGYARLIRRAAL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  116 QSVPLAQKESGLALGLSKTQLFLYVLLPQAFKLELPATINLATRVIKTTSIlmLISVMDVINVGQQIIEANNQKFPTGVF 195
Cdd:pfam00528  76 RSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVL--LEFLGSWPGLGLLLIEAILGYDYPEIQ 153

                         170       180
                  ....*....|....*....|....
gi 504376216  196 WVYGLIFFFYFILDYPLSVWAKSL 219
Cdd:pfam00528 154 GPVLAAALILLLLNLLVDILQRLL 177
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
18-158 8.38e-05

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 42.03  E-value: 8.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  18 LLVGLWTSIWIAALSIFIGLLIGTVFGVL-------RTMPNKIIRCILRVYMEIFRILPSVVLLylVYYI-LPRSLHINW 89
Cdd:PRK10782   9 LVRGVWETLAMTFVSGFFGFVIGLPVGVLlyvtrpgQIIANAKLYRTLSALVNIFRSIPFIILL--VWMIpFTRVIVGTS 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504376216  90 PGTWMAVLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAfkleLPATINLAT 158
Cdd:PRK10782  87 IGLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEA----LPGLVNAAT 151
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
17-145 4.53e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 37.45  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  17 RLLVGLWTSIWIAALSIFIGLLIGTVFGVLRTMPNKIIRCILRVYMEIFRILPSVVLLYLVYYILPRS----------LH 86
Cdd:COG1178   51 YLWRALGNTLLLALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPNgllntllralFG 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504376216  87 INWP---GTWMAVLAFSLWVAAEFSDIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQA 145
Cdd:COG1178  131 LEPPdiyGLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLL 192
PstC COG0573
ABC-type phosphate transport system, permease component [Inorganic ion transport and ...
 22-146 5.92e-03

ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440338 [Multi-domain]  Cd Length: 303  Bit Score: 36.99  E-value: 5.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504376216  22 LWTSIWIAALSIFIGLLIGTVFGV-LRTMPNKIIRCILRVYMEIFRILPSVV-----LLYLVYYILPrslHINWPGTWMA 95
Cdd:COG0573   79 IVGTLLVSLIALLIAVPLGLGIAIfLSEYAPPRLRRILKPAIELLAGIPSVVygfwgLFVLVPLLRD---LFPWPPSGFS 155

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 504376216  96 VLAFSL--------WVAAefsdIVRGALQSVPLAQKESGLALGLSKTQLFLYVLLPQAF 146
Cdd:COG0573  156 LLTAGIvlaimilpTITS----LSRDALRAVPRSLREAALALGATRWETIRKVVLPAAR 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH