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Conserved domains on  [gi|504292597|ref|WP_014479699|]
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MULTISPECIES: class I SAM-dependent methyltransferase [Bacillus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10513475)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens leucine carboxyl methyltransferase 1

CATH:  3.40.50.150
EC:  2.1.1.-
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LCM pfam04072
Leucine carboxyl methyltransferase; Family of leucine carboxyl methyltransferases EC:2.1.1.-. ...
10-207 1.27e-61

Leucine carboxyl methyltransferase; Family of leucine carboxyl methyltransferases EC:2.1.1.-. This family may need divides a the full alignment contains a significantly shorter mouse sequence.


:

Pssm-ID: 427692  Cd Length: 188  Bit Score: 193.99  E-value: 1.27e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597   10 SLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFidiskNMIQGISFFNKEIAErlqndpEKILKWVAQIQLSPTPLARA 89
Cdd:pfam04072   1 ALGVAAARALESRRPADPLIDDPFAEPLVRAAGL-----DLLTRRADGELDPAK------DDPGKWARFPGLNDGIAVRT 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597   90 SYCEKVLHNELM-LGAKQYVILGAGLDTFCFRHPELENsLQVFEVDHPATQQFKKNKLKDANLTIPGHLHFVPMDFTKTF 168
Cdd:pfam04072  70 RFFDDFLLAALAaAGIRQVVILGAGLDTRAYRLPWPAG-TRVFEVDQPDVLEFKRETLAELGALPPAHRRYVPVDLRDDD 148
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 504292597  169 SYDPLLDEGFK-NTKTFFSLLGVSYYVTQEENASLISNLF 207
Cdd:pfam04072 149 WPEALRAAGFDpEQPTAWLAEGLLYYLPPEAQDALLDTIA 188
 
Name Accession Description Interval E-value
LCM pfam04072
Leucine carboxyl methyltransferase; Family of leucine carboxyl methyltransferases EC:2.1.1.-. ...
10-207 1.27e-61

Leucine carboxyl methyltransferase; Family of leucine carboxyl methyltransferases EC:2.1.1.-. This family may need divides a the full alignment contains a significantly shorter mouse sequence.


Pssm-ID: 427692  Cd Length: 188  Bit Score: 193.99  E-value: 1.27e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597   10 SLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFidiskNMIQGISFFNKEIAErlqndpEKILKWVAQIQLSPTPLARA 89
Cdd:pfam04072   1 ALGVAAARALESRRPADPLIDDPFAEPLVRAAGL-----DLLTRRADGELDPAK------DDPGKWARFPGLNDGIAVRT 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597   90 SYCEKVLHNELM-LGAKQYVILGAGLDTFCFRHPELENsLQVFEVDHPATQQFKKNKLKDANLTIPGHLHFVPMDFTKTF 168
Cdd:pfam04072  70 RFFDDFLLAALAaAGIRQVVILGAGLDTRAYRLPWPAG-TRVFEVDQPDVLEFKRETLAELGALPPAHRRYVPVDLRDDD 148
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 504292597  169 SYDPLLDEGFK-NTKTFFSLLGVSYYVTQEENASLISNLF 207
Cdd:pfam04072 149 WPEALRAAGFDpEQPTAWLAEGLLYYLPPEAQDALLDTIA 188
YktD COG3315
O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, ...
20-298 1.44e-58

O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442544  Cd Length: 246  Bit Score: 187.86  E-value: 1.44e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597  20 HSRYDTPlIFDDFIAKDLINEKEFiDISKnmiqgisffnkeiaerlqndpekilkWVAQIQLSPTPLARASYCEKVLHNE 99
Cdd:COG3315    1 ESRRPDP-LFRDPYAARLVGAIGY-DFSR--------------------------LLAGRGLRLGVAARTRFFDDLLRAA 52
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597 100 LMLGAKQYVILGAGLDTFCFRHPELENsLQVFEVDHPATQQFKKNKLKDanLTIPGHLHFVPMDFTKTFSYDPLLDEGF- 178
Cdd:COG3315   53 LAAGIAQVVILGAGLDTRAYRLDNPGG-VRWFEVDLPEVIALKRRLLPE--LGPPARLRLVAVDLRDPDWPDALPAAGFd 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597 179 KNTKTFFSLLGVSYYVTQEENASLISNLFSHVPPGSSIVFDYADETLFTAKGTSNRVEhmvKMAAASGEPMKSCFTYQEI 258
Cdd:COG3315  130 PSRPTLFIAEGVLMYLTEEAVRALLRRIAALFPPGSELAFDYVPPLALKGSKKHPAVR---KLRRDLGAPFKFGIDPDDP 206
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 504292597 259 EHLLESSGLLIYEHLSPDDINDLFFSNRkdNLSAFETIHY 298
Cdd:COG3315  207 AELLEEPGWRLVEELSPLELLARYLPLR--PLRAPRLVHA 244
mthyl_TIGR00027 TIGR00027
methyltransferase, TIGR00027 family; This model represents a set of probable ...
7-266 6.02e-31

methyltransferase, TIGR00027 family; This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272862  Cd Length: 260  Bit Score: 116.65  E-value: 6.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597    7 SLTSLISAFARAYHSRYDTPLiFDDFIAKDLINEkefidisknmiqgisffnkeiAERLQNDPEKILKWVAQIQLSPTPL 86
Cdd:TIGR00027   1 GRTALGVAAARAIETQRPDRL-FRDPYAAAFLGA---------------------AGRAAMPLDGLLRADAGAYDGLLRG 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597   87 ------ARASYCEKVLHNELMLGAKQYVILGAGLDTFCFRHPELENsLQVFEVDHPATQQFKKNKLKDANLTIPGHLHFV 160
Cdd:TIGR00027  59 fadfiaVRTRFFDDFLLAAVAAGIRQVVILGAGLDTRAYRLPWPDG-TRVFEVDQPAVLAFKEKVLAELGAEPPAHRRAV 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597  161 PMDFTKTFSyDPLLDEGFKNTK-TFFSLLGVSYYVTQEENASLISNLFSHVPPGSSIVFDYADEtlfTAKGTSNRVEHMV 239
Cdd:TIGR00027 138 PVDLRQDWP-AALAAAGFDPTApTAWLWEGLLMYLTEEAVDALLAFIAELSAPGSRLAFDYVRP---LDGEWRAGMRAPV 213
                         250       260
                  ....*....|....*....|....*....
gi 504292597  240 --KMAAASGEPMKSCFTYQEIEHLLESSG 266
Cdd:TIGR00027 214 yhAARGVDGSGLVFGIDRADVAEWLAERG 242
 
Name Accession Description Interval E-value
LCM pfam04072
Leucine carboxyl methyltransferase; Family of leucine carboxyl methyltransferases EC:2.1.1.-. ...
10-207 1.27e-61

Leucine carboxyl methyltransferase; Family of leucine carboxyl methyltransferases EC:2.1.1.-. This family may need divides a the full alignment contains a significantly shorter mouse sequence.


Pssm-ID: 427692  Cd Length: 188  Bit Score: 193.99  E-value: 1.27e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597   10 SLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFidiskNMIQGISFFNKEIAErlqndpEKILKWVAQIQLSPTPLARA 89
Cdd:pfam04072   1 ALGVAAARALESRRPADPLIDDPFAEPLVRAAGL-----DLLTRRADGELDPAK------DDPGKWARFPGLNDGIAVRT 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597   90 SYCEKVLHNELM-LGAKQYVILGAGLDTFCFRHPELENsLQVFEVDHPATQQFKKNKLKDANLTIPGHLHFVPMDFTKTF 168
Cdd:pfam04072  70 RFFDDFLLAALAaAGIRQVVILGAGLDTRAYRLPWPAG-TRVFEVDQPDVLEFKRETLAELGALPPAHRRYVPVDLRDDD 148
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 504292597  169 SYDPLLDEGFK-NTKTFFSLLGVSYYVTQEENASLISNLF 207
Cdd:pfam04072 149 WPEALRAAGFDpEQPTAWLAEGLLYYLPPEAQDALLDTIA 188
YktD COG3315
O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, ...
20-298 1.44e-58

O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442544  Cd Length: 246  Bit Score: 187.86  E-value: 1.44e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597  20 HSRYDTPlIFDDFIAKDLINEKEFiDISKnmiqgisffnkeiaerlqndpekilkWVAQIQLSPTPLARASYCEKVLHNE 99
Cdd:COG3315    1 ESRRPDP-LFRDPYAARLVGAIGY-DFSR--------------------------LLAGRGLRLGVAARTRFFDDLLRAA 52
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597 100 LMLGAKQYVILGAGLDTFCFRHPELENsLQVFEVDHPATQQFKKNKLKDanLTIPGHLHFVPMDFTKTFSYDPLLDEGF- 178
Cdd:COG3315   53 LAAGIAQVVILGAGLDTRAYRLDNPGG-VRWFEVDLPEVIALKRRLLPE--LGPPARLRLVAVDLRDPDWPDALPAAGFd 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597 179 KNTKTFFSLLGVSYYVTQEENASLISNLFSHVPPGSSIVFDYADETLFTAKGTSNRVEhmvKMAAASGEPMKSCFTYQEI 258
Cdd:COG3315  130 PSRPTLFIAEGVLMYLTEEAVRALLRRIAALFPPGSELAFDYVPPLALKGSKKHPAVR---KLRRDLGAPFKFGIDPDDP 206
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 504292597 259 EHLLESSGLLIYEHLSPDDINDLFFSNRkdNLSAFETIHY 298
Cdd:COG3315  207 AELLEEPGWRLVEELSPLELLARYLPLR--PLRAPRLVHA 244
mthyl_TIGR00027 TIGR00027
methyltransferase, TIGR00027 family; This model represents a set of probable ...
7-266 6.02e-31

methyltransferase, TIGR00027 family; This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272862  Cd Length: 260  Bit Score: 116.65  E-value: 6.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597    7 SLTSLISAFARAYHSRYDTPLiFDDFIAKDLINEkefidisknmiqgisffnkeiAERLQNDPEKILKWVAQIQLSPTPL 86
Cdd:TIGR00027   1 GRTALGVAAARAIETQRPDRL-FRDPYAAAFLGA---------------------AGRAAMPLDGLLRADAGAYDGLLRG 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597   87 ------ARASYCEKVLHNELMLGAKQYVILGAGLDTFCFRHPELENsLQVFEVDHPATQQFKKNKLKDANLTIPGHLHFV 160
Cdd:TIGR00027  59 fadfiaVRTRFFDDFLLAAVAAGIRQVVILGAGLDTRAYRLPWPDG-TRVFEVDQPAVLAFKEKVLAELGAEPPAHRRAV 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504292597  161 PMDFTKTFSyDPLLDEGFKNTK-TFFSLLGVSYYVTQEENASLISNLFSHVPPGSSIVFDYADEtlfTAKGTSNRVEHMV 239
Cdd:TIGR00027 138 PVDLRQDWP-AALAAAGFDPTApTAWLWEGLLMYLTEEAVDALLAFIAELSAPGSRLAFDYVRP---LDGEWRAGMRAPV 213
                         250       260
                  ....*....|....*....|....*....
gi 504292597  240 --KMAAASGEPMKSCFTYQEIEHLLESSG 266
Cdd:TIGR00027 214 yhAARGVDGSGLVFGIDRADVAEWLAERG 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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