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Conserved domains on  [gi|504274943|ref|WP_014462045|]
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MULTISPECIES: aminodeoxychorismate synthase component I [Priestia]

Protein Classification

anthranilate synthase component I family protein( domain architecture ID 11414943)

anthranilate synthase component I family protein similar to the component I of anthranilate synthase and aminodeoxychorismate synthase, which are part of complexes that catalyze the two-step biosynthesis of anthranilate and 4-amino-4-deoxychorismate (ADC), respectively

CATH:  3.60.120.10
Gene Ontology:  GO:0046872|GO:0009058
PubMed:  16042594|11450855

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 22-459 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


:

Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 590.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  22 YQELSkEEPNHILLESGRGGK----FQMMGLKPVAILRGEQNELHIKTDSQAIVQKGNPLHLMRDWMKKFEAEVNPDLPP 97
Cdd:COG0147   19 FLKLA-DGPYAFLLESAEGGEkwgrYSFIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDALRALLARFRLPPLPGLPP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  98 FQGGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDqekeklwiivndeadckeqahkridqykkdwmeas 177
Cdd:COG0147   98 FTGGLVGYFGYDLVRYFERLPDLAPDDLGLPDAALGLYDRLLVFD----------------------------------- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 178 aeglsyeqiHRvaEKSEVSMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMSYMQTE 257
Cdd:COG0147  143 ---------HL--KGTRSNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSPYMFYLRFG 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 258 EFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEF 337
Cdd:COG0147  212 DFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPEL 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 338 MVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIA 417
Cdd:COG0147  292 MVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGNMDLAIA 371

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 504274943 418 IRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:COG0147  372 IRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRA 413
 
Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 22-459 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 590.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  22 YQELSkEEPNHILLESGRGGK----FQMMGLKPVAILRGEQNELHIKTDSQAIVQKGNPLHLMRDWMKKFEAEVNPDLPP 97
Cdd:COG0147   19 FLKLA-DGPYAFLLESAEGGEkwgrYSFIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDALRALLARFRLPPLPGLPP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  98 FQGGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDqekeklwiivndeadckeqahkridqykkdwmeas 177
Cdd:COG0147   98 FTGGLVGYFGYDLVRYFERLPDLAPDDLGLPDAALGLYDRLLVFD----------------------------------- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 178 aeglsyeqiHRvaEKSEVSMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMSYMQTE 257
Cdd:COG0147  143 ---------HL--KGTRSNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSPYMFYLRFG 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 258 EFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEF 337
Cdd:COG0147  212 DFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPEL 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 338 MVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIA 417
Cdd:COG0147  292 MVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGNMDLAIA 371

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 504274943 418 IRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:COG0147  372 IRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRA 413
trpE_most TIGR00564
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ...
 22-461 7.36e-173

anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273142 [Multi-domain]  Cd Length: 454  Bit Score: 493.39  E-value: 7.36e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943   22 YQELSKeePNHILLES----GRGGKFQMMGLKPVAILRGEQNELHIKTDSQAIVQKGNPLHLMRDWMKKFEAEVNPDLP- 96
Cdd:TIGR00564  10 YLKLAQ--PGSFLLESaepgSERGRYSFIGLNPVLTIKTEGGTEYLGADDRRSGIVGNPLDEIRDVMETFAQHSDPELPi 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943   97 PFQGGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKL----WIIVNDEADCKEQAHKRIDQYKKD 172
Cdd:TIGR00564  88 PFTGGAVGYLGYDTVRLFEKITLPPPDPLNLPDAYLMLCDDFIIFDHVTDKLylihNNRTTASRSAKAAADARLEALVAD 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  173 WMEASAEGLSYEQIHRVAEKSEvsMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMS 252
Cdd:TIGR00564 168 LQDPLLPEVPVPYPAALSFTSN--YEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELYRVLRIVNPSPYMY 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  253 YMQTEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTV 332
Cdd:TIGR00564 246 YLDFGDFQIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGRNDIGRVCEPGSV 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  333 HVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDM 412
Cdd:TIGR00564 326 EVPEFMKIERYSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYGGAVGYLSFDGDM 405

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 504274943  413 ELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKAKE 461
Cdd:TIGR00564 406 DTAIAIRTMVVKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
PRK13571 PRK13571
anthranilate synthase component I; Provisional
 22-459 9.68e-140

anthranilate synthase component I; Provisional


Pssm-ID: 184152 [Multi-domain]  Cd Length: 506  Bit Score: 410.95  E-value: 9.68e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  22 YQELSKEEPNHILLESGRGG----KFQMMGLKPVAILRGEQNELH-IKTDSQAIVQKGNPLHLMRDWMKKFEAEVNPDLP 96
Cdd:PRK13571  40 YRKLAANRPGTFLLESAENGrswsRWSFIGVGSPAALTVRDGEAVwLGTPPAGAPTGGDPLAALRATLELLATPRLPGLP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  97 PFQGGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIVN-----------DEAdcKEQAHKR 165
Cdd:PRK13571 120 PLTGGMVGFLGYDAVRRLERLPELAVDDLGLPEMLLLLATDLAAVDHHEGTITLIANavnwngtdervDAA--YDDAVAR 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 166 IDQYKKD---WMEASAEGLSYEQIHRVAEKSEvsmseAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQV 242
Cdd:PRK13571 198 LDVMTAAlaqPLPSTVATFSRPVPEFRAQRTV-----EEFGAAVEKLVEEIRAGEAFQVVPSQRFEMDTTADPLDVYRVL 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 243 RKINPSPYMSYMQTEE------FHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLV 316
Cdd:PRK13571 273 RVTNPSPYMYLLRVPNsdggtdFSIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLV 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 317 DLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRR 396
Cdd:PRK13571 353 DLGRNDLGRVCRPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAVTACFPAGTLSGAPKVRAMELIEELEPTRR 432

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504274943 397 GIYTGSIGWIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:PRK13571 433 GLYGGVVGYLDFAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAAAVLRA 495
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 200-452 2.86e-126

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 367.26  E-value: 2.86e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  200 AAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQT--HPMHIYEQVRKINPSPYMSYMQTEEFHIVSCSPELLVKKAGDEI 277
Cdd:pfam00425   1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGdiDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  278 STRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKL 357
Cdd:pfam00425  81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  358 ARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVV 437
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240

                         250
                  ....*....|....*
gi 504274943  438 IDSNPKHEYKESLKK 452
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
 
Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 22-459 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 590.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  22 YQELSkEEPNHILLESGRGGK----FQMMGLKPVAILRGEQNELHIKTDSQAIVQKGNPLHLMRDWMKKFEAEVNPDLPP 97
Cdd:COG0147   19 FLKLA-DGPYAFLLESAEGGEkwgrYSFIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDALRALLARFRLPPLPGLPP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  98 FQGGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDqekeklwiivndeadckeqahkridqykkdwmeas 177
Cdd:COG0147   98 FTGGLVGYFGYDLVRYFERLPDLAPDDLGLPDAALGLYDRLLVFD----------------------------------- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 178 aeglsyeqiHRvaEKSEVSMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMSYMQTE 257
Cdd:COG0147  143 ---------HL--KGTRSNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSPYMFYLRFG 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 258 EFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEF 337
Cdd:COG0147  212 DFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPEL 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 338 MVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIA 417
Cdd:COG0147  292 MVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGNMDLAIA 371

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 504274943 418 IRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:COG0147  372 IRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRA 413
trpE_most TIGR00564
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ...
 22-461 7.36e-173

anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273142 [Multi-domain]  Cd Length: 454  Bit Score: 493.39  E-value: 7.36e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943   22 YQELSKeePNHILLES----GRGGKFQMMGLKPVAILRGEQNELHIKTDSQAIVQKGNPLHLMRDWMKKFEAEVNPDLP- 96
Cdd:TIGR00564  10 YLKLAQ--PGSFLLESaepgSERGRYSFIGLNPVLTIKTEGGTEYLGADDRRSGIVGNPLDEIRDVMETFAQHSDPELPi 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943   97 PFQGGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKL----WIIVNDEADCKEQAHKRIDQYKKD 172
Cdd:TIGR00564  88 PFTGGAVGYLGYDTVRLFEKITLPPPDPLNLPDAYLMLCDDFIIFDHVTDKLylihNNRTTASRSAKAAADARLEALVAD 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  173 WMEASAEGLSYEQIHRVAEKSEvsMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMS 252
Cdd:TIGR00564 168 LQDPLLPEVPVPYPAALSFTSN--YEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELYRVLRIVNPSPYMY 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  253 YMQTEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTV 332
Cdd:TIGR00564 246 YLDFGDFQIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGRNDIGRVCEPGSV 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  333 HVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDM 412
Cdd:TIGR00564 326 EVPEFMKIERYSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYGGAVGYLSFDGDM 405

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 504274943  413 ELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKAKE 461
Cdd:TIGR00564 406 DTAIAIRTMVVKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
PRK13571 PRK13571
anthranilate synthase component I; Provisional
 22-459 9.68e-140

anthranilate synthase component I; Provisional


Pssm-ID: 184152 [Multi-domain]  Cd Length: 506  Bit Score: 410.95  E-value: 9.68e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  22 YQELSKEEPNHILLESGRGG----KFQMMGLKPVAILRGEQNELH-IKTDSQAIVQKGNPLHLMRDWMKKFEAEVNPDLP 96
Cdd:PRK13571  40 YRKLAANRPGTFLLESAENGrswsRWSFIGVGSPAALTVRDGEAVwLGTPPAGAPTGGDPLAALRATLELLATPRLPGLP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  97 PFQGGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIVN-----------DEAdcKEQAHKR 165
Cdd:PRK13571 120 PLTGGMVGFLGYDAVRRLERLPELAVDDLGLPEMLLLLATDLAAVDHHEGTITLIANavnwngtdervDAA--YDDAVAR 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 166 IDQYKKD---WMEASAEGLSYEQIHRVAEKSEvsmseAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQV 242
Cdd:PRK13571 198 LDVMTAAlaqPLPSTVATFSRPVPEFRAQRTV-----EEFGAAVEKLVEEIRAGEAFQVVPSQRFEMDTTADPLDVYRVL 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 243 RKINPSPYMSYMQTEE------FHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLV 316
Cdd:PRK13571 273 RVTNPSPYMYLLRVPNsdggtdFSIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLV 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 317 DLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRR 396
Cdd:PRK13571 353 DLGRNDLGRVCRPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAVTACFPAGTLSGAPKVRAMELIEELEPTRR 432

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504274943 397 GIYTGSIGWIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:PRK13571 433 GLYGGVVGYLDFAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAAAVLRA 495
PRK05940 PRK05940
anthranilate synthase component I;
74-465 6.88e-139

anthranilate synthase component I;


Pssm-ID: 235651 [Multi-domain]  Cd Length: 463  Bit Score: 407.19  E-value: 6.88e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  74 GNPLHLMRDWM-KKFEAEVNPDLPPFQGGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIV 152
Cdd:PRK05940  71 GEILPFLRQLLaRSLDPSALPEHLPFTGGWLGWLGYDLAWEIERLPHLNPDPLPFPVAYWYEPESFAILDHQEQILWLAA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 153 NDEADCKEQAHKridqykkdwMEASAEGLSYEQIHRVAEKS-EVSMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQL 231
Cdd:PRK05940 151 SDPSQLDRLEQQ---------LEQPTPEPDLPLDLRTPPSSlIFYTTQQEYEAAVRQAKKYIQAGDIFQANLSLRFQTTT 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 232 QTHPMHIYEQVRKINPSPYMSYMQTEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAE 311
Cdd:PRK05940 222 SADSWQIYRRLQQINPSPFASYWRTPWGDVVSCSPERLVQLQGNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAE 301

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 312 HVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEEL 391
Cdd:PRK05940 302 HIMLVDLERNDLGRVCQWGSVEVDELLTIERYSHVIHLVSNVVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEEL 381

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504274943 392 EPVRRGIYTGSIGWIGFNGDMELNIAIRTMII-----QDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKAKEQSEN 465
Cdd:PRK05940 382 EPVRRNLFYGSCGYLDQRGNLDLNILIRTLLYtplsrGLSTIWGQVGAGIVADSDPEKEWLESLQKAKAQLAALNLVRS 460
TrpE-arch TIGR01820
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of ...
 19-459 1.72e-133

anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of anthranilate synthase component I enzymes. This enzyme is responsible for the first step of tryptophan biosynthesis from chorismate. The Sulfolobus enzyme has been reported to be part of a gene cluster for Trp biosynthesis [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273819 [Multi-domain]  Cd Length: 435  Bit Score: 392.50  E-value: 1.72e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943   19 FKKYQELSKEEPNHILLESGRG----GKFQMMGLKPVAILR-GEQnelhiKTDSQAIVQKGNPLHLMRDWMKKF-EAEVN 92
Cdd:TIGR01820   2 LELYKAIRADGDYAFLLESAEKpskkARYSFIGWDPEFVVRiNGK-----GKSVEGIPEDGDVVDKLRNAFPKLkGINIP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943   93 PDLPPFQGGAIGFISYDYIR-YVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIVNDEADckEQAHKRIDQYKK 171
Cdd:TIGR01820  77 GEDRRFKGGLVGYIAYDAVRdYWEGIVDLKRKAEDWPPAEFFIYPNTIVYDHLEGKVYYVSTPEPE--AELERIVERAKR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  172 DWMEASAEGLSYeqIHRVAEKSEvsmseaaFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYM 251
Cdd:TIGR01820 155 ATDPGEAGVSFE--GESLSDREE-------FEEAVEEAKEYIFAGDIFQVVLSREYEYRLDGDPFELYYNLREINPSPYM 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  252 SYMQTEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGT 331
Cdd:TIGR01820 226 FLLKFGDRYLVGSSPETLVRVEGRTVETNPIAGTRPRGATPEEDERLAKELLSDEKERAEHVMLVDLARNDVRKVSEPGS 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  332 VHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGD 411
Cdd:TIGR01820 306 VKVPEFMYVEKYSHVQHIESTVIGTLKKDYDAFDALRATFPAGTLSGAPKIRAMEIIDELEKEPRGVYGGGVGYFSWNGD 385

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 504274943  412 MELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:TIGR01820 386 ADFAIAIRTAEIDKDKLRIQAGAGIVADSIPEREFEETENKMKAVLKA 433
PabB-clade2 TIGR01824
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely ...
 100-456 3.25e-127

aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.


Pssm-ID: 130883  Cd Length: 355  Bit Score: 373.34  E-value: 3.25e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  100 GGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIVNDEA--DCKEQAHKRIDqykkdwMEAS 177
Cdd:TIGR01824   1 GGRLGWLAYDVARRLEGIPDLGTSDGGWPVAADFRYEAAVARDHQRQIVALATVPAEteGEFATSSDQLP------AVAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  178 AEGLSYEQIHRVAEKSEVSMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQT--HPMHIYEQVRKINPSPYMSYMQ 255
Cdd:TIGR01824  75 ATSLPSPDVGPLPVDLEASIDRAAYETGVRRIKDYIRAGDVFQANLSRRLTAPIAAdvDPLQLFLALRAPNPAPYAIYLE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  256 TEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVD 335
Cdd:TIGR01824 155 EPGVDVASASPELFLAREGRVVQTRPIAGTRPRGATLAEDGALAAELLQHDKDRAEHVMIVDLERNDLGRVCATGTVRVP 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  336 EFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELN 415
Cdd:TIGR01824 235 ELCAVESYSHVHHLVSRVTGRLREGAGLADLIRALFPGGSITGAPKVRAMEIIDELEPQPRGPYTGSVGWIDADGNADLN 314

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 504274943  416 IAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIAL 456
Cdd:TIGR01824 315 ILIRTLEGGGAQLHFRTGAGIVADSDPAGEWDETEAKARAL 355
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 200-452 2.86e-126

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 367.26  E-value: 2.86e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  200 AAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQT--HPMHIYEQVRKINPSPYMSYMQTEEFHIVSCSPELLVKKAGDEI 277
Cdd:pfam00425   1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGdiDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  278 STRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKL 357
Cdd:pfam00425  81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  358 ARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVV 437
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240

                         250
                  ....*....|....*
gi 504274943  438 IDSNPKHEYKESLKK 452
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
PRK09070 PRK09070
aminodeoxychorismate synthase component I;
87-462 7.29e-122

aminodeoxychorismate synthase component I;


Pssm-ID: 236371 [Multi-domain]  Cd Length: 447  Bit Score: 363.25  E-value: 7.29e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  87 FEAEVNP----DLPPFQGGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIvnDEADckeqA 162
Cdd:PRK09070  75 WQAERVPhdgeSSLPFRGGWAVLLDYELAGQVEPILKLPMRTDGLPLALALRAPAAVLRDRHSGRCVLV--AEPG----R 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 163 HKRIDQYKKDWMEASAEGLSYEQIHRVAEKSEvsmSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQT--HPMHIYE 240
Cdd:PRK09070 149 EHLLDQIEADLAACAALPPLPVWLAPQAVEED---PPERFTDGVERVLDYIRAGDVFQVNLSRAWQAQFANavDPAALYA 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 241 QVRKINPSPYMSYMQTEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDqEDQQLADELIHNEKERAEHVMLVDLER 320
Cdd:PRK09070 226 RLRAANPAPFSGLFVAAGRAIVSSSPERLVSVQGGVVQTRPIAGTRPRFAGD-DDAALIRELVGHPKERAEHVMLIDLER 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 321 NDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYT 400
Cdd:PRK09070 305 NDLGRICAPGSVEVDELMTVESYAHVHHIVSNVRGRLRDGVTPGEVIRAVFPGGTITGCPKVRCMQIIAELEQTPRGAYT 384

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504274943 401 GSIGWIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKAKEQ 462
Cdd:PRK09070 385 GSFGYLNRDGDMDLNILIRTAEVQGNQVRFRTGAGIVVDSDPERELDETRAKARGLLRALEQ 446
PLN02445 PLN02445
anthranilate synthase component I
 22-459 4.53e-116

anthranilate synthase component I


Pssm-ID: 215244 [Multi-domain]  Cd Length: 523  Bit Score: 350.90  E-value: 4.53e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  22 YQELSKE---EPNHILLESGRGGK-------FQMMGLKPVAILRGEQNELHI-----KTDSQAIVQkgNPLHLMRDWMKK 86
Cdd:PLN02445  28 YRCLVKEddrEAPSFLFESVEPGSqssnvgrYSVVGAQPAMEIVAKENKVTImdhekGTRTEEIVE--DPMEIPRRISEK 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  87 FEAEVNPDLPP-FQGGAIGFISYDYIRYVET--IP--DLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWII--VN-DEADC 158
Cdd:PLN02445 106 WNPQLIDGLPDvFCGGWVGYFSYDTVRYVEKkkLPfsGAPEDDRNLPDIHLGLYDDVIVFDHVEKKAYVIhwVRlDRYSS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 159 KEQAH----KRIDQYKKDWMEASAEGLSY-------EQIHRVAEKSevSMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQ 227
Cdd:PLN02445 186 VEEAYedgmKRLEALVSRLQDINPPKLSPgsvklstNQFGPSLEKS--NMTSEEYKNAVLQAKEHILAGDIFQIVLSQRF 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 228 SQQLQTHPMHIYEQVRKINPSPYMSYMQTEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEK 307
Cdd:PLN02445 264 ERRTFADPFEVYRALRIVNPSPYMIYLQARGCILVASSPEILTRVKKNKIVNRPLAGTRRRGKTPEEDKALEKDLLADEK 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 308 ERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEI 387
Cdd:PLN02445 344 QCAEHIMLVDLGRNDVGKVSKAGSVKVEKLMNIERYSHVMHISSTVTGELLDHLTSWDALRAALPVGTVSGAPKVRAMEL 423

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 388 IEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMIIQDGQ------------------AYVQAGAGVVIDSNPKHEYKES 449
Cdd:PLN02445 424 IDELEVTRRGPYSGGFGGVSFTGDMDIALALRTMVFPTAArydtmysykdtnsrrewvAHLQAGAGIVADSDPEDEYREC 503

                        490
                 ....*....|
gi 504274943 450 LKKAIALWKA 459
Cdd:PLN02445 504 VNKAAGLARA 513
PRK13574 PRK13574
anthranilate synthase component I; Provisional
 98-456 4.10e-103

anthranilate synthase component I; Provisional


Pssm-ID: 184155 [Multi-domain]  Cd Length: 420  Bit Score: 314.06  E-value: 4.10e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  98 FQGGAIGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWI--IVNDEADCKEQAHKRIDQYkkdwme 175
Cdd:PRK13574  78 FKGGMIGYISYDAVRFWEKIRDLKPAAEDWPYAEFFIPDNIIIYDHNEGKVYVngDLSSVGGCGDMGEFKISFY------ 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 176 asaeglsyeqihrvaeksEVSMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMSYMQ 255
Cdd:PRK13574 152 ------------------DESLNKNNYEKIVSESLEYIRSGYIFQVVLSRFYRYLFSGDPLRIYYNLRRINPSPYMFYLK 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 256 TEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVD 335
Cdd:PRK13574 214 FDERYLIGSSPELLFRVQDNIVETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVRVP 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 336 EFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELN 415
Cdd:PRK13574 294 ELMYVEKYSHVQHIVSKVIGTLKKKYNALDVLKATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFA 373

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 504274943 416 IAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIAL 456
Cdd:PRK13574 374 IAIRTAFLNKDLLRIQAGAGIVYDSNPESEYFETEHKLRAL 414
pabB TIGR00553
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, ...
 128-453 1.77e-101

aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]


Pssm-ID: 273133  Cd Length: 328  Bit Score: 306.61  E-value: 1.77e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  128 PDVYFLIFDDVFVYDQEKEK-LWIIVndeadckeqaHKRIDQYKKDWMEASAEGLSYEQIHrvAEKSEVSMSEAAFSDAT 206
Cdd:TIGR00553  11 PDAAFEPYDAALLADHRRTPlLRFLV----------FERVEAQPRAAVEAEDDAPADRQAP--TSDIQSEMTRAEYGEAI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  207 TRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMSYMQTEEFHIVSCSPELLVKKAGDEISTRPIAGTR 286
Cdd:TIGR00553  79 DQLQDYIRAGDCYQANLTQQFHATWDGDPLAAFRKLRRRQPAPFSAFLDLGDGAILSLSPELFFSIDGSEIETRPIKGTL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  287 SRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDI 366
Cdd:TIGR00553 159 PRGADPQEDRAQASALAESAKDRAENLMIVDLLRNDLGRIAEVGSVKVPELFVVETYPTVHQLVSTITARLREDLTLSDL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  367 VDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEY 446
Cdd:TIGR00553 239 FRALFPGGSITGAPKVRAMEIIDELEPQPRGVYCGAIGYLSPEGDMDFNVAIRTLTLDGGRAVYGVGGGIVADSDPEAEY 318


                  ....*..
gi 504274943  447 KESLKKA 453
Cdd:TIGR00553 319 RECLLKA 325
pabB PRK15465
aminodeoxychorismate synthase component 1;
30-452 8.05e-95

aminodeoxychorismate synthase component 1;


Pssm-ID: 185362 [Multi-domain]  Cd Length: 453  Bit Score: 293.75  E-value: 8.05e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  30 PNHILLESGRG----GKFQMMGLKPVAILRGEQNELHIKTDSQAIVQKGNPLHLMRDWMKK--FEAEVNPDLPpFQGGAI 103
Cdd:PRK15465  29 PWAMLLHSGYAdhpySRFDIVVADPICTLTTFGKETVVSESEKRTTTTDDPLQVLQQVLDRadIRPTHNEDLP-FQGGAL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 104 GFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIVNDEADCKeqahkridqykKDWMEAsaEGLSY 183
Cdd:PRK15465 108 GLFGYDLGRRFESLPEIAEQDIVLPDMAVGIYDWALIVDHQRQTVSLLSHNDVNAR-----------RAWLES--QQFSP 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 184 EQIHRVAEKSEVSMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMSYMQTEEFHIVS 263
Cdd:PRK15465 175 QEDFTLTSDWQSNMTREQYGEKFRQVQEYLHSGDCYQVNLAQRFHATYSGDEWQAFLQLNQANRAPFSAFLRLEQGAILS 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 264 CSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKY 343
Cdd:PRK15465 255 LSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVPELFVVEPF 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 344 SHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMII 423
Cdd:PRK15465 335 PAVHHLVSTITARLPEQLHASDLLRAAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSFCGNMDTSITIRTLTA 414

                        410       420
                 ....*....|....*....|....*....
gi 504274943 424 QDGQAYVQAGAGVVIDSNPKHEYKESLKK 452
Cdd:PRK15465 415 INGQIYCSAGGGIVADSQEEAEYQETFDK 443
PRK13572 PRK13572
anthranilate synthase component I; Provisional
 27-459 3.76e-93

anthranilate synthase component I; Provisional


Pssm-ID: 237432 [Multi-domain]  Cd Length: 435  Bit Score: 288.94  E-value: 3.76e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  27 KEEPNHILLES----GRGGKFQMMGLKPVAILRGEQNelhIKTDSQAIVQKGNPLHLMRDWMKKfeaevNPDLPPFQGGA 102
Cdd:PRK13572  19 RDEGYPFILESaekgQRKARYTYISANPEFMVRIGNK---TKVDGETISKESNPFKALKENFKI-----TQSGDRFTGGF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 103 IGFISYDYIR-YVEtipdlaeDSLKTPDVyFLIFDDVFVYDQEKEKLWII-VNDEADCKEQAHKRIDQYKKdwmeasaeg 180
Cdd:PRK13572  91 VGYIAYDAVHnYIG-------GKIEEPSV-FGYYDHVFVYDHVTRKFYFHsLNNNPEELFNAEKIVEKAKR--------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 181 lsyEQIHRVAEKSEVSMSEAAFSDATTRVH---EYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMSYMQTE 257
Cdd:PRK13572 154 ---FEIEEEDGGSEVLGCDADREEFVEMVEkakEYIYSGDVFQVVLSREYRLKTDLSPFQLYRNLREINPSPYMFLLEFD 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 258 EfHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEF 337
Cdd:PRK13572 231 K-DVVGASPETMASVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARNDVRKVSKSGSVRLERF 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 338 MVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIA 417
Cdd:PRK13572 310 FDVVKYSHVQHIESEVVGELKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKVYGGAVGYFSNSGNADLAIA 389

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 504274943 418 IRtMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:PRK13572 390 IR-MAEIDKVCRVRAGAGIVADSVPEKEFYETERKMAAVLKA 430
PRK13567 PRK13567
anthranilate synthase component I; Provisional
 25-456 4.13e-89

anthranilate synthase component I; Provisional


Pssm-ID: 184148 [Multi-domain]  Cd Length: 468  Bit Score: 279.72  E-value: 4.13e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  25 LSKEEPNHILLESGR----GGKFQMMGLKPVAILRGEQNELHIKTDSQAIVQKGNPLHLMRDWMKKFEAEVN----PDLP 96
Cdd:PRK13567  17 LAQLHSKKIILESTNqqqtKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQITERPYHYLTTKINEDYHNIQdeqlKSLP 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  97 pFQGGAIGFISYDYIRY-VETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIVND------EADCKEQAHKRIDQY 169
Cdd:PRK13567  97 -FISGYVGTCSFDLVRHeFPKLQSIQLEDHKQHDVRLYMVEQVYVFDHYKDELYIIATNqfsnstKSDLENRVNKSIEDL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 170 KKdwMEASAEGLSYEQIHRVAEKSevsMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQS------QQLQTHPMHIYEQVR 243
Cdd:PRK13567 176 TK--IQPFMPTQDFDFKTKEIQSN---ISEERFIEMIQYFKEKITEGDMFQVVPSRIYKyahhasQHLNQLSFQLYQNLK 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 244 KINPSPYMSYMQTEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDL 323
Cdd:PRK13567 251 RQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDI 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 324 GRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSI 403
Cdd:PRK13567 331 HRVSKIGTSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGV 410

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 504274943 404 GWIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIAL 456
Cdd:PRK13567 411 GYINCNHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSL 463
PRK13564 PRK13564
anthranilate synthase component 1;
75-459 4.69e-89

anthranilate synthase component 1;


Pssm-ID: 237428 [Multi-domain]  Cd Length: 520  Bit Score: 280.95  E-value: 4.69e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  75 NPLHLMRDWMKKFEAEVNPDLPPFQGGAigFiSYDYIRYVETIPDLAEDSlKTPDVYFLIFDDVFVYDQEKEKLWIIVN- 153
Cdd:PRK13564 122 SVFDALRLLQKLVNTPKEEREALFLGGL--F-AYDLVAGFEPLPQLPAGN-NCPDYCFYLAETLLVIDHQKKSARLQASl 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 154 --DEADCKEQAHKRIDQYKKDwMEASAEGLSYEQIHrvAEKSEVSMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQL 231
Cdd:PRK13564 198 ftPDEEEKQRLAARLAQLKQQ-LTQPAPPLPVTSVP--DMEVSVNISDEEFCAVVRKLKEHIRAGDIFQVVPSRRFSLPC 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 232 QThPMHIYEQVRKINPSPYMSYMQTEEFHIVSCSPELLVK--KAGDEISTRPIAGTRSRGKD-----DQE-DQQLADELI 303
Cdd:PRK13564 275 PS-PLAAYRVLKKSNPSPYMFYMQDEDFTLFGASPESALKydASSRQVEIYPIAGTRPRGRRadgsiDRDlDSRIELELR 353

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 304 HNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVR 383
Cdd:PRK13564 354 TDHKELAEHLMLVDLARNDLARICQPGSRYVADLLKVDRYSHVMHLVSRVVGELRHDLDALHAYRACMNMGTLTGAPKVR 433

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504274943 384 TMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:PRK13564 434 AMQLIREVEGQRRGSYGGAVGYLTGHGDLDTCIVIRSAFVENGIATVQAGAGVVLDSDPQSEADETRNKAQAVLRA 509
PRK07508 PRK07508
aminodeoxychorismate synthase component I;
197-460 6.65e-83

aminodeoxychorismate synthase component I;


Pssm-ID: 236035 [Multi-domain]  Cd Length: 378  Bit Score: 260.71  E-value: 6.65e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 197 MSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMSYMQTEEFHIVSCSPELLVKKAGDE 276
Cdd:PRK07508 109 WDFADYAQRFERLHRHIRAGDCYQANLTFPLDARWGGDPLALFWALAARQPVGYGALVDLGGPVILSRSPELFFRVDGEG 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 277 -ISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKG 355
Cdd:PRK07508 189 wIETHPMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPELFDIETYPTVHQMVSRVRA 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 356 KLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMII-QDGQAYVQAGA 434
Cdd:PRK07508 269 RLLPGLGLADIFAALFPCGSITGAPKIRAMEILRELEPGPRDLYCGAIGWIAPDGRMRFNVAIRTLSLfPGGRAVFNVGG 348

                        250       260
                 ....*....|....*....|....*.
gi 504274943 435 GVVIDSNPKHEYKEslkkaiALWKAK 460
Cdd:PRK07508 349 GIVFDSTAEAEYEE------CLLKAR 368
trpE_proteo TIGR00565
anthranilate synthase component I, proteobacterial subset; This enzyme resembles some other ...
 104-459 3.19e-75

anthranilate synthase component I, proteobacterial subset; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. This group includes proteobacteria such as E. coli and Helicobacter pylori but also the gram-positive organism Corynebacterium glutamicum. The second group includes eukaryotes, archaea, and most other bacterial lineages; sequences from the second group may resemble pabB more closely than other trpE from this group. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273143 [Multi-domain]  Cd Length: 498  Bit Score: 244.42  E-value: 3.19e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  104 GFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIVN--DEADCKEQAHKRIDQYKKDWMEASAEGL 181
Cdd:TIGR00565 131 GLFSYDLVAFFEDLPHLKAKNNNCPDFIFYLAENLIIIDHQEKSVEILGAcfAERFETQIAQALQDLKELQKSIKSDFVP 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  182 SYEQIHRvaeKSEVSMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLqTHPMHIYEQVRKINPSPYMSYMQTEEFHI 261
Cdd:TIGR00565 211 KKSKQSR---EVSANCSDSEFEGRVLSLQEEIKKGEIFQAVPSRRFSLEC-PEGLAAYYHLKLTNPSPYMFYMKDSDFIL 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  262 VSCSPELLVKKAG--DEISTRPIAGTRSRGKDDQE------DQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVH 333
Cdd:TIGR00565 287 FGASPESALKYNAltRQAEIYPIAGTRPRGKDAQGnidydlDSRMELELRHDHKERAEHLMLVDLARNDMARVCKSGKRY 366

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  334 VDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDME 413
Cdd:TIGR00565 367 VAKLLKVDRYSNVMHLVSRVVGELRKGLDALHAYRACMNMGTLSGAPKISAMQLIYQLENQRRGSYGGAVGYLTSEGSMD 446

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 504274943  414 LNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:TIGR00565 447 TCIVIRSAFVKNGRAVVQAGAGIVLDSVPQNEADETRAKAQAVLDA 492
PLN02889 PLN02889
oxo-acid-lyase/anthranilate synthase
 98-455 1.33e-69

oxo-acid-lyase/anthranilate synthase


Pssm-ID: 215481 [Multi-domain]  Cd Length: 918  Bit Score: 238.21  E-value: 1.33e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  98 FQGGAIGFISYDYirYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIVNDEADCKEQAHKRIDQYKKDWMEAS 177
Cdd:PLN02889 538 FHGGYVGYIGYDL--KVECGMASNRHKSTTPDACFFFADNVVVIDHHYDDVYILSLHEGSTATTQWLDDTEQKLLGLKAS 615

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 178 AEGLSYEQIHRVAEKSEvsmSEAAFSDATTRVH---------EYIGQGDVFQVNLSVRQSQQL-QTHPMHIYEQVRKINP 247
Cdd:PLN02889 616 ATRKLEVQTSPTATFSP---SKAGFLADKSREQyikdvqkclKYIKDGESYELCLTTQMRKRIgEIDSLGLYLHLREKNP 692

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 248 SPYMSYMQ--TEEFHIVSCSPELLVKKAGDEI-STRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLG 324
Cdd:PLN02889 693 APYAAWLNfsNENLCICSSSPERFLKLDRNGMlEAKPIKGTIARGSTPEEDEQLKLQLQYSEKDQAENLMIVDLLRNDLG 772

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 325 RVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIG 404
Cdd:PLN02889 773 RVCEPGSVHVPNLMDVESYTTVHTMVSTIRGKKRSNMSPVDCVRAAFPGGSMTGAPKLRSMELLDSLESSSRGIYSGSIG 852

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 504274943 405 WIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIA 455
Cdd:PLN02889 853 FFSYNQTFDLNIVIRTVVIHEGEASIGAGGAIVALSNPEDEYEEMILKTRA 903
PRK05877 PRK05877
aminodeoxychorismate synthase component I; Provisional
 204-456 2.34e-58

aminodeoxychorismate synthase component I; Provisional


Pssm-ID: 235634 [Multi-domain]  Cd Length: 405  Bit Score: 197.62  E-value: 2.34e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 204 DATTRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIY-EQVRKINPSpYMSYMQTEEFHIVSCSPELLVKKAGDEISTRPI 282
Cdd:PRK05877 146 DGVLACLEAIAAGEVYQACVCTQFTGTVTGSPLDFFaDGVARTAPA-RAAYLAGDWGAVASLSPELFLRRRGSVVTSSPI 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 283 AGTRSRGKDdqedqqlADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKD 362
Cdd:PRK05877 225 KGTLPLDAD-------PSALRASAKDVAENIMIVDLVRNDLGRVARTGTVTVPELLVVRPAPGVWHLVSTVSAQVPDELP 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 363 FVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTM-IIQDGQAYVQAGAGVVIDSN 441
Cdd:PRK05877 298 MSDLLDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVGLASPVAGCELNVAIRTVeFDADGNAVLGVGGGITADSD 377

                        250
                 ....*....|....*
gi 504274943 442 PKHEYKESLKKAIAL 456
Cdd:PRK05877 378 PDAEWQECLHKAAPI 392
PRK13566 PRK13566
anthranilate synthase component I;
136-459 9.21e-56

anthranilate synthase component I;


Pssm-ID: 237429 [Multi-domain]  Cd Length: 720  Bit Score: 197.45  E-value: 9.21e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 136 DDVFVYDQEKEKLWIivndeadckeqahkriDQYKKDWMEASAEGLSyeqihRVAEKSEVSMSEAA--FSDAT------- 206
Cdd:PRK13566 191 DEILVVDHYAARAWV----------------DRYEFAVGGVSTEGLP-----RETAPSPYKPTTARpgFADHApgeyaal 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 207 -TRVHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRKINPSPYMSYMQT-EEFHIVSCSPELLVKKAGDEISTRPIAG 284
Cdd:PRK13566 250 vEKAKESFRRGDLFEVVPGQTFYEPCERSPSEIFRRLKEINPSPYGFFINLgDGEYLVGASPEMFVRVEGRRVETCPISG 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 285 TRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLarnKDFV 364
Cdd:PRK13566 330 TIKRGADAIGDAEQIRKLLNSKKDESELTMCTDVDRNDKSRVCEPGSVKVIGRRQIEMYSRLIHTVDHVEGRL---RPGF 406

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 365 DIVD-------AVfpggTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVV 437
Cdd:PRK13566 407 DALDaflthawAV----TVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGFDGDMNTGLTLRTIRIKDGVAEVRVGATLL 482

                        330       340
                 ....*....|....*....|..
gi 504274943 438 IDSNPKHEYKESLKKAIALWKA 459
Cdd:PRK13566 483 FDSDPEAEEAETELKASALLQA 504
PRK06404 PRK06404
anthranilate synthase component I; Reviewed
 196-453 1.55e-52

anthranilate synthase component I; Reviewed


Pssm-ID: 102361 [Multi-domain]  Cd Length: 351  Bit Score: 180.84  E-value: 1.55e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 196 SMSEAAFSDATTRVHEYIGQGDVFQVNLSvRQSQQLQTHPMHIYEQVRKiNPSPYMSYMQTEEFHIVSCSPELLVKKAGD 275
Cdd:PRK06404 101 NYNDISLSLKIKELIELIRAGEVLQVVIS-REFEANIDFKEKLSEFINN-DRSRYVFYYRFGKYRVVGSSPENVFTVNGN 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 276 EISTRPIAGTRSrgkddqeDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKG 355
Cdd:PRK06404 179 IINVDPIAGTYD-------DKILSNELLNSEKDKLEHRMLLDLARNDLSKFADIGTLNVDKVMKIEEFSSVKHLVSQVTA 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 356 KLArNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGfNGDMELNIAIRTMIIQDGQAYVQAGAG 435
Cdd:PRK06404 252 KFS-NASYRDILASMFPAGTVSGSPKERAIEIINKYEETPRGPYGGAIGIIS-KGYTDMALVIRTAYSHGNGFRVRAGAG 329

                        250
                 ....*....|....*...
gi 504274943 436 VVIDSNPKHEYKESLKKA 453
Cdd:PRK06404 330 IVKDSDPEDEVNEIYSKA 347
MenF COG1169
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ...
 185-459 7.45e-50

Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440783 [Multi-domain]  Cd Length: 353  Bit Score: 173.41  E-value: 7.45e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 185 QIHRVAEKSevsMSEAAFSDATTRVHEYIGQGDVFQVNLSvrQSQQLQT----HPMHIYEQVRKINPSPYMSYMQTEEFH 260
Cdd:COG1169   77 LLRRSRRGV---PDPAEWREAVAQALEAIRAGELDKVVLA--RALDLTLdepiDPRALLARLRRRNPDCYTFAVELGAGD 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 261 I-VSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEygTVHVDEFMV 339
Cdd:COG1169  152 GfVGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVDSIREALAPLCS--SLDVPEEPE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 340 IEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFP----GGTitgaPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELN 415
Cdd:COG1169  230 LLRLRNVQHLATPITGTLDPGVSALDLAAALHPtpavGGT----PREAALALIRELEPFDRGWYAGPVGWVDADGDGEFA 305

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 504274943 416 IAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:COG1169  306 VAIRSALIDGNRARLFAGAGIVAGSDPEAEWAETEAKLRTMLRA 349
isochor_syn TIGR00543
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ...
 184-459 2.63e-48

isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273127  Cd Length: 351  Bit Score: 169.47  E-value: 2.63e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  184 EQIHRVAEKSEvsMSEAAFSDATTRVHEYIGQGDVFQVNLSVRQSQQLQT--HPMHIYEQVRKINPSPYMSYMQTEEFHI 261
Cdd:TIGR00543  76 EQMTTLTTGED--PDKAAWRTAVEEALENIRQGPLDKVVLARALTLKFADdiDPIAVLANLRQQYPNAYIFLLEPPQGGV 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  262 -VSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEygTVHVDEFMVI 340
Cdd:TIGR00543 154 fLGATPERLLSREKGELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPICT--SLDVSETPEL 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  341 EKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRT 420
Cdd:TIGR00543 232 LKLANVQHLYTPISARLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLGWLDGEGNGEFAVGIRS 311

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 504274943  421 MIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIALWKA 459
Cdd:TIGR00543 312 ALVEDGQVRLYAGAGIVADSDPESEWEETELKLQTMLRA 350
PabB-fungal TIGR01823
aminodeoxychorismate synthase, fungal clade; This model represents the fungal clade of a ...
 80-453 9.07e-48

aminodeoxychorismate synthase, fungal clade; This model represents the fungal clade of a para-aminobenzoate synthesis enzyme, aminodeoxychorismate synthase, which acts on chorismate in a pathway that yields PABA, a precursor of folate.


Pssm-ID: 273821 [Multi-domain]  Cd Length: 742  Bit Score: 175.48  E-value: 9.07e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943   80 MRDWMKKFEAEvNPDLP-PFQGGAIGFISYDYIR-----YVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWIIV- 152
Cdd:TIGR01823 345 LGKFMENKKID-NPHREiPFIGGLVGILGYEIGSdlstqYIACGRCNDDENSLVPDAKLVFINRSIVIDHKQGKLYVQSl 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  153 -NDEADCKEQAHKRID---QYKKDWMEASAEGLSYEQIHRVaekseVSM-SEAAFSDATTRVHEYIGQGDVFQVNLS--- 224
Cdd:TIGR01823 424 dNTFPVALEWSGELRDsfvRKKNIKQSLSWPFYLPEEIDFV-----ITFpDKEDYAKAFKACQDYLHAGDSYEMCLTtqt 498

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  225 -VRQSQQLqTHPMHIYEQVRKINPSPYMSYMQTEEFHIVSCSPELLVK-KAGDEISTRPIAGTRSRGKDDQEDQqlADEL 302
Cdd:TIGR01823 499 kVVPPAVI-SPDWEIYQRLRQRNPAPFSGFFRLKHIIFLSTSPEKFLEvGMDTHAKLRPIKGTVKKGPQMNLEK--ARRI 575

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943  303 IHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDF------VDIVDAVFPGGTI 376
Cdd:TIGR01823 576 LKTPKEMGENLMILDLIRNDLYELVPKNDVHVEELMSVEEHATVYQLVSVVKAHGLTSASKktrysgIDVLKHSLPPGSM 655

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504274943  377 TGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMIIQDGQAYVQAGAG--VVIDSNPKHEYKESLKKA 453
Cdd:TIGR01823 656 TGAPKKRSVQLLQDVEGGARGIYSGVTGYWDVNGNGDFSVNIRCAFSYNGGTSWRIGAGgaVTVLSTPEGELEEMYNKL 734
PRK07093 PRK07093
para-aminobenzoate synthase component I; Validated
 209-452 7.57e-39

para-aminobenzoate synthase component I; Validated


Pssm-ID: 235932 [Multi-domain]  Cd Length: 323  Bit Score: 143.09  E-value: 7.57e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 209 VHEYIGQGDVFQVNLSVRQSQQLQTHPMHIYEQVRkinpSPYMSYMQtEEFhiVSCSPELLVKKAGDEISTRPIAGTRSR 288
Cdd:PRK07093  83 VQEEIQAGNSYLLNLTYPTPIETNLSLEEIFQASK----AKYKLLFK-DQF--VCFSPEPFVRIEDNKISTYPMKGTIDA 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 289 GKDDQEDQQLADElihneKERAEHVMLVDLERNDLGRVSEYgtVHVDEFMVIEKYS----HVMHIVSNVKGKLARN--KD 362
Cdd:PRK07093 156 SLPNAEEKLLNDE-----KEFAEHATIVDLLRNDLSMVAKN--VRVTRFRYIDKIKtnkgEILQTSSEISGTLPENwqEN 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 363 FVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWigFNG-DMELNIAIRTMIIQDGQAYVQAGAGVVIDSN 441
Cdd:PRK07093 229 IGDILAKLLPAGSITGAPKEKTVEIIEQAEGYERGFYTGVFGY--FDGeSLDSAVMIRFIEQENDGLYFKSGGGITIDSD 306

                        250
                 ....*....|.
gi 504274943 442 PKHEYKESLKK 452
Cdd:PRK07093 307 LKDEYNELIQK 317
PRK07054 PRK07054
isochorismate synthase;
194-451 4.78e-36

isochorismate synthase;


Pssm-ID: 235920 [Multi-domain]  Cd Length: 475  Bit Score: 139.13  E-value: 4.78e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 194 EVSMSEAA-----FSDATTRVHeyigQGDVFQVNLSVRQSQQL--QTHPMHIYEQVRKINPSPYMSYMQTEEFHIVSCSP 266
Cdd:PRK07054 188 RASALQARewqheVRRAVDAIR----GGAFGKVVLARDVLQQYarPVAIGPLLRRLRLRDPHAHLFAFRRGNACFLGATP 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 267 ELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEygTVHVDEFMVIEKYSHV 346
Cdd:PRK07054 264 ERLVRVAAGDLHTHALAGTIARGADPAEDARLGAALMASAKDRLEHALVVDAIRAALAPLSR--ALDIPDQPSLHRLPRL 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 347 MHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMIIQDG 426
Cdd:PRK07054 342 QHLSTPIRATLAPDATLLQVVAALHPTPAVGGHPRAAALDYIRAHEGFDRGWYAAPIGWLDAHGNGDFAVALRSALITGG 421

                        250       260
                 ....*....|....*....|....*.
gi 504274943 427 QAYVQAGAGVVIDSNPKHEYKES-LK 451
Cdd:PRK07054 422 ACRLFAGCGIVADSEPASEYRETcLK 447
Anth_synt_I_N pfam04715
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) ...
 27-150 8.93e-35

Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) catalyzes the first step in the biosynthesis of tryptophan. Component I catalyzes the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (pfam00425). This region is involved in feedback inhibition by tryptophan. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).


Pssm-ID: 428082 [Multi-domain]  Cd Length: 140  Bit Score: 126.66  E-value: 8.93e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943   27 KEEPNHILLESGRG--GKFQMMGLKPVAILRGEQNEL-HIKTDSQAIVQKGNPLHLMRDWMKKFEAEV-NPDLPPFQGGA 102
Cdd:pfam04715  13 AGEPHSFLLESAEGgeGRYSFIGINPLLTIKSKNGEVsVSGPDGQELEQEDGPLDALRALLARFRIEDsPPTLPPFSGGL 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 504274943  103 IGFISYDYIRYVETIPDLAEDSLKTPDVYFLIFDDVFVYDQEKEKLWI 150
Cdd:pfam04715  93 VGYLGYDLVRYIEKLPRTAPDDLNLPDARLILYEDLIVFDHQENKLYL 140
PRK07912 PRK07912
salicylate synthase;
265-452 1.23e-30

salicylate synthase;


Pssm-ID: 169151 [Multi-domain]  Cd Length: 449  Bit Score: 123.36  E-value: 1.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 265 SPELL--VKKAGdEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEYGTVHVDEFMVIEK 342
Cdd:PRK07912 249 SPELVtaVRADG-VVITEPLAGTRAFGRGAAIDRLARDDLESNSKEIVEHAISVRSSLAEITEIAEPGSAAVIDFMTVRE 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 343 YSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMI 422
Cdd:PRK07912 328 RGSVQHLGSTVRGRLDASSDRMDALEALFPAVTASGIPKAAGVDAIFRLDEAPRGLYSGAVVMLSADGGLDAALTLRAAY 407

                        170       180       190
                 ....*....|....*....|....*....|
gi 504274943 423 IQDGQAYVQAGAGVVIDSNPKHEYKESLKK 452
Cdd:PRK07912 408 QVGGRTWLRAGAGIIEESEPEREFEETCEK 437
PRK06923 PRK06923
isochorismate synthase DhbC; Validated
 265-452 1.29e-29

isochorismate synthase DhbC; Validated


Pssm-ID: 235886 [Multi-domain]  Cd Length: 399  Bit Score: 119.45  E-value: 1.29e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 265 SPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEygTVHVDEFMVIEKYS 344
Cdd:PRK06923 195 SPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEHAVVVEAVAAALRPYCH--TLHVPEKPSVIHTE 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 345 HVMHIVSNVKGKLAR-NKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGFNGDMELNIAIRTMII 423
Cdd:PRK06923 273 AMWHLSTEVKGELKDpNTSSLELAIALHPTPAVCGTPTEEAREAIQQIEPFDREFFTGMLGWSDLNGDGEWIVTIRCAEV 352

                        170       180
                 ....*....|....*....|....*....
gi 504274943 424 QDGQAYVQAGAGVVIDSNPKHEYKESLKK 452
Cdd:PRK06923 353 EENTLRLYAGAGVVAESKPEDELAETSAK 381
PRK06772 PRK06772
salicylate synthase;
243-452 5.48e-28

salicylate synthase;


Pssm-ID: 102546 [Multi-domain]  Cd Length: 434  Bit Score: 115.60  E-value: 5.48e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 243 RKINpSPYMSYM-QTEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERN 321
Cdd:PRK06772 216 RQAN-TPVRSFMfRQEGREALGFSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIA 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 322 DLGRVSEYGTVHVDEFMVIEKYSHVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTG 401
Cdd:PRK06772 295 ELEAVCQPGSVVVEDLMSVRQRGSVQHLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSG 374

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 504274943 402 SIGWIGfNGDMELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKK 452
Cdd:PRK06772 375 AILLLD-DTRFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERELTETREK 424
PLN02786 PLN02786
isochorismate synthase
 198-448 2.26e-22

isochorismate synthase


Pssm-ID: 178383 [Multi-domain]  Cd Length: 533  Bit Score: 99.86  E-value: 2.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 198 SEAAFSDATTRVHEYIGQG--DVFQVNLSVRQSQQLQTH--PMHIYEQVRKINPSPYMSYMQTEE---FhiVSCSPELLV 270
Cdd:PLN02786 258 SKGAWHLAVNKALQIIKRKssPLKKVVLARSSRIITDTDidPIAWLACLQVEGQNAYQFCLQPPDapaF--IGNTPEQLF 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 271 KKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDLERNDLGRVSEygTVHVDEFMVIEKYSHVMHIV 350
Cdd:PLN02786 336 HRKGLGVCSEALAATRPRGGSSARDLQIELDLLTSPKDDLEFSIVRENIREKLEAICD--RVVVEPHKAIRKLARVQHLY 413

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 351 SNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWIGfNGDMELNIAIRTMIIQDGQ-AY 429
Cdd:PLN02786 414 AQLAGRLRSEDDEFDILAALHPTPAVCGHPTEEARLLIAETESFDRGMYAGPVGWFG-GGESEFAVGIRSALVEKGLgAL 492

                        250
                 ....*....|....*....
gi 504274943 430 VQAGAGVVIDSNPKHEYKE 448
Cdd:PLN02786 493 IYAGTGIVEGSNPSSEWNE 511
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 246-449 1.30e-19

isochorismate synthase EntC; Provisional


Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 90.32  E-value: 1.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 246 NPSPYmsymqteEFHI--------VSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVD 317
Cdd:PRK15016 175 NPVSY-------NFHVpladggvlLGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQ 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 318 LERNDLG-RVSEYGTVHVDEFMVIEKyshVMHIVSNVKGKLARNKDFVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRR 396
Cdd:PRK15016 248 AMKEVLReRSSELHVPSSPQLITTPT---LWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQAAKQVIAELEPFDR 324

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 504274943 397 GIYTGSIGWIGFNGDMELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKES 449
Cdd:PRK15016 325 ELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRET 377
PRK15012 PRK15012
menaquinone-specific isochorismate synthase; Provisional
 243-456 3.61e-11

menaquinone-specific isochorismate synthase; Provisional


Pssm-ID: 184974 [Multi-domain]  Cd Length: 431  Bit Score: 64.86  E-value: 3.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 243 RKINPSPYMSYMQ-TEEFHIVSCSPELLVKKAGDEISTRPIAGTRSRGKDDQEDQQLADELIHNEKERAEHVMLVDlern 321
Cdd:PRK15012 215 RRLNLNCYHFYMAfDAENAFLGSSPERLWRRRDKALRTEALAGTVANHPDDKQAQQLGEWLMADDKNQRENMLVVE---- 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504274943 322 DLGRVSEYGTVHVD----EFMVIEKyshVMHIVSNVKGKLARNKDfVDIVDAVFPGGTITGAPKVRTMEIIEELEPVRRG 397
Cdd:PRK15012 291 DICQRLQADTQTLDvlppQVLRLRK---VQHLRRCIWTSLNKADD-VICLHQLQPTAAVAGLPRDLARQFIARHEPFTRE 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 504274943 398 IYTGSIGWIGFNgDMELNIAIRTMIIQDGQAYVQAGAGVVIDSNPKHEYKESLKKAIAL 456
Cdd:PRK15012 367 WYAGSAGYLSLQ-QSEFCVSLRSAKVSGNVVRLYAGAGIVRGSDPEQEWQEIDNKAAGL 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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