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Conserved domains on  [gi|504106832|ref|WP_014340818|]
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class I adenylate cyclase [Pseudomonas ogarae]

Protein Classification

class I adenylate cyclase( domain architecture ID 11459653)

class I adenylate cyclase catalyzes the conversion of ATP to cyclic AMP and pyrophosphate

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
9-940 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


:

Pssm-ID: 442306  Cd Length: 930  Bit Score: 1257.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832   9 PDLDEGIdRKVLSQLRARFLKLNTVRMERALEGLSPRQQGVLTLLPLFFHVNHPLLPGYVSGSTPAGLSNYEPDANILAE 88
Cdd:COG3072    1 PDLDDGM-RKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  89 AQRLTRSFSYKPRHgsNPPRPILGLFLMGSLGTLAQADQSDMDVWVCHGPDLSDDELAELRKKCQLLEIWAATQGAEAHF 168
Cdd:COG3072   80 LQRLARSFDYKQRA--QHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 169 FLIDPTRFVRGERDnQLSSDDCGTTQHYLLLDEFYRTAIWLAGRTPIWWLVPVYEEENYEQYTHTLMSKRFIRADETLDL 248
Cdd:COG3072  158 FLMDENRFRHGERE-SLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDF 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 249 GHLAYIPPGEFVGAGLWQLFKGIESPYKSVLKLLLTEVYASEHPNVRCLSLRFKQAVFANRLDLEELDPYMLVYRRIEEY 328
Cdd:COG3072  237 GGLGTIPAEEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRY 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 329 LNARGESERLELIRRALYLKVNRKLTGQ--ARSSGWQRVLLERLAREWGWDQRQLALLDSRSQWKVRQVSHERRALVNEL 406
Cdd:COG3072  317 LLERNDLKRLELVRRCFYLKVNEKLSRPprERSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDEL 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 407 THSYRFLTQFARTEKTVSLINKRDLNVLGRRLYAAFERKADKVEFINPGIAPDLAEDTLTLVQSPNKKePGQNQWGLYNG 486
Cdd:COG3072  397 MQSYRNLIQFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGR-ANRAGWYLYNQ 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 487 SLHALEWENFAPIKRCRELLELLTWCHRNGVIDSSTRLALHPGDSDLSEFELFNLLGSLQQSIALPLATVDEAQLLRASV 566
Cdd:COG3072  476 SLTPADIIGRQPLKYSRSLVELVAWCYFNGLLTASTRLHLHPGGSDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCE 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 567 PSEVLILVNVGVDPLKHHRDLNILMTTERTDSLSYAGVRENLVLTLDQVTLNSWNEVLVNRFDGEHALLDCLRDYLNDLP 646
Cdd:COG3072  556 IRHLALFINLGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMH 635
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 647 V-TQRQPRLQVRCFCHNRAQFIARRVEEVIETAQTLLLSR---LNHRYLLQVQQHYHVLELVPGQVNHVALGSLSALMDY 722
Cdd:COG3072  636 QdAAPPPSIDVFCYSQTRRGAIANRVEQLFNECISLRLGGtrqPNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRA 715
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 723 LGEELTAYSPLHLDPMALEDHDL-ALILPMGQPECVQVFYRVNEDEADLYVLDEFNALWQQHLPYHDEQSLLVPLQRFLQ 801
Cdd:COG3072  716 LSENKLSYSPLVLDRHALEDHPLpPVIDSFASEGLIQFFFEDNGDGFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYR 795
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 802 SVLYRRDALLPldaaQPLTLETLYYQLLPSGSGRaRRIEARQAPQTPVNKPFYDVQAIIGKAahGQVHVTLYCDQQEFSE 881
Cdd:COG3072  796 SSQDRRTYGSS----FINFNLPQFYQIVRNDGGE-LQVEPFRSPLAASDANYYEVQAIGDEG--DDSLFEFYCDCQEFES 868
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504106832 882 LEHGDQLFRVVAREIVEQRREAQRYRCYITDLDLSG---LVGDGACSSNLYLRYKADLERAL 940
Cdd:COG3072  869 LELEGDLLLVAAVAILLRRRRRRPYPYYITDDDLLSaleLDEQLEQQTVQTLQYLKYLEALE 930
 
Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
9-940 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


Pssm-ID: 442306  Cd Length: 930  Bit Score: 1257.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832   9 PDLDEGIdRKVLSQLRARFLKLNTVRMERALEGLSPRQQGVLTLLPLFFHVNHPLLPGYVSGSTPAGLSNYEPDANILAE 88
Cdd:COG3072    1 PDLDDGM-RKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  89 AQRLTRSFSYKPRHgsNPPRPILGLFLMGSLGTLAQADQSDMDVWVCHGPDLSDDELAELRKKCQLLEIWAATQGAEAHF 168
Cdd:COG3072   80 LQRLARSFDYKQRA--QHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 169 FLIDPTRFVRGERDnQLSSDDCGTTQHYLLLDEFYRTAIWLAGRTPIWWLVPVYEEENYEQYTHTLMSKRFIRADETLDL 248
Cdd:COG3072  158 FLMDENRFRHGERE-SLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDF 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 249 GHLAYIPPGEFVGAGLWQLFKGIESPYKSVLKLLLTEVYASEHPNVRCLSLRFKQAVFANRLDLEELDPYMLVYRRIEEY 328
Cdd:COG3072  237 GGLGTIPAEEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRY 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 329 LNARGESERLELIRRALYLKVNRKLTGQ--ARSSGWQRVLLERLAREWGWDQRQLALLDSRSQWKVRQVSHERRALVNEL 406
Cdd:COG3072  317 LLERNDLKRLELVRRCFYLKVNEKLSRPprERSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDEL 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 407 THSYRFLTQFARTEKTVSLINKRDLNVLGRRLYAAFERKADKVEFINPGIAPDLAEDTLTLVQSPNKKePGQNQWGLYNG 486
Cdd:COG3072  397 MQSYRNLIQFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGR-ANRAGWYLYNQ 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 487 SLHALEWENFAPIKRCRELLELLTWCHRNGVIDSSTRLALHPGDSDLSEFELFNLLGSLQQSIALPLATVDEAQLLRASV 566
Cdd:COG3072  476 SLTPADIIGRQPLKYSRSLVELVAWCYFNGLLTASTRLHLHPGGSDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCE 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 567 PSEVLILVNVGVDPLKHHRDLNILMTTERTDSLSYAGVRENLVLTLDQVTLNSWNEVLVNRFDGEHALLDCLRDYLNDLP 646
Cdd:COG3072  556 IRHLALFINLGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMH 635
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 647 V-TQRQPRLQVRCFCHNRAQFIARRVEEVIETAQTLLLSR---LNHRYLLQVQQHYHVLELVPGQVNHVALGSLSALMDY 722
Cdd:COG3072  636 QdAAPPPSIDVFCYSQTRRGAIANRVEQLFNECISLRLGGtrqPNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRA 715
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 723 LGEELTAYSPLHLDPMALEDHDL-ALILPMGQPECVQVFYRVNEDEADLYVLDEFNALWQQHLPYHDEQSLLVPLQRFLQ 801
Cdd:COG3072  716 LSENKLSYSPLVLDRHALEDHPLpPVIDSFASEGLIQFFFEDNGDGFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYR 795
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 802 SVLYRRDALLPldaaQPLTLETLYYQLLPSGSGRaRRIEARQAPQTPVNKPFYDVQAIIGKAahGQVHVTLYCDQQEFSE 881
Cdd:COG3072  796 SSQDRRTYGSS----FINFNLPQFYQIVRNDGGE-LQVEPFRSPLAASDANYYEVQAIGDEG--DDSLFEFYCDCQEFES 868
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504106832 882 LEHGDQLFRVVAREIVEQRREAQRYRCYITDLDLSG---LVGDGACSSNLYLRYKADLERAL 940
Cdd:COG3072  869 LELEGDLLLVAAVAILLRRRRRRPYPYYITDDDLLSaleLDEQLEQQTVQTLQYLKYLEALE 930
cyaA PRK09450
class I adenylate cyclase;
16-802 0e+00

class I adenylate cyclase;


Pssm-ID: 236522 [Multi-domain]  Cd Length: 830  Bit Score: 1150.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  16 DRKVLSQLRARFLKLNTVRMERALEGLSPRQQGVLTLLPLFFHVNHPLLPGYVSGSTPAGLSNYEPDANILAEAQRLTRS 95
Cdd:PRK09450   1 MRKYLETLKQRLDALNQLRLARALAALSPAFQQVLSLLPLLLHVNHPLLPGYVSGNTPAGICNFTPDETQLAYLQRLELS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  96 FSYKPRHGSNPPRPILGLFLMGSLGTLAQADQSDMDVWVCHGPDLSDDELAELRKKCQLLEIWAATQGAEAHFFLIDPTR 175
Cdd:PRK09450  81 FGYSVQDPPKGELPITGLYTMGSTGSIGQSESSDLDIWVCHRPWLDAEERQLLQRKCSLLEQWAASLGVEVNFFLMDEER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 176 FVRGERDNQLSSDDCGTTQHYLLLDEFYRTAIWLAGRTPIWWLVPVYEEENYEQYTHTLMSKRFIRADETLDLGHLAYIP 255
Cdd:PRK09450 161 FRHNESGSALGGEDCGSTQHILLLDEFYRTAIRLAGKRPLWWLVPVEEEEHYDDYVMTLYSKGFLNPNEWLDLGGLSSLP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 256 PGEFVGAGLWQLFKGIESPYKSVLKLLLTEVYASEHPNVRCLSLRFKQAVFANRLDLEELDPYMLVYRRIEEYLNARGES 335
Cdd:PRK09450 241 AEEYFGASLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLDFKQRLLAGEIDSDGLDPYCLMLERVTRYLTAINDP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 336 ERLELIRRALYLKVNRKLTGQARSSGWQRVLLERLAREWGWDQRQLALLDSRSQWKVRQVSHERRALVNELTHSYRFLTQ 415
Cdd:PRK09450 321 TRLELVRRCFYLKVGEKLSRERACVGWRRELLSQLVSEWGWDEERLALLDNRANWKIGQVREFHNELVDALMQSYRNLIR 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 416 FARTEKTVSLINKRDLNVLGRRLYAAFERKADKVEFINPGIAPDLAEDTLTLVQSPNkKEPGQNQWGLYNGSLHALEWEN 495
Cdd:PRK09450 401 FARRNNLSSSISPQDIGILTRKLYAAFERLPGKVTLLNPQISPDLSEPDLTFIEVPP-GRANRSGWYLYNQAPDPDSIIG 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 496 FAPIKRCRELLELLTWCHRNGVIDSSTRLALHPGDSDLSEFELFNLLGSLQQSIALPLATVDEAQLLRASVPSEVLILVN 575
Cdd:PRK09450 480 HQPLEYNRYLNKLVAWAYFNGLLTSSTRLHLKGNGSDLDLAKLQELVADLRQHFPLRLPAPTPQALLQPCEIRHLLIIVN 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 576 VGVDPLKHHRDLNILMTTERTDSLSYAGVRENLVLTLDQVTLNSWNEVLVNRFDGEHALLDCLRDYLNDLPV-TQRQPRL 654
Cdd:PRK09450 560 LEVDPTAHLRGQVVHFDFRNLDVFSFGGEQENLVGSVDLIYRNSWNEVRTLHFEGEQALLDALKTILGKMHQdAAPPPSV 639
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 655 QVRCFCHNRAQFIARRVEEVIETAQTLLLSRLNH--RYLLQVQQHYHVLELVPGQVNHVALGSLSALMDYLGEELTAYSP 732
Cdd:PRK09450 640 EVFCYSQHLRGLIRTRVQQLVSECIELRLGSTRQepGKALRVAGQTWGLFFERLGVSVQKLENAVEFYGALSENKLHGLP 719
                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504106832 733 LHLDpmaLEDHDLALIL-PMGQPECVQVFYRVNEDEADLYVLDEFNALWQQHLPYHDEQSLLVPLQRFLQS 802
Cdd:PRK09450 720 VQLD---TNFLKLPAVVdGFASEGIIQFFFEDNEDGFNVYILDESNRLEHYHHCEGSKEELVRDVSRFYSS 787
Adenylate_cycl pfam01295
Adenylate cyclase, class-I;
244-779 4.13e-113

Adenylate cyclase, class-I;


Pssm-ID: 426186  Cd Length: 601  Bit Score: 360.42  E-value: 4.13e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  244 ETLDLGHLAYIPPGEFVGAGLWQLFKGIESPYKSVLKLLLTEVYASEHPNVRCLSLRFKQAVFANRLDLEELDPYMLVYR 323
Cdd:pfam01295   1 DWLDLGGLSALPAEEYFGASLWQLYKGIDSPYKAVLKILLLEAYSSEYPNTELLSSQFKRRLLAGDFTSYHLDPYLLMLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  324 RIEEYLNARGESERLELIRRALYLKVNRKLTGQARSSG--WQRVLLERLAREWGWDQRQLALLDSRSQWKVRQVSHERRA 401
Cdd:pfam01295  81 RVTDYLTKINDFKRLDLVRRCFYLKAGEGLSRLQPNGAkdWRRDKLQELVQQWHWSDELIQTLDNRRHWKVGQVKWANNQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  402 LVNELTHSYRFLTQFARTEKTVSLINKRDLNVLGRRLYAAFERKADKVEFINPGIAPDLAEDTLTLVQSPNKKePGQNQW 481
Cdd:pfam01295 161 LLELLMLSYRNLIQFARKHNISESISPEDIGILTRKLYTAFEELPGKVTLLNPLISPDLSEPDLTFIEVPEGR-SNKAGW 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  482 GLYNGSLHALEWENFAPIKRCRELLELLTWCHRNGVIDSSTRLALHPGDSDLSEFELFNLLGSLQQSIALPLATVDEAQL 561
Cdd:pfam01295 240 YLYNQPPDPADLIGRRPLEYAKYLSKLVAWAYFNGLLTESTRLHLVSQGVDLTSDKLSQFVTDLRLSFPVRAPKPTNQDL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  562 LRASVPSEVLILVNVGVDPLKHHRDLNILMTTERTDSLSYAGVRENLVLTLDQVTLNSWNEVLVNRFDGEHALLDCLRDY 641
Cdd:pfam01295 320 SHPCEIRHLVIFINLEQDPTTHWSGQEVMVDIQNADLFSFGRSQENLVGSVDLIYRNSWNEIRTLHFEGENALLKALKTI 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  642 LNDLpvtqRQ---PRLQVRCFCHNR------AQFIARRVEEVIE-----TAQTLLLSRL---NHRYLLQVQQH---YHVL 701
Cdd:pfam01295 400 LNKI----HRdaaPPESIDVFCYSRrlrsqlRNAVKQLLNRCIElrlgtIQSRTQVKPLrigGKNYGLFFERRgvsVQDL 475
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504106832  702 ELVPGQVNHVALGSLSALMDYLGEELTAYSPlhldPMALEDHdlaliLPMGqpeCVQVFYRVNEDEADLYVLDEFNAL 779
Cdd:pfam01295 476 ENAVDFYGQISRNKLVELPRPELGDDPFLHI----PAIIDAF-----ASEG---LIQFFFEDNEDGFNVYILDEKNEL 541
 
Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
9-940 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


Pssm-ID: 442306  Cd Length: 930  Bit Score: 1257.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832   9 PDLDEGIdRKVLSQLRARFLKLNTVRMERALEGLSPRQQGVLTLLPLFFHVNHPLLPGYVSGSTPAGLSNYEPDANILAE 88
Cdd:COG3072    1 PDLDDGM-RKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  89 AQRLTRSFSYKPRHgsNPPRPILGLFLMGSLGTLAQADQSDMDVWVCHGPDLSDDELAELRKKCQLLEIWAATQGAEAHF 168
Cdd:COG3072   80 LQRLARSFDYKQRA--QHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 169 FLIDPTRFVRGERDnQLSSDDCGTTQHYLLLDEFYRTAIWLAGRTPIWWLVPVYEEENYEQYTHTLMSKRFIRADETLDL 248
Cdd:COG3072  158 FLMDENRFRHGERE-SLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDF 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 249 GHLAYIPPGEFVGAGLWQLFKGIESPYKSVLKLLLTEVYASEHPNVRCLSLRFKQAVFANRLDLEELDPYMLVYRRIEEY 328
Cdd:COG3072  237 GGLGTIPAEEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRY 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 329 LNARGESERLELIRRALYLKVNRKLTGQ--ARSSGWQRVLLERLAREWGWDQRQLALLDSRSQWKVRQVSHERRALVNEL 406
Cdd:COG3072  317 LLERNDLKRLELVRRCFYLKVNEKLSRPprERSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDEL 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 407 THSYRFLTQFARTEKTVSLINKRDLNVLGRRLYAAFERKADKVEFINPGIAPDLAEDTLTLVQSPNKKePGQNQWGLYNG 486
Cdd:COG3072  397 MQSYRNLIQFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGR-ANRAGWYLYNQ 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 487 SLHALEWENFAPIKRCRELLELLTWCHRNGVIDSSTRLALHPGDSDLSEFELFNLLGSLQQSIALPLATVDEAQLLRASV 566
Cdd:COG3072  476 SLTPADIIGRQPLKYSRSLVELVAWCYFNGLLTASTRLHLHPGGSDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCE 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 567 PSEVLILVNVGVDPLKHHRDLNILMTTERTDSLSYAGVRENLVLTLDQVTLNSWNEVLVNRFDGEHALLDCLRDYLNDLP 646
Cdd:COG3072  556 IRHLALFINLGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMH 635
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 647 V-TQRQPRLQVRCFCHNRAQFIARRVEEVIETAQTLLLSR---LNHRYLLQVQQHYHVLELVPGQVNHVALGSLSALMDY 722
Cdd:COG3072  636 QdAAPPPSIDVFCYSQTRRGAIANRVEQLFNECISLRLGGtrqPNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRA 715
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 723 LGEELTAYSPLHLDPMALEDHDL-ALILPMGQPECVQVFYRVNEDEADLYVLDEFNALWQQHLPYHDEQSLLVPLQRFLQ 801
Cdd:COG3072  716 LSENKLSYSPLVLDRHALEDHPLpPVIDSFASEGLIQFFFEDNGDGFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYR 795
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 802 SVLYRRDALLPldaaQPLTLETLYYQLLPSGSGRaRRIEARQAPQTPVNKPFYDVQAIIGKAahGQVHVTLYCDQQEFSE 881
Cdd:COG3072  796 SSQDRRTYGSS----FINFNLPQFYQIVRNDGGE-LQVEPFRSPLAASDANYYEVQAIGDEG--DDSLFEFYCDCQEFES 868
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504106832 882 LEHGDQLFRVVAREIVEQRREAQRYRCYITDLDLSG---LVGDGACSSNLYLRYKADLERAL 940
Cdd:COG3072  869 LELEGDLLLVAAVAILLRRRRRRPYPYYITDDDLLSaleLDEQLEQQTVQTLQYLKYLEALE 930
cyaA PRK09450
class I adenylate cyclase;
16-802 0e+00

class I adenylate cyclase;


Pssm-ID: 236522 [Multi-domain]  Cd Length: 830  Bit Score: 1150.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  16 DRKVLSQLRARFLKLNTVRMERALEGLSPRQQGVLTLLPLFFHVNHPLLPGYVSGSTPAGLSNYEPDANILAEAQRLTRS 95
Cdd:PRK09450   1 MRKYLETLKQRLDALNQLRLARALAALSPAFQQVLSLLPLLLHVNHPLLPGYVSGNTPAGICNFTPDETQLAYLQRLELS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  96 FSYKPRHGSNPPRPILGLFLMGSLGTLAQADQSDMDVWVCHGPDLSDDELAELRKKCQLLEIWAATQGAEAHFFLIDPTR 175
Cdd:PRK09450  81 FGYSVQDPPKGELPITGLYTMGSTGSIGQSESSDLDIWVCHRPWLDAEERQLLQRKCSLLEQWAASLGVEVNFFLMDEER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 176 FVRGERDNQLSSDDCGTTQHYLLLDEFYRTAIWLAGRTPIWWLVPVYEEENYEQYTHTLMSKRFIRADETLDLGHLAYIP 255
Cdd:PRK09450 161 FRHNESGSALGGEDCGSTQHILLLDEFYRTAIRLAGKRPLWWLVPVEEEEHYDDYVMTLYSKGFLNPNEWLDLGGLSSLP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 256 PGEFVGAGLWQLFKGIESPYKSVLKLLLTEVYASEHPNVRCLSLRFKQAVFANRLDLEELDPYMLVYRRIEEYLNARGES 335
Cdd:PRK09450 241 AEEYFGASLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLDFKQRLLAGEIDSDGLDPYCLMLERVTRYLTAINDP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 336 ERLELIRRALYLKVNRKLTGQARSSGWQRVLLERLAREWGWDQRQLALLDSRSQWKVRQVSHERRALVNELTHSYRFLTQ 415
Cdd:PRK09450 321 TRLELVRRCFYLKVGEKLSRERACVGWRRELLSQLVSEWGWDEERLALLDNRANWKIGQVREFHNELVDALMQSYRNLIR 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 416 FARTEKTVSLINKRDLNVLGRRLYAAFERKADKVEFINPGIAPDLAEDTLTLVQSPNkKEPGQNQWGLYNGSLHALEWEN 495
Cdd:PRK09450 401 FARRNNLSSSISPQDIGILTRKLYAAFERLPGKVTLLNPQISPDLSEPDLTFIEVPP-GRANRSGWYLYNQAPDPDSIIG 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 496 FAPIKRCRELLELLTWCHRNGVIDSSTRLALHPGDSDLSEFELFNLLGSLQQSIALPLATVDEAQLLRASVPSEVLILVN 575
Cdd:PRK09450 480 HQPLEYNRYLNKLVAWAYFNGLLTSSTRLHLKGNGSDLDLAKLQELVADLRQHFPLRLPAPTPQALLQPCEIRHLLIIVN 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 576 VGVDPLKHHRDLNILMTTERTDSLSYAGVRENLVLTLDQVTLNSWNEVLVNRFDGEHALLDCLRDYLNDLPV-TQRQPRL 654
Cdd:PRK09450 560 LEVDPTAHLRGQVVHFDFRNLDVFSFGGEQENLVGSVDLIYRNSWNEVRTLHFEGEQALLDALKTILGKMHQdAAPPPSV 639
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832 655 QVRCFCHNRAQFIARRVEEVIETAQTLLLSRLNH--RYLLQVQQHYHVLELVPGQVNHVALGSLSALMDYLGEELTAYSP 732
Cdd:PRK09450 640 EVFCYSQHLRGLIRTRVQQLVSECIELRLGSTRQepGKALRVAGQTWGLFFERLGVSVQKLENAVEFYGALSENKLHGLP 719
                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504106832 733 LHLDpmaLEDHDLALIL-PMGQPECVQVFYRVNEDEADLYVLDEFNALWQQHLPYHDEQSLLVPLQRFLQS 802
Cdd:PRK09450 720 VQLD---TNFLKLPAVVdGFASEGIIQFFFEDNEDGFNVYILDESNRLEHYHHCEGSKEELVRDVSRFYSS 787
Adenylate_cycl pfam01295
Adenylate cyclase, class-I;
244-779 4.13e-113

Adenylate cyclase, class-I;


Pssm-ID: 426186  Cd Length: 601  Bit Score: 360.42  E-value: 4.13e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  244 ETLDLGHLAYIPPGEFVGAGLWQLFKGIESPYKSVLKLLLTEVYASEHPNVRCLSLRFKQAVFANRLDLEELDPYMLVYR 323
Cdd:pfam01295   1 DWLDLGGLSALPAEEYFGASLWQLYKGIDSPYKAVLKILLLEAYSSEYPNTELLSSQFKRRLLAGDFTSYHLDPYLLMLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  324 RIEEYLNARGESERLELIRRALYLKVNRKLTGQARSSG--WQRVLLERLAREWGWDQRQLALLDSRSQWKVRQVSHERRA 401
Cdd:pfam01295  81 RVTDYLTKINDFKRLDLVRRCFYLKAGEGLSRLQPNGAkdWRRDKLQELVQQWHWSDELIQTLDNRRHWKVGQVKWANNQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  402 LVNELTHSYRFLTQFARTEKTVSLINKRDLNVLGRRLYAAFERKADKVEFINPGIAPDLAEDTLTLVQSPNKKePGQNQW 481
Cdd:pfam01295 161 LLELLMLSYRNLIQFARKHNISESISPEDIGILTRKLYTAFEELPGKVTLLNPLISPDLSEPDLTFIEVPEGR-SNKAGW 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  482 GLYNGSLHALEWENFAPIKRCRELLELLTWCHRNGVIDSSTRLALHPGDSDLSEFELFNLLGSLQQSIALPLATVDEAQL 561
Cdd:pfam01295 240 YLYNQPPDPADLIGRRPLEYAKYLSKLVAWAYFNGLLTESTRLHLVSQGVDLTSDKLSQFVTDLRLSFPVRAPKPTNQDL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  562 LRASVPSEVLILVNVGVDPLKHHRDLNILMTTERTDSLSYAGVRENLVLTLDQVTLNSWNEVLVNRFDGEHALLDCLRDY 641
Cdd:pfam01295 320 SHPCEIRHLVIFINLEQDPTTHWSGQEVMVDIQNADLFSFGRSQENLVGSVDLIYRNSWNEIRTLHFEGENALLKALKTI 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  642 LNDLpvtqRQ---PRLQVRCFCHNR------AQFIARRVEEVIE-----TAQTLLLSRL---NHRYLLQVQQH---YHVL 701
Cdd:pfam01295 400 LNKI----HRdaaPPESIDVFCYSRrlrsqlRNAVKQLLNRCIElrlgtIQSRTQVKPLrigGKNYGLFFERRgvsVQDL 475
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504106832  702 ELVPGQVNHVALGSLSALMDYLGEELTAYSPlhldPMALEDHdlaliLPMGqpeCVQVFYRVNEDEADLYVLDEFNAL 779
Cdd:pfam01295 476 ENAVDFYGQISRNKLVELPRPELGDDPFLHI----PAIIDAF-----ASEG---LIQFFFEDNEDGFNVYILDEKNEL 541
Adenyl_cycl_N pfam12633
Adenylate cyclase NT domain;
20-217 9.64e-106

Adenylate cyclase NT domain;


Pssm-ID: 432684 [Multi-domain]  Cd Length: 198  Bit Score: 326.06  E-value: 9.64e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832   20 LSQLRARFLKLNTVRMERALEGLSPRQQGVLTLLPLFFHVNHPLLPGYVSGSTPAGLSNYEPDANILAEAQRLTRSFSYK 99
Cdd:pfam12633   2 LETLRQRFDALNQLRLERALAALSPRQQQVLRLLPLLLHVNHPLLPGYVSGDTPCGIANFEPSKFQLALLDRLFRSFTYK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504106832  100 PRHGSNPPRPILGLFLMGSLGTLAQADQSDMDVWVCHGPDLSDDELAELRKKCQLLEIWAATQGAEAHFFLIDPTRFvRG 179
Cdd:pfam12633  82 ETKTDISDPPILGLYLMGSTGSIAQSASSDLDIWVCHRPGLDAEELELLQRKCQLIEQWAAQFGVEVHFFLMDPERF-RS 160
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 504106832  180 ERDNQLSSDDCGTTQHYLLLDEFYRTAIWLAGRTPIWW 217
Cdd:pfam12633 161 NRSSSLTEESSGSAQHLLLLDEFYRTAIRLAGKRPLWW 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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