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Conserved domains on  [gi|504005525|ref|WP_014239519|]
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MULTISPECIES: phosphoribosylaminoimidazolesuccinocarboxamide synthase [Rhodospirillales]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10013199)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

EC:  6.3.2.6
Gene Ontology:  GO:0005524|GO:0004639

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-241 1.52e-159

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


:

Pssm-ID: 181800  Cd Length: 238  Bit Score: 441.85  E-value: 1.52e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   1 MTRRRRIYEGKAKVLFEGPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQL 80
Cdd:PRK09362   1 MEKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  81 VREVEIIPIELVVRNTAAGSLSKRFGIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMVALSLRVND 160
Cdd:PRK09362  81 VKKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKIND 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525 161 YLSGLFLGIGLRLVDFKLEFGRLWENEemrIVLADEISPDNCRLWDIKTNEKLDKDRFRQDLGQVEEAYQEVARRLGILP 240
Cdd:PRK09362 161 VLKGLFAGAGIRLVDFKLEFGRDKDGE---IVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELL 237


                 .
gi 504005525 241 E 241
Cdd:PRK09362 238 E 238
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-241 1.52e-159

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 441.85  E-value: 1.52e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   1 MTRRRRIYEGKAKVLFEGPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQL 80
Cdd:PRK09362   1 MEKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  81 VREVEIIPIELVVRNTAAGSLSKRFGIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMVALSLRVND 160
Cdd:PRK09362  81 VKKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKIND 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525 161 YLSGLFLGIGLRLVDFKLEFGRLWENEemrIVLADEISPDNCRLWDIKTNEKLDKDRFRQDLGQVEEAYQEVARRLGILP 240
Cdd:PRK09362 161 VLKGLFAGAGIRLVDFKLEFGRDKDGE---IVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELL 237


                 .
gi 504005525 241 E 241
Cdd:PRK09362 238 E 238
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 7-238 2.14e-142

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 398.36  E-value: 2.14e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   7 IYEGKAKVLFEGPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQLVREVEI 86
Cdd:cd01415    2 LYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  87 IPIELVVRNTAAGSLSKRFGIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMVALSLRVNDYLSGLF 166
Cdd:cd01415   82 IPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEFF 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504005525 167 LGIGLRLVDFKLEFGRlweNEEMRIVLADEISPDNCRLWDIKTNEKLDKDRFRQDLGQVEEAYQEVARRLGI 238
Cdd:cd01415  162 AEIGIILVDFKLEFGR---DKDGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLGE 230
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-240 1.20e-125

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 356.31  E-value: 1.20e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   1 MTRRRRIYEGKAKVLFEGPEpGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQL 80
Cdd:COG0152    1 MPKLELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREML 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  81 VREVEIIPIELVVRNTAAGSLSKR--------FGIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMV 152
Cdd:COG0152   80 VKKLEMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525 153 ALSLRVNDYLSGLFLGIGLRLVDFKLEFGRLWENEemrIVLADEISPDNCRLWDIKTNEKLDKDRFRQDLG-QVEEAYQE 231
Cdd:COG0152  160 ELALKINERLSELAAERGIILVDTKLEFGRDADGE---IVLADEITPDSSRLWDADTYESLDKDRFRDWLGgNTSEAYIE 236


                 ....*....
gi 504005525 232 VARRLGILP 240
Cdd:COG0152  237 VLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 7-231 1.18e-119

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 340.49  E-value: 1.18e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525    7 IYEGKAKVLFEGPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQLVREVEI 86
Cdd:pfam01259   2 LYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVKI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   87 IPIELVVRNTAAGSLSKRF-GIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMVALSLRVNDYLSGL 165
Cdd:pfam01259  82 IPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKEY 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  166 FLGIGLRLVDFKLEFGRLWENEemrIVLADEISPDNCRLWDIKT----NEKLDKDRFRQDLGQVEEAYQE 231
Cdd:pfam01259 162 AAERGIILVDTKLEFGLDSDGE---IVLADEITPDSSRFWDADTyeksQESLDKDRFRDDLGDVEEAYQE 228
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 1-234 2.98e-88

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 261.56  E-value: 2.98e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525    1 MTRRRRIYEGKAKVLFEGPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQL 80
Cdd:TIGR00081   3 IKKRQKLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   81 VREVEIIPIELVVRNTAAGSLSKRFGIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMVALSLRVND 160
Cdd:TIGR00081  83 VKKLDIIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNE 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504005525  161 YLSGLFLGIGLRLVDFKLEFGRlweNEEMRIVLADEISPDNCRLWDIKTNE----KLDKDRFRQDLGQVEEAYQEVAR 234
Cdd:TIGR00081 163 VLKKYFDEKGIILVDFKLEFGL---DEEGNLILADEVSPDTCRLWDKETYEvgapKLDKDIFRRTLGKLIEAYETVAR 237
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-241 1.52e-159

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 441.85  E-value: 1.52e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   1 MTRRRRIYEGKAKVLFEGPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQL 80
Cdd:PRK09362   1 MEKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  81 VREVEIIPIELVVRNTAAGSLSKRFGIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMVALSLRVND 160
Cdd:PRK09362  81 VKKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKIND 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525 161 YLSGLFLGIGLRLVDFKLEFGRLWENEemrIVLADEISPDNCRLWDIKTNEKLDKDRFRQDLGQVEEAYQEVARRLGILP 240
Cdd:PRK09362 161 VLKGLFAGAGIRLVDFKLEFGRDKDGE---IVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELL 237


                 .
gi 504005525 241 E 241
Cdd:PRK09362 238 E 238
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 7-238 2.14e-142

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 398.36  E-value: 2.14e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   7 IYEGKAKVLFEGPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQLVREVEI 86
Cdd:cd01415    2 LYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  87 IPIELVVRNTAAGSLSKRFGIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMVALSLRVNDYLSGLF 166
Cdd:cd01415   82 IPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEFF 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504005525 167 LGIGLRLVDFKLEFGRlweNEEMRIVLADEISPDNCRLWDIKTNEKLDKDRFRQDLGQVEEAYQEVARRLGI 238
Cdd:cd01415  162 AEIGIILVDFKLEFGR---DKDGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLGE 230
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-240 1.20e-125

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 356.31  E-value: 1.20e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   1 MTRRRRIYEGKAKVLFEGPEpGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQL 80
Cdd:COG0152    1 MPKLELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREML 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  81 VREVEIIPIELVVRNTAAGSLSKR--------FGIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMV 152
Cdd:COG0152   80 VKKLEMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525 153 ALSLRVNDYLSGLFLGIGLRLVDFKLEFGRLWENEemrIVLADEISPDNCRLWDIKTNEKLDKDRFRQDLG-QVEEAYQE 231
Cdd:COG0152  160 ELALKINERLSELAAERGIILVDTKLEFGRDADGE---IVLADEITPDSSRLWDADTYESLDKDRFRDWLGgNTSEAYIE 236


                 ....*....
gi 504005525 232 VARRLGILP 240
Cdd:COG0152  237 VLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 7-231 1.18e-119

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 340.49  E-value: 1.18e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525    7 IYEGKAKVLFEGPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQLVREVEI 86
Cdd:pfam01259   2 LYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVKI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   87 IPIELVVRNTAAGSLSKRF-GIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMVALSLRVNDYLSGL 165
Cdd:pfam01259  82 IPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKEY 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  166 FLGIGLRLVDFKLEFGRLWENEemrIVLADEISPDNCRLWDIKT----NEKLDKDRFRQDLGQVEEAYQE 231
Cdd:pfam01259 162 AAERGIILVDTKLEFGLDSDGE---IVLADEITPDSSRFWDADTyeksQESLDKDRFRDDLGDVEEAYQE 228
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 1-234 2.98e-88

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 261.56  E-value: 2.98e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525    1 MTRRRRIYEGKAKVLFEGPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQL 80
Cdd:TIGR00081   3 IKKRQKLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   81 VREVEIIPIELVVRNTAAGSLSKRFGIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMVALSLRVND 160
Cdd:TIGR00081  83 VKKLDIIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNE 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504005525  161 YLSGLFLGIGLRLVDFKLEFGRlweNEEMRIVLADEISPDNCRLWDIKTNE----KLDKDRFRQDLGQVEEAYQEVAR 234
Cdd:TIGR00081 163 VLKKYFDEKGIILVDFKLEFGL---DEEGNLILADEVSPDTCRLWDKETYEvgapKLDKDIFRRTLGKLIEAYETVAR 237
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 7-237 1.23e-59

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 188.44  E-value: 1.23e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   7 IYEGKAKVLFEgPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQLVREVEI 86
Cdd:cd00476    2 LYRGKTKIVYE-TKDGVLLLEFKDDISAGDGARRNFLDEKGDITAKLTLFIFKYLSEAGIPTHFVERLGPRTLLVDKLK* 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  87 IPIELVVRNTAAGSLSKRF-GIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGWAAPQDLDDMVALSLRVNDYLSGL 165
Cdd:cd00476   81 IPLEVVVRNRATGSFVKRYgGFKEGREFPPPLVEFFYKDDAEHDPIVSEDQLERLGFIGKVDVER*KELAVKINTVLKKL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504005525 166 FLGIGLRLVDFKLEFGRLWENEemrIVLADEISPDNCRLWDIKTNEKL-DKDRFRQDLGQVEEAYQEVARRLG 237
Cdd:cd00476  161 FSPAGLELWDFKLEFGLDEEGE---IVLGDEISPDSSRLWRKGGEPYDkDLFRRRASLGQIIEKYEEVAELVR 230
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 5-235 2.07e-40

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 139.74  E-value: 2.07e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   5 RRIYEGKAKVLFEGPE-PGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIGVPTHFVRRLNMREQLVRE 83
Cdd:cd01416    5 KKLIEGKTKIVYELPDqPGLVLIQSKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSPTAFIARK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  84 VEIIPIELVVRNTAAGSLSKRF-GIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGW------AAPQDLDDMVALSL 156
Cdd:cd01416   85 CEMIPIEWVCRRIATGSFLKRNpGVKEGYRFSPPKLEFFYKDDANHDPQWSEEQLLEAKLncgglkIGKKEVDIMTKSTI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525 157 RVNDYLSGLFLGIGLRLVDFKLEFGRLWENEEmrIVLADEISPDNCRLWDI-KTNEKLDKDRFRqDLGQV-EEAYQEVAR 234
Cdd:cd01416  165 AIFEILEKAWATQDCTLVDMKIEFGVDVTTGE--ILLADVIDNDSWRLWPSgDKRLMKDKQVYR-NLKEVtDEALQEVKK 241


                 .
gi 504005525 235 R 235
Cdd:cd01416  242 N 242
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 7-220 1.53e-21

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 90.69  E-value: 1.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   7 IYEGKAKVLFEgPEPGTLVQYFKDDATAFNNQKKGIITGKGVLNNRISEYLMSRLSEIgVPTHFV-------------RR 73
Cdd:cd01414    2 IYSGKVRDVYD-LGDGRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELTEDI-IPNHLIstdvedlpeikepED 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  74 LNMREQLVREVEIIPIELVVRNTAAGSLSKRF-------------GIPEGTPLPRSIIEYYYKSDELNNPMVTEEHITAf 140
Cdd:cd01414   80 PDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYqkggtvcgiklpeGLREAQKLPEPIFTPSTKAEEGHDENISFEEAVE- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525 141 gWAAPQDLDDMVALSLRVNDYLSGLFLGIGLRLVDFKLEFGRLWENEemrIVLADEI-SPDNCRLWDIKTNEK------L 213
Cdd:cd01414  159 -IIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGE---IILIDEVlTPDSSRFWPADSYEPgkeqpsF 234


                 ....*..
gi 504005525 214 DKDRFRQ 220
Cdd:cd01414  235 DKQFVRD 241
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 8-222 1.17e-13

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 69.47  E-value: 1.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525   8 YEGKAKVLFEGPEPGTLVQyfKDDATAFNnQKKGIITGKGVLNNRISEYLMSRLSEIgVPTHFVRRLNMREQLVREVEII 87
Cdd:PLN02544  79 RRGKVRDIYDLGDYLVLVT--TDRQSAFD-RVLASIPFKGQVLNQTSAWWFNNTKHI-TPNALVSSPDPNVTIAKKCSVF 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  88 PIELVVRNTAAGSLSKRF--------------GIPEGT----PLPRSIIEYYYKSDELNNPmVTEEHITAFGWAAPQDLD 149
Cdd:PLN02544 155 PVEFVVRGYMTGSTSTSLwtvynkgvrnycgnDLPDGMvknqKLPANILTPTTKAADHDVP-ISPEEIVEEGLMTQEDFD 233

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504005525 150 DMVALSLRVNDYLSGLFLGIGLRLVDFKLEFGRlweNEEMRIVLADEI-SPDNCRLWDIKTNEkldkDRFRQDL 222
Cdd:PLN02544 234 EVSSKALALFAFGQEVAAEHGLILVDTKYEFGK---DADGTILLIDEVhTPDSSRYWLADSYE----ERHAAGL 300
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 43-220 7.18e-12

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 64.14  E-value: 7.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  43 ITGKGVLNNRISEYLMSRLSEIgVPTHFVRRLNMREQLVREVEIIPIELVVRNTAAGSLSKRF--------GI--PEG-- 110
Cdd:PRK12607  52 IPYKGQVLNQTAAFWFEATKDI-CPNHVLAVPDPNVVVGKRCEPFPVEMVVRGYLAGSTWRLYkagkremyGVtlPDGlr 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525 111 --TPLPRSII-----EYYYKSDElnnPmVTEEHITAFGWAAPQDLDDMVALSLRvndylsgLF-------LGIGLRLVDF 176
Cdd:PRK12607 131 enQKLPEPIItpttkAEEGGHDE---P-ISPEEILAQGLLTPEDWDELSKYALA-------LFargqemaAERGLILVDT 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 504005525 177 KLEFGRlweNEEMRIVLADEI-SPDNCRLWDIKTNEK----------LDKDRFRQ 220
Cdd:PRK12607 200 KYEFGK---DADGRIVLIDEIhTPDSSRYWYADGYEErfaagepqeqLDKEFVRQ 251
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 43-209 1.64e-06

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 48.27  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  43 ITGKGVLNNRISEYLMSRLSEIgVPTHFV-------------RRLNMREQLVREVEIIPIELVVRNTAAGSLSKRF---G 106
Cdd:PRK13961  50 IPDKGRVLTQMSNFWFDKLAHI-VPNHLTgidvddvvpadeaDQVLGRAVVVKKLKPLPVECVVRGYLTGSGWKDYqatG 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525 107 IPEGTPLPRSIIEyyykSDELNNPMVT----------EEHITafgwaapqdLDDMVAL------------SLRVNDYLSG 164
Cdd:PRK13961 129 TVCGIKLPAGLVE----ASKLPEPIFTpatkaelgdhDENIS---------FEEVVELvgaelaaqlrdaTLAIYKEAAD 195

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 504005525 165 LFLGIGLRLVDFKLEFGRlweNEEMRIVLADEI-SPDNCRLWDIKT 209
Cdd:PRK13961 196 YAATRGIIIADTKFEFGL---DEDGTLTLMDEVlTPDSSRFWPADS 238
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 43-204 3.17e-06

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 47.37  E-value: 3.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  43 ITGKGVLNNRISEYLMSRLSEIGVPTHF--------VRRLNMREQLVREVEI---------------------------- 86
Cdd:PRK13959  41 IPDKGASLCTMGAYNFELLEEEGIKTHYigvvedgeVVRLAEASEPPNEMAVkltqvpdlpfeggsydydayheaageny 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  87 -IPIELVVRNT--AAGSLSKR----------FGIP------EGTPLPRSIIEYYYKSDELNNPMVTEEHITAFGwAAPQD 147
Cdd:PRK13959 121 lIPLEVIFRNYvpVGSSLRDRikegkikpedLGLDadewpeEGVKLPEPIVEFSTKYEEQDRYLSRKEADEIAG-LSRAE 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 504005525 148 LDDMVALSLRVNDYLSGLFLGIGLRLVDFKLEFGrLWENEEmrIVLADEI-SPDNCRL 204
Cdd:PRK13959 200 IEELEELALKVDEIITEEAEKRGLIHEDGKIEFA-LYEERE--IRVVDVVgTFDENRF 254
PRK13960 PRK13960
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 43-222 6.12e-03

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 184420  Cd Length: 367  Bit Score: 37.38  E-value: 6.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525  43 ITGKGVLNNRISEYLMSRLSEIG--------VPTHFVrrlnmreQLVREVEIIPIELVVRNTAAGSLSKRF--------G 106
Cdd:PRK13960  80 VPGKGAALNAISNHWFKLFKENGladshildIPHPFV-------WIVQKARPVMIEAICRQYITGSMWRAYskgerefcG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504005525 107 I--PEG------------TPLPRSI---IEYYYKSDELNnpmVT----EEHITAFGWAAPQDLDDMVALSLRVNDYLSGL 165
Cdd:PRK13960 153 ItlPEGlekdqklpelliTPSTKGIltgIPGVPEADDVN---ISrsdiEANYQAFNFSSADDIDLYEKLLKEGFKVISDA 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504005525 166 FLGIGLRLVDFKLEFGRLWE-NEEMRIVLADEI-SPDNCRLWDI------KTNEKlDKDRFRQDL 222
Cdd:PRK13960 230 LAKLDQIFVDTKFEFGYVTDaAGNEKLIYMDEVgTPDSSRIWDGaayrdgKIVEN-SKEGFRQFL 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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