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Conserved domains on  [gi|503627223|ref|WP_013861299|]
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nucleotidyltransferase domain-containing protein [Microlunatus phosphovorus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Aminoglyc_resit super family cl22941
Aminoglycoside-2''-adenylyltransferase; This family is conserved in Bacteria. It confers ...
 12-49 1.22e-07

Aminoglycoside-2''-adenylyltransferase; This family is conserved in Bacteria. It confers resistance to kanamycin, gentamicin, and tobramycin. The protein is also produced by plasmids in various bacterial species and confers resistance to essentially all clinically available aminoglycosides except streptomycin, and it eliminates the synergism between aminoglycosides and cell-wall active agents.


The actual alignment was detected with superfamily member pfam10706:

Pssm-ID: 402373  Cd Length: 174  Bit Score: 49.26  E-value: 1.22e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 503627223   12 IAELVDAAGELNAPVWLRGGWAMDFFLGRVTREHLDID 49
Cdd:pfam10706   9 IHKILAAADERNLPLWIGGGWAIDARLGRVTRKHDDID 46
 
Name Accession Description Interval E-value
Aminoglyc_resit pfam10706
Aminoglycoside-2''-adenylyltransferase; This family is conserved in Bacteria. It confers ...
 12-49 1.22e-07

Aminoglycoside-2''-adenylyltransferase; This family is conserved in Bacteria. It confers resistance to kanamycin, gentamicin, and tobramycin. The protein is also produced by plasmids in various bacterial species and confers resistance to essentially all clinically available aminoglycosides except streptomycin, and it eliminates the synergism between aminoglycosides and cell-wall active agents.


Pssm-ID: 402373  Cd Length: 174  Bit Score: 49.26  E-value: 1.22e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 503627223   12 IAELVDAAGELNAPVWLRGGWAMDFFLGRVTREHLDID 49
Cdd:pfam10706   9 IHKILAAADERNLPLWIGGGWAIDARLGRVTRKHDDID 46
 
Name Accession Description Interval E-value
Aminoglyc_resit pfam10706
Aminoglycoside-2''-adenylyltransferase; This family is conserved in Bacteria. It confers ...
 12-49 1.22e-07

Aminoglycoside-2''-adenylyltransferase; This family is conserved in Bacteria. It confers resistance to kanamycin, gentamicin, and tobramycin. The protein is also produced by plasmids in various bacterial species and confers resistance to essentially all clinically available aminoglycosides except streptomycin, and it eliminates the synergism between aminoglycosides and cell-wall active agents.


Pssm-ID: 402373  Cd Length: 174  Bit Score: 49.26  E-value: 1.22e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 503627223   12 IAELVDAAGELNAPVWLRGGWAMDFFLGRVTREHLDID 49
Cdd:pfam10706   9 IHKILAAADERNLPLWIGGGWAIDARLGRVTRKHDDID 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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