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Conserved domains on  [gi|503224114|ref|WP_013458775|]
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antibiotic biosynthesis monooxygenase [Oceanithermus profundus]

Protein Classification

antibiotic biosynthesis monooxygenase( domain architecture ID 10006366)

antibiotic biosynthesis monooxygenase similar to Mycobacterium heme utilization degrader (MhuD), a heme-degrading protein from Mycobacterium tuberculosis responsible for extracting the essential nutrient iron from host-derived heme

CATH:  3.30.70.100
EC:  1.14.-.-
Gene Ontology:  GO:0004497
PubMed:  24901029|31399587
SCOP:  4001439

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-98 7.94e-10

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


:

Pssm-ID: 441901  Cd Length: 98  Bit Score: 51.53  E-value: 7.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503224114   1 MIVRMWHGRVPHEKAAAYRDFLNERAvPDYRGTPGNLGVFVLeRPADDAVHFVTLTYWTDLEAIRAFAGEPIERAKYYPE 80
Cdd:COG2329    1 MIVVINRFRVKPGQEEEFEEAFAERR-ELLAEQPGFLGFELL-RSLEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKG 78

                         90
                 ....*....|....*...
gi 503224114  81 DQdfLLEFEPEVVHYEVV 98
Cdd:COG2329   79 RE--ILAGPPRVEHYEVV 94
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-98 7.94e-10

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 51.53  E-value: 7.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503224114   1 MIVRMWHGRVPHEKAAAYRDFLNERAvPDYRGTPGNLGVFVLeRPADDAVHFVTLTYWTDLEAIRAFAGEPIERAKYYPE 80
Cdd:COG2329    1 MIVVINRFRVKPGQEEEFEEAFAERR-ELLAEQPGFLGFELL-RSLEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKG 78

                         90
                 ....*....|....*...
gi 503224114  81 DQdfLLEFEPEVVHYEVV 98
Cdd:COG2329   79 RE--ILAGPPRVEHYEVV 94
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 9-71 8.44e-04

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 35.32  E-value: 8.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503224114    9 RVPHEKAAAYRDFLNERAVPDyRGTPGNLGVFVLeRPADDAVHFVTLTYWTDLEAIRAFAGEP 71
Cdd:pfam03992   8 RVKPGKAEEFEEALAELVEAT-RNEPGCLSYELL-RSLEDPDEYVVLEVWEDEAAFEAHLQSP 68
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-98 7.94e-10

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 51.53  E-value: 7.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503224114   1 MIVRMWHGRVPHEKAAAYRDFLNERAvPDYRGTPGNLGVFVLeRPADDAVHFVTLTYWTDLEAIRAFAGEPIERAKYYPE 80
Cdd:COG2329    1 MIVVINRFRVKPGQEEEFEEAFAERR-ELLAEQPGFLGFELL-RSLEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKG 78

                         90
                 ....*....|....*...
gi 503224114  81 DQdfLLEFEPEVVHYEVV 98
Cdd:COG2329   79 RE--ILAGPPRVEHYEVV 94
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 9-71 8.44e-04

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 35.32  E-value: 8.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503224114    9 RVPHEKAAAYRDFLNERAVPDyRGTPGNLGVFVLeRPADDAVHFVTLTYWTDLEAIRAFAGEP 71
Cdd:pfam03992   8 RVKPGKAEEFEEALAELVEAT-RNEPGCLSYELL-RSLEDPDEYVVLEVWEDEAAFEAHLQSP 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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