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Conserved domains on  [gi|5032177|ref|NP_005646|]
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Krueppel-like factor 10 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 34-369 1.89e-84

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


:

Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 260.30  E-value: 1.89e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   34 AEKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEEnLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPA 113
Cdd:cd21572   1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDD-DLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  114 PSTVHfkslsdtakphiaaPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPmkaasilnyqnnsfrrrthlnv 193
Cdd:cd21572  80 PPAAQ--------------PPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP---------------------- 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  194 eaarknipcaavspnrskcerntvadvdekasaalydfsvpssetvicrsqpapvspqQKSVLVSPPAVSAGGVPPMPVI 273
Cdd:cd21572 124 ----------------------------------------------------------SSPSVVPSVPAGVAGVSPVPVY 145

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  274 CQMVPLPANNP-VVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQS--SKPPVVSPNGTRLSPIAPAPGF 350
Cdd:cd21572 146 CQILPVSSSSTtVVAAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTlyVQPTLVTPGGTKLAAIAPAPGH 225

                       330       340
                ....*....|....*....|
gi 5032177  351 SPSAA-KVTPQIDSSRIRSH 369
Cdd:cd21572 226 TPSEQrKSPPQPEVSRVRSH 245
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 1.67e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.67e-04
                          10        20
                  ....*....|....*....|...
gi 5032177    429 FACPMCDRRFMRSDHLTKHARRH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
374-424 1.58e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.58e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 5032177  374 PGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHT 424
Cdd:COG5048  37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 34-369 1.89e-84

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 260.30  E-value: 1.89e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   34 AEKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEEnLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPA 113
Cdd:cd21572   1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDD-DLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  114 PSTVHfkslsdtakphiaaPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPmkaasilnyqnnsfrrrthlnv 193
Cdd:cd21572  80 PPAAQ--------------PPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP---------------------- 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  194 eaarknipcaavspnrskcerntvadvdekasaalydfsvpssetvicrsqpapvspqQKSVLVSPPAVSAGGVPPMPVI 273
Cdd:cd21572 124 ----------------------------------------------------------SSPSVVPSVPAGVAGVSPVPVY 145

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  274 CQMVPLPANNP-VVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQS--SKPPVVSPNGTRLSPIAPAPGF 350
Cdd:cd21572 146 CQILPVSSSSTtVVAAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTlyVQPTLVTPGGTKLAAIAPAPGH 225

                       330       340
                ....*....|....*....|
gi 5032177  351 SPSAA-KVTPQIDSSRIRSH 369
Cdd:cd21572 226 TPSEQrKSPPQPEVSRVRSH 245
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 135-364 1.16e-04

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 44.43  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   135 KEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPMKA-ASILNYQNNSFRRRTHLnveaarknipcaavspnRSKCE 213
Cdd:PRK13729  37 DMSGNGEAVAEQEPVPDMTGVVDTTFDDKVRQHATTEMQVtAAQMQKQYEEIRRELDV-----------------LNKQR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   214 RNTVADVDEKAS--AALYDfsvpssetvicrsqpapvspQQKSVLVSPPAVSAGGVPPMPVICQMvplPANNPVVTTVVP 291
Cdd:PRK13729 100 GDDQRRIEKLGQdnAALAE--------------------QVKALGANPVTATGEPVPQMPASPPG---PEGEPQPGNTPV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   292 STPPSQPPAVCPPVVF---MGTQVPKGAVMFVVPQPVVQSSKPPVVSP--NGTRLsPIAPAPGFSPSA--------AKVT 358
Cdd:PRK13729 157 SFPPQGSVAVPPPTAFypgNGVTPPPQVTYQSVPVPNRIQRKTFTYNEgkKGPSL-PYIPSGSFAKAMliegadanASVT 235


                 ....*.
gi 5032177   359 PQIDSS 364
Cdd:PRK13729 236 GNESTV 241
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 1.67e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.67e-04
                          10        20
                  ....*....|....*....|...
gi 5032177    429 FACPMCDRRFMRSDHLTKHARRH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
374-424 1.58e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.58e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 5032177  374 PGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHT 424
Cdd:COG5048  37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 93-358 2.68e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 40.33  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177     93 TPPYSPSDFEPSQVSNLMAPAPSTVhfKSLSDTAKPHIAAPFKEEEKSPVSApkLPKAQATSVIRHTADAQLCNHQTCPM 172
Cdd:pfam17823  99 EPATREGAADGAASRALAAAASSSP--SSAAQSLPAAIAALPSEAFSAPRAA--ACRANASAAPRAAIAAASAPHAASPA 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177    173 KAASILNYQNNSFRRRTHLNVEAARKNIPcAAVSPNRSKCErNTVADVDEKASAALYdfSVPSSetvicrsQPAPVSPQQ 252
Cdd:pfam17823 175 PRTAASSTTAASSTTAASSAPTTAASSAP-ATLTPARGIST-AATATGHPAAGTALA--AVGNS-------SPAAGTVTA 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177    253 KSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPP 332
Cdd:pfam17823 244 AVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEP 323

                         250       260
                  ....*....|....*....|....*.
gi 5032177    333 VVSPNGTRLSPIAPAPGFSPSAAKVT 358
Cdd:pfam17823 324 TPSPSNTTLEPNTPKSVASTNLAVVT 349
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 369-393 4.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.16e-03
                          10        20
                  ....*....|....*....|....*
gi 5032177    369 HICSHpgCGKTYFKSSHLKAHTRTH 393
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 34-369 1.89e-84

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 260.30  E-value: 1.89e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   34 AEKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEEnLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPA 113
Cdd:cd21572   1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDD-DLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  114 PSTVHfkslsdtakphiaaPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPmkaasilnyqnnsfrrrthlnv 193
Cdd:cd21572  80 PPAAQ--------------PPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP---------------------- 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  194 eaarknipcaavspnrskcerntvadvdekasaalydfsvpssetvicrsqpapvspqQKSVLVSPPAVSAGGVPPMPVI 273
Cdd:cd21572 124 ----------------------------------------------------------SSPSVVPSVPAGVAGVSPVPVY 145

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  274 CQMVPLPANNP-VVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQS--SKPPVVSPNGTRLSPIAPAPGF 350
Cdd:cd21572 146 CQILPVSSSSTtVVAAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTlyVQPTLVTPGGTKLAAIAPAPGH 225

                       330       340
                ....*....|....*....|
gi 5032177  351 SPSAA-KVTPQIDSSRIRSH 369
Cdd:cd21572 226 TPSEQrKSPPQPEVSRVRSH 245
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 35-369 3.86e-74

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 232.90  E-value: 3.86e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   35 EKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEENLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPAP 114
Cdd:cd21974   1 EQGDLEAVEALVSMSSWWKRRQKRLRKPRPLTPSSDSSDEDDAPESPKDFHSLSSLCMTPPYSPPFFEASHSPSVASLHP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  115 STvhfkslsdtakPHIAAPFKEEEKSPVSAPKLPKAQATSVIRHTADAqlcnhqtcpmkaasilnyqnnsfrrrthlnve 194
Cdd:cd21974  81 PS-----------AASSQPPPEPESSEPPAASPQRAQATSVIRHTADP-------------------------------- 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  195 aarknipcaavspnrskcerntvadvdekasaalydfsvpssetvicrsqpapvspqqksvlvsppavsaGGVPPMPVIC 274
Cdd:cd21974 118 ----------------------------------------------------------------------VPVSPPPVLC 127

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  275 QMVPLPANNPVV-----TTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQS--SKPPVVSPNGTRLSPIAPA 347
Cdd:cd21974 128 QMLPVSSSSGVIvaflkAPQQPSPQPQKPALPQPQVVLVGGQVPQGPVMLVVPQPAVPQpyVQPTVVTPGGTKLLPIAPA 207

                       330       340
                ....*....|....*....|..
gi 5032177  348 PGFSPSAAKVTPQIDSSRIRSH 369
Cdd:cd21974 208 PGFIPSGQSSAPQPDFSRRRNH 229
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 35-367 1.16e-26

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 107.00  E-value: 1.16e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   35 EKSDFEAVEALMSMScSW--KSDFKKYVENRPVTPVSDLSEEENLLPGTP----DFHTIPAFCLTPPYSPSDFEPSqvsn 108
Cdd:cd21584   2 EQNDLEAVEALVCMS-SWgqRSQKGDLLKIRPLTPASDSCDSLTLHPAAPelpkDFHSLSSLCMTPPHSPSFAEPS---- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  109 lmapapstvhfkslsdtakphiaapfkeeeksPVSAPKLPKAQATSVIRHTADAQLCnhqtcpmkaasilnyqnnsfrrr 188
Cdd:cd21584  77 --------------------------------TTAPPPPCRAMATSVIRHTADSSPP----------------------- 101

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  189 thlnveaarknipcaavspnrskcerntvadvdekasaalydFSVPSSeTVICRSQPAPVSPQQKSVLVSPPAVSAGGVP 268
Cdd:cd21584 102 ------------------------------------------VPVPSP-PVLCQMIPVSGQSGMISAFLQPPALSAGTVK 138

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177  269 PMPvicqmvplpannpvvttvvPSTPPSQPPavcppvVFMGTQVPKGAVMFVVPQPVV---QSSKPPVVSPNGTRLSPIA 345
Cdd:cd21584 139 PIL-------------------PQTAPASQP------LLVGSPVPQGTVMLVLPQASVpqpPQCPQTVMTLGNTKLLPLA 193

                       330       340
                ....*....|....*....|..
gi 5032177  346 PAPGFSPSAAKVTPQIDSSRIR 367
Cdd:cd21584 194 PAPVFIPSGQSCAPQVDFSRRR 215
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 135-364 1.16e-04

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 44.43  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   135 KEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPMKA-ASILNYQNNSFRRRTHLnveaarknipcaavspnRSKCE 213
Cdd:PRK13729  37 DMSGNGEAVAEQEPVPDMTGVVDTTFDDKVRQHATTEMQVtAAQMQKQYEEIRRELDV-----------------LNKQR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   214 RNTVADVDEKAS--AALYDfsvpssetvicrsqpapvspQQKSVLVSPPAVSAGGVPPMPVICQMvplPANNPVVTTVVP 291
Cdd:PRK13729 100 GDDQRRIEKLGQdnAALAE--------------------QVKALGANPVTATGEPVPQMPASPPG---PEGEPQPGNTPV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   292 STPPSQPPAVCPPVVF---MGTQVPKGAVMFVVPQPVVQSSKPPVVSP--NGTRLsPIAPAPGFSPSA--------AKVT 358
Cdd:PRK13729 157 SFPPQGSVAVPPPTAFypgNGVTPPPQVTYQSVPVPNRIQRKTFTYNEgkKGPSL-PYIPSGSFAKAMliegadanASVT 235


                 ....*.
gi 5032177   359 PQIDSS 364
Cdd:PRK13729 236 GNESTV 241
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 1.67e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.67e-04
                          10        20
                  ....*....|....*....|...
gi 5032177    429 FACPMCDRRFMRSDHLTKHARRH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 246-359 9.61e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 9.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   246 APVSPQQKSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVttvVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPV 325
Cdd:PRK14951 380 TPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAA---APPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAA 456

                         90       100       110
                 ....*....|....*....|....*....|....
gi 5032177   326 VQSSKPPVVSPNGTRLSPIAPAPGFSPSAAKVTP 359
Cdd:PRK14951 457 PETVAIPVRVAPEPAVASAAPAPAAAPAAARLTP 490
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
374-424 1.58e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.58e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 5032177  374 PGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHT 424
Cdd:COG5048  37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 93-358 2.68e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 40.33  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177     93 TPPYSPSDFEPSQVSNLMAPAPSTVhfKSLSDTAKPHIAAPFKEEEKSPVSApkLPKAQATSVIRHTADAQLCNHQTCPM 172
Cdd:pfam17823  99 EPATREGAADGAASRALAAAASSSP--SSAAQSLPAAIAALPSEAFSAPRAA--ACRANASAAPRAAIAAASAPHAASPA 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177    173 KAASILNYQNNSFRRRTHLNVEAARKNIPcAAVSPNRSKCErNTVADVDEKASAALYdfSVPSSetvicrsQPAPVSPQQ 252
Cdd:pfam17823 175 PRTAASSTTAASSTTAASSAPTTAASSAP-ATLTPARGIST-AATATGHPAAGTALA--AVGNS-------SPAAGTVTA 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177    253 KSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPP 332
Cdd:pfam17823 244 AVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEP 323

                         250       260
                  ....*....|....*....|....*.
gi 5032177    333 VVSPNGTRLSPIAPAPGFSPSAAKVT 358
Cdd:pfam17823 324 TPSPSNTTLEPNTPKSVASTNLAVVT 349
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 243-367 3.67e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.70  E-value: 3.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177   243 SQPAPVSPQQKSVLVSPPAVSAGGVPPMPVIcqmVPLPANNPVVTTVVPSTPP--SQPPAVCPPVvfmgtQVPKGAVMFV 320
Cdd:PRK14951 369 AAEAAAPAEKKTPARPEAAAPAAAPVAQAAA---APAPAAAPAAAASAPAAPPaaAPPAPVAAPA-----AAAPAAAPAA 440

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 5032177   321 VPQPVVQSSKPPVVSPNGTRLSP--IAPAPGFSPSAAKVTPQIDSSRIR 367
Cdd:PRK14951 441 APAAVALAPAPPAQAAPETVAIPvrVAPEPAVASAAPAPAAAPAAARLT 489
PHA03247 PHA03247
large tegument protein UL36; Provisional
 62-353 4.12e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177     62 NRPVTPVSDLSEEENLLPGT---PDFHTIPAfcltPPYSPSD--FEPSQVSNLMAPAPSTVHFKSLSDTAKPHIAAPFKE 136
Cdd:PHA03247 2596 ARPRAPVDDRGDPRGPAPPSplpPDTHAPDP----PPPSPSPaaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLG 2671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177    137 EEKSPVSAPKLPKAQAT--SVIRHTADAQLCNHQTCPMKAASILnyqnnSFRRRTHLNVEAARKNIPCAAVSPNRSKCER 214
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAArpTVGSLTSLADPPPPPPTPEPAPHAL-----VSATPLPPGPAAARQASPALPAAPAPPAVPA 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177    215 NTVADVDEKASAALYDFSVPSSETVIC-------RSQPAPVSPQQKSVLVSPPAVSAGGVPPMPVICQMVPLPANN---- 283
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAapaagppRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAspag 2826

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5032177    284 --PVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPqpvvqsSKPPVVSPNGTRLSPIA--PAPGFSPS 353
Cdd:PHA03247 2827 plPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPP------SRSPAAKPAAPARPPVRrlARPAVSRS 2894
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 369-393 4.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.16e-03
                          10        20
                  ....*....|....*....|....*
gi 5032177    369 HICSHpgCGKTYFKSSHLKAHTRTH 393
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 187-359 4.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177    187 RRTHLNVEAARKNIPCAAVSPN---RSKCERNTVADVDEKASAALYDFSVPSSETVICRSQPAPVSPQqkSVLVSPPAVS 263
Cdd:PHA03247 2659 GRVSRPRRARRLGRAAQASSPPqrpRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPA--AARQASPALP 2736

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177    264 AGGVPPMPVICQMVPL----PANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPPVVSPNGT 339
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGgparPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816

                         170       180
                  ....*....|....*....|...
gi 5032177    340 RLSPIA-PAPGFSP--SAAKVTP 359
Cdd:PHA03247 2817 ALPPAAsPAGPLPPptSAQPTAP 2839
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 371-447 5.96e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.24  E-value: 5.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177    371 CSHPGCGKTYFKSSHLKAHTRTHTGE------KPFSCSWKGCERRFARSDELSRHRRTHTGEKK-FACPMCDRRFMRSDH 443
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRyFKCENCLLRFRTHRS 81


                  ....
gi 5032177    444 LTKH 447
Cdd:pfam15909  82 LFKH 85
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 24-173 7.49e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 7.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032177    24 KESMY-SWNKTAEKSdfEAVEALMSMSCSWKSDFKkyvENRPVTPVSDLSEEENLLPGTPdfhTIPAFCLTPPYSPSDFE 102
Cdd:PTZ00449 672 KEKFYdDYLDAAAKS--KETKTTVVLDESFESILK---ETLPETPGTPFTTPRPLPPKLP---RDEEFPFEPIGDPDAEQ 743

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5032177   103 PSQVSNLMAPAPSTVHFK-SLSDTAKPHIAAP-FKEEE-----KSPVSAPKLPKAQATSVIRHTADaqlcnHQTCPMK 173
Cdd:PTZ00449 744 PDDIEFFTPPEEERTFFHeTPADTPLPDILAEeFKEEDihaetGEPDEAMKRPDSPSEHEDKPPGD-----HPSLPKK 816
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
363-436 8.02e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 8.02e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5032177  363 SSRIRSHICSHPGCGKTYFKSSHLKAHTRT--HTGE--KPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDR 436
Cdd:COG5048 282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNS 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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