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Conserved domains on  [gi|5032117|ref|NP_005857|]
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sigma non-opioid intracellular receptor 1 isoform 1 [Homo sapiens]

Protein Classification

ERG2 family protein( domain architecture ID 10519191)

ERG2 family protein similar to fungal C-8 sterol isomerase erg2 that catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols, and vertebrate sigma non-opioid intracellular receptor 1 (SIGMAR1) that functions in lipid transport from the ER

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ERG2_Sigma1R pfam04622
ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase ...
 25-214 5.31e-87

ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase and mammalian sigma1 receptor. C-8 sterol isomerase (delta-8--delta-7 sterol isomerase), catalyzes a reaction in ergosterol biosynthesis, which results in unsaturation at C-7 in the B ring of sterols. Sigma 1 receptor is a low molecular mass mammalian protein located in the endoplasmic reticulum, which interacts with endogenous steroid hormones, such as progesterone and testosterone. It also binds the sigma ligands, which are are a set of chemically unrelated drugs including haloperidol, pentazocine, and ditolylguanidine. Sigma1 effectors are not well understood, but sigma1 agonists have been observed to affect NMDA receptor function, the alpha-adrenergic system and opioid analgesia.


:

Pssm-ID: 461372  Cd Length: 192  Bit Score: 255.13  E-value: 5.31e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032117     25 VVWLWLGTqSFVFQREEIAQLARQY---AGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLS 101
Cdd:pfam04622   1 LLDQLLPR-FYIFDPKELHELAKKAiakHGNDTTAIFDDIVKELRKEYPDHYNILNEEEWVFNNAGGAMGAMYILHASIT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032117    102 EYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPST 181
Cdd:pfam04622  80 EYLIFFGTAVGTEGHTGRHTADDYFTILTGEQWAYLPGELEPEVYKPGDVHHLPRGEAKQYKMPGGCFALEYARGWIPSM 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 5032117    182 LAFALADTVFSTQDFLTLFYTLRSYARGLRLEL 214
Cdd:pfam04622 160 LPFGFADTFFSTLDFVTLYRTVYITAREMIKNL 192
 
Name Accession Description Interval E-value
ERG2_Sigma1R pfam04622
ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase ...
 25-214 5.31e-87

ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase and mammalian sigma1 receptor. C-8 sterol isomerase (delta-8--delta-7 sterol isomerase), catalyzes a reaction in ergosterol biosynthesis, which results in unsaturation at C-7 in the B ring of sterols. Sigma 1 receptor is a low molecular mass mammalian protein located in the endoplasmic reticulum, which interacts with endogenous steroid hormones, such as progesterone and testosterone. It also binds the sigma ligands, which are are a set of chemically unrelated drugs including haloperidol, pentazocine, and ditolylguanidine. Sigma1 effectors are not well understood, but sigma1 agonists have been observed to affect NMDA receptor function, the alpha-adrenergic system and opioid analgesia.


Pssm-ID: 461372  Cd Length: 192  Bit Score: 255.13  E-value: 5.31e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032117     25 VVWLWLGTqSFVFQREEIAQLARQY---AGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLS 101
Cdd:pfam04622   1 LLDQLLPR-FYIFDPKELHELAKKAiakHGNDTTAIFDDIVKELRKEYPDHYNILNEEEWVFNNAGGAMGAMYILHASIT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032117    102 EYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPST 181
Cdd:pfam04622  80 EYLIFFGTAVGTEGHTGRHTADDYFTILTGEQWAYLPGELEPEVYKPGDVHHLPRGEAKQYKMPGGCFALEYARGWIPSM 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 5032117    182 LAFALADTVFSTQDFLTLFYTLRSYARGLRLEL 214
Cdd:pfam04622 160 LPFGFADTFFSTLDFVTLYRTVYITAREMIKNL 192
 
Name Accession Description Interval E-value
ERG2_Sigma1R pfam04622
ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase ...
 25-214 5.31e-87

ERG2 and Sigma1 receptor like protein; This family consists of the fungal C-8 sterol isomerase and mammalian sigma1 receptor. C-8 sterol isomerase (delta-8--delta-7 sterol isomerase), catalyzes a reaction in ergosterol biosynthesis, which results in unsaturation at C-7 in the B ring of sterols. Sigma 1 receptor is a low molecular mass mammalian protein located in the endoplasmic reticulum, which interacts with endogenous steroid hormones, such as progesterone and testosterone. It also binds the sigma ligands, which are are a set of chemically unrelated drugs including haloperidol, pentazocine, and ditolylguanidine. Sigma1 effectors are not well understood, but sigma1 agonists have been observed to affect NMDA receptor function, the alpha-adrenergic system and opioid analgesia.


Pssm-ID: 461372  Cd Length: 192  Bit Score: 255.13  E-value: 5.31e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032117     25 VVWLWLGTqSFVFQREEIAQLARQY---AGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLS 101
Cdd:pfam04622   1 LLDQLLPR-FYIFDPKELHELAKKAiakHGNDTTAIFDDIVKELRKEYPDHYNILNEEEWVFNNAGGAMGAMYILHASIT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032117    102 EYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPST 181
Cdd:pfam04622  80 EYLIFFGTAVGTEGHTGRHTADDYFTILTGEQWAYLPGELEPEVYKPGDVHHLPRGEAKQYKMPGGCFALEYARGWIPSM 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 5032117    182 LAFALADTVFSTQDFLTLFYTLRSYARGLRLEL 214
Cdd:pfam04622 160 LPFGFADTFFSTLDFVTLYRTVYITAREMIKNL 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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