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Conserved domains on  [gi|502884286|ref|WP_013119262|]
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ornithine carbamoyltransferase [Thermincola potens]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11479232)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

CATH:  3.40.50.720
EC:  2.1.3.3
Gene Ontology:  GO:0004585|GO:0006591|GO:0006526
PubMed:  18062991

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 6-312 0e+00

ornithine carbamoyltransferase; Provisional


:

Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 615.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   6 TLKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQEL 85
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  86 QLGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVGD 165
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 166 GNNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAmadARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAEHAE 245
Cdd:PRK00779 161 GNNVANSLLLAAALLGFDLRVATPKGYEPDPEIVEKI---AKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEE 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502884286 246 RLKIFRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTM 312
Cdd:PRK00779 238 RLKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 6-312 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 615.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   6 TLKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQEL 85
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  86 QLGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVGD 165
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 166 GNNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAmadARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAEHAE 245
Cdd:PRK00779 161 GNNVANSLLLAAALLGFDLRVATPKGYEPDPEIVEKI---AKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEE 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502884286 246 RLKIFRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTM 312
Cdd:PRK00779 238 RLKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 5-313 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 613.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   5 TTLKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQE 84
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  85 LQLGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVG 164
Cdd:COG0078   81 SQLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKLKGLKVAYVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 165 DGNNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAEHA 244
Cdd:COG0078  161 DGNNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAE 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502884286 245 ERLKIFRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTMG 313
Cdd:COG0078  241 ERIKAFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLG 309
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 10-313 0e+00

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 515.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   10 KDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQLGR 89
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   90 GETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVGDGNNV 169
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVKVVYVGDGNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  170 CHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAEHAERLKI 249
Cdd:TIGR00658 161 CNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502884286  250 FRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTMG 313
Cdd:TIGR00658 241 FRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALLG 304
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
11-150 1.66e-83

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 248.11  E-value: 1.66e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   11 DLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQLGRG 90
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   91 ETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIE 150
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 6-312 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 615.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   6 TLKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQEL 85
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  86 QLGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVGD 165
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 166 GNNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAmadARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAEHAE 245
Cdd:PRK00779 161 GNNVANSLLLAAALLGFDLRVATPKGYEPDPEIVEKI---AKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEE 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502884286 246 RLKIFRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTM 312
Cdd:PRK00779 238 RLKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 5-313 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 613.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   5 TTLKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQE 84
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  85 LQLGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVG 164
Cdd:COG0078   81 SQLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKLKGLKVAYVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 165 DGNNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAEHA 244
Cdd:COG0078  161 DGNNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAE 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502884286 245 ERLKIFRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTMG 313
Cdd:COG0078  241 ERIKAFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLG 309
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 10-313 0e+00

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 515.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   10 KDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQLGR 89
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   90 GETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVGDGNNV 169
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVKVVYVGDGNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  170 CHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAEHAERLKI 249
Cdd:TIGR00658 161 CNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502884286  250 FRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTMG 313
Cdd:TIGR00658 241 FRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALLG 304
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 7-313 2.77e-167

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 467.83  E-value: 2.77e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   7 LKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQ 86
Cdd:PRK02102   5 LKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGPNDSQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  87 LGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVGDG 166
Cdd:PRK02102  85 LGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHFGPLKGLKLAYVGDG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 167 -NNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAEHAE 245
Cdd:PRK02102 165 rNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGEEDEWEE 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 246 RLKIFRPYQVNSDLVKR-ARPDYLFMHCLPA-----------------HRGEEVAAEVIDGPNSVVFDEAENRLHAQKAV 307
Cdd:PRK02102 245 RIKLLKPYQVNMDLMKAtGNPDVIFMHCLPAfhdtetkvgkeiaekygLKGLEVTDEVFESKYSIVFDEAENRMHTIKAV 324


                 ....*.
gi 502884286 308 LALTMG 313
Cdd:PRK02102 325 MVATLG 330
PLN02342 PLN02342
ornithine carbamoyltransferase
 6-313 8.83e-154

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 434.22  E-value: 8.83e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   6 TLKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPL-LAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQE 84
Cdd:PLN02342  42 KSKPKHFLHIDDFDKEEILGLLDRAKEVKALLKSGDRSFQpFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  85 LQLGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVG 164
Cdd:PLN02342 122 IQLGKREETRDIARVLSRYNDIIMARVFAHQDVLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEHIGRLEGTKVVYVG 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 165 DGNNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMAdARLSGavVEILEDPCQAVKDADVIYTDVWASMGQEAEHA 244
Cdd:PLN02342 202 DGNNIVHSWLLLAAVLPFHFVCACPKGYEPDAKTVEKARA-AGISK--IEITNDPAEAVKGADVVYTDVWASMGQKEEAE 278

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502884286 245 ERLKIFRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTMG 313
Cdd:PLN02342 279 KRKKAFQGFQVNEALMKLAGPQAYFMHCLPAERGVEVTDGVMEAPNSIVFPQAENRMHAQNAIMLHQLG 347
putr_carbamoyl TIGR04384
putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase ...
 17-309 3.03e-134

putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase (EC 2.1.3.6). There is some overlapping specificity with ornithine carbamoyltransferase (EC 2.1.3.3). The gene regularly is found next to agmatine deiminase and a carbamate kinase, suggesting a conserved catabolic agmatine deiminase pathway. [Energy metabolism, Amino acids and amines]


Pssm-ID: 275177  Cd Length: 330  Bit Score: 384.00  E-value: 3.03e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   17 ELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQLGRGETIADT 96
Cdd:TIGR04384   7 DFTKEEILDIIDLSLKIKEAIKDGYYPPLLKNKSLGMIFEQSSTRTRVSFETAMTQLGGHAQYLAPGQIQLGGHESIEDT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   97 ARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEH--KG-RLEGLKLAYVGDGNNVCHSL 173
Cdd:TIGR04384  87 ARVLSRLVDIIMARVDRHETVVELAKYATVPVINGMSDYNHPTQELGDLFTMIEHlpAGkKLEDCKVVFVGDATQVCVSL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  174 LNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASM-GQEAEHAERLKIFRP 252
Cdd:TIGR04384 167 MFICTKMGMDFVHFGPKGYQIPEEWLAIAEANCKVSGGSVTVTDDVDEAVKGADFIYTDVWYGLyDQELSEEERMAIFYP 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 502884286  253 -YQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLA 309
Cdd:TIGR04384 247 kYQVNPELMAKAGPHAKFMHCLPASRGEEVTDEVMDSPQSICFDEAENRLTAIRALLV 304
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 10-308 8.25e-122

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 351.30  E-value: 8.25e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  10 KDLLALYELTREEITEILKFAAELKQKQKEgiPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQLGR 89
Cdd:PRK14805   2 KHLLSIKELTQQQLLDLLALAKTIKANPAE--YRQALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGALGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  90 GETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVGDGNNV 169
Cdd:PRK14805  80 RESVADFAANLSCWADAIVARVFSHSTIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQFGDVSKVKLAYVGDGNNV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 170 CHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVeILEDPCQAVKDADVIYTDVWASMGQEAEHAERLKI 249
Cdd:PRK14805 160 THSLMYGAAILGATMTVICPPGHFPDGQIVAEAQELAAKSGGKL-VLTSDIEAIEGHDAIYTDTWISMGDDTPLAEIKAK 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 502884286 250 FRPYQVNSDLVKRARPDYlFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVL 308
Cdd:PRK14805 239 FAPYQVNKALMEKAGATF-VMHCQPAHRGVEITSEVMDGEGSLILQQAENRMHAQNAVL 296
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 7-313 4.24e-113

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 330.55  E-value: 4.24e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   7 LKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQ 86
Cdd:PRK04284   4 LRNRSFLTLLDFTPKEIEYLLDLSEDLKRAKYAGIEVQKLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPTGSQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  87 LGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEH-KGRLEGLKLAYVGD 165
Cdd:PRK04284  84 MGKKESTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHlKKPYKDIKFTYVGD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 166 G-NNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAEH- 243
Cdd:PRK04284 164 GrNNVANALMQGAAIMGMDFHLVCPKELNPDDELLNKCKEIAAETGGKITITDDIDEGVKGSDVIYTDVWVSMGEPDEVw 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 244 AERLKIFRPYQVNSDLVKRAR-PDYLFMHCLPA-H----------------RGEEVAAEVIDGPNSVVFDEAENRLHAQK 305
Cdd:PRK04284 244 EERIKLLKPYQVNKEMMKKTGnPNAIFEHCLPSfHdldtkvgkeifekyglKEMEVTDEVFESKASVVFDEAENRMHTIK 323


                 ....*...
gi 502884286 306 AVLALTMG 313
Cdd:PRK04284 324 AVMVATLG 331
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 10-312 1.75e-100

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 298.55  E-value: 1.75e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  10 KDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQLGR 89
Cdd:PRK03515   7 RHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  90 GETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEH--KGRLEGLKLAYVGDG- 166
Cdd:PRK03515  87 KESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlpGKAFNEMTLAYAGDAr 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 167 NNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAE-HAE 245
Cdd:PRK03515 167 NNMGNSLLEAAALTGLDLRLVAPKACWPEAALVTECRALAQKNGGNITLTEDIAEGVKGADFIYTDVWVSMGEPKEvWAE 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 246 RLKIFRPYQVNSDLVK-RARPDYLFMHCLPA------------------HRGEEVAAEVIDGPNSVVFDEAENRLHAQKA 306
Cdd:PRK03515 247 RIALLRPYQVNSKMMQlTGNPQVKFLHCLPAfhddqttlgkkmaeeyglHGGMEVTDEVFESAHSIVFDQAENRLHTIKA 326


                 ....*.
gi 502884286 307 VLALTM 312
Cdd:PRK03515 327 VMVATL 332
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 7-312 5.64e-90

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 271.86  E-value: 5.64e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   7 LKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQ 86
Cdd:PRK01713   5 LKNRHLLSLVNHTEREIKYLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDPNSSQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  87 LGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGR-LEGLKLAYVGD 165
Cdd:PRK01713  85 IGHKESMKDTARVLGRMYDAIEYRGFKQSIVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENCDKpLSEISYVYIGD 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 166 G-NNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEAEH- 243
Cdd:PRK01713 165 ArNNMGNSLLLIGAKLGMDVRICAPKALLPEASLVEMCEKFAKESGARITVTDDIDKAVKGVDFVHTDVWVSMGEPLETw 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 244 AERLKIFRPYQVNSDLVKR-ARPDYLFMHCLPA-HRGE------------------EVAAEVIDGPNSVVFDEAENRLHA 303
Cdd:PRK01713 245 GERIKLLMPYQVTPELMKRtGNPKVKFMHCLPAfHNSEtkvgrqiaekypelangiEVTEDVFESPMNIAFEQAENRMHT 324


                 ....*....
gi 502884286 304 QKAVLALTM 312
Cdd:PRK01713 325 IKAVMVASL 333
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
11-150 1.66e-83

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 248.11  E-value: 1.66e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   11 DLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQLGRG 90
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   91 ETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIE 150
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 5-313 5.13e-83

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 253.83  E-value: 5.13e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   5 TTLKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQE 84
Cdd:PRK12562   2 SGFYKKHFLKLLDFTPAELNSLLQLAAKLKADKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  85 LQLGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEH-KGR-LEGLKLAY 162
Cdd:PRK12562  82 SQIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlPGKaFNEMTLVY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 163 VGDG-NNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASMGQEA 241
Cdd:PRK12562 162 AGDArNNMGNSMLEAAALTGLDLRLVAPQACWPEASLVAECSALAQKHGGKITLTEDIAAGVKGADFIYTDVWVSMGEPK 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 242 EH-AERLKIFRPYQVNSDLVKRA-RPDYLFMHCLPA------------------HRGEEVAAEVIDGPNSVVFDEAENRL 301
Cdd:PRK12562 242 EKwAERIALLRGYQVNSKMMALTgNPQVKFLHCLPAfhddqttlgkkmakefglHGGMEVTDEVFESPASIVFDQAENRM 321

                        330
                 ....*....|..
gi 502884286 302 HAQKAVLALTMG 313
Cdd:PRK12562 322 HTIKAVMVATLA 333
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
159-311 1.59e-79

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 238.28  E-value: 1.59e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  159 KLAYVGDG-NNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEILEDPCQAVKDADVIYTDVWASM 237
Cdd:pfam00185   1 KIAYVGDGhNNVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLDKAKKIAEKSGGSIEITDDPAEAVKGADVVYTDVWQSM 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502884286  238 GQEAEHAERLKIFRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALT 311
Cdd:pfam00185  81 GQEKEREERLKAFKPYQVNEELMKLAKKDAIFMHCLPAHRGEEVTDDVFDGPRSVVFDQAENRLHAQKALLALL 154
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 5-313 3.07e-68

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 214.92  E-value: 3.07e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   5 TTLKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQE 84
Cdd:COG0540    1 MSFKMRHLLSIEDLSREEIEELLDTAEEFKEVLRPIKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  85 LQLGRGETIADTARVLSRY-VDGIMIRtfaHSD---VEELARYADVPVIN-----GltdlNHPCQILADFQTIIEHKGRL 155
Cdd:COG0540   81 SSVSKGESLADTIRTLEAYgADAIVIR---HPQegaARLLAEHVDVPVINagdgaH----EHPTQALLDLYTIREEFGRL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 156 EGLKLAYVGDGNN--VCHSLLNGCAKVGMHISVATPKGYEPDAeivrkamadarLSGAVVEILEDPCQAVKDADVIYtdv 233
Cdd:COG0540  154 DGLKVAIVGDLKHsrVARSNIKALSKLGAEVTLVAPPTLLPEE-----------IEELGVEVTTDLDEALPDADVVY--- 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 234 wasM-------GQEAEHAERLKIFRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKA 306
Cdd:COG0540  220 ---MlriqkerFTDGLFPSYREYKRSYGLTAERLALAKPDAIVMHPGPRNRGVEIDSDVDDTPRSVIFEQVTNGVAVRMA 296


                 ....*..
gi 502884286 307 VLALTMG 313
Cdd:COG0540  297 LLYLLLG 303
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 10-308 4.61e-67

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 212.19  E-value: 4.61e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  10 KDLLALYELTREEITEILKFAAELKQKQKEGIPHplLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLN--GQELQL 87
Cdd:PRK14804   7 KHLISWEDWSDSEILDLLDFAVHVKKNRVNYAGH--MSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDwmASNFQL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  88 grgETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLNHPCQILADFQTIIEHKGR--LEGLKLAYVGD 165
Cdd:PRK14804  85 ---SDIDLEARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMFHPCQSLADIMTIALDSPEipLNQKQLTYIGV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 166 GNNVCHSLLNGCAKVGMHISVATPKGYEPD--AEIVRKAMADARLSGAvveilEDPCQAVKDADVIYTDVWASM------ 237
Cdd:PRK14804 162 HNNVVNSLIGITAALGIHLTLVTPIAAKENihAQTVERAKKKGTLSWE-----MNLHKAVSHADYVYTDTWLDMeffndp 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502884286 238 GQEAEHAERLKIFRPYQVNSDLVKRARPDylFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVL 308
Cdd:PRK14804 237 SYADKKKQRMELMMPYQINSSLMEKTNAK--VMHDMPIHAGYEITREVVLSDRSIIFQQAENRLDAQKAVI 305
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 10-309 1.74e-62

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 201.13  E-value: 1.74e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  10 KDLLALYELTREEITEILKFAAELKQKQkegiPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLN-GQ----- 83
Cdd:PRK04523   4 KHFLNTQDWSRAELDALLTQAAAFKRNK----LGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLQpGKdawpi 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  84 ELQLG------RGETIADTARVLSRYVDGIMIRTFAH-----SDVEE-----LARYADVPVINgLTDLNHPCQILADFQT 147
Cdd:PRK04523  80 EFELGavmdgeTEEHIREVARVLSRYVDLIGVRAFPKfvdwsKDRQDqvlnsFAKYSTVPVIN-METITHPCQELAHALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 148 IIEHKGR-LEGLKL----AYVGDGNN--VCHSLLNGCAKVGMHISVATPK-GYEPDAEIVRKAMADARLSGAVVEILEDP 219
Cdd:PRK04523 159 LQEHFGTtLRGKKYvltwTYHPKPLNtaVANSALLIATRLGMDVTLLCPTpDYILDERYMDWAEQNAAESGGSLTVSHDI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 220 CQAVKDADVIYTDVWASM----GQEAEHAERLKiFRPYQVNSDLVKRARpDYLFMHCLPAHRGEEVAAEVIDGPNSVVFD 295
Cdd:PRK04523 239 DSAYAGADVVYAKSWGALpffgNWEPEKPIRDQ-YQHFIVDERKMALTN-NGVFSHCLPLRRNVKVTDAVMDSPNCIAID 316

                        330
                 ....*....|....
gi 502884286 296 EAENRLHAQKAVLA 309
Cdd:PRK04523 317 EAENRLHVQKAIMA 330
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
5-313 1.48e-61

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 197.60  E-value: 1.48e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   5 TTLKGKDLLALYELTREEITEILKFAAELKQKQKEGIPH-PLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQ 83
Cdd:PRK00856   1 NPLKMKHLLSIEDLSREEIELLLDTAEEFKEVLRREVKKvPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  84 ELQLGRGETIADTARVLSRY-VDGIMIRtfaHSD---VEELARYADVPVINGLTDLN-HPCQILADFQTIIEHKGRLEGL 158
Cdd:PRK00856  81 TSSVSKGETLADTIRTLSAMgADAIVIR---HPQsgaARLLAESSDVPVINAGDGSHqHPTQALLDLLTIREEFGRLEGL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 159 KLAYVGDGNN--VCHSLLNGCAKVGMHISVATPKgyepdaEIVRKAMADARLSgavveilEDPCQAVKDADVIYtdvwas 236
Cdd:PRK00856 158 KVAIVGDIKHsrVARSNIQALTRLGAEVRLIAPP------TLLPEGMPEYGVH-------TDLDEVIEDADVVM------ 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 237 M----------GQEAEHAErlkIFRPYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKA 306
Cdd:PRK00856 219 MlrvqkermdgGLLPSYEE---YKRSYGLTAERLALAKPDAIVMHPGPVNRGVEIASDVADGPQSVIFEQVTNGVAVRMA 295


                 ....*..
gi 502884286 307 VLALTMG 313
Cdd:PRK00856 296 VLELLLG 302
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 10-313 3.92e-54

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 178.71  E-value: 3.92e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   10 KDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQE-LQLG 88
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKEPLKLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSEtSSVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   89 RGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLN-HPCQILADFQTIIEHKGRLEGLKLAYVGDGN 167
Cdd:TIGR00670  81 KGETLADTIKTLSGYVDAIVIRHPLEGAARLAAEVSEVPVINAGDGSNqHPTQTLLDLYTIYEEFGRLDGLKIALVGDLK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  168 N--VCHSLLNGCAKVGMHISVATPKGYEPDAEIVRkamaDARLSGAVVEILEDPCQAVKDADVIYTdvwaSMGQEAEH-- 243
Cdd:TIGR00670 161 YgrTVHSLAEALTRFGVEVYLISPEELRMPKEILE----ELKAKGIKVRETESLEEVIDEADVLYV----TRIQKERFpd 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502884286  244 -AERLKIFRPYQVNSDLVKRARPDYLFMHCLPahRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTMG 313
Cdd:TIGR00670 233 pEEYEKVKGSYGITLERLEAAKKGVIIMHPLP--RVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
PLN02527 PLN02527
aspartate carbamoyltransferase
 10-313 9.96e-36

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 130.64  E-value: 9.96e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  10 KDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFL-NGQELQ-L 87
Cdd:PLN02527   1 SDVIEAQQFDREMLELLFEVAREMEKVERGSPGSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTeNAGEFSsA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  88 GRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVIN-GLTDLNHPCQILADFQTIIEHKGRLEGLKLAYVGDG 166
Cdd:PLN02527  81 AKGETLEDTIRTVEGYSDIIVLRHFESGAARRAAATAEIPVINaGDGPGQHPTQALLDVYTIQREIGRLDGIKVGLVGDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 167 NN--VCHSLLNGCAKV-GMHISVATPKGYEPDAEIvrKAMADARlsGAVVEILEDPCQAVKDADVIY-TDVwasmgQEAE 242
Cdd:PLN02527 161 ANgrTVRSLAYLLAKYeDVKIYFVAPDVVKMKDDI--KDYLTSK--GVEWEESSDLMEVASKCDVLYqTRI-----QRER 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502884286 243 HAERLKIFRP----YQVNSDLVKRARPDYLFMHCLPahRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTMG 313
Cdd:PLN02527 232 FGERIDLYEAargkYIVDKKVMDVLPKHAVVMHPLP--RLDEITTDVDSDPRAAYFRQAKNGLFIRMALLKLLLG 304
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 5-313 9.84e-31

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 118.29  E-value: 9.84e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   5 TTLKGKDLLALYELTREEITEILKFAAE-----LKQKQKEgiphpLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLF 79
Cdd:PRK08192   1 MQFQGSHILSVNQLDRDAIQRIFNVADRmepyaLREKRTR-----VLEGAILGNLFFEPSTRTRVSFGCAFNLLGGHVRE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  80 LNGQELQ-LGRGETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVINGLTDLN-HPCQILADFQTI---IEHKGR 154
Cdd:PRK08192  76 TTGMASSsLSKGESLYDTARVLSTYSDVIAMRHPDAGSVKEFAEGSRVPVINGGDGSNeHPTQALLDLFTIqkeLAHAGR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 155 -LEGLKLAYVGD---GNNVcHSLlngCAKVGMH----ISVATPKGYE-PDaeivrKAMADARLSGAVVEILEDPCQAVKD 225
Cdd:PRK08192 156 gIDGMHIAMVGDlkfGRTV-HSL---SRLLCMYknvsFTLVSPKELAmPD-----YVISDIENAGHKITITDQLEGNLDK 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 226 ADVIYT-----DVWASmgQEAEHAERLKiFRPYQvnSDLVKRARPDYLFMHCLPA-HRGE--EVAAEVIDGPNSVVFDEA 297
Cdd:PRK08192 227 ADILYLtriqeERFPS--QEEANKYRGK-FRLNQ--SIYTQHCKSNTVIMHPLPRdSRAQanELDNDLNSHPNLAIFRQA 301

                        330
                 ....*....|....*.
gi 502884286 298 ENRLHAQKAVLALTMG 313
Cdd:PRK08192 302 DNGLLIRMALFALTLG 317
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 12-313 1.05e-29

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 116.89  E-value: 1.05e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  12 LLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNG-QELQLGRG 90
Cdd:PRK11891  90 LLSVDQFSRDSVEALFRVADVMQPIARRQKISRVLEGAVLGNLFFEASTRTRVSFGAAFCRLGGSVCDTTGfTFSSMAKG 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  91 ETIADTARVLSRYVDGIMIRTFAHSDVEELARYADVPVIN-GLTDLNHPCQILADFQTIIEHKGRLE----GLKLAYVGD 165
Cdd:PRK11891 170 ESIYDTSRVMSGYVDALVIRHPEQGSVAEFARATNLPVINgGDGPGEHPSQALLDLYTIQREFSRLGkivdGAHIALVGD 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 166 ---GNNVcHSLLNGCAKV-GMHISVATPKGYEPDAEIVRKAMADarlsGAVVEILEDPCQAVKDADVIYtdvwASMGQEA 241
Cdd:PRK11891 250 lkyGRTV-HSLVKLLALYrGLKFTLVSPPTLEMPAYIVEQISRN----GHVIEQTDDLAAGLRGADVVY----ATRIQKE 320

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502884286 242 EHA-ERLKIFRP-YQVNSDLVKRA-RPDYLFMHCLPAHR---GEEVAAEVIDGPNSVVFDEAENRLHAQKAVLALTMG 313
Cdd:PRK11891 321 RFAdESFEGYTPdFQINQALVDAVcKPDTLIMHPLPRDSrpgANDLSTDLNRDPRLAIFRQTDNGIPVRMAIFAVLLG 398
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 7-287 1.21e-24

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 102.51  E-value: 1.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286   7 LKGKDLLALYELTREEITEILKFAAELKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGgyplfLNGQEL- 85
Cdd:PRK07200  18 MHEKDFLLTWEKTPDELKAVLDVADALRALREENISTKVFNSGLGISVFRDNSTRTRFSYASACNLLG-----LEVQDLd 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  86 ----QLGRGETIADTARVLSRYVDGIMIRT-----FAHSDVEELARYADVPVINGL-----------TDLNHPCQILADF 145
Cdd:PRK07200  93 egksQIAHGETVRETANMISFMADVIGIRDdmyigKGNAYMREVGAAVDDGYKQGVlpqrptlvnlqCDIDHPTQSMADL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 146 QTIIEHKGRLEGLK-------LAY---VGDGNNVCHSLLNGCAKVGMHISVATPKGYEPDAEIVRKAMADARLSGAVVEI 215
Cdd:PRK07200 173 LHLIEHFGGLENLKgkkiamtWAYspsYGKPLSVPQGIIGLMTRFGMDVTLAHPEGYDLMPEVVEVAKKNAKASGGSFRQ 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 216 LEDPCQAVKDADVIYTDVWA---SMGQ----------------EAEHAERLKIFRPYQVNSDLVKRARP-DYLFMHCLPA 275
Cdd:PRK07200 253 VNSMEEAFKDADIVYPKSWApykVMEErtelyragdhegikalEKELLAQNAQHKDWHCTEEMMKLTKDgKALYMHCLPA 332

                        330
                 ....*....|....*...
gi 502884286 276 H------RGEEVAAEVID 287
Cdd:PRK07200 333 DisgvscKEGEVTESVFD 350
pyrB PRK13814
aspartate carbamoyltransferase;
12-310 4.67e-22

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 94.01  E-value: 4.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  12 LLALYELTREEITEILKFAAE-LKQKQKEGIPHPLLAGKTLAMIFTKSSTRTRVSFEVAMYQLGGYPLFLNGQELQLGRG 90
Cdd:PRK13814   8 LLNMRSLTRDHIEKLIQRANYfLTQGMEKNSVFETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISAISKG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286  91 ETIADTARVLSRY-VDGIMIRTFAHSDVEELARYADVPVINGLTDLN--HPCQILADFQTIIEHKGRLEGLKLAYVGD-- 165
Cdd:PRK13814  88 ETLFDTIKTLEAMgVYFFIVRHSENETPEQIAKQLSSGVVINAGDGNhqHPSQALIDLMTIKQHKPHWNKLCVTIIGDir 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502884286 166 GNNVCHSLLNGCAKVGM-HISVATPKGYEPDaeivrkamadaRLSGAVVEILEDPCQAVKDADVIYTdvwaSMGQEAEHA 244
Cdd:PRK13814 168 HSRVANSLMDGLVTMGVpEIRLVGPSSLLPD-----------KVGNDSIKKFTELKPSLLNSDVIVT----LRLQKERHD 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502884286 245 ERLKI--FR-PYQVNSDLVKRARPDYLFMHCLPAHRGEEVAAEVIDGPNSVVFDEAENRLHAQKAVLAL 310
Cdd:PRK13814 233 NSVDIdaFRgSFRLTPEKLYSAKPDAIVMHPGPVNREVEINSDVADNQQSVILQQVRNGVAMRMAVLEL 301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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