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Conserved domains on  [gi|501468152|ref|WP_012491597|]
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HAMP domain-containing sensor histidine kinase [Lacticaseibacillus paracasei]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
9-311 7.71e-49

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 165.85  E-value: 7.71e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152   9 RWVIWLLLTILLATSFLASWLLANSFEIVLNMWFFATAPLTVIVSIDYWRFRREWQQLQDDHPIDPVQITDPLSLAYYQK 88
Cdd:COG0642    9 VLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  89 IQTLTQKLRTTRDTAHEQEQETLDTLQLWTHQIKTPLTALDLLLQV--EPVNAKDARL------EISKIDRYLAVMLNYL 160
Cdd:COG0642   89 LLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELllEELDEEQREYletilrSADRLLRLINDLLDLS 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 161 KLTTLNTDLVLTELPLKPLVNETVRDLAKLFIAKDLTVTV---GPLPTVISDSQWLHFIFEQLLTNAIKYTPHGS---IK 234
Cdd:COG0642  169 RLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELdlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGtvtVS 248

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501468152 235 IYAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRaNQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:COG0642  249 VRREGDRVRisVEDTGPGIPPEDLERIFEPFFRTDPSR-RGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
9-311 7.71e-49

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 165.85  E-value: 7.71e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152   9 RWVIWLLLTILLATSFLASWLLANSFEIVLNMWFFATAPLTVIVSIDYWRFRREWQQLQDDHPIDPVQITDPLSLAYYQK 88
Cdd:COG0642    9 VLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  89 IQTLTQKLRTTRDTAHEQEQETLDTLQLWTHQIKTPLTALDLLLQV--EPVNAKDARL------EISKIDRYLAVMLNYL 160
Cdd:COG0642   89 LLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELllEELDEEQREYletilrSADRLLRLINDLLDLS 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 161 KLTTLNTDLVLTELPLKPLVNETVRDLAKLFIAKDLTVTV---GPLPTVISDSQWLHFIFEQLLTNAIKYTPHGS---IK 234
Cdd:COG0642  169 RLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELdlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGtvtVS 248

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501468152 235 IYAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRaNQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:COG0642  249 VRREGDRVRisVEDTGPGIPPEDLERIFEPFFRTDPSR-RGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 208-311 7.89e-41

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 138.19  E-value: 7.89e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 208 SDSQWLHFIFEQLLTNAIKYTPHG---SIKIYAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRANQKASGLGLFL 282
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSKQGgkiEIYSETNEQGVVlsIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                         90       100
                 ....*....|....*....|....*....
gi 501468152 283 SKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 209-313 2.92e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 105.42  E-value: 2.92e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152   209 DSQWLHFIFEQLLTNAIKYTPHG---SIKIYAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRANQKASGLGLFLS 283
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGgriTVTLERDGDHVEitVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIV 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 501468152   284 KQIAEKLGLTLTVTSEIGQGSTFAIHFPQT 313
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 209-314 1.04e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.20  E-value: 1.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  209 DSQWLHFIFEQLLTNAIKYTPHGS---IKIYAKGDA-VMVADTGIGILAEDLPRIFEQGYSGynGRANQKASGLGLFLSK 284
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGeitVTLSEGGELtLTVEDNGIGIPPEDLPRIFEPFSTA--DKRGGGGTGLGLSIVR 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 501468152  285 QIAEKLGLTLTVTSEIGQGSTFAIHFPQTR 314
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
PRK09303 PRK09303
histidine kinase;
92-310 1.21e-17

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 82.69  E-value: 1.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  92 LTQKLRTTRDTAHE-----------QEQETL--------DTLQLWTHQIKTPLTALDLLLQVEPVNAKDARLEISK--ID 150
Cdd:PRK09303 114 QPSEIDSGRYSQELlqlsdelfvlrQENETLleqlkfkdRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPalIE 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 151 RYLAVMLNYLKL------------TTLNTDLVL--TELPLKPLVNETVRDLAKLFIAKDLTVTV---GPLPTVISDSQWL 213
Cdd:PRK09303 194 QLQDQARRQLEEierlitdllevgRTRWEALRFnpQKLDLGSLCQEVILELEKRWLAKSLEIQTdipSDLPSVYADQERI 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 214 HFIFEQLLTNAIKYTP-HGSIKIYA-----KGDAVMVADTGIGILAEDLPRIFE--------QGYSGYngranqkasGLG 279
Cdd:PRK09303 274 RQVLLNLLDNAIKYTPeGGTITLSMlhrttQKVQVSICDTGPGIPEEEQERIFEdrvrlprdEGTEGY---------GIG 344

                        250       260       270
                 ....*....|....*....|....*....|.
gi 501468152 280 LFLSKQIAEKLGLTLTVTSEIGQGSTFaiHF 310
Cdd:PRK09303 345 LSVCRRIVRVHYGQIWVDSEPGQGSCF--HF 373
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
9-311 7.71e-49

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 165.85  E-value: 7.71e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152   9 RWVIWLLLTILLATSFLASWLLANSFEIVLNMWFFATAPLTVIVSIDYWRFRREWQQLQDDHPIDPVQITDPLSLAYYQK 88
Cdd:COG0642    9 VLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  89 IQTLTQKLRTTRDTAHEQEQETLDTLQLWTHQIKTPLTALDLLLQV--EPVNAKDARL------EISKIDRYLAVMLNYL 160
Cdd:COG0642   89 LLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELllEELDEEQREYletilrSADRLLRLINDLLDLS 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 161 KLTTLNTDLVLTELPLKPLVNETVRDLAKLFIAKDLTVTV---GPLPTVISDSQWLHFIFEQLLTNAIKYTPHGS---IK 234
Cdd:COG0642  169 RLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELdlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGtvtVS 248

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501468152 235 IYAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRaNQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:COG0642  249 VRREGDRVRisVEDTGPGIPPEDLERIFEPFFRTDPSR-RGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
95-314 3.19e-42

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 145.82  E-value: 3.19e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  95 KLRTTRDTAHEQEQETLDTLQLWTHQIKTPLT----ALDLLL-QVEPVNAKDARL------EISKIDRYLAVMLNYLKLT 163
Cdd:COG2205    1 ELEEALEELEELERLKSEFLANVSHELRTPLTsilgAAELLLdEEDLSPEERRELleiireSAERLLRLIEDLLDLSRLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 164 TLNTDLVLTELPLKPLVNETVRDLAKLFIAKDLTVTV---GPLPTVISDSQWLHFIFEQLLTNAIKYTP-HGSIKIYAKG 239
Cdd:COG2205   81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELdlpPELPLVYADPELLEQVLANLLDNAIKYSPpGGTITISARR 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501468152 240 DA----VMVADTGIGILAEDLPRIFEQGYSGYNGRaNQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFPQTR 314
Cdd:COG2205  161 EGdgvrISVSDNGPGIPEEELERIFERFYRGDNSR-GEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 208-311 7.89e-41

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 138.19  E-value: 7.89e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 208 SDSQWLHFIFEQLLTNAIKYTPHG---SIKIYAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRANQKASGLGLFL 282
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSKQGgkiEIYSETNEQGVVlsIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                         90       100
                 ....*....|....*....|....*....
gi 501468152 283 SKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
7-311 1.86e-36

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 134.68  E-value: 1.86e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152   7 RSRWVIWLLLTILLATSFLASWLLANSFEIVLNMWFFATAPLTVIVSIDYWRFRREWQQLQDDHPIDPVQITDPLSLAYY 86
Cdd:COG5002   54 LLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGR 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  87 QKIQTLTQKLRTTRDTAHEQ---EQETLDTLQ------LwTHQIKTPLTA----LDLLLQvepvnakDARLEISKIDRYL 153
Cdd:COG5002  134 LSLRLSALLLGLLLLAAVERditELERLEQMRrefvanV-SHELRTPLTSirgyLELLLD-------GAADDPEERREYL 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 154 AVM------LNYL--------KLTTLNTDLVLTELPLKPLVNETVRDLAKLFIAKDLTVTV---GPLPTVISDSQWLHFI 216
Cdd:COG5002  206 EIIleeaerLSRLvndlldlsRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELdlpEDPLLVLGDPDRLEQV 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 217 FEQLLTNAIKYTPHGS---IKIYAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRANQKA-SGLGLFLSKQIAEKL 290
Cdd:COG5002  286 LTNLLDNAIKYTPEGGtitVSLREEDDQVRisVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGgTGLGLAIVKHIVEAH 365

                        330       340
                 ....*....|....*....|.
gi 501468152 291 GLTLTVTSEIGQGSTFAIHFP 311
Cdd:COG5002  366 GGRIWVESEPGKGTTFTITLP 386
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 209-313 2.92e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 105.42  E-value: 2.92e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152   209 DSQWLHFIFEQLLTNAIKYTPHG---SIKIYAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRANQKASGLGLFLS 283
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGgriTVTLERDGDHVEitVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIV 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 501468152   284 KQIAEKLGLTLTVTSEIGQGSTFAIHFPQT 313
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 156-311 8.32e-27

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 109.87  E-value: 8.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 156 MLNYLKLTTlnTDLVLTELPLKPLVNETVRDLAKLFIAKDLTVTVGPLPTVISDSQWLHFIFEQLLTNAIKYTPHGS--- 232
Cdd:COG4251  340 LLAYSRVGR--QELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEppr 417

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 233 IKIYAK--GDAVM--VADTGIGILAEDLPRIFE-----QGYSGYNGranqkaSGLGLFLSKQIAEKLGLTLTVTSEIGQG 303
Cdd:COG4251  418 IEIGAEreGGEWVfsVRDNGIGIDPEYAEKIFEifqrlHSRDEYEG------TGIGLAIVKKIVERHGGRIWVESEPGEG 491


                 ....*...
gi 501468152 304 STFAIHFP 311
Cdd:COG4251  492 ATFYFTLP 499
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 220-311 1.38e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 95.64  E-value: 1.38e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 220 LLTNAIKYTPHGSIKIYAKGDAVM---------VADTGIGILAEDLPRIFE---QGYSGYNGRanQKASGLGLFLSKQIA 287
Cdd:cd16922    8 LLGNAIKFTEEGEVTLRVSLEEEEedgvqlrfsVEDTGIGIPEEQQARLFEpfsQADSSTTRK--YGGTGLGLAISKKLV 85

                         90       100
                 ....*....|....*....|....
gi 501468152 288 EKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:cd16922   86 ELMGGDISVESEPGQGSTFTFTLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 209-314 1.04e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.20  E-value: 1.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  209 DSQWLHFIFEQLLTNAIKYTPHGS---IKIYAKGDA-VMVADTGIGILAEDLPRIFEQGYSGynGRANQKASGLGLFLSK 284
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGeitVTLSEGGELtLTVEDNGIGIPPEDLPRIFEPFSTA--DKRGGGGTGLGLSIVR 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 501468152  285 QIAEKLGLTLTVTSEIGQGSTFAIHFPQTR 314
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 118-314 2.20e-20

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 90.79  E-value: 2.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 118 THQIKTPLTALDLLLQ-----VEPVNAKDARleisKIDRYLAVML-----------NYLKLTTLnTDLVLTELPLKPLVN 181
Cdd:COG5000  209 AHEIKNPLTPIQLSAErlrrkLADKLEEDRE----DLERALDTIIrqvdrlkrivdEFLDFARL-PEPQLEPVDLNELLR 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 182 ETVRDLAKLFIAKDLTVTV---GPLPTVISDSQwlhfIFEQLLTN-------AIKytPHGSIKIYAKGDA----VMVADT 247
Cdd:COG5000  284 EVLALYEPALKEKDIRLELdldPDLPEVLADRD----QLEQVLINllknaieAIE--EGGEIEVSTRREDgrvrIEVSDN 357

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501468152 248 GIGILAEDLPRIFEQGYSgyngrANQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFPQTR 314
Cdd:COG5000  358 GPGIPEEVLERIFEPFFT-----TKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAE 419
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 119-311 5.50e-19

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 86.95  E-value: 5.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 119 HQIKTPLTAL----DLLlqvepvnaKDARLEISKidRYLAVMLNYLK--LTTLNTDLVLT--------ELPLKPLVNETV 184
Cdd:COG5809  279 HEIRNPLTSLkgfiQLL--------KDTIDEEQK--TYLDIMLSELDriESIISEFLVLAkpqaikyePKDLNTLIEEVI 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 185 R------DLAKLFIAKDLtvtVGPLPTVISDSQWLHFIFEQLLTNAIKYTPHG---SIKIYAKGD---AVMVADTGIGIL 252
Cdd:COG5809  349 PllqpqaLLKNVQIELEL---EDDIPDILGDENQLKQVFINLLKNAIEAMPEGgniTIETKAEDDdkvVISVTDEGCGIP 425

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501468152 253 AEDLPRIFEQGYSgyngrANQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:COG5809  426 EERLKKLGEPFYT-----TKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 119-311 1.24e-18

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 85.24  E-value: 1.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 119 HQIKTPLTA----LDLLLQV--EPVNAKDARLEISKIDRylAV---------MLNYLKLTTLNtdlvLTELPLKPLVNET 183
Cdd:COG4191  151 HEINNPLAAilgnAELLRRRleDEPDPEELREALERILE--GAeraaeivrsLRAFSRRDEEE----REPVDLNELIDEA 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 184 VRDLAKLFIAKDLTVTV---GPLPTVISDSQwlhfIFEQLLTN-------AIKYTPHGSIKI--YAKGDAVM--VADTGI 249
Cdd:COG4191  225 LELLRPRLKARGIEVELdlpPDLPPVLGDPG----QLEQVLLNllinaidAMEEGEGGRITIstRREGDYVVisVRDNGP 300

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501468152 250 GILAEDLPRIFEQGYSGyngRANQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:COG4191  301 GIPPEVLERIFEPFFTT---KPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
PRK09303 PRK09303
histidine kinase;
92-310 1.21e-17

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 82.69  E-value: 1.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  92 LTQKLRTTRDTAHE-----------QEQETL--------DTLQLWTHQIKTPLTALDLLLQVEPVNAKDARLEISK--ID 150
Cdd:PRK09303 114 QPSEIDSGRYSQELlqlsdelfvlrQENETLleqlkfkdRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPalIE 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 151 RYLAVMLNYLKL------------TTLNTDLVL--TELPLKPLVNETVRDLAKLFIAKDLTVTV---GPLPTVISDSQWL 213
Cdd:PRK09303 194 QLQDQARRQLEEierlitdllevgRTRWEALRFnpQKLDLGSLCQEVILELEKRWLAKSLEIQTdipSDLPSVYADQERI 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 214 HFIFEQLLTNAIKYTP-HGSIKIYA-----KGDAVMVADTGIGILAEDLPRIFE--------QGYSGYngranqkasGLG 279
Cdd:PRK09303 274 RQVLLNLLDNAIKYTPeGGTITLSMlhrttQKVQVSICDTGPGIPEEEQERIFEdrvrlprdEGTEGY---------GIG 344

                        250       260       270
                 ....*....|....*....|....*....|.
gi 501468152 280 LFLSKQIAEKLGLTLTVTSEIGQGSTFaiHF 310
Cdd:PRK09303 345 LSVCRRIVRVHYGQIWVDSEPGQGSCF--HF 373
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 89-311 1.79e-16

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 79.12  E-value: 1.79e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  89 IQTLTQKLrttrdtahEQEQETLDTLQLWTHQIKTPLTALDLLLQVEpvNAKDARLEISKIDRYLAVMLNYLKLTTLNTD 168
Cdd:COG3290  176 LERLEEEL--------EGVKELAEALRAQRHDFRNHLHTISGLLQLG--EYDEALEYIDEISEELQELIDSLLSRIGNPV 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 169 LvltelplKPLVNETVRDLAKLFIakDLTVTVGPLPTVISDSQW-LHFIFEQLLTNAIKYT-----PHGSIKIYAKGDA- 241
Cdd:COG3290  246 L-------AALLLGKAARARERGI--DLTIDIDSDLPDLPLSDTdLVTILGNLLDNAIEAVeklpeEERRVELSIRDDGd 316

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501468152 242 ---VMVADTGIGILAEDLPRIFEQGYSGYNGranqKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:COG3290  317 elvIEVEDSGPGIPEELLEKIFERGFSTKLG----EGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
89-311 6.63e-16

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 77.19  E-value: 6.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  89 IQTLTQKLRTTRDTAHEQEQETLDTL--QLwTHQIKTPLT----ALDLLLQvepvnakdaRLEISKIDRYLAVMLNYLK- 161
Cdd:COG3852  113 LRDITERKRLERELRRAEKLAAVGELaaGL-AHEIRNPLTgirgAAQLLER---------ELPDDELREYTQLIIEEADr 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 162 LTTL---------NTDLVLTELPLKPLVNEtVRDLAKLFIAKDLTVTV---GPLPTVISDSQWLHFIFEQLLTNAIKYTP 229
Cdd:COG3852  183 LNNLvdrllsfsrPRPPEREPVNLHEVLER-VLELLRAEAPKNIRIVRdydPSLPEVLGDPDQLIQVLLNLVRNAAEAMP 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 230 -HGSIKI---YAKGDA-----------VMVADTGIGILAEDLPRIFEQGYSGyngRANqkASGLGLFLSKQIAEKLGLTL 294
Cdd:COG3852  262 eGGTITIrtrVERQVTlgglrprlyvrIEVIDNGPGIPEEILDRIFEPFFTT---KEK--GTGLGLAIVQKIVEQHGGTI 336

                        250
                 ....*....|....*..
gi 501468152 295 TVTSEIGQGSTFAIHFP 311
Cdd:COG3852  337 EVESEPGKGTTFRIYLP 353
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 201-308 7.47e-16

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 78.06  E-value: 7.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 201 GPLP-TVISDSQWLHFIFEQLLTNAIKYTPHGSIKI---YAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRANQK 274
Cdd:PRK11091 386 LPLPhKVITDGTRLRQILWNLISNAVKFTQQGGVTVrvrYEEGDMLTfeVEDSGIGIPEDELDKIFAMYYQVKDSHGGKP 465

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 501468152 275 A--SGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAI 308
Cdd:PRK11091 466 AtgTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTL 501
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 119-311 7.88e-16

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 77.85  E-value: 7.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 119 HQIKTPLTALD---LLLQVEPVNAKD-ARLEISKIDRYLAVMLNYLKLTTLNTDlVLTELPLKPLVNETVRDL---AKL- 190
Cdd:COG5805  296 HEIRNPLTSIKgflQLLQPGIEDKEEyFDIMLSELDRIESIISEFLALAKPQAV-NKEKENINELIQDVVTLLeteAILh 374

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 191 --FIAKDLTvtvGPLPTVISDSQWLHFIFEQLLTNAIKYTPHG---SIKIYAKGDAVM--VADTGIGILAEDLPRIFEQG 263
Cdd:COG5805  375 niQIRLELL---DEDPFIYCDENQIKQVFINLIKNAIEAMPNGgtiTIHTEEEDNSVIirVIDEGIGIPEERLKKLGEPF 451

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 501468152 264 YSgyngrANQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:COG5805  452 FT-----TKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
92-311 1.18e-15

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 77.32  E-value: 1.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  92 LTQKLRTTRDTAHEQ--EQETLDTLQLWT----HQIKTPLTALDLLLQVepVNAKDARLEISKidrYLAVMLNylKLTTL 165
Cdd:PRK11360 366 VIFSDLTERKRLQRRvaRQERLAALGELVagvaHEIRNPLTAIRGYVQI--WRQQTSDPPSQE---YLSVVLR--EVDRL 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 166 NTdlVLTEL-----PLKPL-----VNETVRDLAKLF-------IAKDLTVTVGPLPTVISDSQWLHFIFEQLLTNAIKYT 228
Cdd:PRK11360 439 NK--VIDQLlefsrPRESQwqpvsLNALVEEVLQLFqtagvqaRVDFETELDNELPPIWADPELLKQVLLNILINAVQAI 516

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 229 PH-GSIKI----YAKGD-AVMVADTGIGILAEDLPRIFEQGYSgyngrANQKASGLGLFLSKQIAEKLGLTLTVTSEIGQ 302
Cdd:PRK11360 517 SArGKIRIrtwqYSDGQvAVSIEDNGCGIDPELLKKIFDPFFT-----TKAKGTGLGLALSQRIINAHGGDIEVESEPGV 591


                 ....*....
gi 501468152 303 GSTFAIHFP 311
Cdd:PRK11360 592 GTTFTLYLP 600
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 213-314 1.98e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 71.08  E-value: 1.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 213 LHFIFEQLLTNAIKYTPHGS-IKIY----AKGDAVMVADTGIGILAEDLPRIFEQGYSGYNGRANQKA-SGLGLFLSKQI 286
Cdd:cd16952    1 LRSAFSNLVSNAVKYTPPSDtITVRwsqeESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVKHV 80

                         90       100
                 ....*....|....*....|....*...
gi 501468152 287 AEKLGLTLTVTSEIGQGSTFAIHFPQTR 314
Cdd:cd16952   81 MSRHDARLLIASELGKGSRFTCLFPSSR 108
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 118-296 1.09e-13

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 71.41  E-value: 1.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 118 THQIKTPLTAL---DLLLQVEP-----------VNAKDARLEiSKIDRylavMLNYLKLTTLNTDLVLTELPLKPLVNET 183
Cdd:PRK11100 264 THELKSPLAAIrgaAELLQEDPppedrarftgnILTQSARLQ-QLIDR----LLELARLEQRQELEVLEPVALAALLEEL 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 184 VRDLAKLFIAKDLTVTVGPLPT-VISDSQWLHFIFEQLLTNAIKYTPHGS-IKIYAKGDA----VMVADTGIGILAEDLP 257
Cdd:PRK11100 339 VEAREAQAAAKGITLRLRPDDArVLGDPFLLRQALGNLLDNAIDFSPEGGtITLSAEVDGeqvaLSVEDQGPGIPDYALP 418

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 501468152 258 RIFEQGYS---GYNGRanqKASGLGLFLSKQIAEKLGLTLTV 296
Cdd:PRK11100 419 RIFERFYSlprPANGR---KSTGLGLAFVREVARLHGGEVTL 457
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
81-311 1.32e-13

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 70.97  E-value: 1.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  81 LSLAYYQKIQTLTQKLRttRDTAHEQEQETLDTLQLW-THQIKTPLTALDLLL----QVEPVNAKD---ARLEISKIDRY 152
Cdd:PRK10364 209 LAFFWYRRYLRSRQLLQ--DEMKRKEKLVALGHLAAGvAHEIRNPLSSIKGLAkyfaERAPAGGEAhqlAQVMAKEADRL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 153 LAVMLNYLKLTTlNTDLVLTELPLKPLVNETVR----DLAKLFIAKDLTVTVGpLPTVISDSQWLHFIFEQLLTNAIKYT 228
Cdd:PRK10364 287 NRVVSELLELVK-PTHLALQAVDLNDLINHSLQlvsqDANSREIQLRFTANDT-LPEIQADPDRLTQVLLNLYLNAIQAI 364

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 229 P-HGSIKIYAK--GDAV--MVADTGIGILAEDLPRIFEQGYSGYNgranqKASGLGLFLSKQIAEKLGLTLTVTSEIGQG 303
Cdd:PRK10364 365 GqHGVISVTASesGAGVkiSVTDSGKGIAADQLEAIFTPYFTTKA-----EGTGLGLAVVHNIVEQHGGTIQVASQEGKG 439


                 ....*...
gi 501468152 304 STFAIHFP 311
Cdd:PRK10364 440 ATFTLWLP 447
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 244-318 2.00e-13

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 70.71  E-value: 2.00e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501468152 244 VADTGIGILAEDLPRIFEQGYS--GyNGRanqkasGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFPqtrWQVE 318
Cdd:PRK11086 472 VSDDGPGIAPDEIDAIFDKGYStkG-SNR------GVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP---WDGE 538
PRK15347 PRK15347
two component system sensor kinase;
118-311 3.18e-13

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 70.44  E-value: 3.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 118 THQIKTPLT----ALDLLlQVEPVNAKDARLeiskID--RY-----LAVMLNYLKLTTLNTD---LVLTELPLKPLVNET 183
Cdd:PRK15347 406 SHEIRTPLNgvlgALELL-QNTPLTAEQMDL----ADtaRQctlslLAIINNLLDFSRIESGqmtLSLEETALLPLLDQA 480

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 184 VRDLAKLFIAKDLTvtvgpLPTVISDS--QWLHF-------IFEQLLTNAIKYTPHGSIKIYAKGDAVM----VADTGIG 250
Cdd:PRK15347 481 MLTIQGPAQSKSLT-----LRTFVGAHvpLYLHLdslrlrqILVNLLGNAVKFTETGGIRLRVKRHEQQlcftVEDTGCG 555

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501468152 251 ILAEDLPRIFEqgySGYNGRANQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:PRK15347 556 IDIQQQQQIFT---PFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 232-311 1.15e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 63.08  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 232 SIKIYAKGDAVM--VADTGIGILAEDLPRIFEQGYS--GYNGRanqkasGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFA 307
Cdd:cd16915   27 EVFLRDEGDDLVieVRDTGPGIAPELRDKVFERGVStkGQGER------GIGLALVRQSVERLGGSITVESEPGGGTTFS 100


                 ....
gi 501468152 308 IHFP 311
Cdd:cd16915  101 IRIP 104
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 216-311 2.29e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 62.40  E-value: 2.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 216 IFEQLLTNAIKYTPHGS---IKIYAKGDAV--MVADTGIGILAEDLPRIFEQGYSGYNGRaNQKASGLGLFLSKQIAEKL 290
Cdd:cd16923    4 VFSNLLSNAIKYSPENTriyITSFLTDDVVniMFKNPSSHPLDFKLEKLFERFYRGDNSR-NTEGAGLGLSIAKAIIELH 82

                         90       100
                 ....*....|....*....|.
gi 501468152 291 GLTLTVTSEiGQGSTFAIHFP 311
Cdd:cd16923   83 GGSASAEYD-DNHDLFKVRLP 102
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 209-304 1.58e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 60.17  E-value: 1.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 209 DSQWLHFIFEQLLTNAIKYTPHG---SIKIYAKGDAV--MVADTGIGILAEDLPRIFEQGYSGYNGRANQKASGLGLFLS 283
Cdd:cd16975    1 DTLLLSRALINIISNACQYAPEGgtvSISIYDEEEYLyfEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIA 80

                         90       100
                 ....*....|....*....|.
gi 501468152 284 KQIAEKLGLTLTVTSEIGQGS 304
Cdd:cd16975   81 KNLVEKHGGSLIIENSQKGGA 101
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 205-303 3.36e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 59.34  E-value: 3.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 205 TVISDSQWLHFIFEQLLTNAIKYTPHGS---IKIYAKGDAVM-VADTGIGILAEDLPRIFEQGYSgyNGRANQKASGLGL 280
Cdd:cd16940    6 QVQGDALLLFLLLRNLVDNAVRYSPQGSrveIKLSADDGAVIrVEDNGPGIDEEELEALFERFYR--SDGQNYGGSGLGL 83

                         90       100
                 ....*....|....*....|...
gi 501468152 281 FLSKQIAEKLGLTLTVTSEIGQG 303
Cdd:cd16940   84 SIVKRIVELHGGQIFLGNAQGGG 106
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 88-311 5.99e-11

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 63.39  E-value: 5.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  88 KIQTLTQKLRTTRDTAHEQEQETLDTLQLWTHQIKTPLTAL---DLLLQVEPVNAKdARLEISKI----DRYLAVM---L 157
Cdd:PRK11466 422 ELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGIlgtAQLLADNPALNA-QRDDLRAItdsgESLLTILndiL 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 158 NYLKLTTLNTDLVLTELPLKP--LVNETVRDLAKLFIAKDLTVT---VGPLPTVI-SDSQWLHFIFEQLLTNAIKYTPHG 231
Cdd:PRK11466 501 DYSAIEAGGKNVSVSDEPFEPrpLLESTLQLMSGRVKGRPIRLAtdiADDLPTALmGDPRRIRQVITNLLSNALRFTDEG 580

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 232 SIKIYAKGDA----VMVADTGIGILAEDLPRIFeQGYSGYNGRanQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFA 307
Cdd:PRK11466 581 SIVLRSRTDGeqwlVEVEDSGCGIDPAKLAEIF-QPFVQVSGK--RGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFC 657


                 ....
gi 501468152 308 IHFP 311
Cdd:PRK11466 658 LRLP 661
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 216-311 7.03e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 58.20  E-value: 7.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 216 IFEQLLTNAIK-YTPHGSIKI----YAKGDAVMVADTGIGILAEDLPRIFEQGYSGyngRANQKASGLGLFLSKQIAEKL 290
Cdd:cd16943    7 VLLNLLVNAAQaMEGRGRITIrtwaHVDQVLIEVEDTGSGIDPEILGRIFDPFFTT---KPVGEGTGLGLSLSYRIIQKH 83

                         90       100
                 ....*....|....*....|.
gi 501468152 291 GLTLTVTSEIGQGSTFAIHFP 311
Cdd:cd16943   84 GGTIRVASVPGGGTRFTIILP 104
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 169-311 8.84e-11

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 62.94  E-value: 8.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 169 LVLTELP--LKPLVNETVRDLAKLFIAKDL--TVTVGP-LP-TVISDSQWLHFIFEQLLTNAIKYTPHGSIKI-----YA 237
Cdd:PRK11107 359 LVLENIPfsLRETLDEVVTLLAHSAHEKGLelTLNIDPdVPdNVIGDPLRLQQIITNLVGNAIKFTESGNIDIlvelrAL 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 238 KGDAV----MVADTGIGILAEDLPRIFeQGYsgynGRANQKAS------GLGLFLSKQIAEKLGLTLTVTSEIGQGSTFA 307
Cdd:PRK11107 439 SNTKVqlevQIRDTGIGISERQQSQLF-QAF----RQADASISrrhggtGLGLVITQKLVNEMGGDISFHSQPNRGSTFW 513


                 ....
gi 501468152 308 IHFP 311
Cdd:PRK11107 514 FHLP 517
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 209-311 6.21e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 55.93  E-value: 6.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 209 DSQWLHFIFEQLLTNAIKYT-PHGSIKIYA----KGDAVMVADTGIGILAEDLPRIFEQGYSGYNGRaNQKA--SGLGLF 281
Cdd:cd16946    1 DRDRLQQLFVNLLENSLRYTdTGGKLRIRAaqtpQEVRLDVEDSAPGVSDDQLARLFERFYRVESSR-NRASggSGLGLA 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 501468152 282 LSKQIAEKLGLTLTVT-SEIGqGSTFAIHFP 311
Cdd:cd16946   80 ICHNIALAHGGTISAEhSPLG-GLRLVLTLP 109
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 213-311 1.07e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 55.03  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 213 LHFIFEQLLTNAIKYT---PHGSIKIYAKGDA----VMVADTGIGILAEDLPRIFEQgYSGYNGRANQKASGLGLFLSKQ 285
Cdd:cd16921    1 LGQVLTNLLGNAIKFRrprRPPRIEVGAEDVGeewtFYVRDNGIGIDPEYAEKVFGI-FQRLHSREEYEGTGVGLAIVRK 79

                         90       100
                 ....*....|....*....|....*.
gi 501468152 286 IAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:cd16921   80 IIERHGGRIWLESEPGEGTTFYFTLP 105
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
94-311 1.67e-09

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 58.98  E-value: 1.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152   94 QKLRTTRDTAHEQEQETLDT----------LQLWTHQIKTPLTALDLLLQVEPVN--AKDARLEISKIDR--------YL 153
Cdd:PRK09959  686 QDITETRDLIHALEVERNKAinatvaksqfLATMSHEIRTPISSIMGFLELLSGSglSKEQRVEAISLAYatgqsllgLI 765

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  154 AVMLNYLKLTTLNTDLVLTELPLKPLVNETVRDLAKLFIAKDLTVTVGP-LPT---VISDSQWLHFIFEQLLTNAIKYTP 229
Cdd:PRK09959  766 GEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSStFPDhylVKIDPQAFKQVLSNLLSNALKFTT 845

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  230 HGSIKIYAK------GDAVM---VADTGIGILAEDLPRIFEQgYSGYNGRANQKASGLGLFLSKQIAEKLGLTLTVTSEI 300
Cdd:PRK09959  846 EGAVKITTSlghiddNHAVIkmtIMDSGSGLSQEEQQQLFKR-YSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHP 924

                         250
                  ....*....|.
gi 501468152  301 GQGSTFAIHFP 311
Cdd:PRK09959  925 GIGTTFTITIP 935
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 216-311 2.12e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 54.31  E-value: 2.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 216 IFEQLLTNAIKYTPHGSIKiyakGDAVM--VADTGIGILAEDLPRIFEQGYSGyngRANQKASGLGLFLSKQIAEKLGLT 293
Cdd:cd16919   26 TSNQRVDADYALNYRDLIP----GNYVCleVSDTGSGMPAEVLRRAFEPFFTT---KEVGKGTGLGLSMVYGFVKQSGGH 98

                         90
                 ....*....|....*...
gi 501468152 294 LTVTSEIGQGSTFAIHFP 311
Cdd:cd16919   99 LRIYSEPGVGTTVRIYLP 116
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
220-311 7.25e-09

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 56.91  E-value: 7.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 220 LLTNAIKYTPHGSI--KIYAKGD--AVMVADTGIGILAEDLPRIFEQGYS-GYNGRANQKASGLGLflskQIAEKL---- 290
Cdd:PRK10841 570 LLSNAIKFTDTGCIvlHVRVDGDylSFRVRDTGVGIPAKEVVRLFDPFFQvGTGVQRNFQGTGLGL----AICEKLinmm 645

                         90       100
                 ....*....|....*....|..
gi 501468152 291 -GlTLTVTSEIGQGSTFAIHFP 311
Cdd:PRK10841 646 dG-DISVDSEPGMGSQFTIRIP 666
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
220-312 7.51e-09

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 56.56  E-value: 7.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 220 LLTNAIKYTPHGS-IKI----YAKGDAVMVADTGIGILAEDLPRIFEQGYSGYNGRANQK-ASGLGLFLSKQIAEKLGLT 293
Cdd:PRK11006 325 LVYNAVNHTPEGThITVrwqrVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTgGSGLGLAIVKHALSHHDSR 404

                         90
                 ....*....|....*....
gi 501468152 294 LTVTSEIGQGSTFAIHFPQ 312
Cdd:PRK11006 405 LEIESEVGKGTRFSFVLPE 423
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 209-308 1.80e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 52.13  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 209 DSQWLHFIFEQLLTNAIKYTPHG---SIKIYAKGD--AVMVADTGIGILAEDLPRIFEQGYSGYNGRANQ-KASGLGLFL 282
Cdd:cd16947   17 NTEALQRILKNLISNAIKYGSDGkflGMTLREDEKhvYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAkQGNGLGLTI 96

                         90       100
                 ....*....|....*....|....*.
gi 501468152 283 SKQIAEKLGLTLTVTSEIGQGSTFAI 308
Cdd:cd16947   97 TKRLAESMGGSIYVNSKPYEKTVFTV 122
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 214-311 6.88e-08

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 50.18  E-value: 6.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 214 HFIFeQLLTNAIKYTPHGS-IK-IYAKGDA----VMVADTGIGILAEDLPRIFE---QGySGYNGRAnQKASGLGLFLSK 284
Cdd:cd16925    7 RVVL-NLLSNAFKFTPDGGrIRcILEKFRLnrflLTVSDSGPGIPPNLREEIFErfrQG-DGSSTRA-HGGTGLGLSIVK 83

                         90       100
                 ....*....|....*....|....*..
gi 501468152 285 QIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:cd16925   84 EFVELHGGTVTVSDAPGGGALFQVELP 110
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 216-311 1.00e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 49.49  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 216 IFEQLLTNAIKYTP--HGSIKIYAKGDA----VMVADTGIGILAEDLPRIFEQGYSGYNGRAN-QKASGLGLFLSKQIAE 288
Cdd:cd16953    4 VLRNLIGNAISFSPpdTGRITVSAMPTGkmvtISVEDEGPGIPQEKLESIFDRFYTERPANEAfGQHSGLGLSISRQIIE 83

                         90       100
                 ....*....|....*....|....*..
gi 501468152 289 KLGLTLTVTS----EIGQGSTFAIHFP 311
Cdd:cd16953   84 AHGGISVAENhnqpGQVIGARFTVQLP 110
PRK10337 PRK10337
sensor protein QseC; Provisional
 86-295 1.10e-07

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 52.73  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  86 YQKIQT-LTQKLRTTRDTAHEqeqetldtlqlwthqIKTPLTALDLLLQV------EPVNAKDARLEISK-IDRYLAVML 157
Cdd:PRK10337 227 FARTHAmMVRERRFTSDAAHE---------------LRSPLAALKVQTEVaqlsddDPQARKKALLQLHAgIDRATRLVD 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 158 NYLKLTTLNTDLVL---TELPLKPLVNETVRDLAKLFIAKDLTVTVG-PLPTVISDSQ--WLHFIFEQLLTNAIKYTPHG 231
Cdd:PRK10337 292 QLLTLSRLDSLDNLqdvAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTlNAHPVIRTGQplLLSLLVRNLLDNAIRYSPQG 371

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501468152 232 S-IKIYAKGDAVMVADTGIGILAEDLPRIFEQGYsgyngR---ANQKASGLGLFLSKQIAEKLGLTLT 295
Cdd:PRK10337 372 SvVDVTLNARNFTVRDNGPGVTPEALARIGERFY-----RppgQEATGSGLGLSIVRRIAKLHGMNVS 434
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
87-311 1.15e-07

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 51.93  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  87 QKIQTLTQKLRTTRDTAHEQEQETL-----DTLQlwtHQiktpLTA----LDLLLQVEPVNAKDARLEISKIDRYLAVML 157
Cdd:COG4585   33 ERAAELERELAARAEEAREEERRRIarelhDGVG---QS----LSAiklqLEAARRLLDADPEAAREELEEIRELAREAL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 158 NYLK--LTTLNTDlVLTELPLKPLVNETVRDLAKLFiAKDLTVTVGPLPTVISDSQWLHF--IFEQLLTNAIKYTPHGSI 233
Cdd:COG4585  106 AELRrlVRGLRPP-ALDDLGLAAALEELAERLLRAA-GIRVELDVDGDPDRLPPEVELALyrIVQEALTNALKHAGATRV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 234 KIYAKGDA----VMVADTGIGILAEDLPRifeqgysgyngranqkaSGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIH 309
Cdd:COG4585  184 TVTLEVDDgeltLTVRDDGVGFDPEAAPG-----------------GGLGLRGMRERAEALGGTLTIGSAPGGGTRVRAT 246


                 ..
gi 501468152 310 FP 311
Cdd:COG4585  247 LP 248
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 209-296 1.90e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 48.61  E-value: 1.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 209 DSQWLHFIFEQLLTNAIKYTP-HGSIKIYAKGDA----VMVADTGIGILAEDLPRIFEQGYSGYNGRANQKASGLGLFLS 283
Cdd:cd16945    1 DPFLLRQAINNLLDNAIDFSPeGGLIALQLEADTegieLLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFV 80

                         90
                 ....*....|...
gi 501468152 284 KQIAEKLGLTLTV 296
Cdd:cd16945   81 QEVAQLHGGRITL 93
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 220-303 3.21e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 47.83  E-value: 3.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 220 LLTNAIKYTpHGSIKIYAKGD----AVMVADTGIGILAEDLPRIFEQGYSGYNGRANqKASGLGLFLSKQIAEKLGLTLT 295
Cdd:cd16950    8 LVDNALRYG-GGWVEVSSDGEgnrtRIQVLDNGPGIAPEEVDELFQPFYRGDNARGT-SGTGLGLAIVQRISDAHGGSLT 85


                 ....*...
gi 501468152 296 VTSEIGQG 303
Cdd:cd16950   86 LANRAGGG 93
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 220-306 3.39e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 47.84  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 220 LLTNA---IKYTPHGSIKIYAK---GDAVM-VADTGIGILAEDLPRIFEQGYSgynGRANQKASGLGLFLSKQIAEKLGL 292
Cdd:cd16976    8 LLQNAldaMGKVENPRIRIAARrlgGRLVLvVRDNGPGIAEEHLSRVFDPFFT---TKPVGKGTGLGLSISYGIVEEHGG 84

                         90
                 ....*....|....
gi 501468152 293 TLTVTSEIGQGSTF 306
Cdd:cd16976   85 RLSVANEEGAGARF 98
PRK10490 PRK10490
sensor protein KdpD; Provisional
 91-312 3.79e-07

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 51.58  E-value: 3.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  91 TLTQKLRTTR-DTAHEQEQETLdtLQLWTHQIKTPLTAL---------DLLLQVEP--VNAKDARLEISKIDRYLAVMLN 158
Cdd:PRK10490 646 TLTASEEQARlASEREQLRNAL--LAALSHDLRTPLTVLfgqaeiltlDLASEGSPhaRQASEIRQQVLNTTRLVNNLLD 723

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 159 YLKLTTLNTDLVLTELPLKPLVNETVRDLAKLFIAKDLTVTV-GPLPTVISDSQWLHFIFEQLLTNAIKYT-PHGSIKIY 236
Cdd:PRK10490 724 MARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLpEPLTLIHVDGPLFERVLINLLENAVKYAgAQAEIGID 803

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 237 AKGDA----VMVADTGIGILAEDLPRIFEQgYSgyngRANQKAS----GLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAI 308
Cdd:PRK10490 804 AHVEGerlqLDVWDNGPGIPPGQEQLIFDK-FA----RGNKESAipgvGLGLAICRAIVEVHGGTIWAENRPEGGACFRV 878


                 ....
gi 501468152 309 HFPQ 312
Cdd:PRK10490 879 TLPL 882
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
119-312 9.64e-07

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 50.16  E-value: 9.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 119 HQIKTPLTalDLLLQVEPVNAKDaRLEISKIDRYLAVMLNYLKLTTLNTD-LVLTELPLKPLVNETVR-DLA----KLF- 191
Cdd:PRK09835 271 HEIRTPIT--NLITQTEIALSQS-RSQKELEDVLYSNLEELTRMAKMVSDmLFLAQADNNQLIPEKKMlDLAdevgKVFd 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 192 ----IAKDLTVT---VGPLPTVISDSQWLHFIFEQLLTNAIKYTPHG---SIKIYAKGDAV--MVADTGIGILAEDLPRI 259
Cdd:PRK09835 348 ffeaWAEERGVElrfVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGeaiTVRCQEVDHQVqlVVENPGTPIAPEHLPRL 427

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 501468152 260 FEQGYSGYNGRA-NQKASGLGLFLSKQIAEKLGLTLTVTSEIgQGSTFAIHFPQ 312
Cdd:PRK09835 428 FDRFYRVDPSRQrKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLPR 480
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
230-311 2.06e-06

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 49.29  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 230 HGSIkiyAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGranqkASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFA 307
Cdd:PRK13837 599 HGVL---PPGRYVLlrVSDTGAGIDEAVLPHIFEPFFTTRAG-----GTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFD 670


                 ....
gi 501468152 308 IHFP 311
Cdd:PRK13837 671 VYLP 674
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 171-314 5.59e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 47.59  E-value: 5.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 171 LTELPLKPLVNETVRDLAKLFIAKD--LTVTVGPLPTVISDSQWLHFIFEQLLTNAIKY----TPHGSIKIYAKGDA--- 241
Cdd:COG3920  356 WEGVDLRDYLRELLEPLRDSYGGRGirIELDGPDVELPADAAVPLGLILNELVTNALKHaflsGEGGRIRVSWRREDgrl 435

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501468152 242 -VMVADTGIGilaedLPRIFEQgysgyngranQKASGLGLFLSKQIAEKLGLTLTVTSEigQGSTFAIHFPQTR 314
Cdd:COG3920  436 rLTVSDNGVG-----LPEDVDP----------PARKGLGLRLIRALVRQLGGTLELDRP--EGTRVRITFPLAE 492
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 213-311 1.32e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 43.19  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 213 LHFIFEQLLTNAIKYTpHGSIKIYAKGDA----VMVADTGIGILAEDLPRIFEQGYSGYNGRANQKAS-GLGLFLSKQIA 287
Cdd:cd16939    1 MARALDNLLRNALRYA-HRTVRIALLVSGgrltLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGfGLGLAIVHRVA 79

                         90       100
                 ....*....|....*....|....*
gi 501468152 288 EKLGLTLTVT-SEIGqGSTFAIHFP 311
Cdd:cd16939   80 LWHGGHVECDdSELG-GACFRLTWP 103
PRK13557 PRK13557
histidine kinase; Provisional
 241-313 7.42e-05

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 44.28  E-value: 7.42e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501468152 241 AVMVADTGIGILAEDLPRIFEQGYSGyngRANQKASGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFPQT 313
Cdd:PRK13557 326 SIAVTDTGSGMPPEILARVMDPFFTT---KEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPAS 395
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 241-311 1.62e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 40.46  E-value: 1.62e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501468152 241 AVMVADTGIGILAEDLPRIFEQGYSgyngranQKASGLG--LFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:cd16920   39 TISVKDTGPGIAEEVAGQLFDPFYT-------TKSEGLGmgLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
 76-311 4.14e-04

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 41.84  E-value: 4.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152  76 QITDPLSLAYYQKIQTLTQKLRTTRDTAH-EQEQETLDTLQLWTHQIKTPLTALDLLLQVEPVNAKDARLEISkidryla 154
Cdd:PRK10618 452 AFLQNIGDELKQPLQSLAQLAAQLRQTSDeEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFS------- 524

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 155 vmlnylkLTTLNTDLVLTELPL---KPLvnetvrdlaKLFIAKDLtvtvGPLPTVISDSQWLHFIFEQLLTNAIKYTPHG 231
Cdd:PRK10618 525 -------LQDLIDEVLPEVLPAikrKGL---------QLLIHNHL----KAEQLRIGDRDALRKILLLLLNYAITTTAYG 584

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 232 SIKIYAKGDA-------VMVADTGIGILAEDL-----PRIFEQGYSGYngranQKASGLGLFLSKQIAEKLGLTLTVTSE 299
Cdd:PRK10618 585 KITLEVDQDEsspdrltIRILDTGAGVSIKELdnlhfPFLNQTQGDRY-----GKASGLTFFLCNQLCRKLGGHLTIKSR 659

                        250
                 ....*....|..
gi 501468152 300 IGQGSTFAIHFP 311
Cdd:PRK10618 660 EGLGTRYSIHLK 671
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 229-311 4.50e-04

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 40.26  E-value: 4.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 229 PHGSIKIYAK--GDAV--MVADTGIGILAEDLPR------------------------IFEQGYS------GYNGRanqk 274
Cdd:cd16916   68 PEGTITLRAEhqGNQVviEVSDDGRGIDREKIREkaierglitadeaatlsddevlnlIFAPGFStaeqvtDVSGR---- 143

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 501468152 275 asGLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:cd16916  144 --GVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
220-293 5.19e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 39.51  E-value: 5.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 220 LLTNAIKYT----PHGSIKIYAKGDA----VMVADTGIGILAEDLPRIFEQGYSGyngranqkasGLGLFLSKQIAEKLG 291
Cdd:COG2172   42 AVTNAVRHAyggdPDGPVEVELELDPdgleIEVRDEGPGFDPEDLPDPYSTLAEG----------GRGLFLIRRLMDEVE 111


                 ..
gi 501468152 292 LT 293
Cdd:COG2172  112 YE 113
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
119-280 5.97e-04

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 41.46  E-value: 5.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 119 HQIKTPLTALDLllqvepVNAKDARL-----EISKID---RYLAVMLNYLKL---TTLNTDLVLTELPLKPLVNETVRDl 187
Cdd:PRK09470 252 HELRTPLTRLQL------ATALLRRRqgeskELERIEteaQRLDSMINDLLVlsrNQQKNHLERETFKANSLWSEVLED- 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 188 AKlFIA----KDLTVTVGPLPTVIS-DSQWLHFIFEQLLTNAIKYTpHGSIK--IYAKGDAVM--VADTGIGILAEDLPR 258
Cdd:PRK09470 325 AK-FEAeqmgKSLTVSAPPGPWPINgNPNALASALENIVRNALRYS-HTKIEvaFSVDKDGLTitVDDDGPGVPEEEREQ 402

                        170       180
                 ....*....|....*....|...
gi 501468152 259 IFEQGYSGYNGRANQK-ASGLGL 280
Cdd:PRK09470 403 IFRPFYRVDEARDRESgGTGLGL 425
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 213-280 1.64e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 37.31  E-value: 1.64e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501468152 213 LHFIFEQLLTNAIKYTPHG-SIKIYAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGR-ANQKASGLGL 280
Cdd:cd16949    1 LARALENVLRNALRYSPSKiLLDISQDGDQWTitITDDGPGVPEDQLEQIFLPFYRVDSARdRESGGTGLGL 72
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
220-311 1.92e-03

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 39.62  E-value: 1.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 220 LLTNAIKytpHG----------SIKIYAKGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRanqkasGLGLflsKQIA 287
Cdd:COG2972  344 LVENAIE---HGiepkegggtiRISIRKEGDRLVitVEDNGVGMPEEKLEKLLEELSSKGEGR------GIGL---RNVR 411

                         90       100       110
                 ....*....|....*....|....*....|
gi 501468152 288 EKLGL------TLTVTSEIGQGSTFAIHFP 311
Cdd:COG2972  412 ERLKLyygeeyGLEIESEPGEGTTVTIRIP 441
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 213-311 2.33e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 38.09  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 213 LHFIFEQLLTNAIKYT--PHGS-------IKIY-AKGD---AVMVADTGIGILAEDLPRIFEQGYS----------GYNG 269
Cdd:cd16929   44 LYYILFELLKNAMRATveSHGDdsddlppIKVTvAKGDedlTIKISDRGGGIPREDLARLFSYMYStapqpslddfSDLI 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 501468152 270 RANQKAS----GLGLFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFP 311
Cdd:cd16929  124 SGTQPSPlagfGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 221-311 3.24e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 35.99  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 221 LTNAIKYTP--HGSIKIYAKGDAV--MVADTGIGILAEDLPRifeqgysgyngranqkASGLGLFLSKQIAEKLGLTLTV 296
Cdd:cd16917    9 LTNALKHAGasRVRVTLSYTADELtlTVVDDGVGFDGPAPPG----------------GGGFGLLGMRERAELLGGTLTI 72

                         90
                 ....*....|....*
gi 501468152 297 TSEIGQGSTFAIHFP 311
Cdd:cd16917   73 GSRPGGGTRVTARLP 87
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 209-314 3.35e-03

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 39.05  E-value: 3.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 209 DSQWLHFIFEQLLTNAIK---YTPHGS--IKIYA--KGDAVM--VADTGIGILAEDLPRIFEQGYSGYNGRANQKasGLG 279
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEaslRSDEGNkiVELFLsdEGDDVVieVADQGCGVPESLRDKIFEQGVSTRADEPGEH--GIG 506

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 501468152 280 LFLSKQIAEKLGLTLTVTSEIGQGSTFAIHFPQTR 314
Cdd:PRK15053 507 LYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVK 541
PRK10604 PRK10604
sensor protein RstB; Provisional
 119-311 5.38e-03

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 38.43  E-value: 5.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 119 HQIKTPLTALDLLLQV--EPVNAKDARLE--ISKIDRYLAVMLNYLKLTTLNTDLVLTELPLKPLVNETVRDLAKLFIAK 194
Cdd:PRK10604 221 HELRTPLVRLRYRLEMsdNLSAAESQALNrdIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEK 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501468152 195 DLTVTVGPLPTVI-SDSQWLHFIFEQLLTNAIKYTpHGSIKIYAKGDA----VMVADTGIGILAEDLPRIFEQGYSGYNG 269
Cdd:PRK10604 301 TVRLDTPHQGDYGaLDMRLMERVLDNLLNNALRYA-HSRVRVSLLLDGnqacLIVEDDGPGIPPEERERVFEPFVRLDPS 379

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 501468152 270 RANQKAS-GLGLFLSKQIAEKLGLTLTV-TSEIGqGSTFAIHFP 311
Cdd:PRK10604 380 RDRATGGcGLGLAIVHSIALAMGGSVNCdESELG-GARFSFSWP 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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