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Conserved domains on  [gi|501416405|gb|AGL93537|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Scaptomyza neosilvicola]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 17-185 2.34e-44

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 149.59  E-value: 2.34e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  17 IFNNSSKILFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLML 96
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  97 KNNlnneINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLNNLLMISMILSVMV 176
Cdd:MTH00160  81 NLM----LFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAII 156


                 ....*....
gi 501416405 177 GAIGGLNQT 185
Cdd:MTH00160 157 GAIGGLNQT 165
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 17-185 2.34e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 149.59  E-value: 2.34e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  17 IFNNSSKILFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLML 96
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  97 KNNlnneINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLNNLLMISMILSVMV 176
Cdd:MTH00160  81 NLM----LFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAII 156


                 ....*....
gi 501416405 177 GAIGGLNQT 185
Cdd:MTH00160 157 GAIGGLNQT 165
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 40-185 1.23e-14

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 70.03  E-value: 1.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405   40 SNSWLGAWMGLEINLLSFIPLMSDN-NNFKSTEASLKYFLTQALASTVLLFSVIL-------------LMLKNNLNNEIN 105
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWgKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdelSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  106 ESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMN-ALLLMTWQKIAPLMLI--------SYLNLNNLLMISMILSVMV 176
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVsALLAATLVKAGGYGLIrrsllylpSSPFIQQILLILAIISMLL 160


                  ....*....
gi 501416405  177 GAIGGLNQT 185
Cdd:pfam00361 161 GSLAALVQT 169
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 10-185 4.32e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 48.79  E-value: 4.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405   10 VLILFFLIFNNSSKILFVTMM---IVGTLITVTSNSWLGAWMGLEINLLSFIPLMS-DNNNFKSTEASLKYFLTQALAST 85
Cdd:TIGR01770  88 FFALSYLSKEKINKFEFYILLlfaLLGIFLLVSSNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSG 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405   86 VLLF--------------SVILLMLKNNLNNEINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKI 151
Cdd:TIGR01770 168 LLLFgisliygftgslnfEDLLLFLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKI 247

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 501416405  152 A---PLMLIS-------YLNLNNLLMISMILSVMVGAIGGLNQT 185
Cdd:TIGR01770 248 AifaVFLRLFlyilfgfSEAWQIFLAIIAFLSMLIGNFGALAQK 291
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 25-185 5.09e-07

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 48.57  E-value: 5.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  25 LFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMS-DNNNFKSTEASLKYFLTQALASTVLLF--SVILLMLKNNLN 101
Cdd:COG1007  106 ALLLFATLGMMLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYgiSLLYGATGSLNL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405 102 NEINESFTSMIMLSTLLL------------KSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIA----------PLMLISY 159
Cdd:COG1007  186 AGIAAALAAGGANSPLLLlglvlvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAafaallrllvEAFPGLA 265

                        170       180
                 ....*....|....*....|....*.
gi 501416405 160 LNLNNLLMISMILSVMVGAIGGLNQT 185
Cdd:COG1007  266 ADWQLLLAVLAVLSMTVGNLAALAQT 291
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 17-185 2.34e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 149.59  E-value: 2.34e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  17 IFNNSSKILFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLML 96
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  97 KNNlnneINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLNNLLMISMILSVMV 176
Cdd:MTH00160  81 NLM----LFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAII 156


                 ....*....
gi 501416405 177 GAIGGLNQT 185
Cdd:MTH00160 157 GAIGGLNQT 165
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 24-185 8.40e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 132.66  E-value: 8.40e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  24 ILFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLMLKNN--LN 101
Cdd:MTH00105   7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMYSGqwTI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405 102 NEINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLI----SYLNLnNLLMISMILSVMVG 177
Cdd:MTH00105  87 TKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILyqisPSINP-NLLLTLAILSILIG 165


                 ....*...
gi 501416405 178 AIGGLNQT 185
Cdd:MTH00105 166 GWGGLNQT 173
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 22-185 1.45e-37

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 132.25  E-value: 1.45e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  22 SKILFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLMLKNNL- 100
Cdd:MTH00112   5 AKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNTGQw 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405 101 -NNEINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAP--LMLISYLNLN-NLLMISMILSVMV 176
Cdd:MTH00112  85 dITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPltLLLMTSNSLNpTLLLTLAILSTLI 164


                 ....*....
gi 501416405 177 GAIGGLNQT 185
Cdd:MTH00112 165 GGWGGLNQT 173
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 19-185 1.52e-32

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 118.88  E-value: 1.52e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  19 NNSSKILFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLMLKN 98
Cdd:MTH00041   2 NRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  99 --NLNNEINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLN---LNNLLMISMILS 173
Cdd:MTH00041  82 gsWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISnllNSNILILCGILS 161

                        170
                 ....*....|..
gi 501416405 174 VMVGAIGGLNQT 185
Cdd:MTH00041 162 VLVGGWGGLNQT 173
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 33-185 5.36e-32

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 117.60  E-value: 5.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  33 GTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLMLKN--NLNNEINESFTS 110
Cdd:MTH00135  16 GTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWLTgqWDIQQMSHPLPT 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501416405 111 MIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLNN--LLMISMILSVMVGAIGGLNQT 185
Cdd:MTH00135  96 TMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNptLLITLGLTSTLVGGWGGLNQT 172
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 33-185 7.88e-32

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 116.94  E-value: 7.88e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  33 GTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLMLKNNLNNEIN-ESFTSM 111
Cdd:MTH00070  16 GTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWFTGEWTIMNmQTPLPT 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501416405 112 IMLST-LLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLML---ISYLNLNNLLMISMILSVMVGAIGGLNQT 185
Cdd:MTH00070  96 IMLTIaLMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALliqISHLLNSNLLIIMGLLSTLIGGWGGLNQT 173
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 21-185 7.41e-31

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 114.21  E-value: 7.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  21 SSKILFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLMLKNnl 100
Cdd:MTH00144   4 PSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLS-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405 101 nneiNESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLNN----LLMISMILSVMV 176
Cdd:MTH00144  82 ----FSWFSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYwlayLLCVISVLSALV 157


                 ....*....
gi 501416405 177 GAIGGLNQT 185
Cdd:MTH00144 158 GSIGGLNQT 166
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 25-185 8.97e-28

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 106.02  E-value: 8.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  25 LFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLMLKNNLNNei 104
Cdd:MTH00011  10 LFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSLLK-- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405 105 neSFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPL-MLISYLNLNNLLMISMI--LSVMVGAIGG 181
Cdd:MTH00011  88 --NITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLsILFFFTSHNILPMMTSMaaMSALAGGLGG 165


                 ....
gi 501416405 182 LNQT 185
Cdd:MTH00011 166 MNQT 169
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 25-185 1.12e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 100.81  E-value: 1.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  25 LFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLMLKNNL--NN 102
Cdd:MTH00200   8 LFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSGQwgIS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405 103 EINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLML---ISYLNLNNLLMISMILSVMVGAI 179
Cdd:MTH00200  88 EMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALliqLAPALNSNILLLLGLLSVLVGGW 167


                 ....*.
gi 501416405 180 GGLNQT 185
Cdd:MTH00200 168 GGLNQT 173
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 25-185 2.63e-23

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 93.97  E-value: 2.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  25 LFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILLMLKNNLnnei 104
Cdd:MTH00197   2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNLYL---- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405 105 nESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLN-NLLMISMILSVMVGAIGGLN 183
Cdd:MTH00197  78 -SLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSfMGLLICSVLSSLIGGIGGMN 156


                 ..
gi 501416405 184 QT 185
Cdd:MTH00197 157 QS 158
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 29-185 3.44e-16

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 75.07  E-value: 3.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  29 MMIVGTLITVTSNSWLGAWMGLEINLLS-FIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVI--------------- 92
Cdd:MTH00196   1 MVALGILCLISSSNWLSVYLAIELQTLSlFILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCAllcgttgglhlsyin 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  93 LLMLKNNLNNEINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLN-NLLMISMI 171
Cdd:MTH00196  81 LVLNSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNvNILLIGGL 160

                        170
                 ....*....|....
gi 501416405 172 LSVMVGAIGGLNQT 185
Cdd:MTH00196 161 FSLFVGAIGALNQT 174
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 40-185 1.23e-14

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 70.03  E-value: 1.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405   40 SNSWLGAWMGLEINLLSFIPLMSDN-NNFKSTEASLKYFLTQALASTVLLFSVIL-------------LMLKNNLNNEIN 105
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWgKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdelSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  106 ESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMN-ALLLMTWQKIAPLMLI--------SYLNLNNLLMISMILSVMV 176
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVsALLAATLVKAGGYGLIrrsllylpSSPFIQQILLILAIISMLL 160


                  ....*....
gi 501416405  177 GAIGGLNQT 185
Cdd:pfam00361 161 GSLAALVQT 169
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 16-185 3.17e-14

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 69.66  E-value: 3.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  16 LIFNNSSKILFVTMMIVGTLITVTSNSWLGAWMGLEINLLS-FIPLMSDNNNFKSTEASLKYFLTQALASTVLLFSVILL 94
Cdd:MTH00199  92 LSEGGQSSPILILIVALGSLLLVSSINWLSIYLAIELQTLTlFILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  95 MLKN--NLNNEINESFTS-----MIMLStLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPL-MLISYLNLNNLL 166
Cdd:MTH00199 172 YGLTgeTSIQGINSILTGdvgkiLITIS-LLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFsILVQIGPVTNVV 250

                        170
                 ....*....|....*....
gi 501416405 167 MISMILSVMVGAIGGLNQT 185
Cdd:MTH00199 251 LICAVLSIIYGAIGALNQT 269
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
29-185 1.56e-09

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 55.98  E-value: 1.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  29 MMIVGTLITVTSNSWLGAWMGLEI-NLLSFIPLMSDNNNFKSTEASLKYFLTQALASTVLL--------------FSVIL 93
Cdd:PRK05777 111 FALLGMMVMVSANDLLTLFLGLELlSLPLYALAALRRDRRRSLEAAIKYFVLGALASGFLLygmsllygatgslsFAGIA 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  94 LMLKNNLNNEINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIA---PLMLISYLNLNNL----- 165
Cdd:PRK05777 191 KALADGSGNSLLLLFGLVFLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAafaVLLRLLVVAFGGLsedwq 270

                        170       180
                 ....*....|....*....|..
gi 501416405 166 --LMISMILSVMVGAIGGLNQT 185
Cdd:PRK05777 271 qvLAIIAIASMLVGNLAALSQT 292
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 13-185 2.94e-07

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 49.47  E-value: 2.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  13 LFFLIFNNSSKILFVTMMIVGT--LITVTSNSWLGAWMGLEINLLSFIPLMSDNNNFKST---------EASLKYFLTQA 81
Cdd:MTH00198 178 LLFLTNERGPRSGFALVLIVGLggLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  82 LASTVLLFS---------------VILLMLKNNLNNEINE-SFTSMIMLSTLLLKSGAAPFHFWFPNLMEGL-TWMNALL 144
Cdd:MTH00198 258 MSSGFYLFGcalyfgftgnegmlgTILSATLETTNIELRQgSLGYLFITVAILFKLAAAPFHMWTPDVYEGApTPTTALI 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 501416405 145 LMTWQKIAPLMLISYLNLNNLLMISMILSVMVGAIGGLNQT 185
Cdd:MTH00198 338 AIIPKFTVYILLTSLVITSKLLLSVAIISLVVGAFGALNQT 378
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 10-185 4.32e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 48.79  E-value: 4.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405   10 VLILFFLIFNNSSKILFVTMM---IVGTLITVTSNSWLGAWMGLEINLLSFIPLMS-DNNNFKSTEASLKYFLTQALAST 85
Cdd:TIGR01770  88 FFALSYLSKEKINKFEFYILLlfaLLGIFLLVSSNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSG 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405   86 VLLF--------------SVILLMLKNNLNNEINESFTSMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKI 151
Cdd:TIGR01770 168 LLLFgisliygftgslnfEDLLLFLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKI 247

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 501416405  152 A---PLMLIS-------YLNLNNLLMISMILSVMVGAIGGLNQT 185
Cdd:TIGR01770 248 AifaVFLRLFlyilfgfSEAWQIFLAIIAFLSMLIGNFGALAQK 291
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 25-185 5.09e-07

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 48.57  E-value: 5.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405  25 LFVTMMIVGTLITVTSNSWLGAWMGLEINLLSFIPLMS-DNNNFKSTEASLKYFLTQALASTVLLF--SVILLMLKNNLN 101
Cdd:COG1007  106 ALLLFATLGMMLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYgiSLLYGATGSLNL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501416405 102 NEINESFTSMIMLSTLLL------------KSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIA----------PLMLISY 159
Cdd:COG1007  186 AGIAAALAAGGANSPLLLlglvlvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAafaallrllvEAFPGLA 265

                        170       180
                 ....*....|....*....|....*.
gi 501416405 160 LNLNNLLMISMILSVMVGAIGGLNQT 185
Cdd:COG1007  266 ADWQLLLAVLAVLSMTVGNLAALAQT 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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