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Conserved domains on  [gi|501167742|ref|WP_012211741|]
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MULTISPECIES: cysteine hydrolase family protein [Lactobacillus]

Protein Classification

cysteine hydrolase family protein( domain architecture ID 10003554)

cysteine hydrolase family protein related to isochorismatase and nicotinamidase; catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue

CATH:  3.40.50.850
EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 5-183 8.32e-52

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 163.54  E-value: 8.32e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   5 ALLIIDYTNDFVADkGSLTCGlPAQKIEKQIVSLAEQFLKENKWVILPTDLHFKNNPYHPETKLFPPHNLGHTWGREFYG 84
Cdd:COG1335    1 ALLVIDVQNDFVPP-GALAVP-GADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  85 ELqkwyeDNKDNDHVLmlDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKLVVHKNAVASFDE 164
Cdd:COG1335   79 EL-----APLPGDPVV--DKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                        170
                 ....*....|....*....
gi 501167742 165 TGHKWALNHFKTCLdAKII 183
Cdd:COG1335  152 EAHEAALARLRAAG-ATVV 169
 
Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 5-183 8.32e-52

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 163.54  E-value: 8.32e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   5 ALLIIDYTNDFVADkGSLTCGlPAQKIEKQIVSLAEQFLKENKWVILPTDLHFKNNPYHPETKLFPPHNLGHTWGREFYG 84
Cdd:COG1335    1 ALLVIDVQNDFVPP-GALAVP-GADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  85 ELqkwyeDNKDNDHVLmlDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKLVVHKNAVASFDE 164
Cdd:COG1335   79 EL-----APLPGDPVV--DKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                        170
                 ....*....|....*....
gi 501167742 165 TGHKWALNHFKTCLdAKII 183
Cdd:COG1335  152 EAHEAALARLRAAG-ATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 5-175 3.28e-47

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 151.65  E-value: 3.28e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   5 ALLIIDYTNDFVADKGSLTcgLPAQKIEKQIVSLAEQFLKENKWVILPTDLHFKNNPYHPETkLFPPHNLGHTWGREFYG 84
Cdd:cd00431    1 ALLVVDMQNDFVPGGGLLL--PGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAEL-LWPPHCVKGTEGAELVP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  85 ELqkwyeDNKDNDHVLmlDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKLVVHKNAVASFDE 164
Cdd:cd00431   78 EL-----APLPDDLVI--EKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDE 150

                        170
                 ....*....|.
gi 501167742 165 TGHKWALNHFK 175
Cdd:cd00431  151 EDHEAALERLA 161
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 5-184 1.49e-41

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 137.53  E-value: 1.49e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742    5 ALLIIDYTNDFVADKGslTCGLPAQKIEKQIVSLAEQFLKENKWVILPTDLHFKNNPYHPETKLFPPHNLGHTWGREFYG 84
Cdd:pfam00857   2 ALLVIDMQNDFVDSGG--PKVEGIAAILENINRLLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGTTGAELVP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   85 ELQKWyednkDNDHVLmlDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKLVVHKNAVASFDE 164
Cdd:pfam00857  80 ELAPL-----PGDLVV--DKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSP 152

                         170       180
                  ....*....|....*....|
gi 501167742  165 TGHKWALNHFKTCLdAKIID 184
Cdd:pfam00857 153 EAHDAALERLAQRG-AEVTT 171
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 1-175 1.06e-18

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 79.73  E-value: 1.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   1 MNNEALLIIDYTNDFVADkGSLtcGLP-AQKIEKQI--VSLAEQFlkenKWVILPTDLH------FKNN-------PYHP 64
Cdd:PTZ00331  10 STNDALIIVDVQNDFCKG-GSL--AVPdAEEVIPVInqVRQSHHF----DLVVATQDWHppnhisFASNhgkpkilPDGT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  65 ETKLFPPHNLGHTWGREFYGELQKwyednKDNDHVLMLDKTR----YSAFCG-----TNLDLFLRERKITTLHLTGVCTD 135
Cdd:PTZ00331  83 TQGLWPPHCVQGTKGAQLHKDLVV-----ERIDIIIRKGTNRdvdsYSAFDNdkgskTGLAQILKAHGVRRVFICGLAFD 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 501167742 136 ICVLHTAVDAYNKCYKLVVHKNAVASFDETGHKWALNHFK 175
Cdd:PTZ00331 158 FCVLFTALDAVKLGFKVVVLEDATRAVDPDAISKQRAELL 197
 
Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 5-183 8.32e-52

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 163.54  E-value: 8.32e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   5 ALLIIDYTNDFVADkGSLTCGlPAQKIEKQIVSLAEQFLKENKWVILPTDLHFKNNPYHPETKLFPPHNLGHTWGREFYG 84
Cdd:COG1335    1 ALLVIDVQNDFVPP-GALAVP-GADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  85 ELqkwyeDNKDNDHVLmlDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKLVVHKNAVASFDE 164
Cdd:COG1335   79 EL-----APLPGDPVV--DKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                        170
                 ....*....|....*....
gi 501167742 165 TGHKWALNHFKTCLdAKII 183
Cdd:COG1335  152 EAHEAALARLRAAG-ATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 5-175 3.28e-47

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 151.65  E-value: 3.28e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   5 ALLIIDYTNDFVADKGSLTcgLPAQKIEKQIVSLAEQFLKENKWVILPTDLHFKNNPYHPETkLFPPHNLGHTWGREFYG 84
Cdd:cd00431    1 ALLVVDMQNDFVPGGGLLL--PGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAEL-LWPPHCVKGTEGAELVP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  85 ELqkwyeDNKDNDHVLmlDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKLVVHKNAVASFDE 164
Cdd:cd00431   78 EL-----APLPDDLVI--EKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDE 150

                        170
                 ....*....|.
gi 501167742 165 TGHKWALNHFK 175
Cdd:cd00431  151 EDHEAALERLA 161
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 5-184 1.49e-41

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 137.53  E-value: 1.49e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742    5 ALLIIDYTNDFVADKGslTCGLPAQKIEKQIVSLAEQFLKENKWVILPTDLHFKNNPYHPETKLFPPHNLGHTWGREFYG 84
Cdd:pfam00857   2 ALLVIDMQNDFVDSGG--PKVEGIAAILENINRLLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGTTGAELVP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   85 ELQKWyednkDNDHVLmlDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKLVVHKNAVASFDE 164
Cdd:pfam00857  80 ELAPL-----PGDLVV--DKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSP 152

                         170       180
                  ....*....|....*....|
gi 501167742  165 TGHKWALNHFKTCLdAKIID 184
Cdd:pfam00857 153 EAHDAALERLAQRG-AEVTT 171
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 1-175 1.06e-18

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 79.73  E-value: 1.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   1 MNNEALLIIDYTNDFVADkGSLtcGLP-AQKIEKQI--VSLAEQFlkenKWVILPTDLH------FKNN-------PYHP 64
Cdd:PTZ00331  10 STNDALIIVDVQNDFCKG-GSL--AVPdAEEVIPVInqVRQSHHF----DLVVATQDWHppnhisFASNhgkpkilPDGT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  65 ETKLFPPHNLGHTWGREFYGELQKwyednKDNDHVLMLDKTR----YSAFCG-----TNLDLFLRERKITTLHLTGVCTD 135
Cdd:PTZ00331  83 TQGLWPPHCVQGTKGAQLHKDLVV-----ERIDIIIRKGTNRdvdsYSAFDNdkgskTGLAQILKAHGVRRVFICGLAFD 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 501167742 136 ICVLHTAVDAYNKCYKLVVHKNAVASFDETGHKWALNHFK 175
Cdd:PTZ00331 158 FCVLFTALDAVKLGFKVVVLEDATRAVDPDAISKQRAELL 197
EntB1 COG1535
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
5-174 1.56e-16

Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441144 [Multi-domain]  Cd Length: 204  Bit Score: 73.73  E-value: 1.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   5 ALLIIDYTNDFVaDKGSLTCGLPAQKIEKqIVSLAEQFlKENKW-VILPTdlhfknNPY--HPETKLFpphnLGHTWG-- 79
Cdd:COG1535   21 ALLIHDMQNYFL-RPYDPDEPPIRELVAN-IARLRDAC-RAAGIpVVYTA------QPGdqTPEDRGL----LNDFWGpg 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  80 -------REFYGELQKwyednKDNDHVLmlDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKL 152
Cdd:COG1535   88 ltagpegQEIVDELAP-----APGDTVL--TKWRYSAFQRTDLEERLRELGRDQLIITGVYAHIGCLATAVDAFMRDIQP 160

                        170       180
                 ....*....|....*....|..
gi 501167742 153 VVHKNAVASFDETGHKWALNHF 174
Cdd:COG1535  161 FVVADAVADFSREEHRMALEYV 182
nicotinamidase cd01011
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ...
 3-164 2.74e-15

Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).


Pssm-ID: 238493  Cd Length: 196  Bit Score: 70.37  E-value: 2.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   3 NEALLIIDYTNDFVADkGSLTC--GLpaqkiekQIVSLAEQFLKENKW--VILPTDLHFKNN---------------PYH 63
Cdd:cd01011    1 TDALLVVDVQNDFCPG-GALAVpgGD-------AIVPLINALLSLFQYdlVVATQDWHPANHasfasnhpgqmpfitLPP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  64 PETKLFPPHNLGHTWGREFYGELqkwyeDNKDNDHVLM----LDKTRYSAF------CGTNLDLFLRERKITTLHLTGVC 133
Cdd:cd01011   73 GPQVLWPDHCVQGTPGAELHPGL-----PVPDIDLIVRkgtnPDIDSYSAFfdndrrSSTGLAEYLRERGIDRVDVVGLA 147

                        170       180       190
                 ....*....|....*....|....*....|.
gi 501167742 134 TDICVLHTAVDAYNKCYKLVVHKNAVASFDE 164
Cdd:cd01011  148 TDYCVKATALDALKAGFEVRVLEDACRAVDP 178
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 5-171 1.84e-12

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 61.84  E-value: 1.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   5 ALLIIDYTNDFVADKgslTCGLPAQKIEKQIVSLAEQFLKENKWVILPTDLHFKNNPYHPETKLFpphnlghtwgrEFYG 84
Cdd:cd01014    1 ALLVIDVQNGYFDGG---LPPLNNEAALENIAALIAAARAAGIPVIHVRHIDDEGGSFAPGSEGW-----------EIHP 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  85 ELQkwyedNKDNDHVLmlDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKLVVHKNAVASFDE 164
Cdd:cd01014   67 ELA-----PLEGETVI--EKTVPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFDL 139


                 ....*..
gi 501167742 165 TGHKWAL 171
Cdd:cd01014  140 PDHGGVL 146
PLN02743 PLN02743
nicotinamidase
 6-163 8.63e-12

nicotinamidase


Pssm-ID: 215396  Cd Length: 239  Bit Score: 61.68  E-value: 8.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   6 LLIIDYTNDF-VADKGSLTCGLPAQKIEKQI---VSLAEQFlKENKWVILPT-DLHFKNNPYHPetklFPPHNLGHTWGR 80
Cdd:PLN02743  30 LVLVDEVNGFcTVGAGNLAPREPDKQISKMVdesARLAREF-CERKWPVLAFlDSHHPDKPEHP----YPPHCIVGTGEE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  81 EFYGELQkWYEDNkdnDHVLMLDKTRYSAFCG------TNLDL-FLRERKITTLHLTGVCTDICVLH---TAVDAYNKCY 150
Cdd:PLN02743 105 NLVPALQ-WLEND---PNVTLRRKDCIDGFVGaiekdgSNVFVdWVNNNKIKVILVVGICTDICVLDfvaSALSARNHGI 180

                        170
                 ....*....|....*...
gi 501167742 151 -----KLVVHKNAVASFD 163
Cdd:PLN02743 181 lppleDVVVYSRGCATYD 198
PRK11440 PRK11440
putative hydrolase; Provisional
 70-173 7.59e-11

putative hydrolase; Provisional


Pssm-ID: 183137  Cd Length: 188  Bit Score: 58.20  E-value: 7.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  70 PPHNLGHTWGrEFYGELQKwyednKDNDhvLMLDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKC 149
Cdd:PRK11440  75 PAKVLPENWW-QHPAALGK-----TDSD--IEVTKRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELG 146

                         90       100
                 ....*....|....*....|....
gi 501167742 150 YKLVVHKNAVASFDETGHKWALNH 173
Cdd:PRK11440 147 FNLVIAEDACSAASAEQHQNSMNH 170
CSHase cd01015
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ...
 5-171 2.29e-10

N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.


Pssm-ID: 238497 [Multi-domain]  Cd Length: 179  Bit Score: 56.64  E-value: 2.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   5 ALLIIDYTNDFVADKGSLTCGLPAqkiekqIVSLAEQFLKENKWVILPtdLHFKNNPYHPEtklFPPHNLghtWGREFYG 84
Cdd:cd01015    1 ALLVIDLVEGYTQPGSYLAPGIAA------ALENVQRLLAAARAAGVP--VIHTTVVYDPD---GADGGL---WARKVPA 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  85 ElqKWYEDNKDN---DHVL-------MLDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKLVV 154
Cdd:cd01015   67 M--SDLVEGSPLaaiCDELapqedemVLVKKYASAFFGTSLAATLTARGVDTLIVAGCSTSGCIRATAVDAMQHGFRPIV 144

                        170
                 ....*....|....*..
gi 501167742 155 HKNAVASFDETGHKWAL 171
Cdd:cd01015  145 VRECVGDRAPAPHEANL 161
isochorismatase cd01013
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the ...
 100-177 1.73e-09

Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.


Pssm-ID: 238495  Cd Length: 203  Bit Score: 54.65  E-value: 1.73e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501167742 100 LMLDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAVDAYNKCYKLVVHKNAVASFDETGHKWALNHFKTC 177
Cdd:cd01013  118 TVLTKWRYSAFKRSPLLERLKESGRDQLIITGVYAHIGCLSTAVDAFMRDIQPFVVADAIADFSLEEHRMALKYAATR 195
PLN02621 PLN02621
nicotinamidase
 74-171 5.25e-08

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 50.55  E-value: 5.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  74 LGHTWGR----------EFYGELQKWYEDNKdndhvlMLDKTRYSAFCGTNLDLFLRERKITTLHLTGVCTDICVLHTAV 143
Cdd:PLN02621  73 LGEWWDGdlildgtteaELMPEIGRVTGPDE------VVEKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAR 146

                         90       100
                 ....*....|....*....|....*...
gi 501167742 144 DAYNKCYKLVVHKNAVASFDETGHKWAL 171
Cdd:PLN02621 147 EAFVRGFRVFFSTDATATANEELHEATL 174
PRK11609 PRK11609
bifunctional nicotinamidase/pyrazinamidase;
3-145 8.41e-07

bifunctional nicotinamidase/pyrazinamidase;


Pssm-ID: 183228  Cd Length: 212  Bit Score: 47.29  E-value: 8.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742   3 NEALLIIDYTNDFVADkGSLtcglpAQKIEKQIVSLAEQ----FLKENKWVILPTDLH------FKNN----PYH----- 63
Cdd:PRK11609   2 KRALLLVDLQNDFCAG-GAL-----AVPEGDSTIDVANRlidwCQSRGIPVIASQDWHpanhgsFASNhgaePGTqgeld 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501167742  64 --PETkLFPPHNLGHTWGREFYGELQKWYED-------NKDNDhvlmldktRYSAF------CGTNLDLFLRERKITTLH 128
Cdd:PRK11609  76 glPQT-WWPDHCVQNSEGAALHPLLNQKAIDavfhkgeNPLID--------SYSAFfdnghrQKTALDDWLREHGITELI 146

                        170
                 ....*....|....*..
gi 501167742 129 LTGVCTDICVLHTAVDA 145
Cdd:PRK11609 147 VMGLATDYCVKFTVLDA 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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