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Conserved domains on  [gi|501126541|ref|WP_012175601|]
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transglycosylase SLT domain-containing protein [Desulfosudis oleivorans]

Protein Classification

LT_MltC_MltE domain-containing protein( domain architecture ID 13013998)

LT_MltC_MltE domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 259-421 2.21e-97

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


:

Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 288.30  E-value: 2.21e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 259 PYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDAAQLLFGRQVLLSPSYLYSEQNNINVGTA 338
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 339 YLYILYNRYLREITNPTSRMYCAIAAYNTGAGNVARAFTGTtsVSRAAQAINRMSPQQVYTHLIQRLPHQETRDYLQRVT 418
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSD--RKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVL 158


                 ...
gi 501126541 419 SRM 421
Cdd:cd16893  159 KAK 161
 
Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 259-421 2.21e-97

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 288.30  E-value: 2.21e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 259 PYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDAAQLLFGRQVLLSPSYLYSEQNNINVGTA 338
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 339 YLYILYNRYLREITNPTSRMYCAIAAYNTGAGNVARAFTGTtsVSRAAQAINRMSPQQVYTHLIQRLPHQETRDYLQRVT 418
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSD--RKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVL 158


                 ...
gi 501126541 419 SRM 421
Cdd:cd16893  159 KAK 161
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
240-424 2.67e-50

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 173.70  E-value: 2.67e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 240 SLRVSLPAGGMQRKAMAYRPYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDAAQLLfGRQV 319
Cdd:PRK11671 175 SVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRMK-GKSG 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 320 LLSPSYLYSEQNNINVGTAYLYILYNRYLREITNPTSRMYCAIAAYNTGAGNVARAFtgTTSVSRAAQAINRMSPQQVYT 399
Cdd:PRK11671 254 QPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVF--SNDKIQAANIINTMSPGDVYQ 331

                        170       180
                 ....*....|....*....|....*
gi 501126541 400 HLIQRLPHQETRDYLQRVTSRMTMY 424
Cdd:PRK11671 332 TLTTRHPSAESRRYLYKVNTAQKSY 356
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 247-426 3.77e-38

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 138.20  E-value: 3.77e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 247 AGGMQRKAMAYRPYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRdaaqllFGRQVLL--SPS 324
Cdd:COG0741   93 AALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARR------LGLKLGLgpSPD 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 325 YLYSEQNNINVGTAYLYILYNRYLREItnptsrmYCAIAAYNTGAGNVARAFTGTTSVSraaqainrmspqqvythlIQR 404
Cdd:COG0741  167 DLFDPETNIRAGAAYLRELLDRFDGDL-------VLALAAYNAGPGRVRRWLRRNGDRD------------------GEI 221

                        170       180
                 ....*....|....*....|..
gi 501126541 405 LPHQETRDYLQRVTSRMTMYQS 426
Cdd:COG0741  222 IPYAETRNYVKKVLANYAIYRA 243
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 264-376 1.68e-25

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 100.07  E-value: 1.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541  264 YANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDaaqllfGRQVLLSPSYLYSEQNNINVGTAYLYIL 343
Cdd:pfam01464   4 AAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRL------GLRVNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 501126541  344 YNRYLreitnptSRMYCAIAAYNTGAGNVARAF 376
Cdd:pfam01464  78 YKQYG-------GDLWLALAAYNAGPGRVRKWI 103
 
Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 259-421 2.21e-97

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 288.30  E-value: 2.21e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 259 PYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDAAQLLFGRQVLLSPSYLYSEQNNINVGTA 338
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 339 YLYILYNRYLREITNPTSRMYCAIAAYNTGAGNVARAFTGTtsVSRAAQAINRMSPQQVYTHLIQRLPHQETRDYLQRVT 418
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSD--RKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVL 158


                 ...
gi 501126541 419 SRM 421
Cdd:cd16893  159 KAK 161
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
240-424 2.67e-50

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 173.70  E-value: 2.67e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 240 SLRVSLPAGGMQRKAMAYRPYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDAAQLLfGRQV 319
Cdd:PRK11671 175 SVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRMK-GKSG 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 320 LLSPSYLYSEQNNINVGTAYLYILYNRYLREITNPTSRMYCAIAAYNTGAGNVARAFtgTTSVSRAAQAINRMSPQQVYT 399
Cdd:PRK11671 254 QPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVF--SNDKIQAANIINTMSPGDVYQ 331

                        170       180
                 ....*....|....*....|....*
gi 501126541 400 HLIQRLPHQETRDYLQRVTSRMTMY 424
Cdd:PRK11671 332 TLTTRHPSAESRRYLYKVNTAQKSY 356
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 247-426 3.77e-38

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 138.20  E-value: 3.77e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 247 AGGMQRKAMAYRPYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRdaaqllFGRQVLL--SPS 324
Cdd:COG0741   93 AALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARR------LGLKLGLgpSPD 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 325 YLYSEQNNINVGTAYLYILYNRYLREItnptsrmYCAIAAYNTGAGNVARAFTGTTSVSraaqainrmspqqvythlIQR 404
Cdd:COG0741  167 DLFDPETNIRAGAAYLRELLDRFDGDL-------VLALAAYNAGPGRVRRWLRRNGDRD------------------GEI 221

                        170       180
                 ....*....|....*....|..
gi 501126541 405 LPHQETRDYLQRVTSRMTMYQS 426
Cdd:COG0741  222 IPYAETRNYVKKVLANYAIYRA 243
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 255-425 1.53e-29

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 112.18  E-value: 1.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 255 MAYRPYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDAAQL---LFGRQVLLSPSYlyseqn 331
Cdd:cd13401    4 LPYRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPATAKDVAKKLglpYYSPRDLFDPEY------ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 332 NINVGTAYLYILYNRYlreitnPTSRMYcAIAAYNTGAGNVARAftgttsvsraaqaiNRMSPQQVYTHLIQRLPHQETR 411
Cdd:cd13401   78 NIRLGSAYLAELLDRF------DGNPVL-ALAAYNAGPGRVRRW--------------LKRRGDLDPDLWIETIPFSETR 136

                        170
                 ....*....|....
gi 501126541 412 DYLQRVTSRMTMYQ 425
Cdd:cd13401  137 NYVKRVLENYVVYR 150
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 257-417 5.33e-28

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 107.98  E-value: 5.33e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 257 YRPYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPqSAGRDAAQLLfGRQVLlSPSYLYSEQNNINVG 336
Cdd:cd16896    4 YREYIEKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMP-ETAEWIAEKL-GLEDF-SEDDLYDPETNIRLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 337 TAYLYILYNRYlreitnpTSRMYCAIAAYNTGAGNVARAFTGttsvsraaqaiNRMSPQQVYTHLIqrlPHQETRDYLQR 416
Cdd:cd16896   81 TWYLSYLLKEF-------DGNLVLALAAYNAGPGNVDKWLKD-----------GGWSGDGKTLDQI---PFPETRHYVKK 139


                 .
gi 501126541 417 V 417
Cdd:cd16896  140 V 140
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 264-376 1.68e-25

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 100.07  E-value: 1.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541  264 YANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDaaqllfGRQVLLSPSYLYSEQNNINVGTAYLYIL 343
Cdd:pfam01464   4 AAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRL------GLRVNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 501126541  344 YNRYLreitnptSRMYCAIAAYNTGAGNVARAF 376
Cdd:pfam01464  78 YKQYG-------GDLWLALAAYNAGPGRVRKWI 103
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 272-421 7.43e-23

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 92.66  E-value: 7.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 272 EALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDAAQLlfgrqvllsPSYLYSEQNNINVGTAYLYILYNRYLRei 351
Cdd:cd00254    1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRRG---------VDDLFDPEENIRAGARYLRELLDRFGG-- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 352 tnptsRMYCAIAAYNTGAGNVARAFTGttsvsraaqainrmspqqvythliQRLPHQETRDYLQRVTSRM 421
Cdd:cd00254   70 -----DLELALAAYNAGPGAVDRWGGG------------------------EVPPYKETRNYVQRVLAYY 110
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 257-425 2.36e-20

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 92.43  E-value: 2.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 257 YRPYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRdaaqllFGRQVLLSPsylyseQNNINVG 336
Cdd:COG4623  264 YDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATAKE------LGVDDRLDP------EQSIRAG 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 337 TAYLYILYNRYLREITNPTsRMYCAIAAYNTGAGNVARAftgttsVSRAAQ--------AINRMSPQQVYTHLIQRlPHq 408
Cdd:COG4623  332 AKYLRWLYDRFPEAIDEPD-RWWFALAAYNAGPGHVQDA------RRLAKKqgldpdrwFDVEKSQPKYYDTGYAR-GR- 402

                        170
                 ....*....|....*..
gi 501126541 409 ETRDYLQRVTSRMTMYQ 425
Cdd:COG4623  403 ETVNYVPNIRAYYDIYK 419
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
252-421 1.23e-19

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 86.56  E-value: 1.23e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 252 RKAMAYRPYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDAAQLLfGRQVLLSPSYLYSEQN 331
Cdd:PRK15470  34 QRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRM-GWSGEPTTSELKNPER 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 332 NINVGTAYLYILYNRYLREITNPTSRMYCAIAAYNTGAGNVARAFtgTTSVSRAAQAINRMSPQQVYTHLIQRLPHQETR 411
Cdd:PRK15470 113 NISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTF--SSDRKKAISKINDLDADEFLEHVARNHPAPQAP 190

                        170
                 ....*....|
gi 501126541 412 DYLQRVTSRM 421
Cdd:PRK15470 191 RYIYKLEQAL 200
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 261-375 1.38e-16

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 76.80  E-value: 1.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 261 VKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRdaaqllFGRQVLLSPsylyseQNNINVGTAYL 340
Cdd:cd13403    1 FKKYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPSTARE------LGVNDRLDP------EQNIHAGAKYL 68

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 501126541 341 YILYNRYlREITNPTSRMYCAIAAYNTGAGNVARA 375
Cdd:cd13403   69 RYLRDRF-PPDIDEPDRLKFALAAYNAGPGHVRDA 102
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 251-417 7.97e-16

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 79.72  E-value: 7.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 251 QRKAMAYRPYVKSYANERGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVPQSAGRDAAQllFGRQVLLSPSYLYSEQ 330
Cdd:PRK11619 473 ERFPLAWNDEFRRYTSGKGIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTATHTVKM--FSIPGYSSSSQLLDPE 550

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 331 NNINVGTAYLYILYNRYLReitnptSRMYcAIAAYNTGAGNVaRAFTGTTSVSRAAQAinrmspqqvythLIQRLPHQET 410
Cdd:PRK11619 551 TNINIGTSYLEYVYQQFGN------NRIL-ASAAYNAGPGRV-RTWLGNSAGRIDAVA------------FVESIPFSET 610


                 ....*..
gi 501126541 411 RDYLQRV 417
Cdd:PRK11619 611 RGYVKNV 617
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 267-416 4.96e-12

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 62.92  E-value: 4.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 267 ERGLNEALVF-AVIhtESAFNPMARSHVPAYGLMQIVPQSAgrdaaqllfgRQVLLSPSYLYSEQNNINVGT----AYLY 341
Cdd:cd16894    3 KEGLPEELKYlALV--ESGFNPDAVSSAGAAGLWQFMPATA----------REYGLRVDSWVDERRDPEKSTraaaRYLK 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501126541 342 ILYNRYlreitnptSRMYCAIAAYNTGAGNVARaftgttsvsraaqAINRMSPQQVYTHLIQRLPhQETRDYLQR 416
Cdd:cd16894   71 DLYKRF--------GDWLLALAAYNAGEGRVRR-------------AIKRAGTDKWEDYYRLYLP-AETRRYVPK 123
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
257-377 1.24e-04

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 44.09  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 257 YRPYVKSYAneRGLNEALVFAVIHTESAFNPMARSHVPAYGLMQIVpqsagRDAAQLLfGRQVLLSPsylysEQnNINVG 336
Cdd:PRK10859 290 YQPLFEKYA--GELDWRLLAAIAYQESHWNPQATSPTGVRGLMMLT-----RNTAQSM-GVTDRLDP-----EQ-SIRGG 355

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 501126541 337 TAYLYILYNRyLREITNPTSRMYCAIAAYNTGAGNV--ARAFT 377
Cdd:PRK10859 356 ARYLQDLMER-LPESIPEPERIWFALAAYNIGYGHMldARRLT 397
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 269-368 2.10e-04

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 40.59  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 269 GLNEALVFAVIHTESAFNPMARSHVP----AYGLMQIVPQSAGRDAAQLLFGRQVLLSPSYlyseqnNINVGTAYLYILY 344
Cdd:cd13400    2 GVPPRLLRAIAKVESGFNPNAINRNKngsyDIGLMQINSIWLPELARYGITREELLNDPCT------NIYVGAWILARNI 75

                         90       100
                 ....*....|....*....|....
gi 501126541 345 NRYlreitnptSRMYCAIAAYNTG 368
Cdd:cd13400   76 KRY--------GNTWKAVGAYNSG 91
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 282-375 3.30e-04

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 42.80  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 282 ESAFNPMARSHVPAYGLMQIVPQSagrdaaqllfGRQVLLSPSYLYSEQNNINVGT-AYLYILynRYLreitnptSRMY- 359
Cdd:PRK10783 128 ESAFDPHATSGANAAGIWQIIPST----------GRNYGLKQTRWYDARRDVVASTtAALDMM--QRL-------NKMFd 188

                         90       100
                 ....*....|....*....|
gi 501126541 360 ----CAIAAYNTGAGNVARA 375
Cdd:PRK10783 189 gdwlLTVAAYNSGEGRVMKA 208
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 269-375 3.47e-03

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 36.90  E-value: 3.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501126541 269 GLNEALVFAVIHTESAFNPMA-RSHVPAYGLMQIVPQSA---GRDAAQllFGRQVLLSP-SYLYSEQNninvgtaYLYIL 343
Cdd:cd13399    2 GVPPGILAAILGVESGFGPNAgGSPAGAQGIAQFMPSTWkayGVDGNG--DGKADPFNPeDAIASAAN-------YLCRH 72

                         90       100       110
                 ....*....|....*....|....*....|..
gi 501126541 344 YNRYLREITNPTSRmycAIAAYNTGAGNVARA 375
Cdd:cd13399   73 GWDLNAFLGEDNFL---ALAAYNAGPGAYANA 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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