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Conserved domains on  [gi|501052187|ref|WP_012103798|]
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YidC/Oxa1 family membrane protein insertase [Clostridium kluyveri]

Protein Classification

YidC/Oxa1 family membrane protein insertase( domain architecture ID 10002228)

YidC/Oxa1 family membrane protein insertase functions as a membrane protein chaperone and as an independent insertase for membrane proteins, such as mitochondrial inner membrane protein OXA1/OXA1L and bacterial membrane protein insertase YidC

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
1-282 4.38e-54

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 174.92  E-value: 4.38e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   1 MIDFIAFPIGHLLKFIYEHiaFNNYGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIM 80
Cdd:COG0706    5 WFGFIAKPLFWLLNFLHSL--VGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQEMM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  81 KLYKENNVNPASGCLPLLFQMPILFSLYYVvsqplkymtgkspaaiqqLFEMIpqgsdritnmhdlsiinyfskhldkls 160
Cdd:COG0706   83 KLYKEEGVNPLGGCLPMLIQMPIFIALYRV------------------LRNSI--------------------------- 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 161 dvkgmlekdDLLNMNFLGMNLGSVPNLHFnhidtnnlliLLIPLLAAATTYISTKYSTnqtvsqtsdKQIADSMQGNMNL 240
Cdd:COG0706  118 ---------ELRHAPFLGIPDLSAPDPYY----------IFLPILMGVTMFLQQKLNP---------APAQDPQQKKMMY 169

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 501052187 241 IASVVTGFMAFTLPAGMGIYWITGNIYQIFQQMFMNKFVIKK 282
Cdd:COG0706  170 IMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKK 211
 
Name Accession Description Interval E-value
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
1-282 4.38e-54

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 174.92  E-value: 4.38e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   1 MIDFIAFPIGHLLKFIYEHiaFNNYGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIM 80
Cdd:COG0706    5 WFGFIAKPLFWLLNFLHSL--VGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQEMM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  81 KLYKENNVNPASGCLPLLFQMPILFSLYYVvsqplkymtgkspaaiqqLFEMIpqgsdritnmhdlsiinyfskhldkls 160
Cdd:COG0706   83 KLYKEEGVNPLGGCLPMLIQMPIFIALYRV------------------LRNSI--------------------------- 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 161 dvkgmlekdDLLNMNFLGMNLGSVPNLHFnhidtnnlliLLIPLLAAATTYISTKYSTnqtvsqtsdKQIADSMQGNMNL 240
Cdd:COG0706  118 ---------ELRHAPFLGIPDLSAPDPYY----------IFLPILMGVTMFLQQKLNP---------APAQDPQQKKMMY 169

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 501052187 241 IASVVTGFMAFTLPAGMGIYWITGNIYQIFQQMFMNKFVIKK 282
Cdd:COG0706  170 IMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKK 211
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 26-277 1.72e-49

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 162.16  E-value: 1.72e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  26 GVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMKLYKENNVNPASGCLPLLFQMPILF 105
Cdd:cd20070    1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 106 SLYYVVSQPLkymtgkspaaiqqlfemipqgsdritnmhdlsiinyfskhldklsdvkgmlekdDLLNMNFLGMNLG-SV 184
Cdd:cd20070   81 ALYQVLRNSI------------------------------------------------------ELRGAPFLWWILDlSA 106

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 185 PNLHFnhidtnnllilLIPLLAAATTYISTKYSTNQTVSQtsdkqiaDSMQGNMNLIASVVTGFMAFTLPAGMGIYWITG 264
Cdd:cd20070  107 PDPYY-----------ILPILMGVTMFLQQKLTPTPTDDQ-------APQQKMMMYFMPVMFTFIFLSFPSGLVLYWLVS 168

                        250
                 ....*....|...
gi 501052187 265 NIYQIFQQMFMNK 277
Cdd:cd20070  169 NLFSIIQQLIINK 181
60KD_IMP pfam02096
60Kd inner membrane protein;
25-277 8.34e-48

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 158.02  E-value: 8.34e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   25 YGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMKLYKENNVNPASGCLPLLFQMPIL 104
Cdd:pfam02096   1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  105 FSLYYVVSQPLKYMTGKSPAAIQQLFEMIPQGSDRItnmHDLSIINyfskhldklsdvkgmlekddllnmnflgmnlgsv 184
Cdd:pfam02096  81 IALYRVLRNSIELRHAPFFLWIADLSAPDPISILHY---YILPILM---------------------------------- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  185 pnlhfnhidtnnllillipllaAATTYISTKYSTNQTVSQTSDKQIadsmqgnMNLIASVVTGFMAFTLPAGMGIYWITG 264
Cdd:pfam02096 124 ----------------------GVTMFLQQKLTPAPQDQPPQMKMM-------MLYFMPLMFLFFFLNFPAGLVLYWVVS 174

                         250
                  ....*....|...
gi 501052187  265 NIYQIFQQMFMNK 277
Cdd:pfam02096 175 NLLSIGQQLIINR 187
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
 24-275 1.80e-44

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 149.17  E-value: 1.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   24 NYGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMKLYKENNVNPASGCLPLLFQMPI 103
Cdd:TIGR03592   1 NWGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  104 LFSLYYVVSqplkymtgKSPAAIQQLFEMIpqgsdritnmHDLSiinyfskhldklsdvkgmlEKDDLLNMNFLgmnlgs 183
Cdd:TIGR03592  81 FIALYQVLL--------RSIELRHAPFLWI----------IDLS-------------------SPDPYYILPIL------ 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  184 vpnlhfnhidtnnllillipllAAATTYISTKYSTnqtvSQTSDKQiadsMQGNMNLIASVVTGFMAFTLPAGMGIYWIT 263
Cdd:TIGR03592 118 ----------------------MGVTMFLQQKLSP----KGPPDPA----QQKMMMYFMPLMFLFFFLSFPAGLVLYWVV 167

                         250
                  ....*....|..
gi 501052187  264 GNIYQIFQQMFM 275
Cdd:TIGR03592 168 SNLFTIIQQLII 179
PRK01318 PRK01318
membrane protein insertase; Provisional
 4-292 1.37e-40

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 147.71  E-value: 1.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   4 FIAFPIGHLLKFIYEHIafNNYGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMKLY 83
Cdd:PRK01318 304 FITKPLFWLLDFLHSFV--GNWGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKMQQEMMELY 381

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  84 KENNVNPASGCLPLLFQMPILFSLYYVVsqplkymtgksPAAIqqlfEMipQGSDRITNMHDLSIIN-YFSKHLDKLSdv 162
Cdd:PRK01318 382 KKEKVNPLGGCLPILIQIPIFFALYKVL-----------LVSI----EL--RHAPFIGWIHDLSAPDpYFILHIGLLP-- 442

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 163 kgmlekddLLNMnflgmnlgsvpnlhfnhidtnnllillipllaaATTYISTKYSTNQTvsqtsdkqiaDSMQGNMNLIA 242
Cdd:PRK01318 443 --------ILMG---------------------------------ITMFLQQKLNPTPT----------DPMQAKIMKFM 471

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 501052187 243 SVVTGFMAFTLPAGMGIYWITGNIYQIFQQMFMNKFVIKKSLNNNKKGKK 292
Cdd:PRK01318 472 PLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEKKKLLAANKKKK 521
 
Name Accession Description Interval E-value
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
1-282 4.38e-54

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 174.92  E-value: 4.38e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   1 MIDFIAFPIGHLLKFIYEHiaFNNYGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIM 80
Cdd:COG0706    5 WFGFIAKPLFWLLNFLHSL--VGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQEMM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  81 KLYKENNVNPASGCLPLLFQMPILFSLYYVvsqplkymtgkspaaiqqLFEMIpqgsdritnmhdlsiinyfskhldkls 160
Cdd:COG0706   83 KLYKEEGVNPLGGCLPMLIQMPIFIALYRV------------------LRNSI--------------------------- 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 161 dvkgmlekdDLLNMNFLGMNLGSVPNLHFnhidtnnlliLLIPLLAAATTYISTKYSTnqtvsqtsdKQIADSMQGNMNL 240
Cdd:COG0706  118 ---------ELRHAPFLGIPDLSAPDPYY----------IFLPILMGVTMFLQQKLNP---------APAQDPQQKKMMY 169

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 501052187 241 IASVVTGFMAFTLPAGMGIYWITGNIYQIFQQMFMNKFVIKK 282
Cdd:COG0706  170 IMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKK 211
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 26-277 1.72e-49

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 162.16  E-value: 1.72e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  26 GVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMKLYKENNVNPASGCLPLLFQMPILF 105
Cdd:cd20070    1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 106 SLYYVVSQPLkymtgkspaaiqqlfemipqgsdritnmhdlsiinyfskhldklsdvkgmlekdDLLNMNFLGMNLG-SV 184
Cdd:cd20070   81 ALYQVLRNSI------------------------------------------------------ELRGAPFLWWILDlSA 106

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 185 PNLHFnhidtnnllilLIPLLAAATTYISTKYSTNQTVSQtsdkqiaDSMQGNMNLIASVVTGFMAFTLPAGMGIYWITG 264
Cdd:cd20070  107 PDPYY-----------ILPILMGVTMFLQQKLTPTPTDDQ-------APQQKMMMYFMPVMFTFIFLSFPSGLVLYWLVS 168

                        250
                 ....*....|...
gi 501052187 265 NIYQIFQQMFMNK 277
Cdd:cd20070  169 NLFSIIQQLIINK 181
60KD_IMP pfam02096
60Kd inner membrane protein;
25-277 8.34e-48

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 158.02  E-value: 8.34e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   25 YGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMKLYKENNVNPASGCLPLLFQMPIL 104
Cdd:pfam02096   1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  105 FSLYYVVSQPLKYMTGKSPAAIQQLFEMIPQGSDRItnmHDLSIINyfskhldklsdvkgmlekddllnmnflgmnlgsv 184
Cdd:pfam02096  81 IALYRVLRNSIELRHAPFFLWIADLSAPDPISILHY---YILPILM---------------------------------- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  185 pnlhfnhidtnnllillipllaAATTYISTKYSTNQTVSQTSDKQIadsmqgnMNLIASVVTGFMAFTLPAGMGIYWITG 264
Cdd:pfam02096 124 ----------------------GVTMFLQQKLTPAPQDQPPQMKMM-------MLYFMPLMFLFFFLNFPAGLVLYWVVS 174

                         250
                  ....*....|...
gi 501052187  265 NIYQIFQQMFMNK 277
Cdd:pfam02096 175 NLLSIGQQLIINR 187
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
 24-275 1.80e-44

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 149.17  E-value: 1.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   24 NYGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMKLYKENNVNPASGCLPLLFQMPI 103
Cdd:TIGR03592   1 NWGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  104 LFSLYYVVSqplkymtgKSPAAIQQLFEMIpqgsdritnmHDLSiinyfskhldklsdvkgmlEKDDLLNMNFLgmnlgs 183
Cdd:TIGR03592  81 FIALYQVLL--------RSIELRHAPFLWI----------IDLS-------------------SPDPYYILPIL------ 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  184 vpnlhfnhidtnnllillipllAAATTYISTKYSTnqtvSQTSDKQiadsMQGNMNLIASVVTGFMAFTLPAGMGIYWIT 263
Cdd:TIGR03592 118 ----------------------MGVTMFLQQKLSP----KGPPDPA----QQKMMMYFMPLMFLFFFLSFPAGLVLYWVV 167

                         250
                  ....*....|..
gi 501052187  264 GNIYQIFQQMFM 275
Cdd:TIGR03592 168 SNLFTIIQQLII 179
PRK01318 PRK01318
membrane protein insertase; Provisional
 4-292 1.37e-40

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 147.71  E-value: 1.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   4 FIAFPIGHLLKFIYEHIafNNYGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMKLY 83
Cdd:PRK01318 304 FITKPLFWLLDFLHSFV--GNWGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKMQQEMMELY 381

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  84 KENNVNPASGCLPLLFQMPILFSLYYVVsqplkymtgksPAAIqqlfEMipQGSDRITNMHDLSIIN-YFSKHLDKLSdv 162
Cdd:PRK01318 382 KKEKVNPLGGCLPILIQIPIFFALYKVL-----------LVSI----EL--RHAPFIGWIHDLSAPDpYFILHIGLLP-- 442

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 163 kgmlekddLLNMnflgmnlgsvpnlhfnhidtnnllillipllaaATTYISTKYSTNQTvsqtsdkqiaDSMQGNMNLIA 242
Cdd:PRK01318 443 --------ILMG---------------------------------ITMFLQQKLNPTPT----------DPMQAKIMKFM 471

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 501052187 243 SVVTGFMAFTLPAGMGIYWITGNIYQIFQQMFMNKFVIKKSLNNNKKGKK 292
Cdd:PRK01318 472 PLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEKKKLLAANKKKK 521
PRK00145 PRK00145
putative inner membrane protein translocase component YidC; Provisional
 14-285 4.42e-38

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234665 [Multi-domain]  Cd Length: 223  Bit Score: 134.10  E-value: 4.42e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  14 KFIYEHIAFNN--YGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMKLYKENNVNPA 91
Cdd:PRK00145  18 GFVSSVISNPNfsYGIAIILVTLIIRLLILPLNIKQTKSSLRMNEIQPEIKKLQAKYKNDPQKLQQEMMKLYKEKGVNPL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  92 SGCLPLLFQMPILFSLYYVVSQpLKYMTGKSPAAIQQLFEmipqgsdritnmHDLSIInyfskhLDKLSDVkgmlekddl 171
Cdd:PRK00145  98 GGCLPLLIQWPILIALYYVFNN-LTGINGVSFLWIKDLAK------------PDITWI------LPILSGA--------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 172 lnmnflgmnlgsvpnlhfnhidtnnllillipllaaaTTYISTKYSTNQTVSQtsdkqiaDSMQGNMNLIASVVTGFMAF 251
Cdd:PRK00145 150 -------------------------------------TTYLSGYLMTKADSSQ-------AGQMKTMNIGMSIFMGVMSW 185

                        250       260       270
                 ....*....|....*....|....*....|....
gi 501052187 252 TLPAGMGIYWITGNIYQIFQQMFMNKFVIKKSLN 285
Cdd:PRK00145 186 KFKSALVLYWVIGNLIQIIQTYFIKKLELKKKVE 219
PRK01315 PRK01315
putative inner membrane protein translocase component YidC; Provisional
 25-112 7.96e-30

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234941  Cd Length: 329  Bit Score: 115.22  E-value: 7.96e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  25 YGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMKLYKENNVNPASGCLPLLFQMPIL 104
Cdd:PRK01315  42 WVLSIVGLVIVIRALLIPLFVKQIKSQRNMQEIQPKMKKIQEKYKGDRERMSQEMMKLYKETGTNPLSSCLPLLLQMPIF 121


                 ....*...
gi 501052187 105 FSLYYVVS 112
Cdd:PRK01315 122 FALYRVLD 129
PRK03449 PRK03449
putative inner membrane protein translocase component YidC; Provisional
 1-274 2.01e-23

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 179580  Cd Length: 304  Bit Score: 97.44  E-value: 2.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   1 MIDFIAFPIGHLLKFIYEHIAF-------NNYGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKE 73
Cdd:PRK03449   1 MLDFIYYPVSAILWFWHKLFSFvlgpdngFAWALSVMFLVFTLRALLYKPFVRQIRTTRKMQELQPQIKALQKKYGNDRQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  74 KLNQEIMKLYKENNVNPASGCLPLLFQMPILFSLYYVVSQPLKYMTGkspaaiqqlfemipQGSDRITNMHDLSIINY-F 152
Cdd:PRK03449  81 KMALEMQKLQKEHGFNPILGCLPMLAQIPVFLGLFHVLRSFNRTGTG--------------FGQLGMSVEENRNTPNYvF 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 153 SKHldklsDVKGMLEKddllnmNFLGMNLG---SVPNLHFN-HIDTNNLLILL----IPLLAAATTYISTKYSTN-QTVS 223
Cdd:PRK03449 147 SAE-----DVQSFLDA------RLFGAPLSayiTMPRSGLDaFVDFTRTNIILvgvpLMIIAGVATHFNSRASVArQSAE 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 501052187 224 QTSDKQIAdsMQGNMNL----IASVVTGFMaftLPAGMGIYWITGNIYQIFQQMF 274
Cdd:PRK03449 216 AAANPQTA--MMNKLALwvfpLGVLVGGPF---LPLAILLYWVSNNIWTFGQQHY 265
PRK01622 PRK01622
membrane protein insertase YidC;
3-278 3.74e-23

membrane protein insertase YidC;


Pssm-ID: 179310  Cd Length: 256  Bit Score: 95.59  E-value: 3.74e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   3 DFIAFPIGHLLKFIYEHIAfNNYGVAIIELTVIIKTLLLPLYIKQYHAASGISN----IQYKVQEIQKKHKNNKEK---- 74
Cdd:PRK01622  39 HYFVYPFSFLIQFVAHHIG-GSYGIAIIIVTLIIRSLMIPLAVSQYKSQRGMQEkmavMKPELDKIQAKLKVTKDLekqk 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  75 -LNQEIMKLYKENNVNP-ASGCLPLLFQMPILFSLYYVVSQplkymtgkspaaiqqlfemipqgsdritnmhdlsiinyf 152
Cdd:PRK01622 118 eYQKEMMELYKSGNINPlAMGCLPLLIQMPILSAFYYAIRR--------------------------------------- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 153 skhldklsdvkgmleKDDLLNMNFLGMNLGsvpnlHFNHIdtnnllillIPLLAAATTYISTKYStnQTVSQTSDKQIAD 232
Cdd:PRK01622 159 ---------------TEEIASHSFLWFNLG-----HADHI---------LPIIAGLTYFIQMKVS--QSNGTSPEQVQML 207

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 501052187 233 SMQGnmnLIASVVTGFMAFTLPAGMGIYWITGNIYQIFQQMFMNKF 278
Cdd:PRK01622 208 KIQG---IMMPAMILFMSFAAPSALVLYWITGGLFLMGQTIVLRKV 250
PRK01001 PRK01001
putative inner membrane protein translocase component YidC; Provisional
 4-293 1.00e-21

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234887 [Multi-domain]  Cd Length: 795  Bit Score: 95.25  E-value: 1.00e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   4 FIAFPIGHLLKFIYE--HIAFNNYGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEKLNQEIMK 81
Cdd:PRK01001 553 FITEPFAALLFIIMKffKFLTGSWGISIILLTVFLKLLLYPLNAWSIRSMRRMQKLSPYIQEIQQKYKKEPKRAQMEIMA 632

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  82 LYKENNVNPASGCLPLLFQMPILFSLYYVVsqplkymtgKSPAAIQQLfEMIPQGSDRITnmhdlsiinyfskhldkLSD 161
Cdd:PRK01001 633 LYKTNKVNPITGCLPLLIQLPFLIAMFDLL---------KSSFLLRGA-SFIPGWIDNLT-----------------APD 685

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 162 VKGMLEKDdllnMNFLGMNLGSVPNLhfnhidtnnllillipllAAATTYISTKYSTNQTVSQTSDKQIADSMQGNMnli 241
Cdd:PRK01001 686 VLFSWETP----IWFIGNEFHLLPIL------------------LGVVMFAQQKISSLKRKGPVTDQQRQQEAMGTM--- 740

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 501052187 242 ASVVTGFMAFTLPAGMGIYWITGNIYQIFQQMFMNKFVIKKSLNNN---KKGKKR 293
Cdd:PRK01001 741 MALLFTFMFYNFPSGLNIYWLSSMLLGVIQQWVTNKILDSKHLKNEvvpNKKKHR 795
PRK02654 PRK02654
putative inner membrane protein translocase component YidC; Provisional
 1-108 1.72e-21

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235058  Cd Length: 375  Bit Score: 93.12  E-value: 1.72e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   1 MIDFIA----FPIghlLKFIYEhiAFNNYGVAIIELTVIIKTLLLPLyikqyhAASGISN----------IQYKVQEIQK 66
Cdd:PRK02654   4 GIGFISnnvmLPI---LDFFYG--IVPSYGLAIVALTLVIRFALYPL------SAGSIRNmrrmkiaqpvMQKRQAEIQE 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 501052187  67 KHKNNKEKLNQEIMKLYKENNvNPASGCLPLLFQMPILFSLY 108
Cdd:PRK02654  73 RYKNDPQKQQEEMGKLMKEFG-NPLAGCLPLLVQMPILFALF 113
PRK02944 PRK02944
YidC family membrane integrase SpoIIIJ;
3-111 1.48e-20

YidC family membrane integrase SpoIIIJ;


Pssm-ID: 179508  Cd Length: 255  Bit Score: 88.67  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   3 DFIAFPIGHLLKFIYEHIAfNNYGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKH----KNNKEKLNQE 78
Cdd:PRK02944  38 EYFVYPLSQLITYFANLFG-SNYGLAIIVVTLLIRLLILPLMIKQTKSTKAMQALQPEMQKLKEKYsskdQATQQKLQQE 116

                         90       100       110
                 ....*....|....*....|....*....|...
gi 501052187  79 IMKLYKENNVNPASGCLPLLFQMPILFSLYYVV 111
Cdd:PRK02944 117 MMQLFQKNGVNPLAGCLPIFIQMPILIAFYHAI 149
PRK02463 PRK02463
OxaA-like protein precursor; Provisional
 3-284 3.34e-18

OxaA-like protein precursor; Provisional


Pssm-ID: 235040  Cd Length: 307  Bit Score: 82.86  E-value: 3.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   3 DFIAFPIGHLLKFIYEHIAFNnYGVAIIELTVIIKTLLLPLYIKQYHAASGISN-------IQYKVQEIQKKHKNNKEKL 75
Cdd:PRK02463  39 NFLGAPMSYFIDYFANNLGLG-FGLAIIIVTIIVRLIILPLGLYQSWKATYQSEkmaylkpVFEPINERLKNATTQEEKM 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  76 --NQEIMKLYKENNVNPAS--GCLPLLFQMPILFSLYYVVsqplKYMTGKSPAAiqqlfemipqgsdritnmhdlsiiny 151
Cdd:PRK02463 118 aaQTELMAAQRENGISMLGgiGCLPLLIQMPFFSALYFAA----QYTKGVSTST-------------------------- 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 152 fskhldklsdvkgmlekddllnmnFLGMNLGSvPNLHFNHIdtnnllillipllAAATTYISTKYSTnQTVSQTSDKQIA 231
Cdd:PRK02463 168 ------------------------FLGIDLGS-PSLVLTAI-------------IGVLYFFQSWLSM-MGVPEEQREQMK 208

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 501052187 232 dsmqgNMNLIASVVTGFMAFTLPAGMGIYWITGNIYQIFQQMFMNkFVIKKSL 284
Cdd:PRK02463 209 -----AMMYMMPIMMVVFSFSSPAGVGLYWLVGGFFSIIQQLITT-YILKPRL 255
5TM_Oxa1-like cd20069
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ...
 27-109 4.13e-16

Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410993 [Multi-domain]  Cd Length: 201  Bit Score: 74.87  E-value: 4.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  27 VAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKE--------KLNQEIMKLYKENNVNPASGCLPLL 98
Cdd:cd20069    6 ATIAATTVALRLLLLPLVIKSQRNAARMANLQPELQKLQEKLKEARAsgdqleaaEARKELKELMKKHNVNPLKSLLLPL 85

                         90
                 ....*....|.
gi 501052187  99 FQMPILFSLYY 109
Cdd:cd20069   86 VQAPVFISFFF 96
5TM_YidC_Oxa1_Alb3 cd19751
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ...
 26-275 4.76e-15

Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410992 [Multi-domain]  Cd Length: 189  Bit Score: 71.82  E-value: 4.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  26 GVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNNKEK------LNQEIMKLYKENNVNPASGCLPLLF 99
Cdd:cd19751    1 GLSIIIVTILIRLALLPLTLKQQKSMRKMQVIRPEMEAIREKYKEKASKdkvqqeMQKEMLGLYKKHGVNPMAGCLPLFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 100 QMPILFSLYYVVSQPLKYMTGksPAAIqqlfemipqgsdritnMHDLSIINYfskhLDKLSDVKGMlekddllnmnflgm 179
Cdd:cd19751   81 QLPIFMAFYFAIMRTEEIRYH--TFLW----------------FFDLGQPDY----LYILPFVAGI-------------- 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 180 nlgsvpnlhfnhidtnnllillipllaaaTTYISTKystnQTVSQTSDKQIADSMQGNMNLIASVVTGFMAFTLPAGMGI 259
Cdd:cd19751  125 -----------------------------TTYFQFK----MTMSHQQQMQMMQMQMKVMLYVMPVMIIIAGLSFPSALSL 171

                        250
                 ....*....|....*.
gi 501052187 260 YWITGNIYQIFQQMFM 275
Cdd:cd19751  172 YWIISNLFMIIQTYFI 187
PRK02201 PRK02201
putative inner membrane protein translocase component YidC; Provisional
 28-295 1.90e-11

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235012  Cd Length: 357  Bit Score: 63.88  E-value: 1.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187  28 AIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKN------NKEKLNQEIMKLYKENNVNPASGCLPLLFQM 101
Cdd:PRK02201 136 AIIVVVLIIRLISFLITFKSTFNQEKQEELQGKKAKIDAKYKDykkdkqMKQRKQQEIQELYKKHNISPFSPFVQMFVTL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 102 PILFSLYYVVS--QPLK----YMTGKSPAAIQQLFEmipqgsdriTNMHDLSIINYfskhldklsdvkgmlekddLLNMN 175
Cdd:PRK02201 216 PIFIAVYRVVQslPSIKvttwLGIDLSATSWQEIFA---------GNWIYLPILII-------------------VVPVQ 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187 176 FLGMNLgsvpnlhfnhidtnnllillipllaaaTTYISTKYSTNQTVSQTSDKQIadSMQGNMNLIASVVTGFMAFTLPA 255
Cdd:PRK02201 268 ALSQLL---------------------------PQILNKKKNKERTLNVKEKEAL--KKQNKTQNIISIVFIFFGVIFAA 318

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 501052187 256 GMGIYWITGNIYQIFQQMFMnkFVIKKSLNNNKKGKKRLR 295
Cdd:PRK02201 319 GVQIYWIIGGIWTILQTLGI--HYFKKRKFYKQKYEPKLR 356
PRK00247 PRK00247
putative inner membrane protein translocase component YidC; Validated
 1-111 3.07e-08

putative inner membrane protein translocase component YidC; Validated


Pssm-ID: 178945 [Multi-domain]  Cd Length: 429  Bit Score: 54.47  E-value: 3.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501052187   1 MIDFIAFPIGHLLKFIyeHIAFNN---------YGVAIIELTVIIKTLLLPLYIKQYHAASGISNIQYKVQEIQKKHKNN 71
Cdd:PRK00247   1 MLDIFIYPVSGVMKLW--HLLLHNvlglddslaWFASLFGLVITVRAIIAPFTWQQYKSGRTAAHIRPKRKALREEYKGK 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 501052187  72 KEK-----LNQEIMKLYKENNVNPASGCLPLLFQMPILFSLYYVV 111
Cdd:PRK00247  79 TDEasireLQQKQKDLNKEYGYNPLAGCVPALIQIPVFLGLYQVL 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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