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Conserved domains on  [gi|500592577|ref|WP_011955819|]
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isocitrate/isopropylmalate dehydrogenase family protein [Roseiflexus sp. RS-1]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 10001441)

isocitrate/isopropylmalate dehydrogenase family protein similar to homoisocitrate dehydrogenase, which catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 6-359 3.63e-167

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


:

Pssm-ID: 440241  Cd Length: 346  Bit Score: 469.88  E-value: 3.63e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRAT----GLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGYPVA 81
Cdd:COG0473    2 YKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDDG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  82 -GYRSPIVRLRRELDLYANIRPV--FDDLPENGSNPRRRKVDLVVVRENTEDVYAGRER---VEDDGATAIAERVITRRA 155
Cdd:COG0473   82 vRPESGLLALRKELDLYANLRPAklYPGLPSPLKPEIVEGIDLVIVRENTEGLYFGIGGrigTGTGEEVAIDTRVYTRKG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 156 SARIMRVACDLARARRsarngsdappGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERF 235
Cdd:COG0473  162 IERIARYAFELARKRR----------KKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 236 DVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERH-ALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLagrapadl 314
Cdd:COG0473  232 DVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-------- 303

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 500592577 315 asAMRGWSARIQRAIRHVRAAGPHTPDLGGSAVTTDITNAVLSHM 359
Cdd:COG0473  304 --GEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
 
Name Accession Description Interval E-value
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 6-359 3.63e-167

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 469.88  E-value: 3.63e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRAT----GLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGYPVA 81
Cdd:COG0473    2 YKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDDG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  82 -GYRSPIVRLRRELDLYANIRPV--FDDLPENGSNPRRRKVDLVVVRENTEDVYAGRER---VEDDGATAIAERVITRRA 155
Cdd:COG0473   82 vRPESGLLALRKELDLYANLRPAklYPGLPSPLKPEIVEGIDLVIVRENTEGLYFGIGGrigTGTGEEVAIDTRVYTRKG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 156 SARIMRVACDLARARRsarngsdappGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERF 235
Cdd:COG0473  162 IERIARYAFELARKRR----------KKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 236 DVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERH-ALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLagrapadl 314
Cdd:COG0473  232 DVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-------- 303

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 500592577 315 asAMRGWSARIQRAIRHVRAAGPHTPDLGGSAVTTDITNAVLSHM 359
Cdd:COG0473  304 --GEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 8-356 2.19e-133

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 383.73  E-value: 2.19e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577    8 ILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPgyPVAGYRSPI 87
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTP--ANPGYKSVI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   88 VRLRRELDLYANIRPV-----FDDLPENGsnprrrkVDLVVVRENTEDVYAGRERVEDDGAtaIAERVITRRASARIMRV 162
Cdd:TIGR02088  79 VTLRKELDLYANVRPAkslpgIPDLYPNG-------KDIVIVRENTEGLYAGFEFGFSDRA--IAIRVITREGSERIARF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  163 ACDLARARRSarngsdappgRVTVVHKANVLRETCGLFRSVALEVAQAYpDLQIDEMLVDTCALQLATRPERFDVIVTTN 242
Cdd:TIGR02088 150 AFNLAKERNR----------KVTCVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTN 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  243 LFGDILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADLasamrgws 322
Cdd:TIGR02088 219 MFGDILSDLASALAGSLGLAPSANIGDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKL-------- 290

                         330       340       350
                  ....*....|....*....|....*....|....
gi 500592577  323 arIQRAIRHVRAAGPHTPDLGGSAVTTDITNAVL 356
Cdd:TIGR02088 291 --VWEAVEYYIIEGKKTPDLGGTAKTKEVGDEIA 322
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 6-359 8.06e-133

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 382.56  E-value: 8.06e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGYPVagyrs 85
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETAADV----- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  86 pIVRLRRELDLYANIRPVfddLPENGSNPRRRKVDLVVVRENTEDVYAGRERVEDDGATaIAERVITRRASARIMRVACD 165
Cdd:PRK14025  77 -IVKLRRILDTYANVRPV---KSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVT-VATRVITRKASERIFRFAFE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 166 LARaRRSARNGSdappGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDVIVTTNLFG 245
Cdd:PRK14025 152 MAK-RRKKMGKE----GKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 246 DILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADlasamrgwsaRI 325
Cdd:PRK14025 227 DILSDGAAGLVGGLGLAPSANIGDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEAD----------KV 296

                        330       340       350
                 ....*....|....*....|....*....|....
gi 500592577 326 QRAIRHVRAAGPHTPDLGGSAVTTDITNAVLSHM 359
Cdd:PRK14025 297 EKALEEVLALGLTTPDLGGNLSTMEMAEEVAKRV 330
AksF_Meth NF040619
homoisocitrate dehydrogenase;
6-355 3.63e-130

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 375.64  E-value: 3.63e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRATGlPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASP---GYPVAG 82
Cdd:NF040619   2 PKICVIEGDGIGKEVIPETVRVLKELG-DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPkptELKNKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  83 YRSPIVRLRRELDLYANIRPVFD-DLPENGSNprrrkVDLVVVRENTEDVYAGRERVEDDGATAIAERVITRRASARIMR 161
Cdd:NF040619  81 YKSPILTLRKELDLYANVRPINNfGDGQDVKN-----IDFVIIRENTEGLYVGREYYDEENEIAIAERIISKKGSERIIK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 162 VACDLARarRSARNgsdappgRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQI--DEMLVDTCALQLATRPERFDVIV 239
Cdd:NF040619 156 FAFEYAK--KNNRK-------KVSCIHKANVLRVTDGLFLEIFNEIKKKYKNFNIeaDDYLVDATAMYLIKNPEMFDVIV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 240 TTNLFGDILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADLasamr 319
Cdd:NF040619 227 TTNLFGDILSDEASGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDL----- 301

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 500592577 320 gwsarIQRAIRHVRAAGPHTPDLGGSAVTTDITNAV 355
Cdd:NF040619 302 -----IREAVKKCLENGKVTPDLGGNLKTKEVTDKI 332
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
6-357 2.16e-128

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 371.37  E-value: 2.16e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASpgypVAGYRS 85
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTS----TPGQKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  86 PIVRLRRELDLYANIRPV--FDdlpenGSNPRRRKVDLVVVRENTEDVYAGRERVEDDGaTAIAERVITRRASARIMRVA 163
Cdd:NF040626  78 PIITLRKELDLYANLRPIksYE-----GINCLFKDLDFLIVRENTEGLYSGLEEEYTEE-KAIAERVITRKASERICKFA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 164 CDLARARrsARNgsdappgRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDVIVTTNL 243
Cdd:NF040626 152 FEYAIKL--GRK-------KVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNL 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 244 FGDILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLagrapadlasAMRGWSA 323
Cdd:NF040626 223 FGDILSDEAAGLVGGLGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYL----------GETYEAN 292

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 500592577 324 RIQRAIRHVRAAGP-HTPDLGGSAVTTDITNAVLS 357
Cdd:NF040626 293 KLENALEKVLREGKvVTPDLGGNAKTMEMANEIKK 327
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
7-355 7.12e-113

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 332.34  E-value: 7.12e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577    7 TILVIPGDGIGREVIPAAVAVLRAT----GLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGYPVAG 82
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAAlekaPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   83 YRS--PIVRLRRELDLYANIRPVFDDLPENGSNPRRRK---VDLVVVRENTEDVYAGRERVEDDGAT--AIAERVITRRA 155
Cdd:pfam00180  81 VRPenGLLALRKELGLFANLRPAKVFPPLGDASPLKNEvegVDIVIVRELTGGIYFGIEKGIKGSGNevAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  156 SARIMRVACDLARARrsarngsdaPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERF 235
Cdd:pfam00180 161 IERIARVAFELARKR---------GRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  236 DVIVTTNLFGDILSDVACAWGGGLGLAPSANLGE-RHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPAdl 314
Cdd:pfam00180 232 DVIVTPNLFGDILSDEASMLTGSLGLLPSASLGAnGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDA-- 309

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 500592577  315 asamrgwSARIQRAIRHVRAAGPHTPDLGGSAV---TTDITNAV 355
Cdd:pfam00180 310 -------ADKIEAAVLKVLESGIRTGDLAGSATyvsTSEFGEAV 346
 
Name Accession Description Interval E-value
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 6-359 3.63e-167

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 469.88  E-value: 3.63e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRAT----GLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGYPVA 81
Cdd:COG0473    2 YKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDDG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  82 -GYRSPIVRLRRELDLYANIRPV--FDDLPENGSNPRRRKVDLVVVRENTEDVYAGRER---VEDDGATAIAERVITRRA 155
Cdd:COG0473   82 vRPESGLLALRKELDLYANLRPAklYPGLPSPLKPEIVEGIDLVIVRENTEGLYFGIGGrigTGTGEEVAIDTRVYTRKG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 156 SARIMRVACDLARARRsarngsdappGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERF 235
Cdd:COG0473  162 IERIARYAFELARKRR----------KKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 236 DVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERH-ALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLagrapadl 314
Cdd:COG0473  232 DVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-------- 303

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 500592577 315 asAMRGWSARIQRAIRHVRAAGPHTPDLGGSAVTTDITNAVLSHM 359
Cdd:COG0473  304 --GEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 8-356 2.19e-133

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 383.73  E-value: 2.19e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577    8 ILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPgyPVAGYRSPI 87
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTP--ANPGYKSVI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   88 VRLRRELDLYANIRPV-----FDDLPENGsnprrrkVDLVVVRENTEDVYAGRERVEDDGAtaIAERVITRRASARIMRV 162
Cdd:TIGR02088  79 VTLRKELDLYANVRPAkslpgIPDLYPNG-------KDIVIVRENTEGLYAGFEFGFSDRA--IAIRVITREGSERIARF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  163 ACDLARARRSarngsdappgRVTVVHKANVLRETCGLFRSVALEVAQAYpDLQIDEMLVDTCALQLATRPERFDVIVTTN 242
Cdd:TIGR02088 150 AFNLAKERNR----------KVTCVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTN 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  243 LFGDILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADLasamrgws 322
Cdd:TIGR02088 219 MFGDILSDLASALAGSLGLAPSANIGDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKL-------- 290

                         330       340       350
                  ....*....|....*....|....*....|....
gi 500592577  323 arIQRAIRHVRAAGPHTPDLGGSAVTTDITNAVL 356
Cdd:TIGR02088 291 --VWEAVEYYIIEGKKTPDLGGTAKTKEVGDEIA 322
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 6-359 8.06e-133

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 382.56  E-value: 8.06e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGYPVagyrs 85
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETAADV----- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  86 pIVRLRRELDLYANIRPVfddLPENGSNPRRRKVDLVVVRENTEDVYAGRERVEDDGATaIAERVITRRASARIMRVACD 165
Cdd:PRK14025  77 -IVKLRRILDTYANVRPV---KSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVT-VATRVITRKASERIFRFAFE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 166 LARaRRSARNGSdappGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDVIVTTNLFG 245
Cdd:PRK14025 152 MAK-RRKKMGKE----GKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 246 DILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADlasamrgwsaRI 325
Cdd:PRK14025 227 DILSDGAAGLVGGLGLAPSANIGDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEAD----------KV 296

                        330       340       350
                 ....*....|....*....|....*....|....
gi 500592577 326 QRAIRHVRAAGPHTPDLGGSAVTTDITNAVLSHM 359
Cdd:PRK14025 297 EKALEEVLALGLTTPDLGGNLSTMEMAEEVAKRV 330
AksF_Meth NF040619
homoisocitrate dehydrogenase;
6-355 3.63e-130

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 375.64  E-value: 3.63e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRATGlPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASP---GYPVAG 82
Cdd:NF040619   2 PKICVIEGDGIGKEVIPETVRVLKELG-DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPkptELKNKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  83 YRSPIVRLRRELDLYANIRPVFD-DLPENGSNprrrkVDLVVVRENTEDVYAGRERVEDDGATAIAERVITRRASARIMR 161
Cdd:NF040619  81 YKSPILTLRKELDLYANVRPINNfGDGQDVKN-----IDFVIIRENTEGLYVGREYYDEENEIAIAERIISKKGSERIIK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 162 VACDLARarRSARNgsdappgRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQI--DEMLVDTCALQLATRPERFDVIV 239
Cdd:NF040619 156 FAFEYAK--KNNRK-------KVSCIHKANVLRVTDGLFLEIFNEIKKKYKNFNIeaDDYLVDATAMYLIKNPEMFDVIV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 240 TTNLFGDILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADLasamr 319
Cdd:NF040619 227 TTNLFGDILSDEASGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDL----- 301

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 500592577 320 gwsarIQRAIRHVRAAGPHTPDLGGSAVTTDITNAV 355
Cdd:NF040619 302 -----IREAVKKCLENGKVTPDLGGNLKTKEVTDKI 332
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
6-357 2.16e-128

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 371.37  E-value: 2.16e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASpgypVAGYRS 85
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTS----TPGQKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  86 PIVRLRRELDLYANIRPV--FDdlpenGSNPRRRKVDLVVVRENTEDVYAGRERVEDDGaTAIAERVITRRASARIMRVA 163
Cdd:NF040626  78 PIITLRKELDLYANLRPIksYE-----GINCLFKDLDFLIVRENTEGLYSGLEEEYTEE-KAIAERVITRKASERICKFA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 164 CDLARARrsARNgsdappgRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDVIVTTNL 243
Cdd:NF040626 152 FEYAIKL--GRK-------KVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNL 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 244 FGDILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLagrapadlasAMRGWSA 323
Cdd:NF040626 223 FGDILSDEAAGLVGGLGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYL----------GETYEAN 292

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 500592577 324 RIQRAIRHVRAAGP-HTPDLGGSAVTTDITNAVLS 357
Cdd:NF040626 293 KLENALEKVLREGKvVTPDLGGNAKTMEMANEIKK 327
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 6-359 2.94e-118

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 346.32  E-value: 2.94e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRAT----GLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGY--- 78
Cdd:PRK00772   3 YKIAVLPGDGIGPEVMAEAVKVLDAVaekfGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWdnl 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  79 -----PVAGyrspIVRLRRELDLYANIRP--VFDDLpENGSNPRR---RKVDLVVVRENTEDVYAG---RERVEDDGATA 145
Cdd:PRK00772  83 ppdvrPERG----LLALRKELGLFANLRPakLYPGL-ADASPLKPeivAGLDILIVRELTGGIYFGeprGREGLGGEERA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 146 IAERVITRRASARIMRVACDLARARRsarngsdappGRVTVVHKANVLrETCGLFRSVALEVAQAYPDLQIDEMLVDTCA 225
Cdd:PRK00772 158 FDTMVYTREEIERIARVAFELARKRR----------KKVTSVDKANVL-ESSRLWREVVTEVAKEYPDVELSHMYVDNAA 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 226 LQLATRPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGE-RHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLD 304
Cdd:PRK00772 227 MQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGEsGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLR 306

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 500592577 305 HLAGRAPAdlasamrgwSARIQRAIRHVRAAGPHTPDL---GGSAVTTDITNAVLSHM 359
Cdd:PRK00772 307 YSLGLEEA---------ADAIEAAVEKVLAQGYRTADIaegGGKVSTSEMGDAILAAL 355
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
7-355 7.12e-113

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 332.34  E-value: 7.12e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577    7 TILVIPGDGIGREVIPAAVAVLRAT----GLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGYPVAG 82
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAAlekaPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   83 YRS--PIVRLRRELDLYANIRPVFDDLPENGSNPRRRK---VDLVVVRENTEDVYAGRERVEDDGAT--AIAERVITRRA 155
Cdd:pfam00180  81 VRPenGLLALRKELGLFANLRPAKVFPPLGDASPLKNEvegVDIVIVRELTGGIYFGIEKGIKGSGNevAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  156 SARIMRVACDLARARrsarngsdaPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERF 235
Cdd:pfam00180 161 IERIARVAFELARKR---------GRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  236 DVIVTTNLFGDILSDVACAWGGGLGLAPSANLGE-RHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPAdl 314
Cdd:pfam00180 232 DVIVTPNLFGDILSDEASMLTGSLGLLPSASLGAnGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDA-- 309

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 500592577  315 asamrgwSARIQRAIRHVRAAGPHTPDLGGSAV---TTDITNAV 355
Cdd:pfam00180 310 -------ADKIEAAVLKVLESGIRTGDLAGSATyvsTSEFGEAV 346
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 7-359 2.21e-112

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 330.53  E-value: 2.21e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   7 TILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASP-GypvAGYRS 85
Cdd:PRK08997   4 TITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPvG---EGFTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  86 PIVRLRRELDLYANIRPVfddLPENGSNPRRRKVDLVVVRENTEDVYAGR-ERVEDDGATAIAERVITRRASARIMRVAC 164
Cdd:PRK08997  81 INVTLRKKFDLYANVRPV---LSFPGTKARYDNIDIITVRENTEGMYSGEgQTVSEDGETAEATSIITRKGAERIVRFAY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 165 DLARARrsarngsdappGR--VTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDVIVTTN 242
Cdd:PRK08997 158 ELARKE-----------GRkkVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTN 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 243 LFGDILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADlasamrgws 322
Cdd:PRK08997 227 LFGDILSDLCAGLVGGLGMAPGANIGRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAE--------- 297

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 500592577 323 aRIQRAIRHVRAAGPH-TPDLGGSAVTTDITNAVLSHM 359
Cdd:PRK08997 298 -RIRKAIVAVIEAGDRtTRDLGGTHGTTDFTQAVIDRL 334
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 8-359 1.29e-94

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 285.83  E-value: 1.29e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577    8 ILVIPGDGIGREVIPAAVAVLRAT----GLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGY----- 78
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVaerfGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWdnlpr 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   79 ---PVAGyrspIVRLRRELDLYANIRP--VFDDLpENGSNPRR---RKVDLVVVRENTEDVYAGrERVEDDGAT-AIAER 149
Cdd:TIGR00169  82 dqrPEQG----LLKLRKSLDLFANLRPakVFPGL-EDLSPLKEeiaKGVDFVVVRELTGGIYFG-EPKGREGEGeAWDTE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  150 VITRRASARIMRVACDLARARRsarngsdappGRVTVVHKANVLrETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLA 229
Cdd:TIGR00169 156 VYTVPEIERIARVAFEMARKRR----------KKVTSVDKANVL-ESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLV 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  230 TRPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGER-HALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAG 308
Cdd:TIGR00169 225 KSPTQFDVVVTSNLFGDILSDEASVITGSLGMLPSASLGSDgFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFN 304

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 500592577  309 raPADLAsamrgwsARIQRAIRHVRAAGPHTPDLGGSAVTTDITNAVLSHM 359
Cdd:TIGR00169 305 --LEEAA-------DAIEAAVKKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 6-357 1.83e-91

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 277.87  E-value: 1.83e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577    6 YTILVIPGDGIGREVIPAAVAVLRAT-----GLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPG--- 77
Cdd:TIGR02089   4 YRIAAIPGDGIGKEVVAAALQVLEAAakrhgGFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPAlvp 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   78 --YPVAGYRSPIvrlRRELDLYANIRP--VFDDLPENGSNPRRRKVDLVVVRENTEDVYA---GRERVEDDGATAIAERV 150
Cdd:TIGR02089  84 dhISLWGLLLKI---RREFDQYANVRPakLLPGVTSPLRNCGPGDFDFVVVRENSEGEYSgvgGRIHRGTDEEVATQNAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  151 ITRRASARIMRVACDLARARRsarngsdappGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLAT 230
Cdd:TIGR02089 161 FTRKGVERIMRFAFELAQKRR----------KHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  231 RPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANL---GERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLA 307
Cdd:TIGR02089 231 KPETFDVIVASNLFGDILSDLGAALMGSLGVAPSANInpeGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLG 310

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 500592577  308 GRapaDLAsamrgwsARIQRAIRHVRAAGPHTPDLGGSAVTTDITNAVLS 357
Cdd:TIGR02089 311 EK---EAG-------AKIMDAIERVTAAGILTPDVGGKATTSEVTEAVCN 350
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 7-361 1.02e-85

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 263.12  E-value: 1.02e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   7 TILVIPGDGIGREVIPAAVAVLRAT-----GLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGYpVA 81
Cdd:PRK08194   5 KIAVIPGDGVGKEVVPAAVRVLKAVaevhgGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKL-VP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  82 GYRSP---IVRLRRELDLYANIRPVfDDLPENGSNPRRRK-VDLVVVRENTEDVYA---GRERVEDDgATAIAERVITRR 154
Cdd:PRK08194  84 DHISLwglLIKIRREFEQVINIRPA-KQLRGIKSPLANPKdFDLLVVRENSEGEYSevgGRIHRGED-EIAIQNAVFTRK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 155 ASARIMRVACDLARARRsarngsdappGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPER 234
Cdd:PRK08194 162 GTERAMRYAFELAAKRR----------KHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEE 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 235 FDVIVTTNLFGDILSDVACAWGGGLGLAPSANL---GERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLaGRap 311
Cdd:PRK08194 232 FDVIVASNLFGDILTDIGAAIMGSIGIAPAANInvnGKYPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDHF-GE-- 308

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 500592577 312 ADLASamrgwsaRIQRAIRHVRAAGPHTPDLGGSAVTTDITNAVLSHMLT 361
Cdd:PRK08194 309 EELGS-------HLLDVIEDVTEDGIKTPDIGGRATTDEVTDEIISRLKK 351
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
3-355 9.38e-83

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 259.82  E-value: 9.38e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   3 AAPYTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEA-LPSATLTAARAADAILFGAVASP-GYpv 80
Cdd:PRK09222   2 AEKTPITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIGEKVYKKGWTSgISPSAWESIRRTKVLLKAPITTPqGG-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  81 aGYRSPIVRLRRELDLYANIRPVFDDLPenGSNPRRRKVDLVVVRENTEDVYAGRE-RVEDDgaTAIAERVITRRASARI 159
Cdd:PRK09222  80 -GYKSLNVTLRKTLGLYANVRPCVSYHP--FVETKHPNLDVVIIRENEEDLYAGIEhRQTPD--VYQCLKLISRPGSEKI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 160 MRVACDLARA--RRsarngsdappgRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDV 237
Cdd:PRK09222 155 IRYAFEYARAngRK-----------KVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDV 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 238 IVTTNLFGDILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANP----LAAIgctaLLLDHLaGRapAD 313
Cdd:PRK09222 224 IVTPNLYGDILSDIAAEISGSVGLAGSANIGEEYAMFEAVHGSAPDIAGKNIANPsgllNAAV----MMLVHI-GQ--FD 296

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 500592577 314 LAsamrgwsARIQRAIRHVRAAGPHTPDLGGSAV------TTDITNAV 355
Cdd:PRK09222 297 IA-------ELIENAWLKTLEDGIHTADIYNEGVskkkvgTKEFAEAV 337
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 2-359 3.70e-82

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 253.70  E-value: 3.70e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   2 SAAPYTILVIPGDGIGREVIPAAVAVLRA---TGLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGY 78
Cdd:PRK03437   1 MAKTMKLAVIPGDGIGPEVVAEALKVLDAvaaGGPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  79 PvAGY--RSPIVRLRRELDLYANIRPV--FDDLPENGSNPRrrKVDLVVVRENTEDVYAGRE---RVEDDGATAIAERVI 151
Cdd:PRK03437  81 P-SGVleRGLLLKLRFALDHYVNLRPSklYPGVTSPLAGPG--DIDFVVVREGTEGPYTGNGgalRVGTPHEVATEVSVN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 152 TRRASARIMRVACDLARARrsarngsdaPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATR 231
Cdd:PRK03437 158 TAFGVERVVRDAFERAQKR---------PRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTD 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 232 PERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANL---GERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAG 308
Cdd:PRK03437 229 PSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNInptGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGE 308

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 500592577 309 RAPAdlasamrgwsARIQRAIRHVRAAgphtpDLGGSAVTTDITNAVLSHM 359
Cdd:PRK03437 309 EDAA----------ARIEAAVEADLAE-----RGKMGRSTAEVGDRIAARL 344
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 2-359 7.93e-74

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 233.23  E-value: 7.93e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   2 SAAPYTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASP-Gypv 80
Cdd:PLN00118  38 SSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGLKGPMATPiG--- 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  81 AGYRSPIVRLRRELDLYANIRPVFDdLPenGSNPRRRKVDLVVVRENTEDVYAGRERVEDDGATAiAERVITRRASARIM 160
Cdd:PLN00118 115 KGHRSLNLTLRKELGLYANVRPCYS-LP--GYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVE-SLKIITRQASLRVA 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 161 RVACDLARArrsarNGSDappgRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDVIVT 240
Cdd:PLN00118 191 EYAFHYAKT-----HGRK----RVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVM 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 241 TNLFGDILSDVACAWGGGLGLAPSANLGERH-ALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADlasamr 319
Cdd:PLN00118 262 PNLYGDIISDLCAGLIGGLGLTPSCNIGENGlALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAE------ 335

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 500592577 320 gwsaRIQRAIRHVRAAGPH-TPDLGGSAVTTDITNAVLSHM 359
Cdd:PLN00118 336 ----QIHNAILNTIAEGKYrTADLGGSSTTTDFTKAICDHL 372
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 3-359 2.17e-65

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 211.26  E-value: 2.17e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   3 AAPYTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADagwecFQRQGEALPSATLTAARAADAILFGAVASPgypVAG 82
Cdd:PLN00123  28 GAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYE-----VHGDMKKVPEEVLESIRRNKVCLKGGLATP---VGG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  83 YRSPI-VRLRRELDLYANIRPVFDdLPenGSNPRRRKVDLVVVRENTEDVYAGRERVEDDGATAiAERVITRRASARIMR 161
Cdd:PLN00123 100 GVSSLnVQLRKELDLFASLVNCFN-LP--GLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVE-SLKVITKFCSERIAK 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 162 VACDLARARRSARngsdappgrVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDVIVTT 241
Cdd:PLN00123 176 YAFEYAYLNNRKK---------VTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTP 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 242 NLFGDILSDVACAWGGGLGLAPSANLGERHALFEPVHGAA----PDIAGKGIANPLAAIGCTALLLDHLAGRAPADlasa 317
Cdd:PLN00123 247 NLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFAD---- 322

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 500592577 318 mrgwsaRIQRAIRHVRAAGPH-TPDLGGSAVTTDITNAVLSHM 359
Cdd:PLN00123 323 ------RLETAVKRVIAEGKYrTKDLGGSSTTQEVVDAVIANL 359
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 7-359 1.31e-55

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 187.24  E-value: 1.31e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   7 TILVIPGDGIGREVIPAAVAVLRA-------TGLPFHFENADAGWECFQRQGEALPSATLTAARAadailFG-AVASP-G 77
Cdd:COG0538   20 IIPFIEGDGIGPEITRAIWKVIDAavekaygGKRDIEWKEVDAGEKARDETGDWLPDETAEAIKE-----YGvGIKGPlT 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  78 YPV-AGYRSPIVRLRRELDLYANIRPV--FDDLPENGSNPRrrKVDLVVVRENTEDVYAGRE-RVEDDGA---------- 143
Cdd:COG0538   95 TPVgGGWRSLNVTIRQILDLYVCRRPVryFKGVPSPVKHPE--KVDIVIFRENTEDIYAGIEwKAGSPEAlklifflede 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 144 -----------TAIAERVITRRASARIMRVACD--LARARRSarngsdappgrVTVVHKANVLRETCGLFRSVALEVAQA 210
Cdd:COG0538  173 mgvtvirfpedSGIGIKPVSDEGTERLVRAAIQyaLDNKRKS-----------VTLVHKGNIMKFTEGAFKDWGYEVAEE 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 211 -YPDLQIDEMLVDTCAL-------------------QLATRPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLG-E 269
Cdd:COG0538  242 eFGDKFITEGPWEKYKGpkpagkivykdriaddmlqQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGdD 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 270 RHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADLasamrgwsarIQRAIRHVRAAGPHTPDL-----GG 344
Cdd:COG0538  322 GGAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADL----------IEKAVEKTIESGKVTYDLarlmeGA 391

                        410
                 ....*....|....*.
gi 500592577 345 SAVTT-DITNAVLSHM 359
Cdd:COG0538  392 TELSTsEFGDAIIENL 407
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 6-312 1.29e-52

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 179.50  E-value: 1.29e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   6 YTILVIPGDGIGREVIPAAVAVLRATG----LPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVAspGY--- 78
Cdd:PLN02329  47 YNIALLPGDGIGPEVISVAKNVLQKAGslegLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIG--GYkwd 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  79 -------PVAGyrspIVRLRRELDLYANIRPVfDDLPE--NGSNPRR---RKVDLVVVRENTEDVYAGRER----VEDDG 142
Cdd:PLN02329 125 knekhlrPEMA----LFYLRRDLKVFANLRPA-TVLPQlvDASTLKKevaEGVDMMIVRELTGGIYFGEPRgitiNENGE 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 143 ATAIAERVITRRASARIMRVACDLARARRsarngsdappGRVTVVHKANVLRETCgLFRSVALEVAQAYPDLQIDEMLVD 222
Cdd:PLN02329 200 EVGVSTEIYAAHEIDRIARVAFETARKRR----------GKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVD 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 223 TCALQLATRPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERH-ALFEPVHGAAPDIAGKGIANPLAAIGCTAL 301
Cdd:PLN02329 269 NAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAM 348

                        330
                 ....*....|.
gi 500592577 302 LLDHLAGRAPA 312
Cdd:PLN02329 349 LLKYGLGEEKA 359
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 8-314 4.23e-48

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 167.55  E-value: 4.23e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   8 ILVIPGDGIGREVIPAAVAVLRAT-------GLPFHFENADAGWECFQRQGEA--LPSATLTAARAADAILFGAVASP-G 77
Cdd:PRK07006  22 IPFIEGDGIGPDITPAMLKVVDAAvekaykgERKISWMEIYAGEKATKVYGEDvwLPEETLDLIREYRVAIKGPLTTPvG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  78 ypvAGYRSPIVRLRRELDLYANIRPV--FDDLPengsNPRRR--KVDLVVVRENTEDVYAGRERVEDdgaTAIAERVI-- 151
Cdd:PRK07006 102 ---GGIRSLNVALRQELDLYVCLRPVryFKGVP----SPVKRpeDTDMVIFRENSEDIYAGIEWKAG---SAEAKKVIkf 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 152 -----------------------TRRASARIMRVACDLArarrsARNGSDAppgrVTVVHKANVLRETCGLFRSVALEVA 208
Cdd:PRK07006 172 lqeemgvkkirfpetsgigikpvSEEGTERLVRAAIEYA-----IDNDRKS----VTLVHKGNIMKFTEGAFKDWGYQLA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 209 Q--------------------AYPDLQIDEMLVDTCALQLATRPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLG 268
Cdd:PRK07006 243 EeefgdelidggpwdkiknpeTGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN 322

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 500592577 269 ERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADL 314
Cdd:PRK07006 323 DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADL 368
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
8-330 4.65e-48

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 167.32  E-value: 4.65e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577   8 ILVIPGDGIGREVIPAAVAVL-RATGLPF------HFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASP-Gyp 79
Cdd:PRK06451  26 ILYVEGDGIGPEITHAAMKVInKAVEKAYgsdreiKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPiG-- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  80 vAGYRSPIVRLRRELDLYANIRPV--FDDLPENGSNPRrrKVDLVVVRENTEDVYAGRE--------------------- 136
Cdd:PRK06451 104 -KGWKSINVAIRLMLDLYANIRPVkyIPGIESPLKNPE--KIDLIIFRENTDDLYRGIEypydseeakkirdflrkelgv 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 137 RVEDDgaTAIAERVITRRASARIMRVACDLA--RARRSarngsdappgrVTVVHKANVLRETCGLFRSVALEVA-QAYPD 213
Cdd:PRK06451 181 EVEDD--TGIGIKLISKFKTQRIARMAIKYAidHKRKK-----------VTIMHKGNVMKYTEGAFREWAYEVAlKEFRD 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 214 --------------------LQIDEMLVDTCALQLATRPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERHAL 273
Cdd:PRK06451 248 yvvteeevtknyngvppsgkVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGM 327

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500592577 274 FEPVHGAAPDIAGKGIANPLAAIGCTALLLDHLAGRAPADLASAMrgwsarIQRAIR 330
Cdd:PRK06451 328 FEAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKA------IMESIK 378
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
11-325 5.04e-30

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 119.82  E-value: 5.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  11 IPGDGIGREVIPAA-----VAVLRATGLPFHFE--NADAGWECFQRQG--EALPSATLTAARAADAILFGAVASP-Gypv 80
Cdd:PRK07362  34 IRGDGTGVDIWPATqkvldAAVAKAYGGERKINwfKVYAGDEACDLYGtyQYLPEDTLEAIREYGVAIKGPLTTPiG--- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577  81 AGYRSPIVRLRRELDLYANIRPV--FDDLPENGSNPRrrKVDLVVVRENTEDVYAGRERVEDDG---------------- 142
Cdd:PRK07362 111 GGIRSLNVALRQIFDLYSCVRPCryYAGTPSPHKNPE--KLDVIVYRENTEDIYMGIEWEAGDEigdklikhlneevipa 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 143 -----------ATAIAERVITRRASARIMRVAcdLARARRSARNGSdappgRVTVVHKANVLRETCGLFRSVALEVA--- 208
Cdd:PRK07362 189 spelgkrqiplGSGIGIKPVSKTGSQRHIRRA--IEHALRLPGDKR-----HVTLVHKGNIMKYTEGAFRDWGYELAtte 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 209 -----------------QAYPDLQI------------------------------------------------DEMLVDT 223
Cdd:PRK07362 262 frdecvtereswilsnkEKNPNISIednarmiepgydsltpekkaaicaevkevldsiwsshgngkwkekvlvDDRIADS 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500592577 224 CALQLATRPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLL 303
Cdd:PRK07362 342 IFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKHAGLDRINPGSVILSGVMML 421

                        410       420
                 ....*....|....*....|..
gi 500592577 304 DHLAGRAPADLASamRGWSARI 325
Cdd:PRK07362 422 EYLGWQEAADLIT--KGLSAAI 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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