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Conserved domains on  [gi|500275687|ref|WP_011922397|]
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AAA family ATPase [Streptococcus suis]

Protein Classification

DEAD/DEAH box helicase family protein( domain architecture ID 1000205)

DEAD/DEAH box helicase family protein such as a DEAD/DEAH box-containing ATP-dependent helicase, which catalyzes the unwinding of DNA or RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 3-127 3.65e-05

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member pfam13238:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 128  Bit Score: 40.87  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500275687    3 IWLNGPFGVGKTTLANILHKRIE-----NSYLYNPELLGDFLQHQLPQTVCPEDFQDYsvwrqstykiVFDLAtktdkII 77
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGfgdnvRDLALENGLVLGDDPETRESKRLDEDKLDR----------LLDLL-----EE 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 500275687   78 IIPMTIYKKEYYQEIIQQLIQDKIPLEHYILL-ADKTTILERLDNRVNEDN 127
Cdd:pfam13238  66 NAALEEGGNLIIDGHLAELEPERAKDLVGIVLrASPEELLERLEKRGYEEA 116
 
Name Accession Description Interval E-value
AAA_18 pfam13238
AAA domain;
3-127 3.65e-05

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 40.87  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500275687    3 IWLNGPFGVGKTTLANILHKRIE-----NSYLYNPELLGDFLQHQLPQTVCPEDFQDYsvwrqstykiVFDLAtktdkII 77
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGfgdnvRDLALENGLVLGDDPETRESKRLDEDKLDR----------LLDLL-----EE 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 500275687   78 IIPMTIYKKEYYQEIIQQLIQDKIPLEHYILL-ADKTTILERLDNRVNEDN 127
Cdd:pfam13238  66 NAALEEGGNLIIDGHLAELEPERAKDLVGIVLrASPEELLERLEKRGYEEA 116
APSK cd02027
Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5 ...
 2-43 3.05e-04

Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of inorganic sulfate.


Pssm-ID: 238985 [Multi-domain]  Cd Length: 149  Bit Score: 38.61  E-value: 3.05e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 500275687   2 IIWLNGPFGVGKTTLAN----ILHKRIENSYLynpeLLGDFLQHQL 43
Cdd:cd02027    1 VIWLTGLSGSGKSTIARaleeKLFQRGRPVYV----LDGDNVRHGL 42
apsK TIGR00455
adenylyl-sulfate kinase; This protein, adenylylsulfate kinase, is often found as a fusion ...
 2-43 4.39e-04

adenylyl-sulfate kinase; This protein, adenylylsulfate kinase, is often found as a fusion protein with sulfate adenylyltransferase. Important residue (active site in E.coli) is residue 100 of the seed alignment. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 129547  Cd Length: 184  Bit Score: 38.60  E-value: 4.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 500275687    2 IIWLNGPFGVGKTTLANILHKRIENSYlYNPELL-GDFLQHQL 43
Cdd:TIGR00455  20 VIWLTGLSGSGKSTIANALEKKLESKG-YRVYVLdGDNVRHGL 61
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 1-20 5.40e-04

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 38.88  E-value: 5.40e-04
                         10        20
                 ....*....|....*....|
gi 500275687   1 MIIWlnGPFGVGKTTLANIL 20
Cdd:COG2256   52 MILW--GPPGTGKTTLARLI 69
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 1-20 2.00e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 36.99  E-value: 2.00e-03
                         10        20
                 ....*....|....*....|
gi 500275687   1 MIIWlnGPFGVGKTTLANIL 20
Cdd:PRK13342  39 MILW--GPPGTGKTTLARII 56
 
Name Accession Description Interval E-value
AAA_18 pfam13238
AAA domain;
3-127 3.65e-05

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 40.87  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500275687    3 IWLNGPFGVGKTTLANILHKRIE-----NSYLYNPELLGDFLQHQLPQTVCPEDFQDYsvwrqstykiVFDLAtktdkII 77
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGfgdnvRDLALENGLVLGDDPETRESKRLDEDKLDR----------LLDLL-----EE 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 500275687   78 IIPMTIYKKEYYQEIIQQLIQDKIPLEHYILL-ADKTTILERLDNRVNEDN 127
Cdd:pfam13238  66 NAALEEGGNLIIDGHLAELEPERAKDLVGIVLrASPEELLERLEKRGYEEA 116
APSK cd02027
Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5 ...
 2-43 3.05e-04

Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of inorganic sulfate.


Pssm-ID: 238985 [Multi-domain]  Cd Length: 149  Bit Score: 38.61  E-value: 3.05e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 500275687   2 IIWLNGPFGVGKTTLAN----ILHKRIENSYLynpeLLGDFLQHQL 43
Cdd:cd02027    1 VIWLTGLSGSGKSTIARaleeKLFQRGRPVYV----LDGDNVRHGL 42
apsK TIGR00455
adenylyl-sulfate kinase; This protein, adenylylsulfate kinase, is often found as a fusion ...
 2-43 4.39e-04

adenylyl-sulfate kinase; This protein, adenylylsulfate kinase, is often found as a fusion protein with sulfate adenylyltransferase. Important residue (active site in E.coli) is residue 100 of the seed alignment. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 129547  Cd Length: 184  Bit Score: 38.60  E-value: 4.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 500275687    2 IIWLNGPFGVGKTTLANILHKRIENSYlYNPELL-GDFLQHQL 43
Cdd:TIGR00455  20 VIWLTGLSGSGKSTIANALEKKLESKG-YRVYVLdGDNVRHGL 61
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 1-20 5.40e-04

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 38.88  E-value: 5.40e-04
                         10        20
                 ....*....|....*....|
gi 500275687   1 MIIWlnGPFGVGKTTLANIL 20
Cdd:COG2256   52 MILW--GPPGTGKTTLARLI 69
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 3-127 6.50e-04

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 37.67  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500275687    3 IWLNGPFGVGKTTLANILHKRIENSYLYNPELLgdflqhqlpQTVCPEDFQD---YSVWRQSTYKIVFDLATKTDKI--- 76
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDER---------KRLFGEGRPSisyYTDATDRTYERLHELARIALRAgrp 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 500275687   77 IIIPMTIYKKEYYQEIIQQLIQDKIPLEHYILLADKTTILERLDNRVNEDN 127
Cdd:pfam13671  73 VILDATNLRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARARAGG 123
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
2-122 8.49e-04

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 37.59  E-value: 8.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500275687   2 IIWLNGPFGVGKTTLANILHKRI---------ENSYLYNPELlgdflqhqlpqtvcpEDFQDYSVWRQSTYKIVFDLAT- 71
Cdd:COG0645    1 LILVCGLPGSGKSTLARALAERLgavrlrsdvVRKRLFGAGL---------------APLERSPEATARTYARLLALARe 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 500275687  72 --KTDKIIIIPMTIYKKEYYQEIIQQLIQDKIPLEHYILLADKTTILERLDNR 122
Cdd:COG0645   66 llAAGRSVILDATFLRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEAR 118
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 1-20 2.00e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 36.99  E-value: 2.00e-03
                         10        20
                 ....*....|....*....|
gi 500275687   1 MIIWlnGPFGVGKTTLANIL 20
Cdd:PRK13342  39 MILW--GPPGTGKTTLARII 56
APS_kinase pfam01583
Adenylylsulphate kinase; Enzyme that catalyzes the phosphorylation of adenylylsulphate to 3 ...
 2-43 3.99e-03

Adenylylsulphate kinase; Enzyme that catalyzes the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate. This domain contains an ATP binding P-loop motif.


Pssm-ID: 396247 [Multi-domain]  Cd Length: 154  Bit Score: 35.37  E-value: 3.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 500275687    2 IIWLNGPFGVGKTTLANILHKRIEN----SYLynpeLLGDFLQHQL 43
Cdd:pfam01583   4 TIWLTGLSGAGKSTIANALERKLFEqgrsVYV----LDGDNVRHGL 45
CysC COG0529
Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; ...
 1-43 6.13e-03

Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; Adenylylsulfate kinase or related kinase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 440295 [Multi-domain]  Cd Length: 189  Bit Score: 35.07  E-value: 6.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 500275687   1 MIIWLNGPFGVGKTTLANILHKRIENSYlYNPELL-GDFLQHQL 43
Cdd:COG0529   17 FVVWFTGLSGSGKSTLANALERRLFERG-RHVYLLdGDNVRHGL 59
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 3-33 7.48e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 34.12  E-value: 7.48e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 500275687    3 IWLNGPFGVGKTTLANILHKRIENSYLYNPE 33
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARALLKKLGLPKD 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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