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Conserved domains on  [gi|500101966|ref|WP_011777973|]
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glucose-6-phosphate dehydrogenase (coenzyme-F420) [Mycolicibacterium vanbaalenii]

Protein Classification

glucose-6-phosphate dehydrogenase (coenzyme-F420)( domain architecture ID 10799422)

glucose-6-phosphate dehydrogenase (coenzyme-F420) catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F420_G6P_DH TIGR03554
glucose-6-phosphate dehydrogenase (coenzyme-F420); This family consists of the F420-dependent ...
 3-333 0e+00

glucose-6-phosphate dehydrogenase (coenzyme-F420); This family consists of the F420-dependent glucose-6-phosphate dehydrogenase of Mycobacterium and Nocardia. It shows homology to several other F420-dependent enzymes rather than to the NAD or NADP-dependent glucose-6-phosphate dehydrogenases. [Energy metabolism, Pentose phosphate pathway]


:

Pssm-ID: 213827  Cd Length: 331  Bit Score: 705.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966    3 ELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTKRLQLGTSVLTPTFRYN 82
Cdd:TIGR03554   1 ELKLGYKASAEQFAPRELVELAVLAEAHGMDSATVSDHFQPWRHQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   83 PAVIAQAFATMGCLYPGRIFLGVGTGEALNEIATGYEGDWPEFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASI 162
Cdd:TIGR03554  81 PAVIAQAFATMGCLYPGRVFLGVGTGEALNEIATGYQGEWPEFKERFARLRESVRLMRELWTGDRVDFDGEYYRTKGASI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  163 YDVPEGGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELYKDKLIPAMREGAEAAGKNPDDIDRMIEIKISYDTDPELA 242
Cdd:TIGR03554 161 YDVPEGGVPVYIAAGGPVVAKYAGRAGDGFICTSGKGEELYTEKLMPAVAEGAAKADRDVDSIDKMIEIKISYDTDPELA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  243 LENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVAKVKDYVDWGLNHLVFHAPGHDQRRFLE 322
Cdd:TIGR03554 241 LENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVEQVGQYVDWGLNHLVFHAPGHDQRRFLE 320

                         330
                  ....*....|.
gi 500101966  323 LFRRDLEPRLR 333
Cdd:TIGR03554 321 LFQRDLAPRLR 331
 
Name Accession Description Interval E-value
F420_G6P_DH TIGR03554
glucose-6-phosphate dehydrogenase (coenzyme-F420); This family consists of the F420-dependent ...
 3-333 0e+00

glucose-6-phosphate dehydrogenase (coenzyme-F420); This family consists of the F420-dependent glucose-6-phosphate dehydrogenase of Mycobacterium and Nocardia. It shows homology to several other F420-dependent enzymes rather than to the NAD or NADP-dependent glucose-6-phosphate dehydrogenases. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 213827  Cd Length: 331  Bit Score: 705.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966    3 ELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTKRLQLGTSVLTPTFRYN 82
Cdd:TIGR03554   1 ELKLGYKASAEQFAPRELVELAVLAEAHGMDSATVSDHFQPWRHQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   83 PAVIAQAFATMGCLYPGRIFLGVGTGEALNEIATGYEGDWPEFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASI 162
Cdd:TIGR03554  81 PAVIAQAFATMGCLYPGRVFLGVGTGEALNEIATGYQGEWPEFKERFARLRESVRLMRELWTGDRVDFDGEYYRTKGASI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  163 YDVPEGGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELYKDKLIPAMREGAEAAGKNPDDIDRMIEIKISYDTDPELA 242
Cdd:TIGR03554 161 YDVPEGGVPVYIAAGGPVVAKYAGRAGDGFICTSGKGEELYTEKLMPAVAEGAAKADRDVDSIDKMIEIKISYDTDPELA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  243 LENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVAKVKDYVDWGLNHLVFHAPGHDQRRFLE 322
Cdd:TIGR03554 241 LENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVEQVGQYVDWGLNHLVFHAPGHDQRRFLE 320

                         330
                  ....*....|.
gi 500101966  323 LFRRDLEPRLR 333
Cdd:TIGR03554 321 LFQRDLAPRLR 331
Bac_luciferase pfam00296
Luciferase-like monooxygenase;
11-307 1.97e-71

Luciferase-like monooxygenase;


Pssm-ID: 425589 [Multi-domain]  Cd Length: 313  Bit Score: 224.16  E-value: 1.97e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   11 SAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWrheggHAPFSLAWMTAVGERTKRLQLGTSVLTPTFRyNPAVIAQAF 90
Cdd:pfam00296  16 GAGSESLRYLVELARAAEELGFDGVWLAEHHGGP-----GGPDPFVVLAALAAATSRIRLGTAVVPLPTR-HPAVLAEQA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   91 ATMGCLYPGRIFLGVGTGEALNEIATGyeGDwpEFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASIYDVPEGGI 170
Cdd:pfam00296  90 ATLDHLSGGRFDLGLGTGGPAVEFRRF--GV--DHDERYARLREFLEVLRRLWRGEPVDFEGEFFTLDGAFLLPRPVQGI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  171 PIYIAAGGPQVAKYAGRAGDGFICTSGKGEELYKDkLIPAMREGAEAAGKNPDDIDRMIEIKISYDTDPELALENTR-FW 249
Cdd:pfam00296 166 PVWVAASSPAMLELAARHADGLLLWGFAPPAAAAE-LIERVRAGAAEAGRDPADIRVGASLTVIVADTEEEARAEARaLI 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  250 APLS------------LTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVaSDPDEAVAKVKDYVDWGLNH 307
Cdd:pfam00296 245 AGLPfyrmdsegagrlAEAREIGEEYDAGDWAGAADAVPDELVRAFALV-GTPEQVAERLAAYAEAGVDH 313
SsuD COG2141
Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase ...
 27-334 1.89e-67

Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) [Coenzyme transport and metabolism, General function prediction only]; Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441744 [Multi-domain]  Cd Length: 301  Bit Score: 213.64  E-value: 1.89e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  27 AEEHGMDSATVSDHFQPWrheGGHAPFSLAWMTAVGERTKRLQLGTSVLTPTFRyNPAVIAQAFATMGCLYPGRIFLGVG 106
Cdd:COG2141    1 AERLGFDRVWVADHHFPP---GGASPDPWVLLAALAAATSRIRLGTGVVVLPLR-HPLVVAEQFATLDHLSGGRLDLGVG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966 107 TGEALNEIAT-GYEgdwpeFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASIYDVPEGG--IPIYIAAGGPQVAK 183
Cdd:COG2141   77 RGWGPDEFAAfGLD-----HDERYERFEEALEVLRRLWTGEPVTFEGEFFTVEGARLVPRPVQGphPPIWIAGSSPAGAR 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966 184 YAGRAGDGFICTSGKGEELykDKLIPAMREGAEAAGKNPDDIDRMIEIKISYDTDPELALENTRFW----APLSLTAEQK 259
Cdd:COG2141  152 LAARLGDGVFTAGGTPEEL--AEAIAAYREAAAAAGRDPDDLRVSVGLHVIVAETDEEARERARPYlralLALPRGRPPE 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500101966 260 HSIDDPIEMEKAADALpieqvakRWIVASDPDEAVAKVKDYVDW-GLNHLVFHAPGHD---QRRFLELFRRDLEPRLRK 334
Cdd:COG2141  230 EAEEGLTVREDLLELL-------GAALVGTPEQVAERLEELAEAaGVDEFLLQFPGLDpedRLRSLELFAEEVLPLLRR 301
PRK02271 PRK02271
methylenetetrahydromethanopterin reductase; Provisional
 19-313 3.76e-28

methylenetetrahydromethanopterin reductase; Provisional


Pssm-ID: 235022 [Multi-domain]  Cd Length: 325  Bit Score: 111.57  E-value: 3.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  19 ELVELAVAAEEHGMDSATVSDHFQPwRHegghaPFSLawMTAVGERTKRLQLGTSVLTPtFRYNPAVIAQAFATMGCLYP 98
Cdd:PRK02271  15 KIAYLAKLAEDNGFDYAWITDHYNN-RD-----VYMT--LAAIAAATDTIKLGPGVTNP-YTRHPAITASAIATLDEISG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  99 GRIFLGVGTGEALNEIATGYEGDWPefkerYARLRESVRLMRDLWLGDRVDFEGEYyKTKGASI-YDVPEGGIPIYIAAG 177
Cdd:PRK02271  86 GRAVLGIGPGDKATLDALGIEWEKP-----LRTVKEAIEVIRKLWAGERVEHDGTF-KAAGAKLnVKPVQGEIPIYMGAQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966 178 GPQVAKYAGRAGDGFICTSGKGEELykDKLIPAMREGAEAAGKNPDDIDRMIEIKISYDTDPELALENTR----FWA--- 250
Cdd:PRK02271 160 GPKMLELAGEIADGVLINASNPKDF--EWAVPLIKKGAEEAGKSRGEFDVAAYASVSVDKDEDKAREAAKpvvaFIAags 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500101966 251 -PLSLtaeQKHSIdDPIEMEKAADALP-------IEQVAKRWI----VASDPDEAVAKVKDYVDWGLNHLVFHAP 313
Cdd:PRK02271 238 pPPVL---ERHGI-DLEAVEKIGEALSkgdfgeaFGAVTDEMIdafsIAGTPEDVVEKIEALLEMGVTQIVAGSP 308
Tetrahydromethanopterin_reductase cd01097
N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5, ...
 4-220 5.38e-28

N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420.


Pssm-ID: 238530 [Multi-domain]  Cd Length: 202  Bit Score: 107.87  E-value: 5.38e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   4 LKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSdhfqpwrhegghapfslawmtavgertkrlqlgtsvltptfrynp 83
Cdd:cd01097    1 MRFGIFLSPEQPGPRELVELARAAEEAGFDSVWVS--------------------------------------------- 35

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  84 aviaqafatMGCLYPGRIFLGVGTGEALNEIATGyeGDWPEFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASIY 163
Cdd:cd01097   36 ---------LDALSGGRFILGLGAGGPEVEEGWG--GPWFKPPARRREELEAIRRLRALRRGDPVGEDGRFLGTRSAALP 104

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500101966 164 DVPEGGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELykDKLIPAMREGAEAAGK 220
Cdd:cd01097  105 PPPRGEIPIYIGALGPKMLELAGEIADGWLPVAAPPELY--EAALPAVREGAAAAGR 159
 
Name Accession Description Interval E-value
F420_G6P_DH TIGR03554
glucose-6-phosphate dehydrogenase (coenzyme-F420); This family consists of the F420-dependent ...
 3-333 0e+00

glucose-6-phosphate dehydrogenase (coenzyme-F420); This family consists of the F420-dependent glucose-6-phosphate dehydrogenase of Mycobacterium and Nocardia. It shows homology to several other F420-dependent enzymes rather than to the NAD or NADP-dependent glucose-6-phosphate dehydrogenases. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 213827  Cd Length: 331  Bit Score: 705.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966    3 ELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTKRLQLGTSVLTPTFRYN 82
Cdd:TIGR03554   1 ELKLGYKASAEQFAPRELVELAVLAEAHGMDSATVSDHFQPWRHQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   83 PAVIAQAFATMGCLYPGRIFLGVGTGEALNEIATGYEGDWPEFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASI 162
Cdd:TIGR03554  81 PAVIAQAFATMGCLYPGRVFLGVGTGEALNEIATGYQGEWPEFKERFARLRESVRLMRELWTGDRVDFDGEYYRTKGASI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  163 YDVPEGGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELYKDKLIPAMREGAEAAGKNPDDIDRMIEIKISYDTDPELA 242
Cdd:TIGR03554 161 YDVPEGGVPVYIAAGGPVVAKYAGRAGDGFICTSGKGEELYTEKLMPAVAEGAAKADRDVDSIDKMIEIKISYDTDPELA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  243 LENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVAKVKDYVDWGLNHLVFHAPGHDQRRFLE 322
Cdd:TIGR03554 241 LENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVEQVGQYVDWGLNHLVFHAPGHDQRRFLE 320

                         330
                  ....*....|.
gi 500101966  323 LFRRDLEPRLR 333
Cdd:TIGR03554 321 LFQRDLAPRLR 331
F420_G6P_family TIGR03557
F420-dependent oxidoreductase, G6PDH family; Members of this protein family include ...
 7-333 2.68e-85

F420-dependent oxidoreductase, G6PDH family; Members of this protein family include F420-dependent glucose-6-phosphate dehydrogenases (TIGR03554) and related proteins. All members of this family come from species that synthesize coenzyme F420, with the exception of those that belong to TIGR03885, a clade within this family in which cofactor binding may instead be directed to FMN. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274645  Cd Length: 316  Bit Score: 260.01  E-value: 2.68e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966    7 GYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTKRLQLGTSVLTPTFRYNPAVI 86
Cdd:TIGR03557   2 GYFLMCEQSGPRELVRQAVAAEQAGFDFLWISDHFHPWLDEQGHSPFVWSVLGALAQATERLPLTTAVTCPTMRYHPAIV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   87 AQAFATMGCLYPGRIFLGVGTGEALNEIATGyeGDWPEFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASIYDVP 166
Cdd:TIGR03557  82 AQAAATSAVLSDGRFTLGLGSGENLNEHVVG--DGWPSVDVRLEMLREAVEIIRELWQGGYVDHRGKHYTVDSARLYDLP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  167 EGGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEelykdkLIPAMREGAEAAGKnpddidRMIEIKISYDTDPELALENT 246
Cdd:TIGR03557 160 EEPPPIGVSAFGPRAVRLAARIGDGLIATEPDAD------LVEAFREAGGGGKP------VQGQVPVCWDPDEDAAVKTA 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  247 -RFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVAKVKDYVDWGLNHLVFHAPGHDQRRFLELFR 325
Cdd:TIGR03557 228 hRQFRWFALGWKVNQELPTPAHFAAATQLVREEDVAASIPCGPDPDRHVEAVREYVDAGFDEVALVQIGPDQDGFFDFYA 307


                  ....*...
gi 500101966  326 RDLEPRLR 333
Cdd:TIGR03557 308 TELLPALR 315
Bac_luciferase pfam00296
Luciferase-like monooxygenase;
11-307 1.97e-71

Luciferase-like monooxygenase;


Pssm-ID: 425589 [Multi-domain]  Cd Length: 313  Bit Score: 224.16  E-value: 1.97e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   11 SAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWrheggHAPFSLAWMTAVGERTKRLQLGTSVLTPTFRyNPAVIAQAF 90
Cdd:pfam00296  16 GAGSESLRYLVELARAAEELGFDGVWLAEHHGGP-----GGPDPFVVLAALAAATSRIRLGTAVVPLPTR-HPAVLAEQA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   91 ATMGCLYPGRIFLGVGTGEALNEIATGyeGDwpEFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASIYDVPEGGI 170
Cdd:pfam00296  90 ATLDHLSGGRFDLGLGTGGPAVEFRRF--GV--DHDERYARLREFLEVLRRLWRGEPVDFEGEFFTLDGAFLLPRPVQGI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  171 PIYIAAGGPQVAKYAGRAGDGFICTSGKGEELYKDkLIPAMREGAEAAGKNPDDIDRMIEIKISYDTDPELALENTR-FW 249
Cdd:pfam00296 166 PVWVAASSPAMLELAARHADGLLLWGFAPPAAAAE-LIERVRAGAAEAGRDPADIRVGASLTVIVADTEEEARAEARaLI 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  250 APLS------------LTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVaSDPDEAVAKVKDYVDWGLNH 307
Cdd:pfam00296 245 AGLPfyrmdsegagrlAEAREIGEEYDAGDWAGAADAVPDELVRAFALV-GTPEQVAERLAAYAEAGVDH 313
SsuD COG2141
Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase ...
 27-334 1.89e-67

Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) [Coenzyme transport and metabolism, General function prediction only]; Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441744 [Multi-domain]  Cd Length: 301  Bit Score: 213.64  E-value: 1.89e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  27 AEEHGMDSATVSDHFQPWrheGGHAPFSLAWMTAVGERTKRLQLGTSVLTPTFRyNPAVIAQAFATMGCLYPGRIFLGVG 106
Cdd:COG2141    1 AERLGFDRVWVADHHFPP---GGASPDPWVLLAALAAATSRIRLGTGVVVLPLR-HPLVVAEQFATLDHLSGGRLDLGVG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966 107 TGEALNEIAT-GYEgdwpeFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASIYDVPEGG--IPIYIAAGGPQVAK 183
Cdd:COG2141   77 RGWGPDEFAAfGLD-----HDERYERFEEALEVLRRLWTGEPVTFEGEFFTVEGARLVPRPVQGphPPIWIAGSSPAGAR 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966 184 YAGRAGDGFICTSGKGEELykDKLIPAMREGAEAAGKNPDDIDRMIEIKISYDTDPELALENTRFW----APLSLTAEQK 259
Cdd:COG2141  152 LAARLGDGVFTAGGTPEEL--AEAIAAYREAAAAAGRDPDDLRVSVGLHVIVAETDEEARERARPYlralLALPRGRPPE 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500101966 260 HSIDDPIEMEKAADALpieqvakRWIVASDPDEAVAKVKDYVDW-GLNHLVFHAPGHD---QRRFLELFRRDLEPRLRK 334
Cdd:COG2141  230 EAEEGLTVREDLLELL-------GAALVGTPEQVAERLEELAEAaGVDEFLLQFPGLDpedRLRSLELFAEEVLPLLRR 301
F420_Rv2161c TIGR03619
probable F420-dependent oxidoreductase, Rv2161c family; Coenzyme F420 has a limited ...
 21-226 8.24e-34

probable F420-dependent oxidoreductase, Rv2161c family; Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274680 [Multi-domain]  Cd Length: 246  Bit Score: 124.68  E-value: 8.24e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   21 VELAVAAEEHGMDSATVSDH-------FQPWRHEGGHAPFS-----LAWMTAVGERTKRLQLGTSVLTPTFRyNPAVIAQ 88
Cdd:TIGR03619   1 AELARAAEELGFDSLLAYEHvaiparrETPWPDSGGGDAPDrtldpFVALAFAAAVTSRLRLGTGVLVLPQR-DPLLLAK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   89 AFATMGCLYPGRIFLGVGTGEALNEI-ATGYEgdwpeFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASIYDVPE 167
Cdd:TIGR03619  80 QAATLDLLSGGRLRLGVGVGWLREEFrALGVD-----FDERGRLLDEAIEALRALWTQDPVSFHGEFVDFDPAVVRPKPV 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  168 -GGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELykDKLIPAMREGAEAAGKNPDDID 226
Cdd:TIGR03619 155 qRPPPIWIGGNSEAALRRAARLGDGWMPFGPPVDRL--AAAVARLRDLAAAAGRDPDAVE 212
PRK02271 PRK02271
methylenetetrahydromethanopterin reductase; Provisional
 19-313 3.76e-28

methylenetetrahydromethanopterin reductase; Provisional


Pssm-ID: 235022 [Multi-domain]  Cd Length: 325  Bit Score: 111.57  E-value: 3.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  19 ELVELAVAAEEHGMDSATVSDHFQPwRHegghaPFSLawMTAVGERTKRLQLGTSVLTPtFRYNPAVIAQAFATMGCLYP 98
Cdd:PRK02271  15 KIAYLAKLAEDNGFDYAWITDHYNN-RD-----VYMT--LAAIAAATDTIKLGPGVTNP-YTRHPAITASAIATLDEISG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  99 GRIFLGVGTGEALNEIATGYEGDWPefkerYARLRESVRLMRDLWLGDRVDFEGEYyKTKGASI-YDVPEGGIPIYIAAG 177
Cdd:PRK02271  86 GRAVLGIGPGDKATLDALGIEWEKP-----LRTVKEAIEVIRKLWAGERVEHDGTF-KAAGAKLnVKPVQGEIPIYMGAQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966 178 GPQVAKYAGRAGDGFICTSGKGEELykDKLIPAMREGAEAAGKNPDDIDRMIEIKISYDTDPELALENTR----FWA--- 250
Cdd:PRK02271 160 GPKMLELAGEIADGVLINASNPKDF--EWAVPLIKKGAEEAGKSRGEFDVAAYASVSVDKDEDKAREAAKpvvaFIAags 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500101966 251 -PLSLtaeQKHSIdDPIEMEKAADALP-------IEQVAKRWI----VASDPDEAVAKVKDYVDWGLNHLVFHAP 313
Cdd:PRK02271 238 pPPVL---ERHGI-DLEAVEKIGEALSkgdfgeaFGAVTDEMIdafsIAGTPEDVVEKIEALLEMGVTQIVAGSP 308
Tetrahydromethanopterin_reductase cd01097
N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5, ...
 4-220 5.38e-28

N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420.


Pssm-ID: 238530 [Multi-domain]  Cd Length: 202  Bit Score: 107.87  E-value: 5.38e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   4 LKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSdhfqpwrhegghapfslawmtavgertkrlqlgtsvltptfrynp 83
Cdd:cd01097    1 MRFGIFLSPEQPGPRELVELARAAEEAGFDSVWVS--------------------------------------------- 35

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  84 aviaqafatMGCLYPGRIFLGVGTGEALNEIATGyeGDWPEFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASIY 163
Cdd:cd01097   36 ---------LDALSGGRFILGLGAGGPEVEEGWG--GPWFKPPARRREELEAIRRLRALRRGDPVGEDGRFLGTRSAALP 104

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500101966 164 DVPEGGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELykDKLIPAMREGAEAAGK 220
Cdd:cd01097  105 PPPRGEIPIYIGALGPKMLELAGEIADGWLPVAAPPELY--EAALPAVREGAAAAGR 159
Alkanesulfonate_monoxygenase cd01094
Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the ...
 20-231 5.24e-19

Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).


Pssm-ID: 238527 [Multi-domain]  Cd Length: 244  Bit Score: 84.63  E-value: 5.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  20 LVELAVAAEEHGMDSATVsdhfqPWrHEGGHAPFSLAWmtAVGERTKRLQLGTSVLTPTfrYNPAVIAQAFATMGCLYPG 99
Cdd:cd01094   30 NRQIAQAAEELGFDGALS-----PT-GSSGPDGWTVAA--ALAAATERLKFLVAIRPGL--IAPTVAARQAATLDHISGG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966 100 RIFLGVGTGEalNEIATGYEGDWPEFKERYARLRESVRLMRDLWLGD-RVDFEGEYYKTKGASIY--DVPEGGIPIYIAA 176
Cdd:cd01094  100 RLGLNVVTGG--DPAELRMDGDFLDHDERYARADEFLEVLRRLWTSDePFDFEGKFYRFKNAFLRpkPPQQPHPPIYFGG 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 500101966 177 GGPQVAKYAGRAGDGFICTSGKGEELykDKLIPAMREGAEAAGKNPDDIDRMIEI 231
Cdd:cd01094  178 SSEAAIEFAARHADVYFTWGEPPAQV--AEAIARVRAAAAAAGRDVRFGIRLHVI 230
oxido_grp_1 TIGR03558
luciferase family oxidoreductase, group 1; The Pfam domain family pfam00296 is named for ...
 18-106 9.43e-06

luciferase family oxidoreductase, group 1; The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274646 [Multi-domain]  Cd Length: 323  Bit Score: 46.71  E-value: 9.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966   18 RELVELAVAAEE-----------HGMDSATVSdhfqpwrhegghAPFSLawMTAVGERTKRLQLGT-SVLTPtfRYNPAV 85
Cdd:TIGR03558  20 RNTVELAQHAERlgyhrfwvaehHNMPGIASS------------APEVL--IGHIAAATSRIRVGSgGVMLP--NHSPLK 83

                          90       100
                  ....*....|....*....|.
gi 500101966   86 IAQAFATMGCLYPGRIFLGVG 106
Cdd:TIGR03558  84 VAEQFGTLEALYPGRIDLGLG 104
Nitrilotriacetate_monoxgenase cd01095
nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin ...
 15-143 1.36e-04

nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2.


Pssm-ID: 238528 [Multi-domain]  Cd Length: 358  Bit Score: 43.08  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  15 FAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHA-----PFSLAwmTAVGERTKRLQLGTSVLTpTFrYNPAVIAQA 89
Cdd:cd01095   27 IDFDHYVRLARTAERAKFDAVFLADGLAIRALSRPHPvarlePLTLL--AALAAVTERIGLVATAST-TY-NEPYHLARR 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 500101966  90 FATMGCLYPGRIFLGVGT----GEALNeiaTGYEGDwPEFKERYARLRESVRLMRDLW 143
Cdd:cd01095  103 FASLDHISGGRAGWNVVTsanpGEARN---FGRDEH-PEHDERYARAEEFVEVVKGLW 156
PRK10508 PRK10508
luciferase-like monooxygenase;
65-106 4.38e-04

luciferase-like monooxygenase;


Pssm-ID: 182505 [Multi-domain]  Cd Length: 333  Bit Score: 41.69  E-value: 4.38e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 500101966  65 TKRLQLGTS-VLTPTfrYNPAVIAQAFATMGCLYPGRIFLGVG 106
Cdd:PRK10508  71 TTTLHLGSGgVMLPN--HSPLVIAEQFGTLNTLYPGRIDLGLG 111
PRK00719 PRK00719
alkanesulfonate monooxygenase; Provisional
 83-220 7.40e-04

alkanesulfonate monooxygenase; Provisional


Pssm-ID: 234821 [Multi-domain]  Cd Length: 378  Bit Score: 41.09  E-value: 7.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966  83 PAVIAQAFATMGCLYPGRIFLGVGTGEALNEIATgyEGDWPEFKERYARLRESVRLMRDLWLGDRVDFEGEYYKTKGASI 162
Cdd:PRK00719  83 PTVAARMAATLDRLSNGRLLINLVTGGDPAELAG--DGLFLDHDERYEASAEFLRIWRRLLEGETVDFEGKHIQVKGAKL 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 500101966 163 Y--DVPEGGIPIYIAAGGPQVAKYAGRAGDGFIcTSGKGEELYKDKlIPAMREGAEAAGK 220
Cdd:PRK00719 161 LfpPVQQPYPPLYFGGSSDAAQELAAEQVDLYL-TWGEPPAQVKEK-IEQVRAKAAAHGR 218
Flavin_utilizing_monoxygenases cd00347
Flavin-utilizing monoxygenases
 170-219 1.09e-03

Flavin-utilizing monoxygenases


Pssm-ID: 238209 [Multi-domain]  Cd Length: 90  Bit Score: 37.73  E-value: 1.09e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 500101966 170 IPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELYKDkLIPAMREGAEAAG 219
Cdd:cd00347   41 VAIWFGGSSPPVAEQAGESGDGLLFAAREPPEEVAE-ALARYREAAAAAG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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